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Search Results: 1 - 10 of 4652 matches for " Albert CM "
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Sudden vigorous exercise associated with increased risk of death
Lyford Joanna,Albert CM,Mittleman MA,Chae CU
Current Controlled Trials in Cardiovascular Medicine , 2000, DOI: 10.1186/cvm-2001-72062
Abstract:
Teachers' ideas versus experts' descriptions of 'the good teacher' in postgraduate medical education: implications for implementation. A qualitative study
Thea CM van Roermund, Fred Tromp, Albert JJA Scherpbier, Ben JAM Bottema, Herman J Bueving
BMC Medical Education , 2011, DOI: 10.1186/1472-6920-11-42
Abstract: Recently, a new competency-based description of the good teacher was developed and introduced in all the Departments of Postgraduate Medical Education for Family Physicians in the Netherlands. We compared the views reflected in the new description with the views of teachers who were required to adopt the new framework.Qualitative study. We interviewed teachers in two Departments of Postgraduate Medical Education for Family Physicians in the Netherlands. The transcripts of the interviews were analysed independently by two researchers, who coded and categorised relevant fragments until consensus was reached on six themes. We investigated to what extent these themes matched the new description.Comparing the teachers' views with the concepts described in the new competency-based framework is like looking into two mirrors that reflect clearly dissimilar images. At least two of the themes we found are important in relation to the implementation of new educational methods: the teachers' identification and organisational culture. The latter plays an important role in the development of teachers' ideas about good teaching.The main finding of this study is the key role played by the teachers' feelings regarding their professional identity and by the local teaching culture in shaping teachers' views and expectations regarding their work. This suggests that in implementing a new teaching framework and in faculty development programmes, careful attention should be paid to teachers' existing identification model and the culture that fostered it.In times of change in medical education, teachers are often asked to adapt to a new concept of what being a good teacher includes [1,2]. These new concepts represent what is considered to be best educational practice and are often developed by experts outside the departments where the changes are to be implemented. The concepts are based on an analysis of the teachers' tasks and/or educational theory and operationalized in competency profi
Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study
Abbas Dehghan, Mandy van Hoek, Eric JG Sijbrands, Ben A Oostra, Albert Hofman, Cornelia M van Duijn, Jacqueline CM Witteman
BMC Medicine , 2008, DOI: 10.1186/1741-7015-6-30
Abstract: The Rotterdam Study is a population-based, prospective cohort study among 7983 participants aged 55 years and older. Associations of the polymorphisms with CHD and MI were assessed by use of Cox proportional hazards analyses.In an additive model, the age and sex adjusted hazard ratios (HRs) (95% confidence interval) for CHD and MI were 1.03 (0.90, 1.18) and 0.94 (0.82, 1.08) per copy of the G allele of rs10757274. The corresponding HRs were 1.03 (0.90, 1.18) and 0.93 (0.81, 1.06) for the G allele of rs10757278. The association of the SNPs with CHD and MI was not significant in any of the subgroups of CHD risk factors.we were not able to show an association of the studied SNPs with risks of CHD and MI. This may be due to differences in genes involved in the occurrence of CHD in young and older people.It has been considered for long that genes play a substantial role in susceptibility to coronary heart disease (CHD) [1]. Up to now, a limited number of these genes have been identified through the candidate gene approach and genome wide linkage studies. Recently a number of genome wide association (GWA) studies have identified several genetic variants on chromosome 9p21 associated with the risk of CHD. McPherson et al. found a Single Nucleotide Polymorphism (SNP), rs10757274, on chromosome 9p21 associated with the risk of CHD [2]. Helgadottir et al. found a close-by SNP, rs10757278, in the same 9p21 region associated with the risk of myocardial infarction (MI) [3]. These findings were followed by another GWA study by Samani et al [4], which found rs1333049 to be associated with the risk of coronary artery disease [4]. All three SNPs are located within the same Linkage Disequilibrium (LD) block on chromosome 9 approximately 22 million base pairs from the 9p telomere, adjacent to two tumor suppressor genes, CDKN2A and CDKN2B. These genes are involved in regulation of cell proliferation. Abnormal proliferation is one of the characteristics of atherosclerosis, one of the pa
Survey of Students' Opinions as a Strategy for Improving Lerner-friendly and Defective Classroom Encounters
CM Anikweze
Ethiopian Journal of Education and Sciences , 2007,
Abstract: Based on the fact that virtually all the experiences to which learners are exposed in formal education are derived from a combination of psychological considerations, the expectations and prescriptions of the subject discipline, the society and its culture, the ideas of educational philosophers and curriculum experts, and that no conscious effort is normally made to consult the learners for opinions even at the secondary and tertiary education levels, the deschoolers have accused the school of teaching a hidden curriculum. Worried that even the prescriptions that are usually considered as contributory to effective teaching methodology are attributable to the ideas and principles enunciated by educational psychologists and philosophers, the researcher embarked on a pilot survey of students' opinions about teacher effectiveness. A questionnaire of the data blank to was administered to a sample of 80 Senior Secondary II students randomly selected from two Federal government Colleges (one boys' and one girls') located in the Federal Capital Territory Abuja. Effort was made to ensure gender balance in the selection of samples. The subjects were asked to state three objectives of being in school, three expectations from teachers and three objectives of being in school, three expectations from teachers and three hateful teacher-behaviors. Data were analyzed with descriptive statistics. Results showed that adolescents in secondary schools were fully aware why they were in school and could discriminate the qualities of effective teachers. The researcher recommends that a realistic perception of effective teaching methodology should be a blending of the perspectives from teachers' pedagogical insights, the students' perspectives and the perspectives of the society that is the consumer of the college output. Ethiopian Journal of Education and Sciences Vol. 3 (1) 2007: pp. 11-22
The forgotten resource: Community perspectives on conservation and well - being in Zahamena National Park, Madagascar
CM Raboanarielina
Madagascar Conservation & Development , 2012,
Abstract: This research examines local perceptions of social well - being in two forest - dependent communities near Zahamena National Park (ZNP), Madagascar. Key informant interviews were conducted to observe how local context, including community and ecological factors, influenced perceptions of social well - being. Overall, residents expressed a broad sense of decreased well-being as local forest resource access changed following the creation of ZNP. While one community was more dependent on forest and non - timber forest products for their livelihood, both communities believed lack of access to the park and its resources negatively affected local social well - being. Further, both communities felt ZNP provided few benefits to local residents. In addition, informants alluded to a sense of distrust of conservation managers and believed their needs and concerns were neither heard nor addressed by current conservation programs. Such data confirm people living in rural communities adjacent to protected areas have limited impact on conservation policies and initiatives on the island. Implications of this research suggest a reassessment of institutional conservation policy and practices to reflect locally held social traditions and community beliefs about conservation. RéSUMé Cette étude examine les perceptions locales de la qualité de vie dans deux communautés dépendantes de la forêt et vivant à proximité du Parc National de Zahamena à Madagascar. Des entretiens ont été menés pour analyser comment le contexte local, tant au niveau des facteurs communautaires qu’écologiques, a influencé les perceptions portant sur la qualité de vie. En général, les résidents ont constaté une baisse de leur qualité de vie depuis la création du Parc à cause du changement d accès aux ressources forestières locales. Une des communautés dépendait des produits forestiers ligneux et non ligneux pour sa subsistance et une autre communauté a estimé que le fait de ne pouvoir accéder au Parc et à ses ressources avait détérioré son niveau de vie. En outre, les deux communautés ont considéré que le Parc avait fourni peu d’avantages aux résidents. Les personnes interviewées ont également exprimé une certaine méfiance à l’égard des gestionnaires du programme de conservation qui, selon elles, n’ont répondu ni à leurs besoins ni à leurs préoccupations. Ces résultats confirment que les communautés rurales vivant à proximité des aires protégées ont une influence limitée sur la politique et les initiatives de conservation à Madagascar. Cette recherche suggère que la politique de conservation doit être réévaluée et qu’il y a lieu de rechercher de nouvelles pratiques permettant d’intégrer les traditions sociales locales et les croyances communautaires dans les actions de conservation.
Domiciliary mental health care program in community settings: Is it is feasible in Malawi?
CM Mwale
Malawi Medical Journal , 2011,
Abstract: No
OSA – a risk factor for stroke
Ryan CM
ChronoPhysiology and Therapy , 2011, DOI: http://dx.doi.org/10.2147/CPT.S16490
Abstract: – a risk factor for stroke Review (1549) Total Article Views Authors: Ryan CM Published Date December 2011 Volume 2011:1 Pages 43 - 57 DOI: http://dx.doi.org/10.2147/CPT.S16490 Clodagh M Ryan Centre for Sleep Health and Research, University of Toronto/Toronto General Hospital, Toronto, Canada Abstract: Obstructive sleep apnea is a sleep breathing disorder characterized by recurrent and intermittent hypoxia with continued respiratory effort against a closed glottis. The result of this is a cascade of acute and chronic systemic pathophysiological responses that cause endothelial dysfunction, atherosclerosis and lead to cardiovascular and cerebrovascular disease. This article focuses on the clinical evidence linking obstructive sleep apnea and stroke and on the specific mechanisms perpetuating stroke risk in this population.
Pharmacokinetics and pharmacodynamics of insulin analogs in special populations with type 2 diabetes mellitus
Morello CM
International Journal of General Medicine , 2011, DOI: http://dx.doi.org/10.2147/IJGM.S26889
Abstract: rmacokinetics and pharmacodynamics of insulin analogs in special populations with type 2 diabetes mellitus Review (5096) Total Article Views Authors: Morello CM Published Date December 2011 Volume 2011:4 Pages 827 - 835 DOI: http://dx.doi.org/10.2147/IJGM.S26889 Candis M Morello1,2 1Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 2School of Pharmacy, University of California San Francisco, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA Introduction: The goal of insulin therapy in patients with either type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) is to match as closely as possible normal physiologic insulin secretion to control fasting and postprandial plasma glucose. Modifications of the insulin molecule have resulted in two long-acting insulin analogs (glargine and detemir) and three rapid-acting insulins (aspart, lispro, and glulisine) with improved pharmacokinetic/pharmacodynamic (PK/PD) profiles. These agents can be used together in basal-bolus therapy to more closely mimic physiologic insulin secretion patterns. Methods: This study reviews effects of the multiple demographic and clinical parameters in the insulin analogs glargine, detemir, lispro, aspart, and glulisine in patients with T2DM. A search was conducted on PubMed for each major topic considered (effects of injection site, age, race/ethnicity, obesity, renal or hepatic dysfunction, pregnancy, exercise, drug interactions) using the topic words and name of each type of insulin analog. Information was also obtained from the prescribing information for each insulin analog. Results: The PK/PD profiles for insulin analogs may be influenced by many variables including age, weight, and hepatic and renal function. However, these variables do not have equivalent effects on all long-acting or rapid-acting insulin analogs. Conclusion: Rapid-acting and long-acting insulin analogs represent major advances in treatment for patients with T2DM who require insulin therapy. However, there are potentially important PK and PD differences between the two long-acting agents and among the three rapid-acting insulin analogs, which should be considered when designing treatment regimens for special patient groups.
Management of diabetes across the course of disease: minimizing obesity-associated complications
Apovian CM
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy , 2011, DOI: http://dx.doi.org/10.2147/DMSO.S24022
Abstract: nagement of diabetes across the course of disease: minimizing obesity-associated complications Review (5749) Total Article Views Authors: Apovian CM Published Date October 2011 Volume 2011:4 Pages 353 - 369 DOI: http://dx.doi.org/10.2147/DMSO.S24022 Caroline M Apovian Medicine and Pediatrics, Boston University School of Medicine; Nutrition and Weight Management Center; and Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston Medical Center, Boston, MA, USA Abstract: Obesity increases the risk for developing type 2 diabetes mellitus (T2DM) and this in turn correlates with an elevated probability of long-term diabetes complications once diabetes is established. Interventions aimed at lowering weight via changes in diet and lifestyle have repeatedly been shown to improve glycemic control in patients with T2DM and even to reverse early disease. Weight gain, a potential side effect of treatment for patients with T2DM, is also an important concern, and it has been noted that weight increases associated with antidiabetes therapy may blunt cardiovascular risk reductions achieved by decreasing blood glucose. Among older agents, metformin and acarbose have the lowest risk for weight gain, while sulfonylureas, meglitinides, and thiazolidinediones are all associated with weight increases. Clinical trial results have also consistently demonstrated that treatment with glucagon-like peptide-1 receptor agonists and amylin lowers weight, and that dipeptidyl peptidase-4 inhibitors are weight neutral in patients with T2DM. Conventional human insulin formulations are known to increase weight in patients with T2DM. However, some insulin analogs, particularly insulin detemir, have lower liability for this adverse event. The use of both pharmacologic and surgical therapies aimed at treating obesity rather than lowering blood glucose have the potential to improve glycemic control and even resolve T2DM in some patients.
Descripción clínica y radiológica del Síndrome DYGGVE-Melchior-Clausen
Restrepo CM.
Acta Biológica Colombiana , 2001,
Abstract: El Síndrome Dyggve Melchior Clausen (SDMC) es una displasia esquelética caracterizada por enanismo de tronco corto con cambios radiográficos significativos asociado o no con retardo mental (este último también se le ha llamado Síndrome Smith-McCord). Fue descrito por Dyggve, Melchior y Clausen en 1962, se le considera de baja incidencia, aunque se han descrito más de 50 casos y presenta heterogeneidad genética con formas de herencia Autosómica Recesiva y Ligada al Sexo Recesiva.
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