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Search Results: 1 - 10 of 461911 matches for " Alena A. Bushina "
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‘Sochi’ resort development and functioning in 1935–1950
Alena A. Bushina,Vladimir G. Ivantsov
European Researcher , 2011,
Abstract: The article is focused on the history of ‘Sochi’ rest home establishment and functioning. Later ‘Sochi’ was turned into resort and was included into Sochi group of resorts, first under the supervision of USSR Central Executive Committee and in 1938 it passed into jurisdiction of USSR Council of People's Commissars – USSR Council of Ministers.
Maternal Supplementation of Vitamin D During Lactation to Support Infant Vitamin D Needs: A Systematic Review  [PDF]
Kelly Schossow, Alena M. Clark, Mary A. Harris
Open Journal of Pediatrics (OJPed) , 2018, DOI: 10.4236/ojped.2018.83027
Abstract: Human milk is generally considered to be insufficient in vitamin D. However, research completed in the 1980s showed that the vitamin D content of human milk is directly related to maternal serum vitamin D levels and therefore may potentially be adequate if the mother’s vitamin D levels are sufficient. Approximately one-third of the adult population, which includes breastfeeding women, in the United States have vitamin D insufficiency or deficiency. Among infants, 90.4% of breastfed infants are vitamin D deficient compared to 15.4% of formula fed infants. The American Academy of Pediatrics (AAP) has therefore recommended all breastfed infants be directly supplemented with 400 IU per day of vitamin D to decrease the risk of vitamin D insufficiency and rickets. According to the AAP, compliance rates with this recommendation ranges between 2% - 36%. Because the recommendation to supplement may undermine breastfeeding, many pediatricians do not inform their patients of the need to supplement. Additionally, some parents are concerned about directly supplementing their infant as risks may include allergic reactions to the ingredients, aspiration pneumonia, accidental overdose, and changes in intestinal flora and pH which may compromise the immune benefits of human milk. A literature review was conducted to examine the effect of maternal supplementation with vitamin D during lactation on human milk vitamin D content and maternal and infant serum vitamin D levels. Although there is no current consensus regarding dosage and timing of maternal vitamin D supplementation, the literature suggests that high-dose vitamin D supplementation of the lactating mother is as effective at maintaining infant vitamin D levels as direct infant supplementation, while also correcting the mother’s vitamin D deficiency.
Comparative Analysis of Russian and Foreign Systems for The Neuropsychological Diagnosis of Children From the Standpoint of the Psychometric Approach and its Limitations When Used in Clinical Practice
Alena V. Astaeva,Mikhail A. Berebin
Psychology in Russia : State of Art , 2012,
Abstract: Modern approaches to the psychological diagnostics of children are based onneed analysis and the systematization of existing trends in domestic and foreignchildren’s neuropsychological diagnoses. This article highlights the strengths andweaknesses of each approach, as well as identifying possible areas of integration.One of the most acute problems is the development of experimental psychologicalmethods to determine the quantitative and expressed characteristics of themental development of children by flexibly combining qualitative and quantitativeapproaches, with a view to putting into practice foreign neuroscience principlesand standards of evidence. An analysis of contemporary publications onneuropsychological diagnosis reveals the need to consider the standardization ofneuropsychological research in the context of current approaches, requirements,and psychodiagnostic criteria. In the domestic neuropsychological literature, theseissues are need attention: standardized procedures for presenting stimuli are not,as a rule, described; basic psychometric assessment of the results of the tests islacking; no investigation of their clinical and psychometric validity is carried out.An analysis was made of the nature of the psychometric approach in foreign childneuropsychology, which relies on mathematical procedures of processing qualitative(ordinal) data converted into quantitative indicators. We examined separatelythe mathematical software for clinical trials (based on the principles of evidencebasedmedicine ), which relies on the abnormal nature of the distribution ofclinical phenomena.
On chiral corrections to nucleon GPD
Alena M. Moiseeva,Alexey A. Vladimirov
Physics , 2012, DOI: 10.1140/epja/i2013-13023-x
Abstract: Within the pion-nucleon chiral perturbation theory we derive the leading chiral correction to the nucleon GPD at $\xi=0$. We discuss the difficulties of consideration of nonlocal light-cone operators within the theory with a heavy particle and the methods to solve the difficulties. The consideration of the chiral corrections directly for nonlocal operators allows to resolve the ambiguity of the inverse Mellin transformation. In particular, we show that the mixing between axial and vector GPDs are of order $m_\pi^2/M_N^2$, which is two orders of magnitude less that it follows from the Mellin moments calculation.
On the Activities of Pancreatic Proteases and Alpha-1 Proteinase Inhibitor in Meat-Type Chicken  [PDF]
Vladimir G. Vertiprakhov, Alena A. Grozina, Ivan A. Egorov, Tatiana N. Lenkova, Vardges A. Manukyan, Tatiana A. Egorova
Open Journal of Animal Sciences (OJAS) , 2017, DOI: 10.4236/ojas.2017.73022
Abstract: The study was aimed at the evaluation of the effects of breed, age, different digestion stimulators, and dietary crude protein (CP) level on the activities of proteolytic enzymes in pancreatic tissue and duodenal chymus (in vivo), serum trypsin and α1-proteinase inhibitor (A1PI) concentrations in meat-type chicks. The study of age dynamics of trypsin and A1PI concentrations was performed on the chicks of hybrid cross “Smena-8”and two parental lines (Plymouth Rock and Cornish) fed standard commercial corn-wheat-SBM diets. Twenty birds per breed were euthanized at 1, 7, 14, 21, 28 and 35 days of age to obtain blood samples and pancreatic homogenate. Experiments on the effects of different digestion promotors (probiotic, acidifier, phytobiotic, enzymatic preparation) and different CP levels (finisher diet, CP 20%, vs. ground corn, CP 8.5%) were performed on 12 hybrid chicks with fistulated duodenum from 14 to 50 days of age. The following conclusions were made: 1) At 1 day of age high proteolytic activity in pancreatic tissue and maximal serum concentrations of trypsin and A1PI were found in both hybrid and parental lines. Since 7 to 35 days of age A1PI concentration was nearly constant, serum trypsin concentration decreased while proteolytic activity in pancreatic tissue exhibited undulate increase; 2) Proteolytic activity in pancreatic tissue was higher in hybrids compared to the parental lines from 7 to 35 days of age (p < 0.05); 3) Supplementation of diet with exogenous enzymes stimulated the digestion due to the increase in protease activity in duodenal chymus by 9.1% compared to
Lack of Association between Polymorphisms in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 Sites of FGFR2 Gene with Breast Cancer in the Population of Kazakhstan  [PDF]
Timur S. Balmukhanov, Alexandra K. Khanseitova, Victoria G. Nigmatova, Alena S. Neupokoeva, Daria A. Sharafutdinova, Nagima A. Aitkhozhina
Advances in Breast Cancer Research (ABCR) , 2015, DOI: 10.4236/abcr.2015.44012
Abstract: Worldwide, breast cancer (BC) is the most common invasive cancer in women. Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine kinase receptor that is a member of the family of individually distinct fibroblast growth factor receptors involved in tumorigenesis. FGFR2 gene is amplified and over expressed in breast cancer (1 - 3). The aim of the study was to determine whether polymorphisms in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in FGFR2 gene are associated with breast cancer susceptibility in the population of Kazakhstan. The statistically significant associations between SNPs analyzed and breast cancer risk according χ2 and p < 0.05 criterions were not evaluated. The information describing the association of SNPs in FGFR2 with BC risk in the world populations could not be unambiguously used for Kazakhstan population.
Silica-Based Nanocoating Doped by Layered Double Hydroxides to Enhance the Paperboard Barrier Properties  [PDF]
Vania M. Dias, Alena Kuznetsova, Jo?o Tedim, Aleksey A. Yaremchenko, Mikhail L. Zheludkevich, Inês Portugal, Dmitry V. Evtuguin
World Journal of Nano Science and Engineering (WJNSE) , 2015, DOI: 10.4236/wjnse.2015.54015
Abstract: Paperboard is an environment-friendly multi-layer material widely used for packaging applications. However, for food packaging paperboard lacks essential barrier properties towards oxygen and water vapor. Conventional solutions to enhance these barrier properties (e.g. paperboard film coating with synthetic polymers) require special manufacturing facilities and difficult the end-of-life disposal and recycling of the paperboard. Paperboard coating with silica-based formulations is an eco-friendly alternative hereby disclosed. Silica-nanocoatings were prepared by sol-gel synthesis, with or without the addition of Zn(2)-Al-NO3 layered double hydroxides (LDHs), and applied on the surface (ca 2 g/m2) of industrial paperboard samples by a roll-to-roll technique. The physicochemical features of silica-nanocoatings were studied by FTIR-ATR, SEM/EDS, XRD analysis and surface energy measurements. The barrier properties of uncoated and silica-coated paperboard were accessed by water vapor transmission rate (WVTR) and oxygen permeability (Jo2) measurements. The best barrier results were obtained for paperboard coated with a mixture of tetraethoxysilane (TEOS) and 3-aminopropyltriethoxysilane (APTES), with and without the incorporation of LDHs.
Gene expression-based screening for inhibitors of PDGFR signaling
Alena A Antipova, Brent R Stockwell, Todd R Golub
Genome Biology , 2008, DOI: 10.1186/gb-2008-9-3-r47
Abstract: High throughput screening of small-molecule libraries is a well-established and highly productive tool for the identification of chemical compounds targeting a specific protein function of interest. Traditionally, the high-throughput screening for modulators of molecular pathways involves cell-free biochemical assays, or in some cases, highly specialized cell-based phenotypic assays [1]. However, in many cases the optimal target for therapeutic intervention is not known, or the development of a suitable phenotypic read-out is not technically feasible. For example, it is becoming increasingly of interest to modulate the activity of particular signal transduction pathways, but the components of such pathways are in many cases only partially known. It would therefore be of interest to develop a screening approach that could identify inhibitors of such pathways without first defining the biochemical target of candidate small molecules. Here we demonstrate that it is possible to use mRNA expression levels as a read-out to infer activity of a signal transduction pathway, thus establishing a general approach to screening for modulators of signal transduction pathways.Endogenous mRNA expression has been previously successfully used as a surrogate of cellular states in high-throughput screening for compounds inducing differentiation of acute myeloid leukemia cells, and for identifying inhibitors of androgen receptor-mediated transcriptional activation in prostate cancer [2-5]. It is not obvious, however, that gene expression signatures could be used to identify inhibitors of signal transduction pathways that are regulated at the level of post-translational modification (phosphorylation), as opposed to transcriptional regulation.To test the feasibility of using gene expression-based high-throughput screening (GE-HTS) to identify inhibitors of a signaling pathway, we chose platelet derived growth factor receptor (PDGFR) signaling for a proof-of-concept study, with particular e
A strategy for oligonucleotide microarray probe reduction
Alena A Antipova, Pablo Tamayo, Todd R Golub
Genome Biology , 2002, DOI: 10.1186/gb-2002-3-12-research0073
Abstract: The methodology has been tested on a dataset comprising 317 Affymetrix HuGeneFL GeneChips. The performance of the original and reduced probe sets was compared in four cancer-classification problems. The results of these comparisons show that reduction of the probe set by 95% does not dramatically affect performance, and thus illustrate the feasibility of substantially reducing probe numbers without significantly compromising sensitivity and specificity of detection.The strategy described here is potentially useful for designing small, limited-probe genome-wide arrays for screening applications.DNA microarrays have become commonplace for the genome-wide measurement of mRNA expression levels. The first described microarray for this purpose, the cDNA microarray, involves the mechanical deposition of cDNA clones on glass slides [1]. Although this strategy has proved highly effective, it has two limitations: cross-hybridization can occur between mRNAs and non-unique or repetitive portions of the cDNA clone; and the maintenance and quality control of large, arrayed cDNA libraries can be challenging. For these reasons, oligonucleotide microarrays have at least theoretical advantages. Short probes (25 nucleotides or longer) can be selected on the basis of their sequence specificity, and either synthesized in situ (by photolithography or inkjet technology) on a solid surface or conventionally synthesized and then robotically deposited.The first oligonucleotide microarrays contained hundreds of distinct probes per gene in order to maximize sensitivity and specificity of detection [2]. Over the past few years, the number of probes per gene has decreased as increasing amounts of sequence information have become available, probe-selection algorithms have improved, feature sizes have decreased and researchers have wanted to maximize the number of genes assayable on a single microarray. Nevertheless, no single array representing the entire human genome has been described. Furtherm
ELECTROPORATION OF CONFLUENT HM-1 ES CELLS LEADS TO HIGHER AMOUNT COLONIES
BENCSIK A. ALENA,BENCSIK I.,STANCULET JANA,BURA M.
Lucrari Stiintifice : Zootehnie si Biotehnologii , 2008,
Abstract: Electroporation is used to induce homologous recombination in the genome of the murine ES(embryonic stem) cells. Routinelly subconfluent ES cells are recommended to be used in suchexperiments. Electroporation of immunoglobulin specific targeting vectors with different length ofhomology leads to reduced number of selected colonies. The enrichment of double selected colonies ishigh and thus the amount of HM-1 ES cell colonies for the analysis is very low. Here we show that theelectroporation of confluent HM-1 ES cells leads to an increased amount of simple and doubleselected colonies.
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