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Search Results: 1 - 10 of 217503 matches for " Alberto Ortiz Arduán "
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Bisphenol A in Chronic Kidney Disease
Emilio González-Parra,Jose Antonio Herrero,Usama Elewa,Ricardo J. Bosch,Alberto Ortiz Arduán,Jesus Egido
International Journal of Nephrology , 2013, DOI: 10.1155/2013/437857
Abstract: Phenols are uremic toxins of intestinal origin formed by bacteria during protein metabolism. Of these molecules, p-cresol is the most studied and has been associated with renal function impairment and vascular damage. Bisphenol A (BPA) is a molecule with structural similarity with phenols found in plastic food and beverage containers as well as in some dialyzers. BPA is considered an environmental toxicant based on animal and cell culture studies. Japanese authorities recently banned BPA use in baby bottles based on observational association studies in newborns. BPA is excreted in urine and uremic patients present higher serum levels, but there is insufficient evidence to set cut-off levels or to link BPA to any harmful effect in CKD. However, the renal elimination and potential exposure during dialysis warrant the monitoring of BPA exposure and the design of observational studies in which the potential health risks of BPA for end-stage renal disease patients are evaluated. 1. Uremic Toxins Multiple molecules accumulate in chronic kidney disease (CKD), are responsible for uremic symptoms, and contribute to increased mortality (uremic toxins). Removal of uremic toxins therefore is accompanied by an improvement in the clinical situation. The term of uremic toxin was created by Piorry in 1847 to indicate the “blood contamination with urine” to refer to the signs and symptoms resulting from kidney disease that increase mortality. Bergstrom [1] proposed that a uremic toxin should be defined as one molecule that meets the following premises:(1)the chemical identity and concentration in biological fluids should be known,(2)the concentration in uremic individuals should be higher than in nonuremic subjects,(3)the concentration should correlate with uremic symptoms, and symptoms should disappear by decreasing the concentration. Uremic toxins have been classified according to size [2]. Over 350 small uremic toxins have been described with a molecular weight below 500?Da [3]. Medium-sized molecules have a molecular weight between 500 and 5000?Da. Many uremic toxins are bound to proteins which hamper their clearance. Uremic toxins are responsible for uremic disease. Among the changes that have been directly related to uremic toxins we find progressive loss of renal function, cardiovascular morbidity, and uremic symptoms such as anorexia, vomiting, weakness, sleep disturbances, and neuropathy. The origin of uremic toxins is multiple. Most uremic toxins originate from the endogenous cellular metabolism. However, there is a growing list of uremic toxins originated in
Puesta en marcha de una plataforma de proceso, almacenamiento y gestión de muestras clínicas: organización y desarrollo del Biobanco de REDinREN
Calleros,Laura; Cortés,María A.; Luengo,Alicia; Mora,Inés; Guijarro,Brenda; Martín,Paloma; Ortiz-Arduán,Alberto; Selgas,Rafael; Rodríguez-Puyol,Diego; Rodríguez-Puyol,Manuel;
Nefrología (Madrid) , 2012,
Abstract: background: the biobank creation in network for the kidney research (redinren) promotes the advance of kidney disease clinic research in spain. the biobank's aims are to generate an archive of clinical samples and associated data, furnish those samples to research teams, and coordinate with european biobanks. methods: in the beginning were indispensable the implementation of in force normative (bio-medic investigation law, dates protect law and biologic samples transport normative), a work protocol and the creation of medical database of the red. results: the biobank growth included infastructures and qualified personnel. in 2010 year, the patien samples increased in 2953 achieved 37,042 vials of differect nature stored. mereover in this moment the biobank participates in eleventh research projects. discussion: even if the biobank was designed for the support to redinren is neccesary to opening his biologic samples to all scientific nephrology community for promote the kidney disease research.
Transfer of Machined Patterns on an Aluminum Plate to Pyrex Glass Using Reactive Ion Etching SF6 Plasma without Masks  [PDF]
Carlos M. Ortiz-Lima, Fernando J. Qui?ones-Novelo, Alberto Jaramillo-Nú?ez, Jorge Castro-Ramos
Journal of Surface Engineered Materials and Advanced Technology (JSEMAT) , 2014, DOI: 10.4236/jsemat.2014.45030

A method for etching the surface of a Pyrex glass substrate using the Reactive Ion Etching process without the use of masks is reported. Variations in the machined surface on an auxiliary plate, manufactured in aluminum and placed below a Pyrex glass slide, were transferred to the upper surface of the substrate. SF6 as etching gas and low pressure chamber to promote the increase of mean free path of ions were used. Two etching ratios were found, general, that affects the entire surface of the substrate, and differential, which generates the relief on the surface of the glass. Differential etching depth showed a linear behavior with respect to time; the mean differential etching rate obtained was 43 nm/min. The same phase between the auxiliary plate machining and the etched pattern on the substrate is preserved. With this technique it was possible to manufacture convex and concave surfaces; some examples are given. The arithmetic mean roughness achieved with the proposed method was found to be N1 class, ideal for the development of optical corrector plates.

Seasonality of Lutzomyia fairtigi (Diptera: Psychodidae: Phlebotominae), a species endemic to Eastern Colombia
Molina, Jorge Alberto;Ortiz, Mario Iván;Guhl, Felipe;
Memórias do Instituto Oswaldo Cruz , 2008, DOI: 10.1590/S0074-02762008000500012
Abstract: the bionomics of sand flies (diptera: phlebotominae) was studied monthly for two consecutive years in alluvial gallery forests in the department of casanare, northeastern colombia. a total of 2,365 specimens and 10 species were captured using cdc light traps and shannon traps, and from diurnal resting places, and human landing collections. lutzomyia fairtigi martins (55%), lutzomyia micropyga (mangabeira) (20.9%), and lutzomyia antunesi (coutinho) (13.5%) were the predominant species in the region. lutzomyia flaviscutellata and lutzomyia panamensis, potential vectors of leishmania in colombia and neighboring countries, were also collected, but in low numbers. lu. fairtigi is an endemic species to colombia, and minimal data are available on its biology and distribution. the present study provides additional information about lu. fairtigi, such as the diurnal activity displayed by females on cloudy days, the greater density during the rainy season (april to october), marked anthropophilia, and the presence of flagellates in the midgut of one female.
Industria Farmacéutica y Psiquiatría
Mata Ruiz,Iván de la; Ortiz Lobo,Alberto;
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2003, DOI: 10.4321/S0211-57352003000200005
Abstract: we analyse the shift of the pharmaceutical companies activity: from investigation to marketing and promotion. we describe the different strategies that they use for this purpose and we discuss about the consequencies on psychiatry (on investigation, on mental disorder model, on psychiatrists, on mental health attention and on social speech).
Sesgos y dificultades en la investigación de los nuevos antipsicóticos
Mata Ruiz,lván de la; Ortiz Lobo,Alberto;
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2001, DOI: 10.4321/S0211-57352001000300005
Abstract: we describe the limitations of randomised clinical trials of drugs because of pifalls in methodological design, analysis and interpretation of results, ethical conflicts and publication bias. we analyse trials on new antipsychotics as example of these pitfalls and limitations.
Iván de la Mata Ruiz,Alberto Ortiz Lobo
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2005,
Abstract: David Healy. LET THEM EAT PROZAC. THE UNHEALTHY RELATIONSHIP BETWEEN THE PHARMACEUTICAL INDUSTRY AND DEPRESSION. Editorial: New York University Press. NewYork and London 2004 Idioma: ingles 350 páginas. Iván de la Mata Ruiz Christopher Dowrick. BEYOND DEPRESSION Oxford University Press, Oxford, 2004 .Alberto Ortiz Lobo
Sesgos y dificultades en la investigación de los nuevos antipsicóticos.
Iván de la Mata Ruiz,Alberto Ortiz Lobo
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2001,
Abstract: En este trabajo se pone de manifiesto lo limitados y poco generalizables que son los ensayos clínicos controlados aleatorizados con fármacos debido a errores y dificultades de dise o, análisis e interpretación de resultados, los conflictos éticos que plantean y lo sesgada que es la información que nos llega a través de las revistas científicas, todo ello ejemplificado con los nuevos antipsicóticos.
Industria Farmacéutica y Psiquiatría.
Iván de la Mata Ruiz,Alberto Ortiz Lobo
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2003,
Abstract: Se analiza el cambio que ha experimentado la industria farmacéutica desde una labor centrada en la investigación a una actividad volcada en el marketing y la promoción. Describimos las diferentes estrategias que están utilizando para ello y discutimos las repercusiones que están teniendo sobre la psiquiatría (en la investigación, en el modelo de enfermedad mental, en los psiquiatras, en la asistencia y en el discurso social)
Materiales docentes para el desarrollo de los seminarios de Morfofisiología Humana I
Ortiz Rodríguez,Felino; Gómez álvarez,Ana María; Román Collazo,Carlos Alberto;
Educaci?3n M??dica Superior , 2012,
Abstract: the inclusion of human morphophysiology discipline in the medical studies curriculum demands the improvement of the learning evaluation. a literature review was made on the learning evaluation as well as on the teaching process documents kept in the human morphology department of the latin american school of medicine (known as elam). based on this, a handbook called "teaching materials for the development of evaluative activities in human morphopysiology i" was drafted, which is available at http://www.uvs.sld.cu/repositorio/recursos-uvs/ and covers teaching tasks for development of evaluated classes (seminars) in human morphopysiology i subject, methodological suggestions to carry out evaluation activities (seminars) in human morphopysiology i, and recommendations to improve construction of written questions. thus, the students can have at their disposal a set of teaching tasks to prepare themselves prior to the evaluated classes, and the faculty avails of three pedagogically substantiated instruments endorsed by eight experts to contribute to the improvement of the human morphopysiology i seminars.
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