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Search Results: 1 - 10 of 543 matches for " Alexandros Sarantopoulos "
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TRAF1/C5 rs3761847 SNP Is Associated with Severe Pattern of Rheumatoid Arthritis in Greek Patients  [PDF]
Alexandros Sarantopoulos, Ioannis Theodorou, Panagiota Boura
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2016, DOI: 10.4236/ojra.2016.61002
Abstract: The era of whole genome study analysis has introduced a profound research in the genetics of autoimmune diseases. Some of the new genetic loci that have been associated with the development or the severity of autoimmune diseases have been thoroughly studied, conferring a more detailed understanding of disease pathophysiology. Furthermore, single nucleotide polymorphisms (SNPs) have been described not only in coding regions of the human genome but also in non-coding areas (introns), the importance of which has not been yet clarified. Over the last years, such an SNP has been associated with the development of rheumatoid arthritis, the most frequent autoimmune disease. This SNP is at the position 122730060 of chromosome 9 in the TRAF1/C5 region and consists of a substitution of the nucleotide base guanine (G)—which is considered the ancestral phenotype— by alanine (A). It has been indicated that G is the aggravating nucleotide, and that G/G is the disease predisposing phenotype, conferring >1.3× risk for RA. On this background, we performed a genome study on a Greek population of northern Greece (Macedonia) in order to identify the association of this SNP with RA in our group.
Chronic Brucellosis Patients Retain Low Frequency of CD4+ T-Lymphocytes Expressing CD25 and CD28 after Escherichia coli LPS Stimulation of PHA-Cultured PBMCs
Panagiotis Skendros,Alexandros Sarantopoulos,Konstantinos Tselios,Panagiota Boura
Clinical and Developmental Immunology , 2008, DOI: 10.1155/2008/327346
Abstract: Chronic brucellosis patients display a defective Th1 response to PHA. We have previously shown that heat-killed B. abortus (HKBA) can downregulate the PHA-induced increase of CD4
Influenza A/H1N1 septic shock in a patient with systemic lupus erythematosus. A case report
Konstantinos Tselios, Ritsa Tsioka, Alexandros Sarantopoulos, Eleni Mouloudi, Panagiota Boura
BMC Infectious Diseases , 2011, DOI: 10.1186/1471-2334-11-358
Abstract: In this case report, an SLE patient with viral-induced septic shock, without overt pulmonary involvement, is discussed. The patient was administered oseltamivir and supportive treatment, including wide-spectrum antibiotics, vasopressors and steroids, according to the guidelines proposed for bacterial sepsis and septic shock. She finally survived and experienced a lupus flare soon after intensive care unit (ICU) discharge.To our knowledge, this is the first case to report severe septic shock from influenza A/H1N1 virus, without overt pulmonary involvement.Infections are among the most important causes of morbidity and mortality in systemic lupus erythematosus (SLE). However, viruses are not considered to cause serious infections in these patients; they, usually, represent reactivation of herpes viruses, such as herpes simplex virus and varicella-zoster virus [1]. Nevertheless, it is reported that immunocompromised patients have an increased risk of mortality, following influenza infection [2].In the recent pandemic, influenza A H1N1 virus has been estimated to cause approximately 18.449 deaths in 214 different countries until August 1st 2010 [3]. Adult respiratory distress syndrome (ARDS), along with bacterial co-infections were the direct causes of death in most cases [4]. However, no cases of viral-induced septic shock without severe pulmonary involvement have been reported. Nevertheless, little is known about this infection in SLE patients [5]. Herein, we report a case of an SLE patient, who developed septic shock due to influenza A H1N1 infection, without acute lung injury.A 46-year old female was admitted to the hospital because of low-grade fever, sore throat and fatigue for four days; she was on clarithromycin 500 mg twice daily, as she was considered to suffer from upper respiratory tract infection by her general practitioner.The patient had a history of SLE for 24 years, antiphospholipid syndrome and autoimmune hypothyroidism. SLE was diagnosed in the backgr
Advances in the therapy of cancer pain: from novel experimental models to evidence-based treatments
Sarantopoulos, Constantine D.
Signa Vitae , 2007,
Abstract: Cancer related pain may be due to the malignant disease itself, or subsequent to treatments, such as surgery, chemotherapy or radiation therapy. The pathophysiology of pain due to cancer may be complex and include a variety of nociceptive, inflammatory, and neuropathic mechanisms. Despite modern advances in pharmacotherapy, cancer pain remains overall under-treated in a world-wide scale, and a main reason is lack of understanding of its pertinent pathophysiology and basic pharmacology. Recently, pertinent animal models have facilitated understanding of the pathobiology and have advanced the pharmacology of cancer pain, with significant translational applicability to clinical practice. Furthermore, quantitative and qualitative systematic reviews, integrating the best available evidence, indicate the validity of treatments that fit into an expanded view of the WHO-analgesic ladder. Appropriate current treatments include a valid therapeutic role of non-opioid and opioid analgesics, adjuvants -such as gabapentin, biphosphonates, palliative radiation therapy and radiopharmaceutical compounds, and interventional pain therapy (including neuraxial drug infusion and verterbroplasty for spine metastases) in selected patients. Overall, experimental animal models simulating cancer pain have been useful in providing pertinent information on the pathophysiology of cancer pain, and provide a testing ground for established and novel therapies, which are validated by clinical evidence. This is clinically significant, considering the epidemiological dimensions and the problematic nature of cancer pain.
Circle products as restrictions of the square product
V. Anagnostopoulos,Y. Sarantopoulos
Mathematics , 2011,
Abstract: We equip the tensor algebra of a vector space $U$ over the real or complex field with an alternative product. The new product has the property that if we specialize it to the symmetric tensor algebra becomes the circle product introduced by Brouder while specialization to the antisymmetric algebra becomes the circle product introduced by Rota and Stein. We prove some interesting properties of this product analogous to the properties proved by the previous authors. We use Hopf algebraic methods to simplify our results. Finally we prove that the classical algebraic structure of the tensor algebra and the new one are homomorphically isomorphic.\bigskip
The Nature of Economic Turbulence: The Power Destructing Economies, with Application to Shipping  [PDF]
Alexandros M. Goulielmos, Alexandros M. Goulielmos
Modern Economy (ME) , 2018, DOI: 10.4236/me.2018.95066
Abstract: Studying the history of “economic turbulence”, we ended up with the certainty that the statistical methods used so far, by economists, are unsuitable to model it. We have mainly the methods of Normal distribution and Random Walk in mind. Moreover, the picture of reality we get from time series depends on the time-frame of the data used… Different time-frame data, different reality… In addition, econometricians provided a whole family of econometric models to approach reality, starting in early 1980s, with “autoregressive models—AR” combined or not with MA (moving averages). But even its 1986 flagship, the GARCH, with its many variations, cannot cope with a number of characteristics, one of which is leptokurtosis (small alpha, higher peaks and long tails), though some argue that it can cater for outliers. Economic turbulence, low or high—despite its characterization by Science as rare—became frequent since 1987 (Black Monday)... In late 1990s e.g. the global financial system underwent 6 crises—which have been called “near turbulences”—over a number of countries, including Russia in 1998. The next turbulence will not be one generation apart—we reckon. This paper is an attempt to invite writers to write a “theory of economic turbulence”. Turbulence is a nightmare, which wakes people up suddenly, and unexpectedly, but it is something people wish to forget… till it strikes again: turbulence stroke in 1929 on (Black) Tuesday, then in 1987 on (Black) Monday and in end-2008, the Great Recession—on 29th September. In Black Monday stock markets around the world crashed losing a huge value in a matter of very short time (Hong Kong, Europe, and USA). The Dow fell ~23%. At that time OPEC collapsed in 1986 and the price of oil doubled… The dry cargo shipping sector entered a turbulent situation since 1989, which has been deteriorated since 2015 reaching finally an alpha equal to ~1.43 < 1.70 by 2035…
The Impact of an Environmental Educational Program of a School Garden on Pupils with Intellectual Disabilities—A Comparative Approach  [PDF]
Alexandros Stavrianos, Alexia Spanoudaki
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.34005
Abstract: The following research describes an attempt to combine environmental education through outdoor activities in Special Education. It examines the use of a school garden as a learning environment in Special Education by looking at the stances and opinions of 10 pupils, diagnosed with mild to moderate intellectual disability, towards Environmental Education and prognoses barriers that may occur in the learning process. Specifically, the study focuses on the skills and subject knowledge those students have cultivated through a project called “School Garden”, highlighting the ideas pupils have, regarding the position of environmental education in their school curriculum. Using descriptive statistical analysis to compare the two groups of pupils, this research suggests the further practice of Environmental Education in Special Education. The research took place in two Special Education Primary Schools in Greece, while the data were collected using semi-structured interviews. The main conclusions of the research were that students who participated in their school’s environmental educational program seem to be more familiarized with a range of concepts related to the environment and possess skills linked directly to Environmental Education in relation to their peers that did not engage in the project, while pupils who participated in the “School Garden”, unlike their peers, perceived outdoor activities of their school as part of the learning process, in formal education. This study proposes further research to take place in the area of Environmental Education and Special Education.
The Contribution of Management Commentary Index (Ma.Co.I) in Annual Banking Reports (ABR) and the Chronicle of the Great Greek Crisis  [PDF]
Alexandros Garefalakis, Augustinos Dimitras
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.65103
Abstract: The research explores the extent to which the implementation of International Financial Reporting Standards (IFRS) in the Greek banking sector has affected its financial and narrative reporting between the periods prior (2002-2004) and after (2005-2010) the implementation of the IFRS. In particular, we examine the relation between Price per Share (P), Earnings per Share (EPS) and the Book Value (BV) per share using data from listed banks of Athens Stock Exchange (ASE). Further, the change of the narrative reporting quality of the Greek banking sector is studied along with the key financial indicators trends between the two above periods. Moreover, we investigate the disclosure quality of narrative information of annual reports for the period after the Greek financial crisis (i.e. from 2008 to 2010). Finally, we assess the relation between the key financial indicators and Management Commentary (MC). The findings indicate a positive relationship between P, BV and EPS after the first period of IFRS adoption (i.e. from 2005 to 2007). In addition, we report that MC has been considerably improved in the same period, while a positive impact in the key financial Indicators has been observed. Furthermore, empirical evidence specifies that Debt tends to be the most important indicator of Management Commentary. Finally, in the beginning of Greek crisis period the disclosure quality of narrative portion of annual reports are lower except. An important innovative characteristic of the above results is that the Management Commentary Index (Ma.Co.I) is able to measure the actual quality of Annual Banking Reports (ABR) and provide a reliable and unique tool for the investors.
The “Kondratieff Cycles” in Shipping Economy since 1741 and till 2016  [PDF]
Alexandros M. Goulielmos
Modern Economy (ME) , 2017, DOI: 10.4236/me.2017.82022
Abstract: The theory of “long waves”, due to Russian economist Kondratieff, which appeared in the 1920s, is presented, and a search whether a similar pattern exists in shipping economy since 1741 is made. Kondratieff believed in the existence —inherent in capitalistic system—of at least 21/2 long cycles of a non-random duration of 54 years on average since 1780—with 27 years up and 27 years down. As we showed—using mainly a diagrammatic analysis—economic history verified—till end-2008—Kondratieff’s theories, though it rejected his claimed harmony in their duration. Given that history may be repeated, and only for this is useful, we tried a nonlinear dynamic forecasting model for dry cargo shipping market for 20 years ahead using “Rescaled Range Analysis” and “Kernel Density estimation method” and found that cycles are here to stay. Presented also is the merger-waves in capitalistic economies since 1893— a factor ignored by Joan Robinson in her macroeconomic analysis for the trade cycle in the 1960s. Further we confirm/reject previous analysts, including Schumpeter, who claimed: 1) that technology has created the long shipping cycles (since 1741); 2) that the impact of major wars since 1740 on freight markets was another cyclical cause; 3) that economies of scale play the significant role and 4) that the impact of risk emerged at a certain time though this outcome was too ignored by macroeconomists. The paper “discovered” the secular shipping cycles of a total duration of 139 years using the proper extra-long time data. This means that the discovery of unknown cycles is a matter of data’s longevity. We have also verified Kondratieff’s cycles—when data were divided in 3 separate technological periods: 1741-1871; 1872-1947 and 1947-today, but lasting longer i.e. 58 years on average. We saw that the great gift of capitalism, which is the “free will”, is to be accompanied by “rationality”, and by a deep knowledge of how capitalistic system functions—a warning placed by Kondratieff a century ago—so that to avoid crises like that at end-2008; also globalization has to be used for the benefit of all nations. This paper indicated new tools: the “Joseph effect”—for cycles and the “Hurst exponent” for
Strategies in “Shipping Business Management”  [PDF]
Alexandros M. Goulielmos
Modern Economy (ME) , 2017, DOI: 10.4236/me.2017.810083
Abstract: The paper deals with the tactics and strategies applied by global shipping companies. During current depression in the dry cargo sector, shipowners adopted two tactics: 1) to survive and 2) look after opportunities. Shipowners are mostly reactive-managers and apply Porter’s strategy of cost leadership mainly through economies of scale, cutting-down fleet’s average age as well total cost. This has been applied in the 1986 depression and in 2016 one. A short history of shipping business management showed a heavy reliance of managers on larger ships (par excellence up to 1973; and till today in a lesser degree). This needed 3 actions: 1) planning, 2) improved decision-making and 3) knowledge of finance.
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