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Search Results: 1 - 10 of 3896 matches for " Alessandra Tessitore "
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Serum Biomarkers Identification by Mass Spectrometry in High-Mortality Tumors
Alessandra Tessitore,Agata Gaggiano,Germana Cicciarelli,Daniela Verzella
International Journal of Proteomics , 2013, DOI: 10.1155/2013/125858
Serum Biomarkers Identification by Mass Spectrometry in High-Mortality Tumors
Alessandra Tessitore,Agata Gaggiano,Germana Cicciarelli,Daniela Verzella,Daria Capece,Mariafausta Fischietti,Francesca Zazzeroni,Edoardo Alesse
International Journal of Proteomics , 2013, DOI: 10.1155/2013/125858
Abstract: Cancer affects millions of people worldwide. Tumor mortality is substantially due to diagnosis at stages that are too late for therapies to be effective. Advances in screening methods have improved the early diagnosis, prognosis, and survival for some cancers. Several validated biomarkers are currently used to diagnose and monitor the progression of cancer, but none of them shows adequate specificity, sensitivity, and predictive value for population screening. So, there is an urgent need to isolate novel sensitive, specific biomarkers to detect the disease early and improve prognosis, especially in high-mortality tumors. Proteomic techniques are powerful tools to help in diagnosis and monitoring of treatment and progression of the disease. During the last decade, mass spectrometry has assumed a key role in most of the proteomic analyses that are focused on identifying cancer biomarkers in human serum, making it possible to identify and characterize at the molecular level many proteins or peptides differentially expressed. In this paper we summarize the results of mass spectrometry serum profiling and biomarker identification in high mortality tumors, such as ovarian, liver, lung, and pancreatic cancer. 1. Introduction Cancer-related mortality is one of the leading causes of death worldwide. The most effective treatment to fight cancer is still early diagnosis. On the other hand, it is known that the correct classification of the tumor, coupled to a suitable therapy and to a stringent follow-up, helps to prevent and detect relapses. Cancer is a very heterogeneous disease, and, at the diagnostic level, is defined by many indexes such as histological grade, tumor stage, patient age, sex and, more importantly, genetic background and profiles. Histological evaluation of tumor specimens obtained from tissue biopsy is the gold standard of diagnosis, but often tumors with the same histopathological features respond differently to the same therapy. New generation diagnostic platforms, previously unavailable, have enabled to better characterize transcriptomic signatures that predict tumor behaviour, helping to define diagnosis, prognosis, and the most appropriate therapies [1–3]. Tumor biomarker discovery in biological fluids, such as serum, plasma, and urine, is one of the most challenging aspects of proteomic research [4]. Many researchers have attempted to identify biomarkers in serum that reflect a particular pathophysiological state. Since the expressed proteins, native, fragmented, or posttranslationally modified, quickly change in response to environmental
Sensorimotor connectivity in Parkinson’s disease: the role of functional neuroimaging
Alessandro Tessitore
Frontiers in Neurology , 2014, DOI: 10.3389/fneur.2014.00180
Abstract: The diagnosis of PD remains still clinical; nevertheless, in the last decades, the rapid evolution of advanced MRI techniques have made it possible to detect structural and, increasingly, functional brain changes in patients with PD. Indeed, functional MRI (fMRI) techniques have offered the opportunity to directly measure the brain’s activity and connectivity in patients with PD both in early and complicated stage of the disease. The aims of the following review are: 1) to present an overview of recent fMRI reports investigating the activity and connectivity of sensorimotor areas in patients with PD using both task-related and “resting state” fMRI analysis 2) to elucidate potential pathophysiological mechanisms underlying dyskinetic motor complications in the advanced stage of PD.
Education Not for Money: An Economic Analysis on Education, Civic Engagement and Life Satisfaction  [PDF]
Leonardo Becchetti, Nazaria Solferino, M. Elisabetta Tessitore
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.61006
Abstract: Many recent theoretical and empirical findings both in Economics and in Psychology show that, in addition to the effects on policy outcomes, political participation may affect individual utility and increase happiness and well-being. In this paper we devise a theoretical model where the individual utility grows through the civic engagement, which may be enjoyed only with a sufficient level of investment in civic capital accumulated through education. We show that investing in education may have important consequences for subjective well-being by enhancing civic capacities which are relevant to improve individual’s civic engagement and social outcomes, even without any monetary effects. More specifically, we identify a form of non pecuniary benefits of education represented by the possibility of taking an active and successful part in social and civic life which significantly contribute to life satisfaction.
A Dynamic Model of Gambling Addiction with Social Costs: Theory and Policy Solutions  [PDF]
Nazaria Solferino, Leonardo Becchetti, Maria Elisabetta Tessitore
Modern Economy (ME) , 2018, DOI: 10.4236/me.2018.912127
Abstract: We investigate the effects of gambling addiction in a dynamic model in which wellbeing crucially depends on the accumulation of relational goods which is weakened by the consumption of gambling. We outline conditions under which gambling may become addictive leading to a suboptimal equilibrium from a social point of view. We examine the relative effectiveness of different policy solutions (tax on gambling, gambling restrictions) in bridging the distance between the equilibrium without intervention and social optimum.
Well Posedness of Operator Valued Backward Stochastic Riccati Equations in Infinite Dimensional Spaces
Giuseppina Guatteri,Gianmario Tessitore
Mathematics , 2014,
Abstract: We prove existence and uniqueness of the mild solution of an infinite dimensional, operator valued, backward stochastic Riccati equation. We exploit the regularizing properties of the semigroup generated by the unbounded operator involved in the equation. Then the results will be applied to characterize the value function and optimal feedback law for a infinite dimensional, linear quadratic control problem with stochastic coefficients.
Manipulating Persuasion in Debates: Fact Checking’s Usefulness  [PDF]
Nazaria Solferino, Serena Fiona Taurino, Maria Elisabetta Tessitore
Theoretical Economics Letters (TEL) , 2015, DOI: 10.4236/tel.2015.54052
Abstract: Persuasion can be considered as a situation where subjects having an opinion or an argument are willing to change it in favor of others’ proposal only if the new message has personal relevance and significant consequences on their lives. In this paper, we argue that improvements in the information set and the knowledge of the fundamental rules of a “well-formed formula” are necessary to minimize errors when people make their choices. Arguments can be manipulated either in terms of the truth of premises or in terms of the logical connectives among propositions. The emerging mechanism of the so-called fact-checking, used to verify candidates’ statements during the electoral campaign, may be a very useful instrument to realize these improvements in political debates.
Sporadic ALS is not associated with VAPB gene mutations in Southern Italy
Francesca Conforti, Teresa Sprovieri, Rosalucia Mazzei, Carmine Ungaro, Alessandro Tessitore, Gioacchino Tedeschi, Alessandra Patitucci, Angela Magariello, AnnaLia Gabriele, Vincenzo Labella, Isabella Simone, Giovanni Majorana, Maria Monsurrò, Paola Valentino, Maria Muglia, Aldo Quattrone
Journal of Negative Results in BioMedicine , 2006, DOI: 10.1186/1477-5751-5-7
Abstract: Genetic analysis for all exons of the VAPB gene by DHPLC revealed 5 variant profiles in 83 out of 125 SALS patients. Direct sequencing of these PCR products revealed 3 nucleotide substitutions. Two of these were found within intron 3 of the gene, harbouring 4 variant DHPLC profiles. The third nucleotide variation (Asp130Glu) was the only substitution present in the coding region of the VAPB gene, and it occurred within exon 4. It was found in three patients out of 125. The frequency of the detected exon variation in the VAPB gene was not significantly different between patients and controls. In conclusion, our study suggests that VAPB mutations are not a common cause of adult-onset SALS.Amyotrophic Lateral Sclerosis (ALS) is a progressive lethal disorder of motor neurons of the spinal cord and brain. More than 90% of ALS patients are sporadic (SALS), not showing any familial trait. Approximately 10% of cases are familial (FALS), and within these lie several distinct forms of the disease. The most common form of FALS is autosomal dominant for which to date 2 genes have been identified: ALS1, with adult-onset caused by mutations in the gene encoding the cytosolic antioxidant enzyme Cu, Zn-superoxide dismutase (Sod1) [1,2]; and ALS4, a rare juvenile-onset disorder, associated with mutations of the senataxin gene (SETX) [3]. An autosomal recessive, juvenile-onset form (ALS2), has been associated with mutations of the Alsin gene located at 2q33 [4]. To date over 100 different missense mutations in the Sod1 gene [5] and up to eight described mutations in the Alsin gene have been reported [6].By contrast, sporadic ALS is believed to be a multi-factorial disease in which modifying genes and environmental agents affect its clinical manifestation, but few associated genes have so far been identified [7-13]. De novo mutations in the Sod1 gene have only occasionally been observed in sporadic cases of ALS suggesting that mutations in this gene are a rare cause of non familial fo
Corrado Lupo,Giancarlo Condello,Antonio Tessitore
Journal of Sports Science and Medicine , 2012,
Abstract: The present study aimed to analyze the water polo matches of the men's World Championships, comparing technical and tactical aspects of winning and losing teams, during closed (< 3 goals of margin of victory at the end of the 4th quarter; winning, W; losing, L) and unbalanced (>3 goals; winning, MW; losing, ML) games. Therefore, 42 of the 48 (6 were draw at end of the 4th quarter) matches were considered. According to each game situation (i.e., even, counterattack, power-play, transition), a notational analysis was performed in relation to the following aspects: occurrence of actions, action outcome, execution and origin of shots, and mean duration. In addition, the occurrence of the offensive (and role) and defensive arrangements of even and power-play were analyzed. To show differences (p < 0.05) in terms of margin of victory, an analysis of variance was applied. Although ML (74 ± 11%) performed more even actions than W (68 ± 7%) and MW (69 ± 6%), the latter teams (W = 9 ± 6%; MW = 13 ± 6%) performed more counterattacks than L (3 ± 2%) and ML (5 ± 5%). Power-play is more played during closed (W = 20 ± 3%; L = 22 ± 3%) than unbalanced games (MW = 17 ± 4%; ML = 16 ± 7%). Moreover, differences in terms of margin of victory emerged for mean duration (even, power-play, transition), action outcome (even, power-play), zone origin (even, counterattack, power-play) and technical execution (even, power-play) of shots, and even and power-play offensive (and role) and defensive arrangements. Divergences mainly emerged between closed and unbalanced games, highlighting that the water polo matches of the men's World Championships need to be analyzed either considering the winning and losing outcome of match and specific margins of victory. Thus, coaches can advance their knowledge, considering that closed and unbalanced games are largely characterized by the opponent's exclusion fouls to perform power-play actions, and by a divergent grade of defensive skills regardless of game situation, respectively
Ergodic BSDEs and Optimal Ergodic Control in Banach Spaces
Marco Fuhrman,Ying Hu,Gianmario Tessitore
Mathematics , 2007,
Abstract: In this paper we introduce a new kind of Backward Stochastic Differential Equations, called ergodic BSDEs, which arise naturally in the study of optimal ergodic control. We study the existence, uniqueness and regularity of solution to ergodic BSDEs. Then we apply these results to the optimal ergodic control of a Banach valued stochastic state equation. We also establish the link between the ergodic BSDEs and the associated Hamilton-Jacobi-Bellman equation. Applications are given to ergodic control of stochastic partial differential equations.
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