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Role of Adaptive Immunity in Alcoholic Liver Disease
Emanuele Albano
International Journal of Hepatology , 2012, DOI: 10.1155/2012/893026
Abstract: Stimulation of innate immunity is increasingly recognized to play an important role in the pathogenesis of alcoholic liver disease (ALD), while the contribution of adaptive immunity has received less attention. Clinical and experimental data show the involvement of Th-1 and Th-17 T-lymphocytes in alcoholic hepatitis. Nonetheless, the mechanisms by which alcohol triggers adaptive immunity are still incompletely characterized. Patients with advanced ALD have circulating IgG and T-lymphocytes recognizing epitopes derived from protein modification by hydroxyethyl free radicals and end products of lipid-peroxidation. High titers of IgG against lipid peroxidation-derived antigens are associated with an increased hepatic production of proinflammatory cytokines/chemokines. Moreover, the same antigens favor the breaking of self-tolerance towards liver constituents. In particular, autoantibodies against cytochrome P4502E1 (CYP2E1) are evident in a subset of ALD patients. Altogether these results suggest that allo- and autoimmune reactions triggered by oxidative stress might contribute to hepatic inflammation during the progression of ALD.
Fazendo sentido do som
Eleonora Albano
Ilha do Desterro , 2008,
Abstract: é um lugar comum na Linguistica deste século dizer-se que s o fonológicas apenas aquelas diferen as de som que ervem para distinguir significa es (Jakobson 1976:12[1932], Troubetzkoy1957119391: 1-15, Chomsky & Halle 1968:3-14). 0 que poucos linguistas reconhecem é que essa afirma o pode ser virada pelo avesso se interpretada à luz da Semántica e da Pragmática contemporaneas. Para simplificar, tomemos como ponto-de-partida a distin o feita por Lyons entre significado descritivo e n o descritivo (1977, vol. 1:50-56). Se esse último contribui para diferenciar entre os enunciados possíveis, ent o há mais trilhas entre o som e a "coisa" do que sonha a nossa v Fonologia. Pois um signatum elástico, variável, que vai além de um estado de coisas determinado num mundo objetivo, para incluir o social e até subjetivo, como querem, por exemplo, Austin (1962), Searle(1969) ou Ducrot (1973), sup e também um signans elástico, variável, que possa, ao menos, apontar para os contornos - vagos - de um tal real. Em outras palavras, assumir a existência de uma lista aberta de diferen as de sentido implica abrir m o de uma lista fechada de diferen as pertinentes de som.
The Need and the Present Situation of Educational Sciences. Conference given at the Lisbon Science Academy, on 27th July 2006
Albano Estrela
Sísifo : Educational Sciences Journal , 2006,
Abstract:
The brain drain: winners and losers. Socio-economic effects of highly skilled migrations on both sending and host countries
Alessandro Albano
Sfera Politicii , 2012,
Abstract: The aim of this paper is to provide an overview of the most important theories on brain drain” socio-economic effects both on sending and host countries. Therefore, all the main results of the analysis of three generations of Authors will be examined. So, this study will allow to understand which countries should have benefits from highly skilled migrations.
Carleman estimates for the Euler-Bernoulli plate operator
Paolo Albano
Electronic Journal of Differential Equations , 2000,
Abstract: We present some a-priori estimates of Carleman type for the Euler-Bernoulli plate operator. As an application, we consider a problem of boundary observability for the Euler-Bernoulli plate coupled with the heat equation.
Role of Adaptive Immunity in Alcoholic Liver Disease
Emanuele Albano
International Journal of Hepatology , 2012, DOI: 10.1155/2012/893026
Abstract: Stimulation of innate immunity is increasingly recognized to play an important role in the pathogenesis of alcoholic liver disease (ALD), while the contribution of adaptive immunity has received less attention. Clinical and experimental data show the involvement of Th-1 and Th-17 T-lymphocytes in alcoholic hepatitis. Nonetheless, the mechanisms by which alcohol triggers adaptive immunity are still incompletely characterized. Patients with advanced ALD have circulating IgG and T-lymphocytes recognizing epitopes derived from protein modification by hydroxyethyl free radicals and end products of lipid-peroxidation. High titers of IgG against lipid peroxidation-derived antigens are associated with an increased hepatic production of proinflammatory cytokines/chemokines. Moreover, the same antigens favor the breaking of self-tolerance towards liver constituents. In particular, autoantibodies against cytochrome P4502E1 (CYP2E1) are evident in a subset of ALD patients. Altogether these results suggest that allo- and autoimmune reactions triggered by oxidative stress might contribute to hepatic inflammation during the progression of ALD. 1. Introduction According to the World Health Organization, alcohol-related diseases are the third cause of death and disability in most well-developed countries and a leading cause of disease in the developing countries in Eastern Europe, Central and South America, and East Asia [1]. Although several organs are injured by ethanol, alcoholic liver disease (ALD) is the most common medical consequence of excessive alcohol intake accounting for about 70% of the recorded mortality [2]. Thus, understanding the mechanisms responsible for alcohol liver injury has a relevant clinical and social impact. Current view indicates that multiple factors including oxidative stress, endoplasmic reticulum stress, metabolic alterations, and interferences with the transduction of intracellular signals are involved in ALD pathogenesis [3]. Furthermore, emerging evidence suggests that chronic inflammation represents the driving force in the evolution of alcohol liver injury. In this context, a large number of studies have investigate the role of innate immunity in ALD ([4–8] for recent review), while the contribution of adaptive immunity to alcohol-induced hepatic inflammation has received much less attention. This paper will give an overview of the possible implications of adaptive immunity in the inflammatory processes associated with ALD. Early studies have shown that liver inflammatory infiltrates in alcoholic hepatitis and active alcoholic
Dynamics of reactant interfaces in irreversible reaction systems
Albano, Ezequiel V.;
Brazilian Journal of Physics , 2000, DOI: 10.1590/S0103-97332000000100002
Abstract: recent progress in the study and understanding of the properties of interfaces between reactants in irreversible reaction systems, gained from monte carlo simulations, is reviewed and discussed. the displacement of unstable phases by stable ones causes the formation of interfaces. this mechanism is particularly relevant close to first-order irreversible phase transitions, where phase coexistence is observed. different variants of the monomer-momomer and the monomer-dimer models exhibit such transitions, and they are therefore suitable for the study of interfacial properties. more specifically, due to stimulating experimental findings, the monomer-dimer model, which mimics the catalytic oxidation of carbon monoxide, has been the subject of extensive studies, which are discussed in detail.
Arte e pedagogia: além dos territórios demarcados
Albano, Ana Angélica;
Cadernos CEDES , 2010, DOI: 10.1590/S0101-32622010000100003
Abstract: this paper presents an educational experience in a social project for children living in at-risk conditions, involving one pedagogue and one artist. both of them were working on the same project and studying at the same university, but only met at the project site. they partook of the same responsibilities, but didn't share them with each other. as i taught both of these students, though they were in different institutes and teacher training courses, i could follow their debates very closely. my aim here is to reflect on the necessity, despite the difficulties, of bringing together professionals from the fields of art and education. i also focus on the importance of finding methodologies for art education research that respect the specificities of this field. using jungian psychology as my primary reference, i discuss the importance of using images as guidelines for research in art and the need to develop very attentive and respectful observation strategies, so that everything that needs to be discovered has time to emerge.
O Português brasileiro e as controvérsias da fonética atual: pelo aperfei?oamento da Fonologia Articulatória
ALBANO, Eleonora Cavalcante;
DELTA: Documenta??o de Estudos em Lingüística Teórica e Aplicada , 1999, DOI: 10.1590/S0102-44501999000300002
Abstract: the paper examines the recent trends of phonetic studies in brazil, a productive area which analyses brazilian-portuguese data and contributes to phonetic theory. the central question discussed in the approach is the relationship between phonetic and phonology.
A rela??o entre o desenvolvimento de formalismos gramaticais de base lexicalista e as exigências do PLN
Pria, Albano Dalla;
DELTA: Documenta??o de Estudos em Lingüística Teórica e Aplicada , 2008, DOI: 10.1590/S0102-44502008000200003
Abstract: this paper aims to associate the development of formal grammars under lexicalist hypothesis and requirements of nlp systems. structured lexicons and formal grammars are required to nlp systems. this work is supported by the development of hpsg model. since its inception hpsg has been conceived as a formal theory involved with formal descriptions and implementations of linguistic phenomena. nowadays, hpsp engagement with nlp is reinforced by its implementations for many languages.
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