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Search Results: 1 - 10 of 1466 matches for " Akiko Nakagawa "
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Cognitive Behavioral Therapy as the Basis for Preventive Intervention in a Sleep Health Program: A Quasi-Experimental Study of E-Mail Newsletters to College Students  [PDF]
Kenichi Asano, Ikuo Ishimura, Hironori Abe, Michiko Nakazato, Akiko Nakagawa, Eiji Shimizu
Open Journal of Medical Psychology (OJMP) , 2015, DOI: 10.4236/ojmp.2015.41002
Abstract: Several reports suggest that college students often have atypical sleep patterns and experience poor sleep quality. We examined the effect of a cognitive behavioral therapy (CBT) based intervention program to improve sleep quality and overall mental health among college students. The intervention was delivered in the form of e-mail newsletters. Fifty-three students participated in the intervention group, and another 50 students participated in the control group. The intervention group received a lecture on sleep hygiene; once-weekly e-mail newsletters on sleep health topics (sleep hygiene, stimulus control, sleep restriction, sleep titration, and relapse prevention) and were asked to maintain a four-week sleep diary. The Pittsburgh Sleep Quality Index (PSQI), a measure of sleep quality, and the Kessler 6, a measure of psychological distress, were administered before the lecture (as the baseline measurement) and again 16 weeks later (follow-up measurement). PSQI and K6 scores were reduced in the intervention group compared with the control group. A CBT-based sleep health program utilizing e-mail newsletters may work to improve sleep quality and mental health. This program may represent a cost effective way for Japanese students to receive treatment for poor sleep and may also serve to prevent psychiatric problems.
Carbon-Ion Beams Efficiently Induce Cell Killing in X-Ray Resistant Human Squamous Tongue Cancer Cells  [PDF]
Akihisa Takahashi, Hongyu Ma, Akiko Nakagawa, Yukari Yoshida, Tatsuaki Kanai, Tatsuya Ohno, Yoshikazu Kuwahara, Manabu Fukumoto, Takashi Nakano
International Journal of Medical Physics,Clinical Engineering and Radiation Oncology (IJMPCERO) , 2014, DOI: 10.4236/ijmpcero.2014.33019

In order to see whether carbon ion (C-ion) beams have a biological advantage over X-rays, studies were designed to examine the effects of C-ion beams on radiosensitivity in X-ray resistant cells. Clinically relevant X-ray resistant SAS-R cells derived from human tongue cancer SAS cells were used. The cells were exposed to X-rays or Spread-Out Bragg peak (SOBP) beam C-ions. Cell survival was measured using a modified high-density survival assay. Cell survival signaling and cell death signaling were analyzed using flow cytometry. The cells were labeled with putative cancer stem cell markers such as CD44 and CD326. SAS-R cells were 1.6 times more radioresistant than SAS cells after exposure to X-rays. Cell survival was similar in each cell line after exposure to C-ion beams. SAS-R cells displayed enhanced cell survival signaling when compared to SAS cells under normal conditions. On the other hand, the phosphorylation of AKT-related proteins decreased and polycaspase activities were enhanced when cells were irradiated with C-ion beams in both cell lines. More CD44 and CD326 positive cells were seen in SAS-R cells than in SAS cells. Moreover, the marker positive cell numbers significantly decreased after exposure to C-ion beams when compared to X-rays at iso-survival doses in SAS-R cells. C-ion beams efficiently induced cell killing in X-ray resistant cells which displayed activated cell survival signaling and contained more numerous cancer stem-like cells. 

Effect of illness duration on cognitive function of OCD: a neuropsychological and functional neuroimaging study
Nakao Tomohiro,Nakagawa Akiko,Nakatani Eriko,Nabeyama Maiko
Annals of General Psychiatry , 2006, DOI: 10.1186/1744-859x-5-s1-s138
Use of FDG-PET in Radiation Treatment Planning for Thoracic Cancers
Katsuyuki Shirai,Akiko Nakagawa,Takanori Abe,Masahiro Kawahara,Jun-ichi Saitoh,Tatsuya Ohno,Takashi Nakano
International Journal of Molecular Imaging , 2012, DOI: 10.1155/2012/609545
Abstract: Radiotherapy plays an important role in the treatment for thoracic cancers. Accurate diagnosis is essential to correctly perform curative radiotherapy. Tumor delineation is also important to prevent geographic misses in radiotherapy planning. Currently, planning is based on computed tomography (CT) imaging when radiation oncologists manually contour the tumor, and this practice often induces interobserver variability. F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) has been reported to enable accurate staging and detect tumor extension in several thoracic cancers, such as lung cancer and esophageal cancer. FDG-PET imaging has many potential advantages in radiotherapy planning for these cancers, because it can add biological information to conventional anatomical images and decrease the inter-observer variability. FDG-PET improves radiotherapy volume and enables dose escalation without causing severe side effects, especially in lung cancer patients. The main advantage of FDG-PET for esophageal cancer patients is the detection of unrecognized lymph node or distal metastases. However, automatic delineation by FDG-PET is still controversial in these tumors, despite the initial expectations. We will review the role of FDG-PET in radiotherapy for thoracic cancers, including lung cancer and esophageal cancer. 1. Introduction Radiotherapy plays an important role in the treatment of thoracic cancers, such as non-small-cell lung cancer (NSCLC), small-cell lung cancer (SCLC), and esophageal cancer [1, 2]. Recent advances in accurate diagnosis improve the practice of curative radiotherapy, because patients with unsuspected metastases may avoid unnecessary local therapies and receive necessary systemic treatment. Accurate delineation of tumor volume is also important to prevent geographic misses in treatment planning. Indeed, an underestimation of tumor extension will result in tumor recurrence. In contrast, overestimation of the extension may increase unnecessary side effects. Therefore, delineation of tumor volumes is a crucial factor in curative radiotherapy. Currently, treatment planning is based on computed tomography (CT) imaging to contour the tumor. Tumor delineation is manually performed by each radiation oncologist in clinical practice, which leads to interobserver variability in tumor delineation. Accurate delineation of tumor volume requires the identification of anatomic borders of tumors based on accurate diagnosis. F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and PET/CT have been reported to enable accurate staging and
The Process of How Elderly Patients with Lung Cancer Who Are Receiving Molecularly Targeted Therapy with Oral Agents Establish Self-Management  [PDF]
Akiko Fukawa
Health (Health) , 2017, DOI: 10.4236/health.2017.913131
Abstract: Purpose: In Japan, many elderly cancer patients are receiving chemotherapy using oral molecularly targeted drugs. They receive treatment in outpatient setting and have a need to self-manage at home. The purpose of this study was to clarify how elderly patients with lung cancer who are undergoing treatment with molecularly targeted drugs in outpatient setting establish self-management. Methods: The study used Kinoshita’s Modified Grounded Theory. Semi-structured interviews were conducted with 17 patients (eight males and nine females). Results: This study identified six categories: Accepting life with cancer, Maintaining activities of daily living without feeling shackled by cancer, Reconsidering how to continue being themselves in daily life until life comes to an end, Using trial and error to integrate treatment and daily living, Formulating their criteria for continuing treatment, and Obtaining help from caregivers. Conclusion: The self-management process in elderly patients consisted of maintaining treatment and integrating treatment with daily living. And they are exploring the effects of treatment and side effects in order to live their own life. Implications for Nursing: In many elderly patients with lung cancer the purpose of treatment is curative extension of survival and improved quality of life. Our findings suggest that is important we help patients to identify how patients want to live, identify ways to improve their quality of life, and share the goals of treatment between the patient and the caregiver.
Asset Pricing with Stochastic Habit Formation  [PDF]
Masao Nakagawa
Journal of Mathematical Finance (JMF) , 2012, DOI: 10.4236/jmf.2012.22018
Abstract: This paper examines optimal consumption/portfolio choices under stochastic habit formation in which it is uncertain how deep consumers would become in the habit of consuming in future. By extending Shroder and Skiadas [1] to stochastic habit formation, the optimization problem with stochastic habit forming preferences is transformed into that with simple time-additive preferences. Optimal portfolios are composed of the tangency portfolio and habit hedging portfolio. Resulting risk premia are characterized by consumption beta, which is proportionate to the covariance with consumption changes, and habit beta, defined by using the covariance with habit.
Tricyclic Antidepressant Amitriptyline Indirectly Increases the Proliferation of Adult Dentate Gyrus-Derived Neural Precursors: An Involvement of Astrocytes
Shuken Boku, Kazue Hisaoka-Nakashima, Shin Nakagawa, Akiko Kato, Naoto Kajitani, Takeshi Inoue, Ichiro Kusumi, Minoru Takebayashi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0079371
Abstract: Antidepressants increase the proliferation of neural precursors in adult dentate gyrus (DG), which is considered to be involved in the therapeutic action of antidepressants. However, the mechanism underlying it remains unclear. By using cultured adult rat DG-derived neural precursors (ADP), we have already shown that antidepressants have no direct effects on ADP. Therefore, antidepressants may increase the proliferation of neural precursors in adult DG via unknown indirect mechanism. We have also shown that amitriptyline (AMI), a tricyclic antidepressant, induces the expressions of GDNF, BDNF, FGF2 and VEGF, common neurogenic factors, in primary cultured astrocytes (PCA). These suggest that AMI-induced factors in astrocytes may increase the proliferation of neural precursors in adult DG. To test this hypothesis, we examined the effects of AMI-induced factors and conditioned medium (CM) from PCA treated with AMI on ADP proliferation. The effects of CM and factors on ADP proliferation were examined with BrdU immunocytochemistry. AMI had no effect on ADP proliferation, but AMI-treated CM increased it. The receptors of GDNF, BDNF and FGF2, but not VEGF, were expressed in ADP. FGF2 significantly increased ADP proliferation, but not BDNF and GDNF. In addition, both of a specific inhibitor of FGF receptors and anti-FGF2 antibody significantly counteracted the increasing effect of CM on ADP proliferation. In addition, FGF2 in brain is mainly derived from astrocytes that are key components of the neurogenic niches in adult DG. These suggest that AMI may increase ADP proliferation indirectly via PCA and that FGF2 may a potential candidate to mediate such an indirect effect of AMI on ADP proliferation via astrocytes.
Maternal Separation Enhances Conditioned Fear and Decreases the mRNA Levels of the Neurotensin Receptor 1 Gene with Hypermethylation of This Gene in the Rat Amygdala
Hiroyuki Toda, Shuken Boku, Shin Nakagawa, Takeshi Inoue, Akiko Kato, Naoki Takamura, Ning Song, Masashi Nibuya, Tsukasa Koyama, Ichiro Kusumi
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097421
Abstract: Stress during postnatal development is associated with an increased risk for depression, anxiety disorders, and substance abuse later in life, almost as if mental illness is able to be programed by early life stressors. Recent studies suggest that such “programmed” effects can be caused by epigenetic regulation. With respect to conditioned fear, previous studies have indicated that early life stress influences its development in adulthood, whereas no potential role of epigenetic regulation has been reported. Neurotensin (NTS) is an endogenous neuropeptide that has receptors densely located in the amygdala and hippocampus. Recently, NTS systems have constituted an emerging target for the treatment of anxiety. The aim of the present work is to clarify whether the NTS system is involved in the disturbance of conditioned fear in rats stressed by maternal separation (MS). The results showed that MS enhanced freezing behaviors in fear-conditioned stress and reduced the gene expression of NTS receptor (NTSR) 1 but not of NTS or NTSR2 in the amygdalas of adult rats. The microinjection of a NTSR1 antagonist into the amygdala increased the percentage of freezing in conditioned fear, whereas the microinjection of NTSR1 agonist decreased freezing. These results suggest that NTSR1 in the amygdala may play a role in the effects of MS on conditioned fear stress in adult rats. Moreover, MS increased DNA methylation in the promoter region of NTSR1 in the amygdala. Taken together, MS may leave epigenetic marks in the NTSR1 gene in the amygdala, which may enhance conditioned fear in adulthood. The MS-induced alternations of DNA methylation in the promoter region of NTSR1 in the amygdala may be associated with vulnerability to the development of anxiety disorders and depression in adulthood.
Structure of Professional Identity of Public Health Nurses Working for Governmental Agencies  [PDF]
Akiko Kanefuji, Hisae Nakatani
Health (Health) , 2017, DOI: 10.4236/health.2017.913129
Abstract: Background: Public health nurses in Japan are nationally licensed professionals who act as members of local governments and provide services to local community residents. Public health nurses must establish their professional identity early on in order to deliver high quality public health services. However, the structure of their professional identity is not fully understood. Objectives: Our purpose was to investigate structures of professional identity of public health nurses working for governmental agencies, and to clarify characteristics of their professional identity. Methods: Questionnaire surveys were conducted on 670 PHNs working for local governmental agencies. The investigation items included measurement indices for professional identity of PHNs, basic attributes, and scales which reflect aspects of self-respect. After analyzing the investigated items, we conducted exploratory factor analysis. Also we named extracted factors, and investigated reliability and appropriateness. Relationships with the attributes or self-respect aspects were also analyzed. Results: Of 350 respondents (52.2%), 309 effective answers (effective answer ratio: 88.2%) were analyzed. Item and factor analyses identified 12 items, which were categorized into 3 factors: “intention to develop professionally”, “confidence in own abilities”, and “occupational affinity”. Scales of self-respect aspects and the index for professional identity showed positive correlation. The coefficient for all 12 items was 0.89. Significant difference with the attributes were noted for “age”, “years of experience as PHNs”, and “number of PHN in the workplace”. Conclusion: Professional identify of PHNs is found to be consisted of 3 factors.
Properties of active galactic star-forming regions probed by imaging spectroscopy with the Fourier transform spectrometer (FTS) onboard AKARI
Yoko Okada,Mitsunobu Kawada,Noriko Murakami,Takafumi Ootsubo,Hidenori Takahashi,Akiko Yasuda,Daisuke Ishihara,Hidehiro Kaneda,Hirokazu Kataza,Takao Nakagawa,Takashi Onaka
Physics , 2009, DOI: 10.1051/0004-6361/200912489
Abstract: We investigate the structure of the interstellar medium (ISM) and identify the location of possible embedded excitation sources from far-infrared (FIR) line and mid-infrared continuum emission maps. We carried out imaging spectroscopic observations of four giant Galactic star-forming regions with the Fourier Transform Spectrometer (FTS) onboard AKARI. We obtained [OIII] 88 micron and [CII] 158 micron line intensity maps of all the regions: G3.270-0.101, G333.6-0.2, NGC3603, and M17. For G3.270-0.101, we obtained high-spatial-resolution [OIII] 88 micron line-emission maps and a FIR continuum map for the first time, which imply that [OIII] 88 micron emission identifies the excitation sources more clearly than the radio continuum emission. In G333.6-0.2, we found a local [OIII] 88 micron emission peak, which is indicative of an excitation source. This is supported by the 18 micron continuum emission, which is considered to trace the hot dust distribution. For all regions, the [CII] 158 micron emission is distributed widely as suggested by previous observations of star-forming regions. We conclude that [OIII] 88 micron emission traces the excitation sources more accurately than the radio continuum emission, especially where there is a high density and/or column density gradient. The FIR spectroscopy provides a promising means of understanding the nature of star-forming regions.
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