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Search Results: 1 - 10 of 8157 matches for " Akshay Sharma "
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Organising Training Events/Conferences: The Cost Effective Way
Akshay Sharma
Australasian Medical Journal , 2011,
Abstract: .
Nanoparticle Paclitaxel (Nanoxel) as a Safe and Cost-Effective Radio-Sensitizer in Locally Advanced Head and Neck Carcinoma  [PDF]
Akshay Nigam, Anupama Sharma, Sanjeev Kumar Singh
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.31006
Abstract: Squamous cell carcinoma of the head and neck (SCCHN) is a common malignancy. It is the 7th most common malignancy. Approximately 45,000 new cases are diagnosed each year in the USA. In present study 10 patients were selected of age group between 40 - 60 years from Gwalior-Chambal region, among them 3 were females and 7 were males. 3 patients were suffering from tonsilitis, 4 from Laryngeal carcinoma, 2 from carcinoma in maxillary antrum and 1 patient was suffering from carcinoma of whole tongue. The aim of present study is to evaluate the safety of nanoparticle paclitaxel (Nanoxel, a plant alkaloid) in combination with radiation in the treatment of locally advanced head and neck carcinoma. Further the patients were divided in 2 groups. The 1st group received nanoxel (plant alkaloid) administered concomitantly with radiation therapy. 2nd group received gemcitabine administered in combination with radiation therapy. 9 patients showed response for the therapy. The adverse effects in arm A, 2 patients showed anemia less than 8 gm of Hemoglobin, 2 patient showed leucopenia and 1 patient showed diarrhoea, Nausea/vomiting were shown by 4 patients, in arm B, 1 patient showed leucopenia, 1 patient showed anemia less than 9 gm hemoglobin and 5 patient showed sensory neuropathy. Nanoxel (plant alkaloid) showed best results in the case of head and neck carcinoma. The dose of 30 mg/kg b.w showed best safety with best clinical effect in term of less time of patient admission (hardly 30 mins) with less side effects with greater clinical effects in our study.
Migration and Health
Akshay Sharma,Elizabeth Cottrell
Australasian Medical Journal , 2010,
Abstract: Migrants are a significant and diverse population. Manymigrants have no different health needs from native people,but multiple health harms can result from the process ofmigration itself as well as the underlying reasons formigration. There are a number of hurdles in improving thehealth of migrants and they are sometimes referred to as the‘mobile underserved populations’. This editorial discusses thisdiverse group of migrants in relation to the individuals’ healthbut also as they impact on the healthcare services in hostnations.
Sub Acute Sclerosing Pan Encephalitis
Akshay Sharma,Prem Dass Sharma,Anand Kumar Bhardwaj,Bhawna Malik
Australasian Medical Journal , 2012,
Abstract: Subacute sclerosing pan encephalitis (SSPE) is a rare neurodegenerative disorder related to a persistent and aberrant measles virus infection. It is associated with poor prognosis and high mortality. We report a case of a seven-year-old boy who manifested the disease despite proper vaccination and with no documented past history of measles. The case is being reported for its atypical presentation, rarity and its possibility of occurrence in young vaccinated subjects, possibly due to undocumented pre-vaccination measles infection.
Premature Menarche Associated with Primary Hypothyroidism in a 5.5-Year-Old Girl
Dhrubajyoti Sharma,Devi Dayal,Anju Gupta,Akshay Saxena
Case Reports in Endocrinology , 2011, DOI: 10.1155/2011/678305
Abstract: Children with hypothyroidism generally have delayed pubertal development. Rare association with precocious puberty may occur especially in long standing untreated patients. The cardinal features of hypothyroidism induced pseudo precocious pubertal development include thelarche, galactorrhea and menarche. Other characteristics features are an absence of sexual hair and retardation of linear growth. Its manifestation as isolated menarche has been rarely reported. Recently, a five and half year old girl presented to us with history of one episode of vaginal bleeding. A pelvic ultrasonogram revealed multiple cysts in both ovaries and subsequent investigations led to a diagnosis of autoimmune hypothyroidism.
Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in amyotrophic lateral sclerosis (ALS) patients
Pawan K Gupta, Sudesh Prabhakar, Suresh Sharma, Akshay Anand
Journal of Neuroinflammation , 2011, DOI: 10.1186/1742-2094-8-97
Abstract: The authors observe that, in Table two of our study [1], crude ORs and adjusted ORs for serum VEGFA were also repeated for CSF VEGFA, however, these values for CSF VEGFA are different from serum VEGFA. Correct OR values of CSF VEGFA are given below.Smoking: [crude OR(95% CI) = 1.7 (0.3-9.1), p = 0.4; adj OR (95% CI) = 0.6 (0.08-4.4), p = 0.6].Alcohol consumption: [crude OR(95% CI) = 0.6 (0.1-2.2), p = 0.4; adj OR (95% CI) = 0.8 (0.1-4.4), p = 0.8].Meat consumption: [crude OR(95% CI) = 2.2 (0.6-7.7), p = 0.2; adj OR (95% CI) = 2.1 (0.5-7.7), p = 0.2].
Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in amyotrophic lateral sclerosis (ALS) patients
Pawan K Gupta, Sudesh Prabhakar, Suresh Sharma, Akshay Anand
Journal of Neuroinflammation , 2011, DOI: 10.1186/1742-2094-8-47
Abstract: Sporadic ALS patients were included on the basis of El Escorial criteria. VEGF-A and CCL2 levels were analyzed in serum and cerebrospinal fluid (CSF) of 50 ALS patients using enzyme linked immunosorbent assay (ELISA) and compared with normal controls. Their levels were adjusted for possible confounders like cigarette smoking, alcohol and meat consumption.Contrary to previous studies, VEGF-A was found to be elevated significantly in serum and CSF in ALS patient population studied. We also found an increase in CCL2 levels in CSF of these ALS patients. Serum and CSF from definite ALS revealed higher VEGF-A as compared to probable and possible ALS. CCL2 was unaltered between definite, probable and possible ALS. Univariate and multivariate analysis revealed a lack of association of smoking, alcohol and meat consumption with VEGF-A and CCL2 levels.VEGF-A upregulation may indicate an activation of compensatory responses in ALS which may reflect or in fact account for increased survival of North Indian ALS patients after disease onset. The intrathecal synthesis of CCL2 suggests the involvement of adult neural stem cells and microglial activation in ALS pathogenesis which needs further investigation.Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with genetic and clinical heterogeneity. Existing evidence suggests that Vascular endothelial growth factor-A (VEGF-A) delivery delays the onset and progression of ALS in superoxide dismutase-1 (SOD1) mutated transgenic mouse model by activating PI3-K/Akt anti apoptotic pathway [1,2]. VEGF-A also shown to be involved in proliferation and differentiation of adult mouse neural progenitor's cells [3]. On the other hand, chemokine ligand-2 (CCL2), a proinflammatory molecule, enhances microglial recruitment after injury to central nervous system (CNS) and exacerbates ALS [4]. It has been observed that CCL2 knockout mice have reduced involvement of immune cells and are resistant to stroke and autoimmune encephalomyelit
Surgical repair of D-TGA with an aortopulmonary window and ventricular septal defects
Reddy, Srikrishna M;Bisoi, Akshay Kumar;Sharma, Pranav;Chauhan, Sandeep;
Revista Brasileira de Cirurgia Cardiovascular , 2010, DOI: 10.1590/S0102-76382010000400024
Abstract: d-transposition of great arteries with an aortopulmonary window is a rare congenital anomaly. we describe a case of d-transposition of great arteries with an aortopulmonary window and multiple ventricular septal defects in a 5-month boy who underwent successful surgical repair.
Functional outcome following quadriceps tendon lengthening in congenital dislocation of the knee, with special reference to extensor weakness
Alok Sud,Aashish Chaudhry,Anil Mehtani,Akshay Tiwari,Deep Sharma
Strategies in Trauma and Limb Reconstruction , 2009, DOI: 10.1007/s11751-009-0072-1
Abstract: This study reports the incidence and proposes a probable cause of flexion deformity and extensor weakness following lengthening of quadriceps tendon for the congenital dislocation of the knee and also proposes a modification of the functional grading given in the literature to this effect. Seventeen knees in ten patients were treated with a follow-up from 3 to 8 years. Fifteen knees were grade III and were operated with quadriceps lengthening and anterior capsulotomy. Two knees were Grade II and were initially closed reduced, but operated later due to recurrence. The results were graded on a modification of functional grading system given in the literature [1]. There were excellent results in four, good in five and fair in eight knees. There was an extensor weakness in ten knees (average 12.2°) and flexion deformity (15°) in one. Eight patients could squat and all started walking independently by 10–20 months of age, except one. V-lengthening of the quadriceps tendon produced a satisfactory improvement in the knee function. The theoretical role of the gastrocnemius and hamstring muscles in abetting flexion deformity and extensor weakness is suggested.
Solitary fibrous tumor of the orbit presenting in pregnancy
Das Jayanta,Sharma Angshuman,Deka Akshay,Das Dipankar
Indian Journal of Ophthalmology , 2009,
Abstract: A 32-year-old woman, three months pregnant, reported with the complaint of protrusion of the right eye for six months. She gave history of rapid protrusion of eyeball for the last two months along with the history of double vision for the last one month. Computer tomography (CT) scan revealed a well-defined mass lesion in the intraconal space of the right orbit which was excised through a lateral orbitotomy approach. Histological examination and immunohistochemistry revealed a solitary fibrous tumor, which showed a rapid progression in pregnancy.
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