OALib Journal期刊

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匹配条件: “Akram Ranjbar” ,找到相关结果约810条。
Propofol: Attenuating or Inducting of Oxidative Stress?: A Review Article
Akram Ranjbar
Pajouhan Scientific Journal , 2012,
Abstract: A radical (often, but unnecessarily called a free radical) is an atom or group of atoms that have one or more unpaired electrons. A prominent feature of radicals is that they have extremely high chemical reactivity, which explains not only their normal biological activities, but how they inflict damage on cells. The free radical formation in a living system leads to oxidative damage of macromolecules, such as DNA, proteins and lipids. Oxidative stress is defined most simply as the imbalance between the production of free radicals and the body’s antioxidant defense. Propofol (2,6-diisopropylphenol) is a versatile, short-acting, intravenous (i.v.)sedative-hypnotic agent initially marketed as an anesthetic, and now also widely used for the sedation of patients in the intensive care unit (ICU). Propofol's structure contains a phenolic hydroxyl group and thus resembles that of a-tocopherol (vitamin E), a natural antioxidant. As shown by both in vitro and in vivo studies, the antioxidant activity of propofol results partly from this phenolic chemical structure. Propofol has been reported to inhibit lipid peroxidation in various experimental models to protect cells against oxidative stress and to increase the antioxidant capacity of plasma in humans.
Oxidative Stress Indexes in Normal Delivery and Its Correlation with Indexes in Newborns
Katayon Vakilian,Akram Ranjbar,Mahtab Atarha
Knowledge & Health Journal , 2010,
Abstract: Introduction: Lipid peroxidation is a normal phenomenon that occurs continuously at low parts of the human body. However, if these peroxidation reactions are not controlled by antioxidant defense, they can in part be toxic to cells and membranes. It seems that pregnancy and labor can produce oxidative stress. So, this research was carried out to assess oxidative stress in pregnancy and normal delivery. Methods: In this analytic cross sectional study, two 60-membrgroups of pregnant and normally delivering women were selected. Having signed an informed consent form, in order to measure oxidative stress indexes, the researchers obtained 5cc vein blood from the participants. The blood from the pregnant women was obtained in 38-40 weeks of pregnancy, and in the normally delivering group the blood was obtained during the full dilatation in labor. Inclusion criteria for the two groups were not having any acute or chronic diseases, being prim para and having singleton pregnancy. Immediately after delivery of the fetus, and after providing care for the delivering mothers, blood samples were collected from their newborns. Results: The mean age of the pregnant group was 22.8±.52 and of the delivering group 21.4±1.8. The mean of lipid peroxidation significantly higher in the delivering women (5.58 nmol/l) than pregnant women (3.64 nmol/l). There was also a positive correlation between labor lipid peroxidation, and thiol groups and total antioxidant capacity women with newborns. Conclusion: The data showed a significant difference between lipid peroxidation in pregnancy and labor, so that peroxidation was higher in delivery. Furthermore, there was a positive correlation between oxidative stress indexes in delivering mothers and their newborns. It seems it is necessary to reinforce antioxidant defense in mothers and mothers need to use antioxidant supplements during pregnancy
The study of malathion on nitrosative stress in rat liver
Akram Ranjbar,Hajir Sifpanahi,Farshad Rostampour
Pajouhan Scientific Journal , 2013,
Abstract: Introduction: Organophosphorus compounds are the most important and most widely used insecticides and malathion is one of this toxins that has been used in the world widely. Oxidative stress and nitrosative stress are the new mechanisms of these compounds. The aim of this study was evaluate the effect of malathion on nitrotyrosins’ cosentration in rat liver.Material and Methods: In this experimental study 12 male wistar rats with 180-250grs were separated into case and control equal groups. Case group administrated 200mg/kg/day for a week and control group have normal salin at this course. Then rats’ livers were homogenized and biomarkers of nitrotyrosin were measured by ElIZA test in them. The statistical software used for this analysis was SPSS version 16 and P< 0.05 was considered as the minimum level of significance.Results: Mean of nitrotyrosins’ biomarker in liver tissue for case group were 0.265±0.094nmol/mg protein reported and the mean of nitrotyrosins’ biomarker in liver tissue for control group were 0.180±0.007nmol/mg protein reported, p= 0.051.Conclusion: The Difference between two groups is very near to level of significance and mean of case group is more than control group, thus we result that malathion increase nitrotyrosin level and increase nitrosative stress in liver rat.
Urinary Extraction of Oxidative Damage in Carpet Weavers  [PDF]
Rashid Heidarimoghadam, Akram Ranjbar, Neda Mahdavi, Tvakol Heidary Shayesteh, Mohammad Faridan, Leila Tajik
Health (Health) , 2014, DOI: 10.4236/health.2014.614199
Abstract: Nearly 8.5 million people in Iran directly or indirectly make a living from hand-made carpet weaving industry. Ongoing work, poor postures, breathing problems and skin irritations are among factors affecting the health, safety and wellbeing of those involved in this industry. Hence, considering such factors seem to improve the quality of carpet as a valuable cultural commodity and expand its export. Accordingly, this study investigates the oxidative stress biomarkers among involved and non-involved people in the hand-made carpet industry. 25 carpet maker and 25 ordinary people (not involved in carpet industry) who had been matched for age and sex were selected as study groups. The level of oxidative stress biomarkers such as antioxidant capacity, total thiols and catalase were measured among subjects, and finally the biomarkers were compared between the two groups. To compare the oxidative stress biomarkers in two groups, Independent Sample T Test was used. The mean levels of total antioxidant capacity showed no significant difference between the two groups (0.05 < p-value). Two other markers, thiols and catalase, in both groups showed significant differences (0.05 > p-value). In conclusion, carpet weaving industry induces oxidative stress and natural antioxidant may be considered beneficial for the protection of oxidative damage in such subjects.
Anti Oxidative Stress Potential of Cinnamon (Cinnamomum zeylanicum) in Operating Room Personnel; A Before/After Cross Sectional Clinical Trial
Akram Ranjbar,Sara Ghaseminejhad,Hassan Takalu,Akram Baiaty
International Journal of Pharmacology , 2007,
Abstract: Regarding role of oxidative stress in operating room personnel and the anti oxidative stress potential of Cinnamon zeylanicum (cinnamon) in healthy subjects, the present study aimed to examine anti oxidative stress potential of cinnamon in operating room personnel. A group of 18 operating room personnel was invited to drink cinnamon (100 mg/300 mL tea) once daily for 10 days. Blood samples were obtained before and after entering the study and plasma was measured for oxidative stress biomarkers including Lipid Peroxidation Level (LPO), Total Antioxidant Power (TAP) and Total Thiol Molecules (TTM). Treatment of subjects with cinnamon induced a significant reduction in plasma LPO (5.03±2.01 vs. 3.25±1.32 nmol mL-1, p = 0.016). No statistically significant alteration was found for plasma TAP (1.24±0.12 vs. 1.28±0.12, p>0.05) and TTM (0.78±0.05 vs. 0.82±0.03, p>0.05) after 10 days treatment by cinnamon. In conclusion, reduction of cellular LPO by cinnamon as a dietary supplement can be a rational protocol to control source of hazards in operating room personnel.
Place of scientific research journals in the student research committees
Hazhir Seifpanahi-sha’bani,Farshad Rostampour,Akram Ranjbar
Pajouhan Scientific Journal , 2013,
Abstract: Place of scientific research journals in the student research committees
Antioxidant Activity of Iranian Echium amoenum Fisch & C.A. Mey Flower Decoction in Humans: A cross-sectional Before/After Clinical Trial
Akram Ranjbar,Sara Khorami,Mehdi Safarabadi,Amene Shahmoradi,Ali Akbar Malekirad,Katyon Vakilian,Ali Mandegary,Mohammad Abdollahi
Evidence-Based Complementary and Alternative Medicine , 2006, DOI: 10.1093/ecam/nel031
Abstract: Medicinal plants are recognized as sources of natural antioxidants that can protect from biological system oxidative stress. The present cross-sectional before/after clinical trial was carried out to investigate the antioxidant properties of the decoction of the flowers of Echium amoenum Fisch & C.A. Mey in humans. A group of 38 healthy subjects was invited to use the E. amoenum (7 mg kg−1) twice daily for 14 days. Blood samples before and after entering the study were measured for lipid peroxidation level (LPO), total antioxidant capacity (TAC) and total thiol (SH) molecules. A significant reduction of blood LPO (24.65 ± 11.3 versus 19.05 ± 9.7, P = 0.029) was observed after 14 days of E. amoenum consumption. Blood TAC (1.46 ± 0.51 versus 1.70 ± 0.36, P = 0.018) and total thiol molecules (0.49 ± 0.11 versus 0.56 ± 0.12, P = 0.001) increased after 14 days of E. amoenum consumption. In conclusion, this antioxidative stress potential of E. amoenum may be due to its bioactive antioxidant components, especially rosmarinic acid and flavonoids. In recent years the importance of oxidative stress in the pathophysiology of many human disorders has been confirmed, thus use of this plant as a dietary supplement is highly recommended.
A Novel Mathematical/Numerical Formula for Assessing Right Ventricular Torsion Using Echocardiographic Imaging
Saeed Ranjbar
Physics , 2015,
Abstract: Recently, the ventricular torsional parameters have received special attention because of their significant role in the ventricular systolic and diastolic function. Right ventricular (RV) rotational deformation is a sensitive index for RV performance but difficult to measure. Having assumed RV as a conic shape, the present study serves a novel mathematical formula of right ventricular rotation that uses velocity vector imaging (VVI) for quantifying RV.
ASIP Solution for Implementation of H.264 Multi Resolution Motion Estimation  [PDF]
Fethi Tlili, Akram Ghorbel
Int'l J. of Communications, Network and System Sciences (IJCNS) , 2010, DOI: 10.4236/ijcns.2010.35060
Abstract: Motion estimation is the most important module in H.264 video encoding algorithm since it offer the best compression ratio compared to intra prediction and entropy encoding. However, using the allowed features for inter prediction such as variable block size matching, multi-reference frames and fractional pel search needs a lot of computation cycles. For this purpose, we propose in this paper an Application Specific Instruction-set Processor (ASIP) solution for implementing inter prediction. An exhaustive full and fractional pel combined with variable block size matching search are used. The solution, implemented in FPGA, offers both performance and flexibility to the user to reconfigure the search algorithm.
Spatio-Temporal Land Cover Dynamics in Open Cast Coal Mine Area of Singrauli, M.P., India  [PDF]
Imran Khan, Akram Javed
Journal of Geographic Information System (JGIS) , 2012, DOI: 10.4236/jgis.2012.46057
Abstract: Singrauli is an opencast coal mining area where large scale mining activities are going on continuously, land use/land cover studies are of vital importance to observe the changes in the land use/land cover. The present study utilizes multi-spectral/multi-temporal data of Indian Remote Sensing Satellite (IRS) LISS II geocoded (FCC) of 4th May 1993 and LISS III of 4th May 2010 for thematic mapping. Survey of India toposheet 63L/12 on scale 1:50,000 were used for preparation of base map which was overlaid on the FCC for land use/land cover mapping through visual interpretation. Visual interpretation of satellite imagery led to the identification of 15 land use/land cover categories such as dense forest, open forest, open scrub, plantation, cultivated land, uncultivated land, mining pit, overburden dumps, wasteland and settlement. The ground truth verification was carried out in key areas to rectify the errors in generated maps and then land use/land cover maps were finalized. The comparative analysis of land use/land cover shows that dense forest has been degraded to open forest, open scrubs and mining pits due to the expansion of mining activity. Open scrubs has increased, overburden dumps has increased, settlement has also increased, cultivated land has decreased and changed into uncultivated land and wasteland. It has also been observed that the plantation has been done on overburden dumps and residential colonies of NCL and NTPC. It has been identified that the main drivers which has increased the rate of change in land use/land cover are mainly coal mining activities and industrial expansion.

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