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Aqueous extract of Salvia officinalis and Ruta graveolens: Potential source of reactive nitrogen species
Al-Nimer Marwan,Ali Eham
International Journal of Green Pharmacy , 2010,
Abstract: There are scarce evidences about the effects of herbs on nitrogen species that induced nitrosative stress. We here investigated the effect of simple water distilled extract of dry leaves salvia officinalis (sage) and Ruta graveolens (Rue) on the nitric oxide (NO) - peroxynitrite (ONOO-) cycle biochemistry in vitro experiments. Aqueous extract of sage or rue (1%) were prepared by simple distillation and scanned by UV-visible spectrophotometer. Their effects were studied on the synthesized ONOO- as well as their ability to generate ONOO. It is ability to donate NO or to scavange released NO by sodium nitroprusside (10 mM) also investigated. UV-visible scan of sage extract revealed the presence of peaks at λ195 and 348.5 while that of rue extract at λ 200, λ242, λ291.5. Both extracts not generate ONOO- radical in form of nitrophenols. Rue extract increased the yield of prepared ONOO- by more than five times. Rue extract donated NO and improved the release NO from sodium nitroprusside while sage extract only improved the release of NO released by sodium nitroprusside. We conclude that simple distilled - aqueous extract of rue and sage extracts improved nitric oxide bioavailability that may be helpful in coronary artery disease with nitrate tolerance.
Neuropathic manifestations in rheumatoid arthritis : A clinical and electrophysiological assessment in a small sample of Iraqi patients.
Sakini Riyadh,Abdul-Zehra Ihsa,Al-Nimer Marwan
Annals of Saudi Medicine , 2005,
Abstract:
Rofecoxib prevents ctdsDNA against damage
Marwan S. M. Al-Nimer,Suad M. Al-Deen,Zainab W. Abdul Lateef
Journal of Basic and Clinical Pharmacy , 2011,
Abstract: Rofecoxib is a selective cyclooxygenase COX-2 enzyme inhibitor withchemoprotective effect against cancer in experimental models. This study aimed to investigate the effect of rofecoxib against ctds DNA damage induced by copper ions or ultraviolet (UV)B radiation. Aliquot ctdsDNA samples were incubated with copper sulfate solution (50 nmol) and rofecoxib (0.8 mol) was added either before or afterthe admixing the ctdsDNA with copper sulfate. In another experimental series, aliquot of ctdsDNA were exposed to UVB radiation for 30 min in absence or presence of rofecoxib. Rofecoxib significantly attenuated the separation of double strands of DNA (detected by increase the absorbance of DNA at 260 nm) induced by Cu ions.Rofecoxib significantly offered protection against UVB-induced DNA damage. It is concluded that rofecoxib offered protection against copper ions or UVB induced-DNA damage via different mechanisms not related to the inhibition COX-2.
Gender Differences in Psychomotor Performance After Six Minutes Cycling Exercise
Marwan S.M. Al-Nimer,Hayder M.K. Al-Kurashy
Journal of Medical Sciences , 2007,
Abstract: The purpose of the present study was to explore the effect of interaction between gender and cycling exercise on the psychomotor performance. Fourteen young subjects (7 women and 7 men) underwent 6 min cycling at constant speed of 30 m min-1 and then their psychomotor performance was assessed after exercise. Results show that 6 min cycling exercise is significantly (p< 0.05) improved the critical flicker fusion threshold tasks in women but not in men. The effect of exercise on sensorimotor performance does not reach to the level of significance (p>0.05). We conclude that six minute cycling exercise at a constant speed and work interacts with gender in improving the cognitive function.
Magnetized solutions altered the absorbance of tramadol HCl: UV-spectrophotometer study
Marwan S.M. Al-Nimer,Fezaa Sh. Neda,Zainab W. Abdul Lateef
Journal of Basic and Clinical Pharmacy , 2010,
Abstract: Magnetized water showed alterations in the electrolyte potential and vibration modes. This study aimed to investigate the effect of magnetic water and physiological solutions on the UV-spectra of tramadol HCl. Distilled water as well as full strength or diluted physiological solutions are magnetized by magnetic disc. Then tramadol HCl was dissolved in each magnetic and in non-magnetic solution to obtain the following final concentrations: 0, 25, 50, 100, and 200μg/mL. The pH of each solution and the absorbance (O.D.) was recorded at wavelength 271 nm. Magnetized water or physiological solutions showed alterations in pH as well as in the absorbance (O.D.) of tramadol HCl detected by ultraviolet spectra at λ271 nm. It concludes that magnetized physiological solutions adversely altered the stability of tramadol HCl
X-Rays Irradiation Produced Dual Effects on the Constituents of Medicinal Plants Extracts
Zainab W. Abdul Lateef,Marwan S.M. Al-Nimer
Journal of Biological Sciences , 2009,
Abstract: The objective of this study is to show the effect of free radicals induced by fixed dose rate of X-rays radiation on the chemical constituents of some medicinal plants; barks of Cinnamomum verum (cinnamon), leaves of Salvia officinalis (sage) and Camellia sinensis (green tea). Four extracts (1%) were prepared for each medicinal plant; hydro-distilled, aqueous, ethanol and methanol. Each extract was subjected to X-rays radiation at rate of 1.9 Gy min-1. The UV-Visible spectra, physiochemical properties and biochemical constituents of each non irradiated and irradiated extracts were determined. The results showed that the effect of irradiation on the hydro-distilled and aqueous extract differed from alcohol extract. Favorable effect of irradiation was observed on the green tea extract. Considerable loses of total polyphenols and flavonoids quantities were observed in aqueous extracts. X-rays radiation remarkably induced degradation of allantoin and a slight changes in release nitrogen species. In conclusion X-ray radiation of medicinal plants in solutions produced dual effect in terms of improving and degrading the active ingredients depending on the extracted solution as well as the native constituents of each medicinal plant.
An Exploratory Study of the Level of Sophistication of Management Accounting Practices in Jordan
Nimer Sleihat,Munther Al-Nimer,Soud Almahamid
International Business Research , 2012, DOI: 10.5539/ibr.v5n9p217
Abstract: Purpose – The research aims to provide a view of the present role of management accounting to identify the extent of usage of management accounting practices (MAPs) and finally to determine the sophistication level of MAPs by employing International Federation of Accountants model (IFAC) in the Jordanian financial sector. Design/methodology/approach – To attain these objectives, the research used the questionnaire method 64 valid questionnaires were returned, giving a 67.3% response rate. Descriptive statistical analysis was used to analyse the responses. Findings – Regarding the life-cycle stages, it was revealed that 67.2% of the respondent companies are located in the first two stages. The research reported that traditional practices are still widespread and highly used, rarely using the more sophisticated or advanced practices, and that there is a diversity of practices used in the financial sector context. In general, the research revealed that budgeting practices and financial measures are heavily used, and there is a lack of usage of decision making practices and strategic analysis practices. Concerning the sophistication level of MAPs, the research revealed that almost all of the Jordanian financial sector companies are located in the first stage by 64.1% and 29.7% of companies in the second stage based on the IFAC model, thus indicating the simplicity of information that they require. This, in turn, reflects the simplicity of practices that are used in the Jordanian financial sector. Originality/value – Provides a broad overview of management accounting practices in the Jordanian financial sector, indicates is a lack of using MAPs in the developing countries, and indicates the improvement which would take place in the Jordanian financial sector in terms of the adoption of more sophisticated or advance MAPs.
Dual Effects of Interaction Between Meloxicam, Diclofenac Sodium or Tramadol and Nitrogen Species Radicals: In vitro Comparative Study
M.S. M. Al-Nimer,E. A. Ali
International Journal of Pharmacology , 2009,
Abstract: This study aimed to investigate the interaction between synthetic peroxynitrite or sodium nitroprusside (nitric oxide donor) and meloxicam, diclofenac sodium or tramadol HCl. Meloxicam, diclofenac sodium or tramadol HCl (100-500 μg) were incubated in phosphate buffer saline in presence or absence of synthetic peroxynitrite (180 μM) or sodium nitroprusside as nitric oxide donor (10 mM). The level of peroxynitrite and nitric acid in solution were measured using UV-visible spectrophotometer. The results showed that meloxicam scavenged synthetic peroxynitrite and involved in peroxynitrite mediated phenol nitration when it incubated alone in phosphate buffer. All tested compounds, in vitro, behaved like sodium nitroprusside in releasing nitric oxide. Both meloxicam and diclofenac sodium reduced the activity of sodium nitroprusside-releasing nitric oxide. Tramadol HCl was not interacted with sodium nitroprusside at any concentration. We concluded that selective or non selective nonsteroidal anti-inflammatory drugs reduced the activity of nitric oxide donor while tramadol HCl is free from this effect.
The Diffusion of Performance Evaluation Measures: An Empirical Study in Jordanian Banks
Munther Al-Nimer,Nimer Sleihat,Haitham Al Abbadi,Soud Almahamid
International Journal of Business and Management , 2012, DOI: 10.5539/ijbm.v7n14p76
Abstract: This research aims to provide a view of the present role of performance evaluation measures, to identify the extent of usage of performance evaluation measures, and finally to examine the contingent variables in order to find out their effect upon the extent of usage in the Jordanian banks. In order to achieve these objectives, the research used a questionnaire method; 80 (out of 140) valid questionnaires were returned, giving a (57.14%) response rate. Several statistical tests were used to analyze the data, namely, descriptive and bivariate correlation analysis (Kendall`s tau test). The results revealed that there is a lack of use of non-financial measures that are considered as contemporary management accounting practices. However, the financial measures were considered as the highest practice being utilised. In addition, the results confirmed the hypothesized relationships between contingency variables and the extent of usage, namely; age of the company; net sale growth, number of employees; sophistication of operations; professional certificates; and academic certificates. Finally, it can be concluded that the traditional Performance evaluation measures are still widely used.
Numerical and Geophysical Tools Applied for the Prediction of Mine Induced Seismicity in French Coalmines  [PDF]
Marwan Al Heib
International Journal of Geosciences (IJG) , 2012, DOI: 10.4236/ijg.2012.324084
Abstract: The determination of the influence of mining works and the induced seismicity is essentially obtained, separately from in-situ observations and seismic analysis, field measurements (particularly surface survey) as well as from numerical investigations. The paper presents a methodology applied for the analysis of induced seismicity due to underground coalmines based on combining numerical modelling and seismic analysis. The methodology is based on the comparing between the observations, the seismic activity and the numerical modelling for establishing a close correlation between the location of seismic activity and the induced stresses. The paper presents two case studies using seismic and geotechnical investigations, the first one concerns a fatal accident affected Lorraine coalmine (East France). The second case concerns the application of the methodology on Provence coalmines (South France). The application of the methodology shows such a coupling can be an efficient way for detecting areas subjected to rockburst hazard. This is also a powerful tool for assisting the planning of underground workings in complex geological and mining conditions. The coupling of geotechnical investigations (numerical modelling, in-situ stress measurements) and seismic analysis are strongly recommended.
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