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Search Results: 1 - 10 of 209666 matches for " Alexander D Simms "
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Acute coronary syndromes: an old age problem
Alexander D Simms,Philip D Batin,John Kurian,Nigel Durham
老年心脏病学杂志(英文版) , 2012,
Abstract: The increasing population in older age will lead to greater numbers of them presenting with acute coronary syndromes (ACS). This has implications on global healthcare resources and necessitates better management and selection for evidenced-based therapies. The elderly are a high risk group with more significant treatment benefits than younger ACS. Nevertheless, age related inequalities in ACS care are recognised and persist. This discrepancy in care, to some extent, is explained by the higher frequency of atypical and delayed presentations in the elderly, and less diagnostic electrocardiograms at presentation, potentiating a delay in ACS diagnosis. Under estimation of mortality risk in the elderly due to limited consideration for physiological frailty, co-morbidity, cognitive/psychological impairment and physical disability, less input by cardiology specialists and lack of randomised, controlled trials data to guide management in the elderly may further confound the inequality of care. While these inequalities exist, there remains a substantial opportunity to improve age related ACS outcomes. The selection of elderly patients for specific therapies and medication regimens are unanswered. There is a growing need for randomised, controlled trial data to be more representative of the population and enroll those of advanced age with co-morbidity. A lack of reporting of adverse events, such as renal impairment post coronary angiography, in the elderly further limit risk benefit decisions. Substantial improvements in care of elderly ACS patients are required and should be advocated. Ultimately, these improvements are likely to lead to better outcomes post ACS. However, the improvement in outcome is not infinite and will be limited by non-modifiable factors of age-related risk.
Acute coronary syndromes: an old age problem

Alexander D Simms,Philip D Batin,John Kurian,Nigel Durham,Christopher P Gale,

老年心脏病学杂志(英文版) , 2012,
Abstract: The increasing population in older age will lead to greater numbers of them presenting with acute coronary syndromes (ACS). This has implications on global healthcare resources and necessitates better management and selection for evidenced-based therapies. The elderly are a high risk group with more significant treatment benefits than younger ACS. Nevertheless, age related inequalities in ACS care are recognised and persist. This discrepancy in care, to some extent, is explained by the higher frequency of atypical and delayed presentations in the elderly, and less diagnostic electrocardiograms at presentation, potentiating a delay in ACS diagnosis. Under estimation of mortality risk in the elderly due to limited consideration for physiological frailty, co-morbidity, cognitive/psychological impairment and physical disability, less input by cardiology specialists and lack of randomised, controlled trials data to guide management in the elderly may further confound the inequality of care. While these inequalities exist, there remains a substantial opportunity to improve age related ACS outcomes. The selection of elderly patients for specific therapies and medication regimens are unanswered. There is a growing need for randomised, controlled trial data to be more representative of the population and enroll those of advanced age with co-morbidity. A lack of reporting of adverse events, such as renal impairment post coronary angiography, in the elderly further limit risk benefit decisions. Substantial improvements in care of elderly ACS patients are required and should be advocated. Ultimately, these improvements are likely to lead to better outcomes post ACS. However, the improvement in outcome is not infinite and will be limited by non-modifiable factors of age-related risk.
Potential Compressive Sites of the Anterior Interosseous Nerve in the Proximal Forearm: An Anatomic Study  [PDF]
Laurent Mathieu, Eric R. Simms, Frédéric Rongiéras, Eric J. Voiglio, Christophe Oberlin
Open Journal of Orthopedics (OJO) , 2012, DOI: 10.4236/ojo.2012.24031
Abstract:

Background: The etiology and treatment of spontaneous paralysis variants of anterior interosseous nerve (AIN) syndrome remains controversial. Variation and multiple sites of potential compression complicate the successful performance of neurolysis. This anatomic study of the AIN and sites of potential compression in the proximal forearm facilitates critical steps involved in neurolytic procedures and management. Methods: Upper extremities of twelve cadavers were examined to evaluate potential sites of AIN compression in the proximal forearm. Potential sites of musculoaponeurotic compression were evaluated, including: lacertus fibrosus; inferior fibrous arch of the humeral head of the pronator teres (PT) muscle; inferior fibrous arch of the ulnar head of the PT muscle; fibrous arch in the flexor digitorum superficialis (FDS) muscle; Gantzers muscle; and vascular structures near the AIN and median nerve. Results: The AIN arose at a mean distance of 54.5 mm distal to the elbow from the posterior (n = 9) or ulnar side (n = 3) of the median nerve. Relative positions of AIN branches were variable. A fibrous arch was found between the lacertus fibrosus and the PT in two cases. Nine cadavers had two fibrous arches in the PT and FDS, and three cadavers had one arch. An accessory head in the FDS was found to be a risk of AIN compression. Gantzer’s muscle was

Academic Culture: A student’s guide
Maria Simms
Literacy and Numeracy Studies , 2011,
Abstract: ACADEMIC CULTURE: A STUDENT’S GUIDE TO STUDYING AT UNIVERSITY By JEAN BRICK National Centre for English Language Teaching and Research (NCELTR) 2006, Sydney, ISBN 978 74138 135 (pbk) ISBN 1 74138 135 5 (pbk) 263 pages Jean Brick’s book is an excellent guide to academic culture and skills for students and academics alike. Although she describes the book as being about academic culture it is much more than that. I found it to be a comprehensive, useful and very readable guide to English for a variety of academic purposes.
Modeling of Work of Filling Granular Filter with Active Cooling  [PDF]
Alexander D. Rychkov
Smart Grid and Renewable Energy (SGRE) , 2010, DOI: 10.4236/sgre.2010.11004
Abstract: The solid propellant gas generators having high gas capacity are widely used for fast pressurization of elastic shells of saving devices of different applications. A typical example of such devices are safety system of automobile (airbags). After collision of an automobile with an obstacle the combustion products of gas generator fill the shell during 60 – 100 milliseconds. However the temperature of combustion products even of “low-temperature” fuel compositions of gas generators appears not below 1500К and to reduce of its it is necessary to apply a various types of porous and filling granular filters. There are passive and active granular filters. The passive filter can cool of combustion products as a result of absorption of heat only. The active cooling is evaporation of the granule material and in this case takes a place more intensive cooling of combustion products in the filter. The numerical modeling of cooling process of high- temperature combustion products at their movement in bulk of granular filter of active cooling is investigated. As the material of granules was used the carbonate of magnesium. At its heating takes a place process of gasification and formation of a porous slag shell which sublimates at higher temperature. The physical model of such spherical granule can be presented as the central part consisting of the carbonate magnesium surrounded with the porous slag spherical shell through which gaseous products of gasification of the central part are filtered. The problem of distribution of heat in each granule is Stefan problem when at the given temperature on the surface of sphere there is the front of gasification moving inside of the bulk of material. It is assumed that combustion products are the perfect gas moving in the filter. The upwind difference scheme of the second order of the accuracy with TVD properties was applied to calculation of the movement of gas. The results of calculations at various values of key parameters of the active and passive filters allow to draw a conclusion about enough high efficiency of active cooling filters.
Investigation of Element Profiles, Defects, Phase Composition and Physical and Mechanical Properties of Superhard Coatings Ti-Hf-Si-N  [PDF]
Alexander D. Pogrebnjak
Materials Sciences and Applications (MSA) , 2013, DOI: 10.4236/msa.2013.44A004
Abstract:

This paper investigates the microstructure, physical, chemical and mechanical of superhard nanocomposite of Ti-Hf-Si-N. The coatings were grown by C-PVD method. Profiles of elements and vacancy-type defects (S-parameter measurements of the Doppler broadening of the annihilation peak DBAP) in the studied coatings were investigated. Defined and calculated the elastic modulus E, hardness H, friction, adhesion. Wear rate was determined as a function of the bias potential supplied to the substrate and the pressure in the chamber. The developed coatings have hardness of 37.8 to 48 GPa, the friction coefficient of 0.48 to 0.15, the grain size of the solid solution from 3.9 to 10.8 nm (depending on deposition conditions). It was found that positrons are trapped by defects at the junction of three or more nanograins interfaces. In some cases, there was formed two phases in coatings: a solid solution (Ti, Hf)N with different volume content of Hf in a solid solution, and an amorphous phase α-Si3N4 (the layer between the nanograins).

Carboxymethylcellulase Activity in Lettuce Seeds Prior to Germination  [PDF]
Alexander D. Pavlista
American Journal of Plant Sciences (AJPS) , 2017, DOI: 10.4236/ajps.2017.84049
Abstract: Does the endosperm pose a mechanical resistance on embryonic axis (radicle) growth for lettuce seed (achene) germination? To aid answering this question, the cell wall degrading enzyme, carboxymethylcellulase (CMCase) was extracted and assayed from lettuce seeds imbibed for 0 to 12 h, prior to germination. Measuring the loss of viscosity of carboxymethylcellulose, CMCase activity was high in dry seeds, low after 6 h of imbibition, high after 9 and 10 h, and then reduced again after 12 h. Fractions from Sephadex columns showed CMCase activity in three peaks labeled E1, E2, E3. The greatest change in CMCase activity during imbibition was with E3 (molecular weight of about 40,000 Daltons) and some reduction in E2 (molecular weight about 280,000). The RNA synthesis inhibitor, 6-methyl purine, eliminated CMCase activity when present from 4.5 to 7 h of imbibition and the protein synthesis inhibitor, cycloheximide, eliminated CMCase activity when present between 5.5 and 9 h. Imbibition in darkness lowered CMCase activity while 15 min of light at 3.5 h restored it and 30 min of far-red light at 3 h eliminated it. Increasing the imbibition temperature to 35°C under light reduced activity while under darkness, activity was eliminated under 24°C and 35°C. CMCase activity was localized in the endosperm surrounding the embryonic axis (micropylar end) of 9 h imbibed seeds. These observations showed that CMCase was active in degrading the cell wall in the endosperm surrounding the radicle, weakening it, prior to radicle protrusion so that the radicle remains undamaged.
Implementation of 3D spatial indexing and compression in a large-scale molecular dynamics simulation database for rapid atomic contact detection
Rudesh D Toofanny, Andrew M Simms, David AC Beck, Valerie Daggett
BMC Bioinformatics , 2011, DOI: 10.1186/1471-2105-12-334
Abstract: Our implementation of spatial indexing speeds up the calculation of contacts over a 1 nanosecond (ns) simulation window by between 14% and 90% (i.e., 1.2 and 10.3 times faster). For a 'full' simulation trajectory (51 ns) spatial indexing reduces the calculation run-time between 31 and 81% (between 1.4 and 5.3 times faster). Compression resulted in reduced table sizes but resulted in no significant difference in the total execution time for neighbour discovery. The greatest compression (~36%) was achieved using page level compression on both the data and indexes.The spatial indexing scheme significantly decreases the time taken to calculate atomic contacts and could be applied to other multidimensional neighbor discovery problems. The speed up enables on-the-fly calculation and visualization of contacts and rapid cross simulation analysis for knowledge discovery. Using page compression for the atomic coordinate tables and indexes saves ~36% of disk space without any significant decrease in calculation time and should be considered for other non-transactional databases in MS SQL SERVER 2008.Molecular dynamics (MD) simulations are routinely used to study the dynamic and structural properties of proteins and other macromolecules. MD simulations provide atomic-level resolution of a protein andits surrounding solvent environment as a function of time. There are no experimental techniques that can provide this level of detail. The direct results of an MD simulation are the coordinates of all atoms as a function of simulation time. Simulation time is divided into discrete time points or frames (akin to movie frames) that represent the coordinates for the entire system at that precise time. The assembled coordinate 'trajectories' (i.e. all frames) can be analysed for various factors and visualized to produce movies (examples of which can be found at http://www.dynameomics.org webcite).Nonbonded interactions within a protein are critical to its thermodynamic behaviour, contri
Evidential recovery from GPS devices
Brian Cusack,Mark Simms
Journal of Applied Computing and Information Technology , 2011,
Abstract: Global Positioning Systems (GPS) have become more affordable, are now widely used in motor vehicles and in other frequently used applications. As a consequence GPS are increasingly becoming an important source of evidential data for digital forensic investigations. This paper acknowledges there are only disparate documents for the guidance of an investigator when extracting evidence form such systems. The focus of this paper is to provide the technical details of recovering artifacts from four GPS currently available to the New Zealand market. Navman brand GPS are used, following a forensically robust process. The steps of the process are described, results analysed and the associated risks are discussed. In addition, the paper discusses techniques related to the visual presentation of evidence suitable for Google Maps. Automation attempts to speed up the analysis to visualization steps are also included. The outcome is a road map that may assist digital forensic investigators develop GPS examination strategies for implementation in their own organizations.
Book Review of "Communities living with hazards"
D. Alexander
Natural Hazards and Earth System Sciences (NHESS) & Discussions (NHESSD) , 2010, DOI: 10.5194/nhess-10-1031-2010
Abstract:
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