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Search Results: 1 - 10 of 11403 matches for " Alenda Rafael "
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Genetic relationship of discrete-time survival with fertility and production in dairy cattle using bivariate models
González-Recio Oscar,Alenda Rafael
Genetics Selection Evolution , 2007, DOI: 10.1186/1297-9686-39-4-391
Abstract: Bivariate analyses of functional longevity in dairy cattle measured as survival to next lactation (SURV) with milk yield and fertility traits were carried out. A sequential threshold-linear censored model was implemented for the analyses of SURV. Records on 96 642 lactations from 41 170 cows were used to estimate genetic parameters, using animal models, for longevity, 305 d-standardized milk production (MY305), days open (DO) and number of inseminations to conception (INS) in the Spanish Holstein population; 31% and 30% of lactations were censored for DO and INS, respectively. Heritability estimates for SURV and MY305 were 0.11 and 0.27 respectively; while heritability estimates for fertility traits were lower (0.07 for DO and 0.03 for INS). Antagonist genetic correlations were estimated between SURV and fertility (-0.78 and -0.54 for DO and INS, respectively) or production (-0.53 for MY305), suggesting reduced functional longevity with impaired fertility and increased milk production. Longer days open seems to affect survival more than increased INS. Also, high productive cows were more problematic, less functional and more liable to being culled. The results suggest that the sequential threshold model is a method that might be considered at evaluating genetic relationship between discrete-time survival and other traits, due to its flexibility.
Dimensiones de la movilización en torno a conciencia de patria: Hacia un modelo explicativo de un caso de neopopulismo boliviano
Stéphanie Alenda
Revista de Ciencia Política , 2003,
Abstract:
La resurgence du populisme en Bolivie: 'conscience de la patrie' ou la construction de nouvelles identités urbaines dans un contexte compétitif
Alenda, Stéphanie
Bulletin de l'Institut Francais d'études Andines , 2001,
Abstract: à travers l'étude du cas de Conscience de la Patrie (CONDEPA), parti politique bolivien fondé en 1988 à la suite de la fermeture des médias de Carlos Palenque, il s agit d examiner la pertinence pour la compréhension des mouvements dits néo-populistes de deux postulats des théories du populisme latino-américain : l'absence de conscience de classe des couches populaires et leur attachement à des valeurs traditionnelles, dites prémodernes . L étude du condépisme ne valide pas l hypothèse d une mobilisation populaire synonyme de résistance au changement. Elle ne valide pas non plus l inverse, à savoir l uniformisation des masses apathiques sous l effet des médias. S il appara t que ce sont les plus discriminés qui ont les plus fortes chances de voter pour CONDEPA, on observe également que, dans cette catégorie, les plus prédisposés à soutenir le parti sont aussi les mieux intégrés à l univers urbain où ils mettent en uvre des tactiques individuelles d ascension sociale. L autonomie des acteurs condépistes, bien qu ils appartiennent à un mouvement au verticalisme marqué, rend en effet quelque peu réductrice la perception du social en termes de reproduction des inégalités. L étude du lien entre le leader et ses bases met au contraire en évidence que des mécanismes d identification (à Radio Télévision Populaire , CONDEPA ou encore Carlos Palenque) contribuent à organiser une réalité sociale incertaine dans un contexte compétitif d érosion des identités collectives. EL RESURGIMIENTO DEL POPULISMO EN BOLIVIA CONCIENCIA DE PATRIA O LA CONSTRUCCIóN DE NUEVAS IDENTIDADES URBANAS EN UN CONTEXTO COMPETITIVO. A través del estudio de Conciencia de Patria (CONDEPA), partido político boliviano fundado en 1988 tras la clausura de los medios de comunicación de su leader Carlos Palenque, se trata de examinar la pertinencia de dos postulados de las teorías del populismo latinoamericanolos para comprender los movimientos denominados neopopulistas: la carencia de conciencia de clase atribuida a las capas populares y su apego a valores tradicionales o premodernos. El estudio del condepismo no valida la hipótesis de una movilización popular sinónima de resistencia al cambio. Tampoco valida lo contrario, es decir la uniformización de las masas apáticas bajo el efecto de los medios de comunicación. Si bien los que más tienden a votar por CONDEPA son los más discriminados, en esta categoría, los más propensos a apoyar al partido son también los mejor integrados en el universo urbano donde desarrollan tácticas individuales de ascenso. En efecto, la autonomía de lo
Squamous Cell Carcinoma Clinically Mimicking a Rhinophyma in a Black Male  [PDF]
L. Richard Njock, E. G. S. Minka Ngom, G. Alenda, J. V. Fokouo Fogha, V. Fonyam
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.32031
Abstract: The clinical features of rhinophyma can mask the existence or coexistence of a skin cancer. Many tumours can mimic rhinophyma. Many authors report cases of cancerisation of rhinophyma or the coexistence of rhinophyma and a cancer. Few authors have however reported cases of squamous cell carcinoma mimicking rhinophyma. We present the clinical case of a 48 year-old male with squamous cell carcinoma of the nose (tip of the nasal pyramid and vestibule), a histologic diagnosis after being confronted by an atypical clinical presentation of rhinophyma. Treatment consisted of radiation therapy and evolution was characterised by tumoral regression.
Comparative concept similarity over Minspaces: Axiomatisation and Tableaux Calculus
Régis Alenda,Nicola Olivetti,Camilla Schwind
Computer Science , 2009,
Abstract: We study the logic of comparative concept similarity $\CSL$ introduced by Sheremet, Tishkovsky, Wolter and Zakharyaschev to capture a form of qualitative similarity comparison. In this logic we can formulate assertions of the form " objects A are more similar to B than to C". The semantics of this logic is defined by structures equipped by distance functions evaluating the similarity degree of objects. We consider here the particular case of the semantics induced by \emph{minspaces}, the latter being distance spaces where the minimum of a set of distances always exists. It turns out that the semantics over arbitrary minspaces can be equivalently specified in terms of preferential structures, typical of conditional logics. We first give a direct axiomatisation of this logic over Minspaces. We next define a decision procedure in the form of a tableaux calculus. Both the calculus and the axiomatisation take advantage of the reformulation of the semantics in terms of preferential structures.
TGFBR1 Intralocus Epistatic Interaction as a Risk Factor for Colorectal Cancer
Ana Martinez-Canto, Adela Castillejo, Trinidad Mata-Balaguer, Maria-Isabel Castillejo, Eva Hernandez-Illan, Esperanza Irles, Victor Manuel Barbera, Cecilia Egoavil, Carla Guarinos, Cristina Alenda, Enrique Ochoa, Rafael Lazaro, Silvia Fajardo, Javier Lacueva, Rafael Calpena, Jose Luis Soto
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030812
Abstract: In colorectal cancer (CRC), an inherited susceptibility risk affects about 35% of patients, whereas high-penetrance germline mutations account for <6% of cases. A considerable proportion of sporadic tumors could be explained by the coinheritance of multiple low-penetrance variants, some of which are common. We assessed the susceptibility to CRC conferred by genetic variants at the TGFBR1 locus. We analyzed 14 polymorphisms and the allele-specific expression (ASE) of TGFBR1 in 1025 individuals from the Spanish population. A case-control study was undertaken with 504 controls and 521 patients with sporadic CRC. Fourteen polymorphisms located at the TGFBR1 locus were genotyped with the iPLEX Gold (MassARRAY-Sequenom) technology. Descriptive analyses of the polymorphisms and haplotypes and association studies were performed with the SNPator workpackage. No relevant associations were detected between individual polymorphisms or haplotypes and the risk of CRC. The TGFBR1*9A/6A polymorphism was used for the ASE analysis. Heterozygous individuals were analyzed for ASE by fragment analysis using cDNA from normal tissue. The relative level of allelic expression was extrapolated from a standard curve. The cutoff value was calculated with Youden's index. ASE was found in 25.4% of patients and 16.4% of controls. Considering both bimodal and continuous types of distribution, no significant differences between the ASE values of patients and controls were identified. Interestingly, a combined analysis of the polymorphisms and ASE for the association with CRC occurrence revealed that ASE-positive individuals carrying one of the most common haplotypes (H2: 20.7%) showed remarkable susceptibility to CRC (RR: 5.25; 95% CI: 2.547–5.250; p<0.001) with a synergy factor of 3.7. In our study, 54.1% of sporadic CRC cases were attributable to the coinheritance of the H2 haplotype and TGFBR1 ASE. These results support the hypothesis that the allelic architecture of cancer genes, rather than individual polymorphisms, more accurately defines the CRC risk.
Lymphoma of the Nasopharynx in an HIV Sero-Positive Patient in the General Hospital of Douala  [PDF]
Gisele Alenda Ngulefac, Jean Valentin Fokouo Fogha, Esthelle Genevieve Stephanie Minka Ngom, Vincent Fonyam, Louis Richard Njock
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.32032
Abstract: Humman immunodeficiency virus (HIV) infection is associated with opportunistic cancers notably Non-Hodgkin lymphoma (NHL). Generally the response to chemotherapy or radiation therapy is satisfactory but requires nursing measures to protect these patients from superinfection to which they are highly predisposed by the double immunosuppression. We report the case of a 54 year-old known HIV sero-positive female with lymphoma of the nasopharynx who presented lately and died of septic shock despite the favorable evolution of the tumor on treatment.
Gross Tumour of Minor Salivary Glands in HIV Sero-Positive Patient  [PDF]
Jean Valentin Fokouo Fogha, Gisele Alenda Ngulefac, Esthelle Genevieve Stephanie Minka Ngom, Vincent Fonyam, Louis Richard Njock
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.33043
Abstract: Tumours of minor salivary glands are rare. We report the case of a 58-year-old HIV positive woman with a palatal adenocarcinoma evolving for 15 years, followed by a literature review. The case enlightens on the deleterious effect of delayed specialist consultation, which in our context is multifactorial in origin.
Evidence for classification of c.1852_1853AA>GC in MLH1 as a neutral variant for Lynch syndrome
Adela Castillejo, Carla Guarinos, Ana Martinez-Canto, Victor-Manuel Barbera, Cecilia Egoavil, Maria-Isabel Castillejo, Lucia Perez-Carbonell, Ana-Beatriz Sanchez-Heras, Angel Segura, Enrique Ochoa, Rafael Lazaro, Clara Ruiz-Ponte, Luis Bujanda, Montserrat Andreu, Antoni Castells, Angel Carracedo, Xavier Llor, Juan Clofent, Cristina Alenda, Artemio Paya, Rodrigo Jover, Jose-Luis Soto
BMC Medical Genetics , 2011, DOI: 10.1186/1471-2350-12-12
Abstract: The following approach was used to assess the clinical significance of the p.Lys618Ala variant: frequency in a control population, case-control comparison, co-occurrence of the p.Lys618Ala variant with a pathogenic mutation, co-segregation with the disease and microsatellite instability in tumours from carriers of the variant. We genotyped p.Lys618Ala in 1034 individuals (373 sporadic colorectal cancer [CRC] patients, 250 index subjects from families suspected of having LS [revised Bethesda guidelines] and 411 controls). Three well-characterized LS families that fulfilled the Amsterdam II Criteria and consisted of members with the p.Lys618Ala variant were included to assess co-occurrence and co-segregation. A subset of colorectal tumour DNA samples from 17 patients carrying the p.Lys618Ala variant was screened for microsatellite instability using five mononucleotide markers.Twenty-seven individuals were heterozygous for the p.Lys618Ala variant; nine had sporadic CRC (2.41%), seven were suspected of having hereditary CRC (2.8%) and 11 were controls (2.68%). There were no significant associations in the case-control and case-case studies. The p.Lys618Ala variant was co-existent with pathogenic mutations in two unrelated LS families. In one family, the allele distribution of the pathogenic and unclassified variant was in trans, in the other family the pathogenic variant was detected in the MSH6 gene and only the deleterious variant co-segregated with the disease in both families. Only two positive cases of microsatellite instability (2/17, 11.8%) were detected in tumours from p.Lys618Ala carriers, indicating that this variant does not play a role in functional inactivation of MLH1 in CRC patients.The p.Lys618Ala variant should be considered a neutral variant for LS. These findings have implications for the clinical management of CRC probands and their relatives.Genetic testing is conducted for diverse purposes, including confirmation of diagnosis, risk prediction, carr
La imagen de fusión anatomo-metabólica en el diagnóstico oncológico.
Maldonado, Antonio. Dr.,González Alenda, Javier. Dr.
Alasbimn Journal , 2006,
Abstract: Hay una frase que bien podría resumir la aportación de la imagen diagnóstica en el campo de la Oncología: La PET ve las lesiones y la CT y/o RM ayudan a especificar su origen. Aunque esto no es del todo cierto, es el punto de partida que impulsó el desarrollo de los equipos híbridos PET-CT. Lógicamente, la obtención de la imagen de fusión anatomo-metabólica en tiempo real debería permitir a priori la caracterización de los hallazgos de la CT y la localización precisa de las captaciones de la PET, con lo cual, aparte de reducir dos pruebas a una con el consiguiente ahorro de recursos y confort para el paciente, aumentaría de forma considerable la exactitud diagnóstica.
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