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Search Results: 1 - 10 of 401230 matches for " Akhyani M "
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Comparative study of cryotherapy and interlesional Glucantime in the treatment of cutaneous leishmaniasis
Akhyani M
Tehran University Medical Journal , 1997,
Abstract: The World Health Organization estimates that approximately 400.000 new cases of Leishmaniasis occur worldwide each year. Cutaneous Leishmaniasis is an endemic disease in Iran. CL is caused by several species of Leishmania. Physical and Chemical Modalities have been used to treatment of cutaneous Leishmaniasis. Cryotherapy is a physical and interalesional glucantime is a chemical modality. In this study cryotherapy and interalesional glucantime were compared. In the first group 35 patients treated with cryotherapy. 91.4% had complete cure both clinical and parasitological. In the second group 30 patients treated with interalesional glucantime. 63.33% had complete cure both clinical and parasitological. Results: Our study show that cryotherapy is better than interalesional glucantime in treatment of CL (P=0.003). Further studies are recommended
"TREATMENT OF CHRONIC PLAQUE TYPE PSORIASIS WITH SYSTEMIC MYCOPHENOLATE MOFETIL "
M. Akhyani,S. Toosi R. M. Robati
Acta Medica Iranica , 2006,
Abstract: Chronic plaque-type psoriasis may be difficult to control without the use of potent systemic therapies that are accompanied by systemic toxicity. Mycophenolate mofetil is a novel agent that may be effective in the treatment of chronic plaque type psoriasis. Our purpose was to investigate of the safety and efficacy of oral mycophenolate mofetil in the treatment of chronic plaque-type psoriasis. Four patients with severe stable plaque-type psoriasis and a psoriasis area and severity index (PASI) between 7.2 and 30.4 (mean 19) were included in the study. They received oral mycophenolate mofetil 1 g twice daily for 3 months. The PASI were determined at baseline (week 0) and every two weeks thereafter. Within 4 weeks of this therapy, there was a reduction in PASI of between 52% and 68% in patients (mean PASI: 7.45). The mean PASI was 3.7 and a PASI decrease of 62.5-90% obtained after 3 month of therapy. The drug was tolerated by all the patients and severe side-effects especially hematological and liver toxicity, were not observed in any of them. Oral mycophenolate mofetil might be a safe and effective drug to treat chronic plaque type psoriasis. We think that randomized controlled trials are needed to clarify this opinion.
Evaluation of Antimicrobial Resistance of Acinetobacter baumannii to Imipenem, Ciporofloxacin and Ceftazidime using E Test
MA Boroumand,H Akhyani,M Sheikhvatan,S Hekmat Yazdi
Iranian Journal of Public Health , 2009,
Abstract: "nBackground: Resistance patterns among nosocomial bacterial pathogens in hospitals may vary widely from country to coun-try at any given point and within the same country over time. Acinetobacter baumannii is one of the most important bacte-rium causes hospital acquired infections. Therefore, surveillance of antibiotic resistance of A. baumannii is necessary, espe-cially in our country which there is no have much data in this field."nMethods: In a prospective study, strain comprised of a total of 191 recent clinical isolates selected consecutively from clini-cal infections of separate patients from three University hospitals in Tehran. Minimum inhibitory concentration (MIC) of these organisms for imipenem, ciprofloxacin and ceftazidime was determined using E test method according to CLSI guide-line. Also, MIC50 and MIC90 percent was calculated for each of these antibiotics."nResults: The percentages of Acinetobacter baumannii isolates susceptible to ciprofloxacin and ceftazidime by E test were 55.5% and 44.5%, respectively. The percentage of bacterium susceptible to imipenem by E test was 72.8%. MIC50 and MIC90 of imipenem in E test were 1.5 and >32, respectively."nConclusion: High antimicrobial resistance against A. baumannii species has been seen in Iran; therefore, it is necessary to imple-ment some approaches for prevention of bacterial spread.
Prevalence of anti-gliadin antibody in patients with alopecia areata: a case-control study
Hallaji Z,Akhyani M,Ehsani AH,Noormohammadpour P
Tehran University Medical Journal , 2011,
Abstract: "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 st1":*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Alopecia areata, a non-cicatricial form of hair loss, is believed to be an immunologic response that targets hair follicles. Genetic background is important in the pathogenesis of this disorder, although some evidence point to the role of melanocytic antigens. There are some reports on the relationship between alopecia areata and celiac disease. The aim of the present study was to identify antigliadin antibodies in patients with alopecia areata. "n"nMethods: Fifty patients, aged 2.5-50 years, with alopecia areata presenting to the dermatology clinic of Razi Educational Hospital in Tehran, Iran, and fifty healthy individuals, aged 5-48 were matched and enrolled in the study. After signing an informed consent form, blood samples (10 ml clotted blood) were obtained from the participants and sent to referral laboratory for the presence of antigliadin IgA and IgG antibodies. Concentrations of antibodies were measured by ELISA through a full automatic ELISA reader. The data were analyzed statistically."n"nResults: The study included 29(58%) male and 21(42%) female patients with a mean age of 24.6 years. The control group included 29(58%) male and 21(42%) female individuals with a mean age of 24 years. In the case group, 9(18%) patients were positive for antigliadin antibody, while only one (2%) individual was positive for the antibody in the control group (p<0.001). No other differences were of statistical significance."n"nConclusions: Regarding the higher prevalence of antigliadin antibodies in patients with alopecia areata, it would be wise to screen the patients for celiac disease.
Evaluation of Perioperative Blood Glucose Changes During Elective Eye Surgeries Under General Anesthesia, With Two Methods: Glucometer and Lab Assay
H. Zahedi,V. Akhyani,Z. Hussain Khan,M. Yunesian
Tehran University Medical Journal , 2006,
Abstract: Background: Hyperglycemia is a metabolic response to surgical stress. In this study, patients’ blood glucose changes were measured before, during and after elective eye surgeries under general anesthesia, with two methods: glucometer and glucose oxidase enzyme lab assay. Probable influencing factors and the correlation rate of these two methods were evaluated. Methods: This analytic cross – sectional original study was performed on 230 American Society of Anesthesiologists (ASA) Class 1or 2 non–diabetic patients. All the patients underwent a similar general anesthesia and their blood glucose levels were measured simultaneously with two cited methods on three occasions. Results: In all cases, post-surgery blood glucose in comparison to pre-surgery levels increased significantly in both methods irrespective of independent variables of the study. Considering these independent variables, increase in blood glucose levels was significant in most of the patients. The mean increase in blood glucose post-surgery in comparison to pre–surgery, measured with lab assay, had significant statistical correlation with the type of eye surgery but not with other variables like age, gender and duration of surgery. Correlation of the two methods were also partially significant statistically. Conclusion: Considering the results of this study and the fact that blood glucose changes under general anesthesia is usually unrecognized clinically, we recommend blood glucose measurement in non–diabetic patients during long surgeries. It is advantageous to use Accu–chek (Sensor model) glucometer for this purpose.
An epidemiologic clinical and pathological study of basal cell epithelioma (BCE) in Razi Dermatological Hospital
Akhyani M,Ghaninezhad Ahary H,Safaie Naraghi Z,Rezaie A
Tehran University Medical Journal , 1998,
Abstract: Our purpose was demographic clinical and pathological aspect of BCE in patients seen in Razi Hospital, during a six-month period (75.8.12 to 76.2.12). Results: From the total 20000 patients, 103 cases of BCE were detected. (0.5%). The male female ratio was 1.71 BCE was more frequent in sixth decade. 40.8% of patients were fair skin (Type II), 54.4% tawny (Type III) and 4.9% brown (Type IV, V). 15.5% of patients had a past history of freckles and history of radiotherapy in childhood was present in 41.7% 89.3% had no history of acne and seborrhea. The scalp was the most common site of BCE. The most common clinical type was nodular BCE and solid BCE was the dominant histological feature. Conclusion: BCE was more common in male and fair skin patients with dry skin. In those having history of radiotherapy of the scalp, lesions were seen mostly on the scalp, forehead and neck: pigmented BCE was predominant in this group.
CYTOLOGICAL DIAGNOSIS OF CUTANEOUS BASAL CELL CARCINOMA
Z. Naraghi,H. Ghaninejad,M. Akhyani,D. Akbari
Acta Medica Iranica , 2005,
Abstract: Basal cell carcinoma (BCC) is the most common cancer of the skin. Definite diagnosis usually requires histological examination but recently it has been suggested that cytological examination of skin smear can be used as an alternative. To evaluate sensitivity and specificity of cytological examination, a total of 125 skin lesions, clinically suspected to be BCC were studied. Cytological samples were taken by scraping a scalpel blade over the lesion and smearing the cells on to a glass slide. The specimens were air- dried and stained with May-Grünwald-Giemsa. An incision biopsy was performed for histopathological study. The cytological results were compared with the histopathological results of the lesions. Histopathology revealed BCC in 102 lesions (81.6%), squamous cell carcinoma (SCC) in 11 lesions (8.8%), seborrheic keratosis in 6 lesions (4.8%), actinic keratosis in 5 lesions (4%) and keratoacanthoma in 1 lesion (0.8%). Cytological examination reported BCC in 90(72%), SCC in 13 ( 10.4%) and seborrheic keratosis in 6 lesions (4.8%) and was non-diagnostic in 16 lesions (12.8%). The sensitivity and specificity of the cytology in identifying all of the BCC types were 87.3% and 95.3%, respectively. In conclusion, cytological examination is easy to perform, saves time, requires a minimum of equipments and can be considered a reliable method in the diagnosis of suspected cutaneous BCC.
Ectodermal dysplasia with alopecia, onychodysplasia, hypohidrosis, keratoderma, abnormal teeth and deafness
Akhyani Maryam,Kiavash Katrin
Indian Journal of Dermatology, Venereology and Leprology , 2007,
Abstract: The ectodermal dysplasias are a heterogeneous group of disorders with primary defect in hair, teeth, nail and sweat gland function. Numerous types have been described and several classifications exist. Here, we present a patient with ectodermal dysplasia with alopecia, dysplastic nails, hypohidrosis, sensorineural deafness, palmoplantar keratoderma, abnormal teeth and dry skin. To our knowledge, combination of all these features in ectodermal dysplasia has not been reported in the past. The etiology is unknown, but consanguinity of parents points to an autosomal recessive inheritance.
Tongue lesions in psoriasis: a controlled study
Maryam Daneshpazhooh, Homayoon Moslehi, Maryam Akhyani, Marjan Etesami
BMC Dermatology , 2004, DOI: 10.1186/1471-5945-4-16
Abstract: The oral mucosa was examined in 200 psoriatic patients presenting to Razi Hospital in Tehran, Iran, and 200 matched controls.Fissured tongue (FT) and benign migratory glossitis (BMG) were the two most frequent findings. FT was seen more frequently in psoriatic patients (n = 66, 33%) than the control group (n = 19, 9.5%) [odds ratio (OR): 4.69; 95% confidence interval (CI): 2.61–8.52] (p-value < 0.0001). BMG, too, was significantly more frequent in psoriatic patients (28 cases, 14%) than the control group (12 cases, 6%) (OR: 2.55; 95% CI: 1.20–5.50) (p-value < 0.012). In 11 patients (5.5%), FT and BMG coexisted.FT was more frequent in pustular psoriasis (7 cases, 53.8%) than erythemato-squamous types (56 cases, 30.4%). On the other hand, the frequency of BMG increased with the severity of psoriasis in plaque-type psoriasis assessed by psoriasis area and severity index (PASI) score.Nonspecific tongue lesions are frequently observed in psoriasis. Further studies are recommended to substantiate the clinical significance of these seemingly nonspecific findings in suspected psoriatic cases.The occurrence of psoriatic lesions on oral mucous membranes was a subject of controversy [1,2]. Some investigators stated that they do not occur [3]; others, have claimed that they are uncommon. Still others say that they occur only in generalized pustular psoriasis (GPP) [4,5]. Nowadays, there is sufficient evidence that a subset of patients have oral lesions in association with skin disease [2].Oppenheim, in 1903, was the first to substantiate oral psoriasis with biopsy [6]. Since then, various lesions have been described, including grey, yellowish, white or translucent plaques or annular forms, diffuse areas of erythema, geographic tongue and fissured tongue [7-16].In all the cases reported in the literature, a positive biopsy showing a psoriasiform pattern has been the crucial component of the diagnosis [5,17-20]. Thus hyperkeratosis, parakeratosis, and an inflammatory infiltrate c
Erythroderma: A clinical study of 97 cases
Maryam Akhyani, Zahra S Ghodsi, Siavash Toosi, Hossein Dabbaghian
BMC Dermatology , 2005, DOI: 10.1186/1471-5945-5-5
Abstract: We reviewed the clinical, laboratory and biopsy material of 97 patients diagnosed with erythroderma who were treated in our department over a 6-year period (1996 through 2002).The male-female ratio was 1.85:1. The mean age at diagnosis was 46.2 years. The most common causative factors were dermatoses (59.7%), followed by drug reactions (21.6%), malignancies (11.3%) and idiopathic causes (7.2%). Carbamazepine was the most common drug (57.1%). The best clinicopathologic correlation was found in cutaneous T-cell lymphoma and pityriasis rubra pilaris related erythroderma. Apart from scaling and erythema that were present in all patients, pruritus was the most common finding (97.5%), followed by fever (33.6%), lymphadenopathy (21.3%), edema (14.4%) and hyperkeratosis (7.2%).This study outlines that underlying etiologic factors of erythroderma may show geographic variations. Our series had a high percentage of erythroderma secondary to preexisting dermatoses and a low percentage of idiopathic cases. There was no HIV-infected patient among our series based on multiple serum antibody tests. The clinical features of erythroderma were identical, irrespective of the etiology. The onset of the disease was usually insidious except in drug-induced erythroderma, where it was acute. The group associated with the best prognosis was that related to drugs.Erythroderma or exfoliative dermatitis is a rare skin disorder that may be the result of many different causes. It represents an extreme state of skin irritation involving the whole or most of the skin surface. Because most patients are elderly and skin involvement is widespread, the disease implies an important risk to the life of the patient [1]. Hasan and Jansen estimated the annual incidence of erythroderma to be 1 to 2 per 100,000 patients [2].Sehgal and Strivasta recorded the incidence of erythroderma in a large prospective study from the Indian subcontinent as 35 per 100,000 dermatologic outpatients [3]. The causative factors
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