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Search Results: 1 - 10 of 478616 matches for " Alexander A Hanke "
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In Vitro impairment of whole blood coagulation and platelet function by hypertonic saline hydroxyethyl starch
Alexander A Hanke, Stephanie Maschler, Herbert Sch?chl, Felix Fl?ricke, Klaus G?rlinger, Klaus Zanger, Peter Kienbaum
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2011, DOI: 10.1186/1757-7241-19-12
Abstract: The study was designed as experimental non-randomized comparative in vitro study. Following institutional review board approval and informed consent blood samples were taken from 10 healthy volunteers and diluted in vitro with either HH (HyperHaes?, Fresenius Kabi, Germany), hypertonic saline (HT, 7.2% NaCl), hydroxyethylstarch (HS, HAES6%, Fresenius Kabi, Germany) or NaCl 0.9% (ISO) in a proportion of 5%, 10%, 20% and 40%. Coagulation was studied in whole blood by rotation thrombelastometry (ROTEM) after thromboplastin activation without (ExTEM) and with inhibition of thrombocyte function by cytochalasin D (FibTEM), the latter was performed to determine fibrin polymerisation alone. Values are expressed as maximal clot firmness (MCF, [mm]) and clotting time (CT, [s]). Platelet aggregation was determined by impedance aggregrometry (Multiplate) after activation with thrombin receptor-activating peptide 6 (TRAP) and quantified by the area under the aggregation curve (AUC [aggregation units (AU)/min]). Scanning electron microscopy was performed to evaluate HyperHaes induced cell shape changes of thrombocytes.Statistics: 2-way ANOVA for repeated measurements, Bonferroni post hoc test, p < 0.01.Dilution impaired whole blood coagulation and thrombocyte aggregation in all dilutions in a dose dependent fashion. In contrast to dilution with ISO and HS, respectively, dilution with HH as well as HT almost abolished coagulation (MCFExTEM from 57.3 ± 4.9 mm (native) to 1.7 ± 2.2 mm (HH 40% dilution; p < 0.0001) and to 6.6 ± 3.4 mm (HT 40% dilution; p < 0.0001) and thrombocyte aggregation (AUC from 1067 ± 234 AU/mm (native) to 14.5 ± 12.5 AU/mm (HH 40% dilution; p < 0.0001) and to 20.4 ± 10.4 AU/min (HT 40% dilution; p < 0.0001) without differences between HH and HT (MCF: p = 0.452; AUC: p = 0.449).HH impairs platelet function during in vitro dilution already at 5% dilution. Impairment of whole blood coagulation is significant after 10% dilution or more. This effect can be pinpoin
Critical adsorption on curved objects
A. Hanke,S. Dietrich
Physics , 1998, DOI: 10.1103/PhysRevE.59.5081
Abstract: A systematic fieldtheoretic description of critical adsorption on curved objects such as spherical or rodlike colloidal particles immersed in a fluid near criticality is presented. The temperature dependence of the corresponding order parameter profiles and of the excess adsorption are calculated explicitly. Critical adsorption on elongated rods is substantially more pronounced than on spherical particles. It turns out that, within the context of critical phenomena in confined geometries, critical adsorption on a microscopically thin `needle' represents a distinct universality class of its own. Under favorable conditions the results are relevant for the flocculation of colloidal particles.
A proof of the S-genus identities for ternary quadratic forms
Alexander Berkovich,Jonathan Hanke,William Jagy
Mathematics , 2010,
Abstract: In this paper we prove the main conjectures of Berkovich and Jagy about weighted averages of representation numbers over an S-genus of ternary lattices (defined below) for any odd squarefree S \in N. We do this by reformulating them in terms of local quantities using the Siegel-Weil and Conway-Sloane formulas, and then proving the necessary local identities. We conclude by conjecturing generalized formulas valid over certain totally real number fields as a direction for future work.
Understanding Collective Dynamics of Soft Active Colloids by Binary Scattering
Timo Hanke,Christoph A. Weber,Erwin Frey
Physics , 2013, DOI: 10.1103/PhysRevE.88.052309
Abstract: Collective motion in actively propelled particle systems is triggered on the very local scale by nucleation of coherently moving units consisting of just a handful of particles. These units grow and merge over time, ending up in a long-range ordered, coherently-moving state. So far, there exists no bottom-up understanding of how the microscopic dynamics and interactions between the constituents are related to the system's ordering instability. In this paper, we study a class of models for propelled colloids allowing an explicit treatment of the microscopic details of the collision process. Specifically, the model equations are Newtonian equations of motion with separate force terms for particles' driving, dissipation and interaction forces. Focusing on dilute particle systems, we analyze the binary scattering behavior for these models, and determine-based on the microscopic dynamics-the corresponding collision-rule, i.e., the mapping of pre-collisional velocities and impact parameter on post-collisional velocities. By studying binary scattering we also find that the considered models for active colloids share the same principle for parallel alignment: the first incoming particle (with respect to the center of collision) is aligned to the second particle as a result of the encounter. This behavior is distinctively different to alignment in non-driven dissipative gases. Moreover, the obtained collision rule lends itself as a starting point to apply kinetic theory for propelled particle systems in order to determine the phase boundary to a long-range ordered, coherently-moving state. The microscopic origin of the collision rule offers the opportunity to quantitatively scrutinize the predictions of kinetic theory for propelled particle systems through direct comparison with multi-particle simulations.
Polymer depletion effects near mesoscopic particles
A. Hanke,E. Eisenriegler,S. Dietrich
Physics , 1998, DOI: 10.1103/PhysRevE.59.6853
Abstract: The behavior of mesoscopic particles dissolved in a dilute solution of long, flexible, and nonadsorbing polymer chains is studied by field-theoretic methods. For spherical and cylindrical particles the solvation free energy for immersing a single particle in the solution is calculated explicitly. Important features are qualitatively different for self-avoiding polymer chains as compared with ideal chains. The results corroborate the validity of the Helfrich-type curvature expansion for general particle shapes and allow for quantitative experimental tests. For the effective interactions between a small sphere and a wall, between a thin rod and a wall, and between two small spheres quantitative results are presented. A systematic approach for studying effective many-body interactions is provided. The common Asakura-Oosawa approximation modelling the polymer coils as hard spheres turns out to fail completely for small particles and still fails by about 10% for large particles.
Electronic structure of zinc-blende MnTe within the GW approximation
A. Fleszar,M. Potthoff,W. Hanke
Physics , 2007, DOI: 10.1002/pssc.200775407
Abstract: Using the local spin-density approximation (LSDA) and the (non self-consistent) GW approach, the (quasi-particle) band structure is calculated for MnTe in zinc-blende geometry. Different parameters characterizing the electronic structure are computed for an antiferromagnetic and the ferromagnetic phase and compared with the experiment. The strong Hubbard-type repulsion on the Mn-3d orbitals and the p-d hybridization are seen to be responsible for substantial defects found in the LSDA picture. It is discussed to which extent these can be improved upon by means of the GW approach.
Critical Casimir Forces in Colloidal Suspensions
F. Schlesener,A. Hanke,S. Dietrich
Physics , 2002,
Abstract: Some time ago, Fisher and de Gennes pointed out that long-ranged correlations in a fluid close to its critical point Tc cause distinct forces between immersed colloidal particles which can even lead to flocculation [C. R. Acad. Sc. Paris B 287, 207 (1978)]. Here we calculate such forces between pairs of spherical particles as function of both relevant thermodynamic variables, i.e., the reduced temperature t = (T-Tc)/Tc and the field h conjugate to the order parameter. This provides the basis for specific predictions concerning the phase behavior of a suspension of colloidal particles in a near-critical solvent.
Spin effects govern DNA/RNA nucleotide polymerization  [PDF]
Alexander A. Tulub
Journal of Biophysical Chemistry (JBPC) , 2011, DOI: 10.4236/jbpc.2011.23034
Abstract: A new radical mechanism of nucleotide polymerization is found. The finding is based on the Car-Parrinello molecular dynamics computations at 310 K with an additional spin-spin coupling term for 31P and 1H atoms and a radical pair spin term included. The mechanism is initiated by a creation of a high-energy spin-separated Mg-ATP complex in a triplet state in which the Mg prefers an uncommon chelation to the O2-O3 oxygens of the ATP. The cleavage of the complex produces the .AMP- and .O- radicals. The latter captures a proton from acidic solution (the Zundel cation) that converts it into the .OH radical. The process agrees with the protoncoupled electron transfer (PCET) mechanism. Through interacting with the HO-C3' group of the deoxyribose/ribose the .OH radical captures its hydrogen atom. The process is accompanied by producing water and the .AMP radical. The .AMP- and .AMP radicals then interact yielding a dimer. The described mechanism is easily generalized for a bigger number of adjoining nucleotides and their type. The radical mechanism is highly sensitive to the .AMP-..OH radical pair spin symmetry and the radius of the .OH diffusion. This confines the operation of the radical mechanism: it is applicable to nucleotide polymerization through the HO-C3’ group of deoxyribose/ribose (DNA/RNA polymerization) and inapplicable through the HO-C2’ group of ribose (RNA) . a result that nature has developed over evolution.
Embeddings of Almost Hermitian Manifold in Almost Hyper Hermitian Manifold and Complex (Hypercomplex) Numbers in Riemannian Geometry  [PDF]
Alexander A Ermolitski
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.516238
Abstract: Tubular neighborhoods play an important role in differential topology. We have applied these constructions to geometry of almost Hermitian manifolds. At first, we consider deformations of tensor structures on a normal tubular neighborhood of a submanifold in a Riemannian manifold. Further, an almost hyper Hermitian structure has been constructed on the tangent bundle TM with help of the Riemannian connection of an almost Hermitian structure on a manifold M then, we consider an embedding of the almost Hermitian manifold M in the corresponding normal tubular neighborhood of the null section in the tangent bundle TM equipped with the deformed almost hyper Hermitian structure of the special form. As a result, we have obtained that any Riemannian manifold M of dimension n can be embedded as a totally geodesic submanifold in a Kaehlerian manifold of dimension 2n (Theorem 6) and in a hyper Kaehlerian manifold of dimension 4n (Theorem 7). Such embeddings are “good” from the point of view of Riemannian geometry. They allow solving problems of Riemannian geometry by methods of Kaehlerian geometry (see Section 5 as an example). We can find similar situation in mathematical analysis (real and complex).
Pathway Analysis of Differentially Expressed Genes in Patients with Acute Aortic Dissection
Salah A. Mohamed,Hans H. Sievers,Thorsten Hanke,Doreen Richardt
Biomarker Insights , 2009,
Abstract: Background: Acute aortic dissection (AAD) is a life-threatening condition with high mortality and a relatively unclarified pathophysiological mechanism. Although differentially expressed genes in AAD have been recognized, interactions between these genes remain poorly defined. This study was conducted to gain a better understanding of the molecular mechanisms underlying AAD and to support the future development of a clinical test for monitoring patients at high risk.Materials and Methods: Aortic tissue was collected from 19 patients with AAD (mean age 61.7 ± 13.1 years), and from eight other patients (mean age 32.9 ± 12.2 years) who carried the mutated gene for Marfan syndrome (MS). Six patients (mean age 56.7 ± 12.3 years) served as the control group. The PIQORTM Immunology microarray with 1076 probes in quadruplicates was utilized; the differentially expressed genes were analysed in a MedScan search using PathwayAssist software. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and protein analysis were performed.Results: Interactions of MS brillin-1 (FBN1) in the MedScan pathway analysis showed four genes, fibulin-1 (FBLN1), fibulin-2 (FBLN2), decorin (DCN) and microfibrillar associated protein 5 (MFAP5), which were differentially expressed in all tissue from AAD. The validation of these genes by qRT-PCR revealed a minimum of three-fold downregulation of FBLN1 (0.5 ± 0.4 vs. 6.1 ± 2.3 fold, p = 0.003) and of DCN (2.5 ± 1.0 vs. 8.5 ± 4.7 fold, p = 0.04) in AAD compared to MS and control samples.Conclusions: Downregulation of fibrillin-1 (FBN1) may weaken extracellular components in the aorta and/or interfer with the transmission of cellular signals and eventually cause AAD. Additional research on these four identified genes can be a starting point to develop a diagnostic tool.
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