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Search Results: 1 - 10 of 10520 matches for " Alexandre Dalet "
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Free spaces over some proper metric spaces
Aude Dalet
Mathematics , 2014,
Abstract: We prove that the Lipschitz-free space over a countable proper metric space is isometric to a dual space and has the metric approximation property. We also show that the Lipschitz-free space over a proper ultrametric space is isometric to the dual of a space which is isomorphic to c_0.
Free Spaces over Countable Compact Metric Spaces
Aude Dalet
Mathematics , 2013,
Abstract: We prove that the Lipschitz-free space over a countable compact metric space is isometric to a dual space and has the metric approximation property.
Induction of GADD34 Is Necessary for dsRNA-Dependent Interferon-β Production and Participates in the Control of Chikungunya Virus Infection
Giovanna Clavarino equal contributor,Nuno Cláudio equal contributor,Thérèse Couderc equal contributor,Alexandre Dalet,Delphine Judith,Voahirana Camosseto,Enrico K. Schmidt,Till Wenger,Marc Lecuit,Evelina Gatti ? ,Philippe Pierre ?
PLOS Pathogens , 2012, DOI: 10.1371/journal.ppat.1002708
Abstract: Nucleic acid sensing by cells is a key feature of antiviral responses, which generally result in type-I Interferon production and tissue protection. However, detection of double-stranded RNAs in virus-infected cells promotes two concomitant and apparently conflicting events. The dsRNA-dependent protein kinase (PKR) phosphorylates translation initiation factor 2-alpha (eIF2α) and inhibits protein synthesis, whereas cytosolic DExD/H box RNA helicases induce expression of type I-IFN and other cytokines. We demonstrate that the phosphatase-1 cofactor, growth arrest and DNA damage-inducible protein 34 (GADD34/Ppp1r15a), an important component of the unfolded protein response (UPR), is absolutely required for type I-IFN and IL-6 production by mouse embryonic fibroblasts (MEFs) in response to dsRNA. GADD34 expression in MEFs is dependent on PKR activation, linking cytosolic microbial sensing with the ATF4 branch of the UPR. The importance of this link for anti-viral immunity is underlined by the extreme susceptibility of GADD34-deficient fibroblasts and neonate mice to Chikungunya virus infection.
Characterization of metric spaces whose free space is isometric to $\ell_1$
Aude Dalet,Pedro L. Kaufmann,Antonín Procházka
Mathematics , 2015,
Abstract: We characterize metric spaces whose Lipschitz free space is isometric to $\ell_1$. In particular, the Lipschitz free space over an ultrametric space is not isometric to $\ell_1(\Gamma)$ for any set $\Gamma$. We give a lower bound for the Banach-Mazur distance in the finite case.
Editorial Special Issue on “Energetic Complementarity”  [PDF]
Alexandre Beluco
Energy and Power Engineering (EPE) , 2017, DOI: 10.4236/epe.2017.99033
Abstract: This editorial presents the motivations that were the focus of the papers that make up this Special Issue on energetic complementarity. The articles deal with the application of the concept of energetic complementarity in time under certain conditions and with the proposition of new means to evaluate complementarity in time between more than two renewable energy resources. An article further proposes a method for establishing energetic complementarity in space, a concept that is important and necessary for management and planning of energy resources but does not yet have tools that allow it to be quantified and handled appropriately. In addition, two letters to the editor discuss issues that still need to be matured for a better understanding and application of the concept of energetic complementarity, both in time and space.
Minamata Disease—Review  [PDF]
Alexandre Semionov
World Journal of Neuroscience (WJNS) , 2018, DOI: 10.4236/wjns.2018.82016
Abstract: Minamata disease is the name given to a neurological syndrome caused by or-ganic mercury intoxication. Most commonly it results from consumption of methylmercury contaminated seafood and in severe cases is classically mani-fested by concentric constriction of the visual fields, ataxia and sensory dis-turbance in the distal extremities. The radiographic and neuropathological find-ings parallel the clinical picture and typically consist of lesions selectively in-volving the visual cortex, cerebellum and postecentral gyri.
On Approximating the Gradient of the Value Function  [PDF]
Alexandre Dmitriev
Theoretical Economics Letters (TEL) , 2019, DOI: 10.4236/tel.2019.91011
Abstract:

The optimality conditions for macroeconomic problems with limited commitment often contain partial derivatives of the optimal value function, corresponding to the outside option. This paper contributes to the literature on recursive contracts by proposing an algorithm for approximating the gradient of the value function using simulation-based methods. Our method combines numerical solution and simulation of the model, Monte-Carlo integration and numerical differentiation. It does not suffer from the curse of dimensionality and is therefore convenient for models involving many state variables. The algorithm inherits the speed and accuracy limitations of the numerical solution method it relies on. Our accuracy analysis is limited to a few classical examples from macroeconomic literature.

Glutamate Transporters EAAT4 and EAAT5 Are Expressed in Vestibular Hair Cells and Calyx Endings
Antoine Dalet, Jérémie Bonsacquet, Sophie Gaboyard-Niay, Irina Calin-Jageman, Robstein L. Chidavaenzi, Stephanie Venteo, Gilles Desmadryl, Jay M. Goldberg, Anna Lysakowski, Christian Chabbert
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0046261
Abstract: Glutamate is the neurotransmitter released from hair cells. Its clearance from the synaptic cleft can shape neurotransmission and prevent excitotoxicity. This may be particularly important in the inner ear and in other sensory organs where there is a continually high rate of neurotransmitter release. In the case of most cochlear and type II vestibular hair cells, clearance involves the diffusion of glutamate to supporting cells, where it is taken up by EAAT1 (GLAST), a glutamate transporter. A similar mechanism cannot work in vestibular type I hair cells as the presence of calyx endings separates supporting cells from hair-cell synapses. Because of this arrangement, it has been conjectured that a glutamate transporter must be present in the type I hair cell, the calyx ending, or both. Using whole-cell patch-clamp recordings, we demonstrate that a glutamate-activated anion current, attributable to a high-affinity glutamate transporter and blocked by DL-TBOA, is expressed in type I, but not in type II hair cells. Molecular investigations reveal that EAAT4 and EAAT5, two glutamate transporters that could underlie the anion current, are expressed in both type I and type II hair cells and in calyx endings. EAAT4 has been thought to be expressed almost exclusively in the cerebellum and EAAT5 in the retina. Our results show that these two transporters have a wider distribution in mice. This is the first demonstration of the presence of transporters in hair cells and provides one of the few examples of EAATs in presynaptic elements.
A Magnetically Levitated Precise Pointing Mechanism for Application to Optical Communication Terminals  [PDF]
Thomas Edward Donaldson Frame, Alexandre Alexandre Pechev
Optics and Photonics Journal (OPJ) , 2012, DOI: 10.4236/opj.2012.22012
Abstract: Increasing data bandwidth requirements from spacecraft systems is beginning to pressure existing microwave communications systems. Free-Space optical communications allows for larger bandwidths for lower relative power consumption, smaller size and weight when compared to the microwave equivalent. However optical communication does have a formidable challenge that needs to be overcome before the advantages of the technology can be fully utilized. In order for the communication to be successful the transmitter and receiver terminals need to be pointed with a high accuracy (generally in the order of ≤10 μradians) for the duration of communication. In this paper we present a new concept for the precise pointing of optical communications terminals (termed the Precise Pointing Mechanism). In this new concept we combine the separate pointing mechanisms of a conventional optical terminal into a single mechanism, reducing the complexity and cost of the optical bench. This is achieved by electromagnetically actuating the whole telescope assembly in 6 degrees-of-freedom with an angular resolution of less than ±3 μradians within a 10 (Az. El.) field of view and linear resolution of ±2 μm. This paper presents the new pointing mechanism and discusses the modelling, simulation and experimental work undertaken using the bespoke engineering model developed.
Bounds for Goal Achieving Probabilities of Mean-Variance Strategies with a No Bankruptcy Constraint  [PDF]
Alexandre Scott, Francois Watier
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.312A278
Abstract:

We establish, through solving semi-infinite programming problems, bounds on the probability of safely reaching a desired level of wealth on a finite horizon, when an investor starts with an optimal mean-variance financial investment strategy under a non-negative wealth restriction.

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