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Search Results: 1 - 10 of 1081 matches for " Akiko Kuroda "
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Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism
Yuta Fuse, Akiko Hirao, Hiroaki Kuroda, Makiko Otsuka, Yu Tahara, Shigenobu Shibata
Journal of Circadian Rhythms , 2012, DOI: 10.1186/1740-3391-10-4
Abstract: We examined whether the parameters of metabolic syndrome were differentially affected in mice that consumed a large meal at the beginning of the awake period (breakfast; one meal group) and a relatively smaller meal at end of the awake period (dinner; two meals group). The mice of each group were provided equal food volume per day.Mice on one meal exhibited an increase in body weight gain, hyperinsulinemia, hyperleptinemia, and a decrease of gene expression associated with β-oxidation in adipose tissue and liver compared with those on two meals. The circadian expression pattern of the Clock gene in mice on one meal was disturbed compared with those on two meals.In conclusion, a bigger breakfast with a smaller dinner (two meals per day) but not breakfast only (one meal per day) helps control body weight and fat accumulation in mice on a high-fat meals schedule. The findings of this study suggest that dietary recommendations for weight reduction and/or maintenance should include information on the timing and quantity of dietary intake.
The Effect of Metal Materials on Heat Shock Protein 70B Gene Expression
Junko Okuda-Shimazaki, Akiko Yamamoto, Daisuke Kuroda, Takao Hanawa and Akiyoshi Taniguchi
The Open Biotechnology Journal , 2007, DOI: 10.2174/1874070700701010014]
Abstract: To avoid the toxic effect of released nickel ions and compounds from conventional stainless steels, nickel-free austenitic stainless steels have been developed. We previously established a new manufacturing process to produce nickel-free austenitic stainless steel that involves nitrogen adsorption treatment. Although the cytocompatibility of nickelfree austenitic stainless steel produced using this method has been evaluated using two viability assay, molecular level analysis, such as gene expression analysis, has not been previously performed. In the present study, the cytotoxicity of our nickel-free austenitic stainless steel, as well as of commercially available metal materials, was evaluated by analysis of heat shock protein 70B’ (HSP70B’) gene expression as a stress response marker. Furthermore, to investigate the effect of metal materials on cytotoxicity, HSP70B’ gene expression was quantified using human osteoblast-like SaOS-2 cells, human monocyte THP-1 cells and the mouse macrophage cell line J774A.1. We found no significant differences in HSP70B’ expression among the various metal materials, including the nickel-free austenitic stainless steel, indicating that the nickel-free austenitic stainless steel produced using our nitrogen adsorption method has the same cytocompatibility as commercially available metal materials.
Predicting Optimal Trading Actions Using a Genetic Algorithm and Ensemble Method  [PDF]
Kazuma Kuroda
Intelligent Information Management (IIM) , 2017, DOI: 10.4236/iim.2017.96012
Abstract: Machine learning has been applied to the foreign exchange market for algorithmic trading. However, the selection of trading algorithms is a difficult problem. In this work, an approach that combines trading agents is designed. In the proposed approach, an artificial neural network is used to predict the optimum actions of each agent for USD/JPY currency pairs. The agents are trained using a genetic algorithm and are then combined using an ensemble method. We compare the performance of the combined agent to the average performance of many agents. Simulation results show that the total return is better when the combined agent is used.
The Process of How Elderly Patients with Lung Cancer Who Are Receiving Molecularly Targeted Therapy with Oral Agents Establish Self-Management  [PDF]
Akiko Fukawa
Health (Health) , 2017, DOI: 10.4236/health.2017.913131
Abstract: Purpose: In Japan, many elderly cancer patients are receiving chemotherapy using oral molecularly targeted drugs. They receive treatment in outpatient setting and have a need to self-manage at home. The purpose of this study was to clarify how elderly patients with lung cancer who are undergoing treatment with molecularly targeted drugs in outpatient setting establish self-management. Methods: The study used Kinoshita’s Modified Grounded Theory. Semi-structured interviews were conducted with 17 patients (eight males and nine females). Results: This study identified six categories: Accepting life with cancer, Maintaining activities of daily living without feeling shackled by cancer, Reconsidering how to continue being themselves in daily life until life comes to an end, Using trial and error to integrate treatment and daily living, Formulating their criteria for continuing treatment, and Obtaining help from caregivers. Conclusion: The self-management process in elderly patients consisted of maintaining treatment and integrating treatment with daily living. And they are exploring the effects of treatment and side effects in order to live their own life. Implications for Nursing: In many elderly patients with lung cancer the purpose of treatment is curative extension of survival and improved quality of life. Our findings suggest that is important we help patients to identify how patients want to live, identify ways to improve their quality of life, and share the goals of treatment between the patient and the caregiver.
Effect of the Position of Reaction-Site in Amphipathic-Type Thioester in Aqueous Amidation Reaction  [PDF]
Ikumi Otomo, Chiaki Kuroda
Advances in Chemical Engineering and Science (ACES) , 2015, DOI: 10.4236/aces.2015.53032
Abstract: Amphipathic-type thioesters CH3(CH2)mCOS(CH2)nCOONa (m + n = 12) were synthesized and their reaction with various alkylamines was examined. Compounds having thioester moiety close to carboxylate (m = 10, n = 2) afforded the corresponding amides in good yields, while the substrate having thioester moiety distant from carboxylate (m = 2, n = 10) afforded the amides in relatively low yield. In all cases, the difference in yield due to the chain length of amine was not observed. The results indicated that the reaction took place effectively near the surface of micelle. However, the reaction was found to occur not only on micelle surface but also in solution.
Enhancement of HIFU Effect by Simultaneous Short Course Degarelix for Early Stage Prostate Cancer: A Pilot Study  [PDF]
Teiichiro Aoyagi, Isao Kuroda
Open Journal of Urology (OJU) , 2016, DOI: 10.4236/oju.2016.63010
Abstract: Objective: To obtain complete prostatic cell death in the treatment of early stage prostate cancer by High Intensity Focused Ultrasound (HIFU) therapy, we use Degarelix (GnRH antagonist) twice simultaneously. Patients and Methods: The first Degarelix subcutaneous injection was made two weeks before HIFU therapy, and second Degarelix was applied two weeks after the HIFU therapy. No additional maintenance Degarelix was used. To confirm the apoptosis induced by Degarelix, specimens obtained by transurethral resection simultaneously on HIFU were stained with caspase 3 and TUNEL. PSA was monitored every three months after this combination therapy as long as two years. These PSA values were compared with those who previously treated with HIFU without Degarelix. Results: Nine T1cN0M0 prostate cancer patients were enrolled to “HIFU + Degarelix” therapy. Pre treatment mean PSA level was 6.11 ± 1.83 ng/ml (SD), and PSA 3 months after the treatment was 0.02 ± 0.02. These low PSA levels continued thereafter (0.16 ng/ml ± 0.19 at 24 months). The mean pretreatment PSA level of the 34 patients underwent HIFU without Degarelix was 11.07 ± 13.9 ng/ml, 3 months post HIFU was 1.68 ± 3.04, (2.80 ± 3.97 at 24 months). Caspase 3 and TUNEL were positive on the glandular cells in TUR specimens of “HIFU + Degarelix” patients, suggesting Degarelix induced apoptosis. Conclusion: Although the number of our patients was small, the results of “Short course Degarelix + HIFU” would be promising for better long-term outcome than HIFU mono-therapy.
Osteoconductivity Control Based on the Chemical Properties of the Implant Surface  [PDF]
Kensuke Kuroda, Masazumi Okido
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2018, DOI: 10.4236/jbnb.2018.91003
Abstract: Metallic materials, such as Ti, Zr, Nb, Ta, and their alloys, and also stainless steels are widely attractive as osteoconductive materials in the dental and orthopedic fields. Ceramics and polymers are also commonly used as biomaterials. However, they do not have high osteoconductivity in their pure form, and surface coatings with bioactive substances, such as hydroxyapatite or TiO2, are needed before implantation into the bone. Many reports claim that the surface chemical properties of implants, in particular, hydrophilicity and hydrophobicity, strongly affect the biological reactions. However, the effect of surface properties on osteoconductivity is not clear. In this review, we focus on the relationship between the surface hydrophilicity of metallic implants and osteoconductivity using in vivo evaluation, and the control of the osteoconductivity is discussed from the viewpoint of protein adsorption in implants.
Risk Factors for Dysmotility, Acid Reflux Symptoms, and Overlap Using FSSG in Japan
Seiji Shiota,Kazunari Murakami,Kunimitsu Inoue,Kyoko Yamamoto,Akiko Kuroda,Kazuhiro Mizukami,Tadayoshi Okimoto,Aoi Yoshiiwa,Masaaki Kodama,Koh Abe,Yoshio Yamaoka,Toshio Fujioka
Epidemiology Research International , 2012, DOI: 10.1155/2012/984039
Abstract: Aims. FSSG {frequency scale for the symptoms of gastroesophageal reflux disease (GERD)} was developed as a diagnostic tool for dysmotility and acid reflux symptoms. We first used FSSG to investigate the prevalence and risk factors for dysmotility and acid reflux symptoms and overlap of the two symptoms in a Japanese population. Methods. A cross-sectional survey was performed in Japanese underwent the routine medical examination. Dysmotility and acid reflux symptom were diagnosed by using FSSG. Subjects met both criteria were considered as overlap group. Results. Among 778 subjects, 395 persons were included in the final analyses. Dysmotility symptoms were found in 32.6% and acid reflux symptoms in 20.5%. Their overlap was found in 13.9% of all 395 subjects, which in 42.6% of dysmotility symptoms and 67.9% of acid reflux symptoms. Multiple logistic analysis showed that female gender was significantly associated with dysmotility symptoms compared with controls. Female gender, smoking, and hiatus hernia were significantly associated with overlap. Smoking was significantly associated with overlap compared with dysmotility symptoms alone and acid reflux symptoms alone. Conclusions. Overlap between dysmotility and acid reflux symptoms was common in Japan. Smoking was an independent risk factor for overlap among two symptoms. 1. Introduction Dyspepsia such as dysmotility and epigastric pain and acid reflux symptoms including heartburn are common gastrointestinal symptoms and major symptoms for functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) in general population [1, 2]. Several studies showed that there is a significant overlap between dyspepsia and acid reflux symptoms [1, 3, 4]. As disturbances of gastrointestinal sensory and motor function are commonly accepted as the underlying pathogenesis of both dyspepsia and acid reflux symptoms, it is possible that the overlap induces by common risk factors. However, the risk factors for overlap of dyspepsia and acid reflux symptoms have not been enough elucidated. Regarding dyspepsia, dysmotility symptoms are the major type in Japan [5, 6]. In 2004, Kusano et al. developed a screening tool for dysmotility symptoms and acid reflux symptoms, named frequency scale for the symptoms of GERD (FSSG) [7]. Although several studies reported the usefulness of FSSG regarding GERD [7, 8], there is no epidemiological study examined the prevalence of dysmotility symptoms by using FSSG. Recently, many reports have shown that metabolic risk factors including obesity were related with gastrointestinal diseases
Structure of Professional Identity of Public Health Nurses Working for Governmental Agencies  [PDF]
Akiko Kanefuji, Hisae Nakatani
Health (Health) , 2017, DOI: 10.4236/health.2017.913129
Abstract: Background: Public health nurses in Japan are nationally licensed professionals who act as members of local governments and provide services to local community residents. Public health nurses must establish their professional identity early on in order to deliver high quality public health services. However, the structure of their professional identity is not fully understood. Objectives: Our purpose was to investigate structures of professional identity of public health nurses working for governmental agencies, and to clarify characteristics of their professional identity. Methods: Questionnaire surveys were conducted on 670 PHNs working for local governmental agencies. The investigation items included measurement indices for professional identity of PHNs, basic attributes, and scales which reflect aspects of self-respect. After analyzing the investigated items, we conducted exploratory factor analysis. Also we named extracted factors, and investigated reliability and appropriateness. Relationships with the attributes or self-respect aspects were also analyzed. Results: Of 350 respondents (52.2%), 309 effective answers (effective answer ratio: 88.2%) were analyzed. Item and factor analyses identified 12 items, which were categorized into 3 factors: “intention to develop professionally”, “confidence in own abilities”, and “occupational affinity”. Scales of self-respect aspects and the index for professional identity showed positive correlation. The coefficient for all 12 items was 0.89. Significant difference with the attributes were noted for “age”, “years of experience as PHNs”, and “number of PHN in the workplace”. Conclusion: Professional identify of PHNs is found to be consisted of 3 factors.
Interview: Prof. F. Miura.
T. Kuroda
Hellenic Orthodontic Review , 2001,
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