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Search Results: 1 - 10 of 18456 matches for " Ali MousaviZadeh "
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High-tech biomedical research: lessons from Iran's experience
Ali Samadikuchaksaraei, Kazem Mousavizadeh
BioMedical Engineering OnLine , 2008, DOI: 10.1186/1475-925x-7-17
Abstract: Biomedical research activities in Iran have significantly increased in recent years. Several factors contribute to such improvement. For example, research budget allocated to the health sector that was 5% of total public funding in research in 1997[1] was increased to 9% in 2005[2]. Additionally, employment of faculty members for health research and education that was 9 783 faculties in 1999[1] was increased to 11 050 in 2002[2]. Furthermore, 4 biomedical research centers throughout the country in 1997 have been increased to 64 in 2006[3]. Moreover, the number of Iranian articles indexed under PubMed showing 19 times increase from 1997 through 2006 is another sign of a forward movement.These developments are the results of highly coordinated efforts of Iranian biomedical research community. This community is expanding its research capabilities and activities over a range of subjects, ranging from epidemiological studies to high-tech medical interventions, to address the national health problems. Iranian scientists have succeeded to set up numerous high-tech research centers and start projects in technologically advanced fields including stem cell biology and cell therapy, tissue engineering, monoclonal antibody, recombinant drugs and proteins, radiobiology, and nanobiotechnology.The high-tech Iranian research initiative is intended to build a strong national infrastructure to assist country's development in health sector. Any new initiative might face potential pitfalls and inherent obstacles. Therefore, it would be valuable to review the current impediments to the progress of high-tech biomedical research in Iranian setting and consider such drawbacks for troubleshooting purposes. For careful assessment of such progress, it is important to consider fundamental factors upon which Iran's new high-tech biomedical research is developing.Amongst several components that constitute the research infrastructure, two main areas in Iran's research infrastructure need particul
Prevalence of Asthma in Elementary School Age Children in Iran- A Systematic Review and Meta Analysis Study
Abolfazl Mohammadbeigi,Jafar Hassanzadeh,Ali Mousavizadeh
Pakistan Journal of Biological Sciences , 2011,
Abstract: Asthma is a common chronic disease of childhood which causes considerable morbidity. Asthma affects 1 in 13 school-age children and is a leading cause of office and emergency department visits, hospitalizations, and school absenteeism. Estimating the prevalence of asthma in the community is important in assessing the impact of asthma at the level of population. Since the pooled prevalence of asthma in Iranian elementary school age children (6-12 years old) was not identified, we decide to conduct a meta-analysis study to estimate the prevalence of asthma in elementary school age children in Iran. In order to gather the data, we searched a number of international electronic sources such as Pub Med, Embase, science direct, and ISI for English articles, and Iranian National Knowledge Infrastructure (scientific information) sources such as Iranmedx, Iran-doc, and SID for Persian articles from February 1995 to January 2010 to access the data. We used the words childhood, asthma, prevalence, and Iranian for searching relevant papers and used a data extraction form for the extracted data. The outcome in this Meta analysis study was response to the question, Ever had asthma, based on the ISSAC program questionnaire. Eleven relevant articles were included for the Meta analysis. The pooled prevalence for girls, boys, and the two genders was obtained as 3.2% (CI; 2.5 to 3.9%), 4.3% (CI; 3.5 to 5.1%) and 3.9% (CI; 3.2 to 4.7%), respectively. The pooled prevalence of asthma in Iranian elementary school age children is low in comparison to the other reports.
General Versus Spinal Anesthesia in Percutaneous Nephrolithotomy
Sadrollah Mehrabi,Ali MousaviZadeh,Mehdi AkbartabarToori,Farhad Mehrabi
Urology Journal , 2013,
Abstract: PURPOSE:To compare efficacy and complications of spinal anesthesia versus general anesthesia in percutaneous nephrolithotomy (PCNL).MATERIALS AND METHODS:In a prospective randomized study, 110 patients were randomly assigned into two groups for PCNL; group 1 (n = 52) underwent general anesthesia and group 2 (n = 58) received spinal anesthesia. In group 1, PCNL was performed using standard technique under general anesthesia. In group 2, spinal anesthesia was done by injecting bupivacaine and fentanyl in spinal space L4 in sitting position. Thereafter, a urethral catheter was placed in lithotomy position, head of the bed was tilted down for 5 to 10 minutes, and the level of anesthesia was checked. Then, PCNL was done by standard technique. Complications were recorded and analyzed by SPSS software using Chi-Square and Student’s t tests.RESULTS: Mean stone size in groups 1 and 2 was 34.2 ± 9.8 mm and 31.3 ± 7.9 mm, respectively. Intra-operative hypotension and postoperative headache and low back pain were more in spinal group than the general group with a significant difference (P< .05). No neurologic complication was observed in both groups. Need to narcotic medications on the day of operation in groups 1 and 2 was 12.4 ± 3.1 mg and 7.8 ± 2.3 mg of morphine sulphate, respectively (P = .03). The cost of anesthetic drugs was 23±3.7 US $ and 4.5 ± 1.3 US $ in groups 1 and 2, respectively (P = .001).CONCLUSION:Spinal anesthesia with combined bupivacaine and fentanyl is a safe, effective, and cost-effective method for performing PCNL in adult patients.
Evaluation of Bcl-2 Family Gene Expression in Hippocampus of 3, 4-methylenedioxymethamphetamine Treated Rats
Sara Soleimani Asl,Mohammad Hassan Farhadi,Kazem Mousavizadeh,Ali Samadikuchaksaraei
Cell Journal , 2012,
Abstract: Objective: 3,4-methylenedioxymethamphetamine (MDMA) is an illicit, recreational drugthat causes cellular death and neurotoxicity. This study evaluates the effects of differentdoses of MDMA on the expression of apoptosis–related proteins and genes in the hippocampusof adult rats.Materials and Methods: In this expremental study,a total of 20 male Sprague Dawley rats(200-250 g ) were treated with MDMA (0, 5, 10, 20 mg/kg i.p. twice daily) for 7 days. Sevendays after the last administration of MDMA, the rats were killed. Bax and Bcl-2 genesin addition to protein expressions were detected by western blot and reverse transcriptionpolymerasechain reaction (RT-PCR).Results were analyzed using one-way ANOVA andp≤0.05 was considered statistically significant.Results: Our results showed that MDMA caused dose dependent up-regulation of Baxand down-regulation of Bcl-2 in the hippocampus. There was a significant alteration inbcl-2 and bax genes density.Conclusion: Changes in apoptosis-related proteins and respective genes relating to Baxand Bcl-2 might be involved in the molecular mechanism of MDMA-induced apoptosis.
Annual International Geographic Medicine Congress Meetings in Shiraz, Iran: Publication Rates during 1999-2006
Forouz Nader,Kazem Mousavizadeh,Pedram Ghafourifar
International Journal of Biomedical Science , 2009,
Abstract: The present study aimed to examine which portion of abstracts presented between 1999 to 2006 at Annual International Geographic Medicine Congress meetings in Shiraz, Iran, were published during 1999-2006, and to identify factors affecting publication rate of those abstracts. Two hundred fifty abstracts were reviewed and categorized according to the type of presentation, study design, sample size, main findings, source of funding, and statistical significance of the results. Principal investigators of those abstracts were provided with a questionnaire inquiring whether their abstracts lead to full-length publications in peer-reviewed journals indexed under PubMed. One hundred twenty five authors responded to the questionnaire. The publication rate of the meeting presentations was found 27.2%. Statistically significant associations were found between publication rate and certain characteristics of the presentations including type of the study, achieving positive results, and conducting multi-center trial funded by a sponsor. Insufficient fluency in English, insufficient time to prepare the manuscript, and assuming journals are unlikely to accept those studies were most common reasons for not preparing or submitting the manuscripts. The publication rate of research studies presented in this annual scientific meeting in Shiraz, Iran, is lower than many similar meetings in other countries.
G Proteins and Regulation of Effector Function
A.R. Dehpour,?K. Mousavizadeh
DARU : Journal of Pharmaceutical Sciences , 1991,
Abstract: Cell surface receptors use a variety of membrane signalling mechanisms to translate information encoded in neurotransmitters, hormones, and growth factors into cellular responses.Collectively these mechanisms are refered to as transmembrane signalling or signal transduction. In the simplest example,the process involves a receptor protein-encompassed ion channel whose conductance is regulated by receptor activation.A second type of transmembrane signalling system involves the coupling of at least three separate components, a receptor protein, a guanine nucleotide binding protein (G protein) , and an effector mechanism. In some receptor" effector systems the signal transduction pathways is entirely confined to the membrane, in which no intracellular messenger is involved.Alternatively, the activity of an enzyme may be changed to generate a specific intracellular signal molecule or second messenger. Receptors in this latter category may regulate the activity of adenylyl cyclase in a positive manner through a stimulatory G protein( G ) or in a negative manner through an inhibitory G protein( G. ) thereby controlling the intracellular level of cAMP. Another membrane- associated enzyme, similar to adenylate cyclase, is phospholipase C which catalizes the hydrolysis of PIP2into IP3and DAG. Phospholipase C coupled receptors are physiologically very important because both products of the reaction act as a second messenger; diacylglycerol activates protein kinase C and IP3 stimulates calcium release from Intracellular stores.
Prevalence and Severity of Carpal Tunnel Syndrome in Women
P Yazdanpanah,S Aramesh,A Mousavizadeh,P Ghaffari
Iranian Journal of Public Health , 2012,
Abstract: Background: Carpal tunnel syndrome (CTS) is entrapment of median nerve in carpal tunnel of the wrist. The prevalence of CTS related to pregnancy and non-pregnancy is unknown in some countries such as Iran. The main aim of this study was to determine the prevalence of CTS in women of Boyerahmad Township located in South-West part of Iran.Methods: This cross-sectional descriptive analytic study was done since February 2010 to January 2011 in Obstetrics and Gynecology clinics in 2656 non-pregnant and 1508 pregnant women. The women that had clinical symptoms of CTS performed standard electro diagnostic techniques for rule in or rule out of CTS.Results: The prevalence of CTS in pregnant and non- pregnant women was 3.4and 2 .3 percent respectively. The prevalence of CTS in all women was 2.7%. Overall, 51 pregnant women had CTS that 59.4% had mild, 18.8 % had moderate and 21.9% had severe CTS. Sixty-one non-pregnant women had CTS that 73.6 %had mild, 20.8 %t had moderate and 5.6 % had severe CTS."nConclusion: Although the prevalence of CTS in Iranian pregnancy is higher than non-pregnancy women conservative treatment is safe and more effective.
Retrospective study of factors related to preterm labor in Yasuj, Iran
Nabavizadeh SH,Malekzadeh M,Mousavizadeh A,Ghaffarian Shirazi HR
International Journal of General Medicine , 2012,
Abstract: Seyed Hesamedin Nabavizadeh,1 Mohammad Malekzadeh,2,* Ali Mousavizadeh,1 Hamid Reza Ghaffarian Shirazi,1 Parvin Ghaffari,1 Nooshin Karshenas,3 Tahmineh Malekzadeh,3 Mohammad Zoladl11Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran; 2Department of Psychology, Osmania University, Hyderabad, India; 3Students' Research Committee, Yasuj University of Medical Sciences, Yasuj, IranIntroduction: Premature labor is a serious worldwide problem that can cause neonatal death and other serious disorders. This study aimed to determine the most important factors related to preterm labor in Yasuj, Iran.Method: This case-control study was conducted in the maternity ward of Imam Sajjad Hospital, the obstetrics and gynecology center of Yasuj, in 2010. Among eligible samples, mothers with preterm labor were selected as the case group, and for each sample in the case group, one mother with full-term labor was selected by using clipper-matched sampling to make up the control group. Data were collected by a researcher-made questionnaire and the 28-item General Health Questionnaire. Finally, after deleting imperfect questionnaires, collected data of 52 subjects of case group and the same amount in control group were analyzed.Results: Among the 5400 live birth infants in Yasuj in 2010, 130 infants were premature (2.4%). The preterm labor risk in women with two or more pregnancies was 5.5 times more than women with less than two pregnancies, its risk in women with low general health status was 2.9 times more than in women with normal general health status, and the preterm labor risk in women with a history of diabetes mellitus/thyroid dysfunction/cardiac disease was 2.3 times more than healthy mothers (P < 0.01).Conclusion: With respect to the above and due to the role and importance of mother–infant health in community health, it is necessary that the health-care system improve health education with regard to the appropriate number of pregnancies, diagnose and cure disease during pregnancy, especially diabetes and cardiovascular disease (hypertension and/or eclampsia), and recognize pregnant mothers with mental pressure or lack of sufficient support and help them.Keywords: premature labor, general health, psychosomatic disorder, number of pregnancies
Cyclic Strain Alters the Expression and Release of Angiogenic Factors by Human Tendon Cells
Rouhollah Mousavizadeh, Shahram Khosravi, Hayedeh Behzad, Robert G. McCormack, Vincent Duronio, Alex Scott
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097356
Abstract: Angiogenesis is associated with the tissue changes underlying chronic overuse tendinopathy. We hypothesized that repetitive, cyclic loading of human tendon cells would lead to increased expression and activity of angiogenic factors. We subjected isolated human tendon cells to overuse tensile loading using an in vitro model (1 Hz, 10% equibiaxial strain). We found that mechanically stimulated human tendon cells released factors that promoted in vitro proliferation and tube formation by human umbilical vein endothelial cells (HUVEC). In response to cyclic strain, there was a transient increase in the expression of several angiogenic genes including ANGPTL4, FGF-2, COX-2, SPHK1, TGF-alpha, VEGF-A and VEGF-C, with no change in anti-angiogenic genes (BAI1, SERPINF1, THBS1 and 2, TIMP1-3). Cyclic strain also resulted in the extracellular release of ANGPTL4 protein by tendon cells. Our study is the first report demonstrating the induction of ANGPTL4 mRNA and release of ANGPTL4 protein in response to cyclic strain. Tenocytes may contribute to the upregulation of angiogenesis during the development of overuse tendinopathy.
Ultrastructural Identification of the Basal-Granulated Cells in the Duodenum of Albino Rat  [PDF]
Ali Hassan A. Ali
Open Journal of Gastroenterology (OJGas) , 2014, DOI: 10.4236/ojgas.2014.47041
Abstract: The fine structure of the crypt epithelium of the duodenal mucosa in albino rats was studied to represent the types and distribution of the basal-granulated or endocrine cells. Twenty male animals were used. Perfusion-fixation was made and samples of duodenal mucosa were taken and processed to prepare epon-embedded specimens for examination by a transmission electron microscope. Cells containing membrane-bound granules were seen in the crypt epithelium. They were identified to be basal-granulated cells. Six different types of such cells were demonstrated. All of the cells were of the closed type. The possible functional significance of these closed cell types was discussed. Correlation among the distributions of such cells in the intestine of albino rat might enable the physiologists, internists and other research workers to study several biologically active peptides with well-established functions other than those which have long been investigated.
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