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Search Results: 1 - 10 of 325571 matches for " Alaa S. Deeb "
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Gastroesophageal Reflux in Children with Refractory Asthma
Alaa S. Deeb,Amal Al-Hakeem,Ghazal S. Dib
Oman Medical Journal , 2010,
Abstract: Objectives: To investigate the association between clinical and macroscopic findings of GER and severity of refractory asthma (statistical study).Methods: A prospective study in a university-based practice of 75 children who were diagnosed with refractory asthma because they exhibited no satisfactory response for at least three months of treatment. Medical history, physical examination, spirometrical measurements and prick skin test were conducted on all patients. Endoscopic and macroscopic evaluations for esophagitis were performed on all patients regardless of the presence of GER symptoms.Results: Endoscopy was done for 75 children with refractory asthma. GER was symptomatic in 65% of all patients with no statistical significance (p>0.05) and the most frequent symptom was abdominal pain (67%). The frequency of these symptoms was 50% in mild asthma, 58% in moderate asthma and 72% in severe asthma with no statistical significance (p>0.05). The frequency of macroscopic esophagitis was 71%, distributed in three asthmatic groups as in order of 75% in mild asthma, 58.3% in moderate asthma and 76.6% in severe asthma (p>0.05). Regarding the relationship between GER and nocturnal attacks or spasmodic cough, the frequency of the latest was 66.7%. The differences have no statistical significance regarding GER symptoms (p>0.05), but they are statistically significant regarding the reflux esophagitis (p<0.05). Also endoscopic reflux was as frequent as76.3% in non allergic patients, and this result is statistically significant (p<0.05).Conclusion: In spite of the fact that there was no relationship between the severity of asthma and the symptoms of GER, or its endoscopic findings, the frequency of GER in asthmatic children was higher than its frequency in other children.
Integrated Geophysical, Remote Sensing and GIS Studies for Groundwater Assessment, Abu Zenima Area, West Sinai, Egypt  [PDF]
Mohamed H. Khalil, Khalid S. Ahmed, Alaa Eldin H. Elnahry, Alaa N. Hasan
International Journal of Geosciences (IJG) , 2014, DOI: 10.4236/ijg.2014.59078
Abstract:

The integration between advanced techniques for groundwater exploration is necessary to protect and to manage the vital resources. Enhanced Thematic Mapper Landsat (ETM+) images, a geographic information system (GIS), hydrological modeling and direct current (DC) resistivity geoelectrical techniques were used in integrated manner to identify the groundwater potentialities in the study area. The study area is approximately 1195 km2, located at the western portion of south Sinai. From the results of the eight thematic layers as input to GIS model, the suitable locations for dams could be estimated in the two main drainage basins Matulla and Tayiba.

Extracellular Biosynthesis of AgNPs by the Bacterium Proteus mirabilis and Its Toxic Effect on Some Aspects of Animal Physiology  [PDF]
Mohammad S. Al-Harbi, Bahig A. El-Deeb, Nasser Mostafa, Sayed A. M. Amer
Advances in Nanoparticles (ANP) , 2014, DOI: 10.4236/anp.2014.33012
Abstract:
The development of a reliable green chemistry process for the biogenic synthesis of nanomaterials is an important aspect of current nanotechnology research. Silver nanoparticles (AgNPs) have been used as antimicrobial and disinfectant agents. However, there is limited information about its toxicity. Therefore, this study focused on the biosynthesis of AgNPs by the bacterium Proteus mirabilis and on determining its preliminary toxic effect on some aspects of animal physiology. A green method for the synthesis of AgNPs using culture supernatant of Proteus mirabilis has been developed in this study and the synthesized AgNPs were characterized by several techniques. The AgNPs showed a maximum absorbance at 445 nm on ultraviolet-visible spectra. The presence of proteins was identified by Fourier transform-infrared spectroscopy. The reduction of Ag+ to elemental silver was characterized by X-ray spectroscopy analysis. The transmission electron micrograph revealed the formation of polydispersed nanoparticles of 5 - 45 nm. The AgNPs were evaluated for their toxic effect on pregnant female albino rat. The result showed that liver enzymes (AST and ALP) were decreased significantly in the group treated with AgNPs. Mean corpuscular hemoglobin concentration also showed significant increase.
The Role of the PGC1 Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy
Samir S. Deeb,John D. Brunzell
PPAR Research , 2009, DOI: 10.1155/2009/649286
Abstract: The Diabetes Control and Complications Trial (DCCT) involved intensive diabetes therapy of subjects with type 1 diabetes mellitus (T1DM) for an average period of 6.5 years. A subset of these subjects gained excessive weight. We tested for association of polymorphisms in 8 candidate genes with the above trait. We found the Gly482Ser polymorphism in the peroxisome proliferator-activated receptor coactivator-1 (PGC1) to be significantly associated with weight gain in males (=.0045) but not in females. The Ser allele was associated with greater weight gain than the Gly allele (=.005). Subjects with a family history of type 2 diabetes mellitus (T2DM) were more common among those who gained excessive weight. We conclude that T2DM and the Gly482Ser polymorphism in PGC1 contribute to the effect of intensive diabetes therapy on weight gain in males with T1DM.
The Frequency of Nail Changes and Disorders in Iraqi People above 50 Years Old  [PDF]
Azar H. Maluki, Alaa S. Al-Hulli
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2016, DOI: 10.4236/jcdsa.2016.64016
Abstract: Background: Nail changes associated with ageing are common in the elderly and include characteristic modifications of color, contour, growth, surface, thickness and histology. No cutaneous examination is complete without a careful clinical evaluation of the nails. Objective: The aim of present work is to assess the frequency of senile nail changes and disorders in Iraqi people above 50 years old compared with control age group (20 - 30 years old). Patients and methods: This case-controlled, cross-sectional study was performed in the outpatient clinic of Dermatology and Venereology Department at the Kufa College of Medicine Teaching Hospital in Najaf Province in the period from September 2010 to April 2011. The study included 200 subjects, of which 100 patients were above 50 years old (study group), and the other 100 subjects were from 20 - 30 years old (control group). A detailed history from each subject was recorded to detect the onset, duration and progression of nail changes and/or disorders, their occupation and any environmental exposure. A careful examination of the nails was carried out to assess the type of nail changes, site and symmetry. Any patient with systemic disease, dermatological disease or with suspected drug intake was excluded from the study. Results: The present work has shown that many nail changes were more frequent among older age individuals than younger age group with significant statistical difference (p = 0.043 - 0.000) like dull opaque appearance, rough lusterlessness, longitudinal ridging, altered thickness, ragged cuticle, altered contour, subungual hyperkeratosis and scaling nail folds. Chromonychia was not statistically significant (14% of study group versus 16% of the control) with p = 0.692. Longitudinal melanonychia was significantly higher in the study group (6% versus 0% of the control) with p = 0.013, while punctate leukonychia was significantly higher in the control group (16% versus 4% of study group) with p = 0.005. Conclusion: Some changes of the nail are significantly correlated with advanced age like dull opaque nails, rough lusterlessness, longitudinal ridging. Therefore, these signs can be regarded as indicative of ageing of healthy Iraqi people.
Preparation and Characterization of Oligomer from Recycled PET and Evaluated as a Corrosion Inhibitor for C-Steel Material in 0.1 M HCl  [PDF]
Ali H. Yasir, Alaa S. Khalaf, Moayad N. Khalaf
Open Journal of Organic Polymer Materials (OJOPM) , 2017, DOI: 10.4236/ojopm.2017.71001
Abstract: Polyethylene terephthalate waste (PET) was depolymerized by thiodiglycol into thioglycolyzed product. The product was characterized by FTIR and 1HNMR spectroscopy and the thermal properties (TGA, DTA) showed that the prepared compound was thermally stable until 250°C. The efficiency of the prepared corrosion inhibitor for carbon steel was measured by using acid media (0.1 HCl) as corrosive environment and the inhibitor concentration was (0, 10, 20, 30, 40 and 50 ppm). The electrochemical technique used Tafel plot to measure the efficiency of inhibitor. Factors effect on the rate of corrosion like temperature (298, 308, 318, 328 K) and concentration (10, 20, 30, 40, 50 ppm) of inhibitor were studied. From the obtained results many factors were calculated that determined the efficiency of the inhibitor like corrosion rate, charge transfer resistance and inhibitor efficiency. It was observed that the corrosion rate and charge transfer of the carbon steel for the inhibitor increase with increase of temperature and decrease with increase of the inhibitor concentration in the same temperature. The results showed that the inhibitor had high inhibition in reducing the corrosion rate. The inhibition efficiency (% IE) reached 97.1% for the 40 ppm concentration at 308 K.
Exploring QSARs for Inhibitory Activity of Cyclic Urea and Nonpeptide-Cyclic Cyanoguanidine Derivatives HIV-1 Protease Inhibitors by Artificial Neural Network  [PDF]
Omar Deeb, Mohammad Jawabreh
Advances in Chemical Engineering and Science (ACES) , 2012, DOI: 10.4236/aces.2012.21010
Abstract: Quantitative structure–activity relationship study using artificial neural network (ANN) methodology were conducted to predict the inhibition constants of 127 symmetrical and unsymmetrical cyclic urea and cyclic cyanoguanidine derivatives containing different substituent groups such as: benzyl, isopropyl, 4-hydroxybenzyl, ketone, oxime, pyrazole, imidazole, triazole and having anti-HIV-1 protease activities. The results obtained by artificial neural network give advanced regression models with good prediction ability. The two optimal artificial neural network models obtained have coefficients of determination of 0.746 and 0.756. The lowest prediction’s root mean square error obtained is 0.607. Artificial neural networks provide improved models for heterogeneous data sets without splitting them into families. Both the external and cross-validation methods are used to validate the performances of the resulting models. Randomization test is employed to check the suitability of the models.
Qualification of Soft Costs of the US Federal Guidance When Considering Greenhouse Gas Emissions and the Effects of Climate Change in NEPA Reviews  [PDF]
Maria Angelica Deeb
Journal of Geoscience and Environment Protection (GEP) , 2015, DOI: 10.4236/gep.2015.36010
Abstract:

A notice by the Council of Environmental Quality (CEQ) was published on December 14, 2014 regarding the revised “Draft Guidance for Federal Departments and Agencies on Consideration of Greenhouse Gas Emissions and the Effects of Climate Change in NEPA Reviews”. The review of this 2014 draft guidance suggested increased analysis, work, review and approvals required by the State Department of Transportation (DOT) and Federal Highway Administration (FHWA) working with and on behalf of local public agencies (LPAs) in order to authorize and obligate roadway projects funded with federal-aid money. All federal-aid-funded roadway projects require a NEPA analysis to be done on the action (project) and an environmental clearance document to be obtained prior to finalizing the design. The 2014 draft guidance may complicate an already lengthy and often critical path activity for roadway projects requiring NEPA documentation.

Study of the Efficacy of Triple Therapy of Sofosbuvir, Pegylated INFalpha 2a and Ribavirin in Treatment of Chronic Hepatitis C Patients Genotype 4 with High Fibrosis  [PDF]
Alaa Aboud
Open Journal of Gastroenterology (OJGas) , 2017, DOI: 10.4236/ojgas.2017.71002
Abstract: Purpose: The aim is evaluation of the efficacy of triple therapy of sofosbuvir, pegylated INFalpha 2a and ribavirin in treatment of chronic hepatitis C (CHC) patients genotype 4 who have high fibrosis. Materials and Methods: Fifty HCV patients with high fibrosis (F3 & F4) were included in the study. Results: SVR rate was 54%; non-responders rate was 12% and relapsers rate was 34%. When comparing SVR between F3 group patients and F4 group, it was 88% and 66% respectively, which means that SVR was higher in the F3 group. Conclusion: Triple therapy including pegylated INFalpha 2a is not an ideal therapy in treatment of CHC patients genotype 4 with cirrhosis because of low sustained virological response rates and high incidence of side effects.
Autofluorescence of routinely hematoxylin and eosinstained sections without exogenous markers
S Deeb, KH Nesr, E Mahdy, M Badawey, M Badei
African Journal of Biotechnology , 2008,
Abstract: Hematoxylin and eosin stained paraffin section was examined by fluorescence microscopy to study the pattern and distribution of fluorescence. Autofluorescence was sensitive and specific for detection of elastic and collagen fibers. It was concluded that analytical morphological techniques based on autofluorescence can obtain information about morphological and pathological state of tissue and cells.
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