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Search Results: 1 - 10 of 15 matches for " Akerele "
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Post open prostatectomy bladder exteriorization mimicking “acquired bladder extrophy’’
AO Takure, VC Onuora, W Akerele
Research and Reports in Urology , 2010, DOI: http://dx.doi.org/10.2147/RRU.S9181
Abstract: st open prostatectomy bladder exteriorization mimicking “acquired bladder extrophy’’ Case report (4195) Total Article Views Authors: AO Takure, VC Onuora, W Akerele Published Date March 2010 Volume 2010:2 Pages 31 - 34 DOI: http://dx.doi.org/10.2147/RRU.S9181 AO Takure1, VC Onuora2, W Akerele3 1Urology Division, Department of Surgery, University College Hospital, Ibadan, Nigeria; 2College of Health Sciences, Igbinedion University, Okada, Benin, Nigeria; 3Urology Unit, Department of Surgery, Irrua Specialist Teaching Hospital, Irrua, Nigeria Abstract: A 58-year-old Nigerian male had open prostatectomy undertaken in a private hospital 3 months before presenting at our out-patient clinic with leakage of urine and a widening supra pubic defect of 10 weeks duration. Examination showed the posterior bladder wall and visible trigone. Subsequently the defect was closed and he remained continent at follow up.
Studies on the Genotoxic and Mutagenic Potentials of Mefloquine.
JO Akerele, EE Obaseiki-Ebor
Tropical Journal of Pharmaceutical Research , 2002,
Abstract: Purpose: The detection of mefloquine mutagenicity has not been achieved by the use of Salmonella typhimurium his TA1535, TA1537 as tester strains. With the introduction of improved and more sensitive strains, it is of interest to evaluate the current mutagenic and genotoxic status of the drug. This study presents data on the in-vitro mutagenic and genotoxic potentials of mefloquine hydrochloride clinically used as an antimalarial agent. Method: The mutagenicity potentials was investigated in the Escherichia coli WP2 trp and WP2 uvrA trp tester strains containing the plasmids, pEB017 and pKM101, and the Salmonella typhimurium TA97 containing pKM101. The genotoxicity potential was determined using the microscreen phage-induction assay. Results: The presence of plasmids pEBO17 and pKM101 enhanced the detection of mutagenicity of mefloquine. Microsomal-activated mefloquine unequivocally elicited base-pair substitution mutagenicity. The genotoxicity test indicated that mefloquine was generally not genotoxic but was of the same potential mutagenicity as chloroquine phosphate. Conclusion: Melfloquine hydrochloride exhibits base pair substitution mutagenesis, but not potentially genotoxic, even though it showed concentration dependent cytotoxicity. Its use as a last line antimalarial agent should still be encouraged.
Aspects of microbial contamination of tablets dispensed in hospitals and community pharmacies in Benin City, Nigeria
John O. Akerele, Godwin C. Ukoh
Tropical Journal of Pharmaceutical Research , 2002,
Abstract: Purpose: A research was carried out to investigate the incidence of microflora in tablets dispensed from large container packages used in hospitals and community pharmacies. It was designed to provide base-line data on the common biodegrading microorganisms associated with tablets in retail containers and to highlight the health implications of such observations and roles for pharmacists in self medication phenomenon in Nigeria. Methods: The protocol for the study involved structured selection of representative named tablets from some public hospitals and community pharmacies within Benin metropolis. Constitutive microorganisms were elaborated and enumerated using standard microbiological protocols. Results: Our results showed that all the tablets sampled had some form of microbial growth. However, aerobic mesophilic bacteria and fungi observed were within standard numerical limits. It was additionally observed that ascorbic acid and folic acid tablets, particularly from the community pharmacies failed the exclusive criteria for Enterobactereacea and Staphylococci. Tablets from public hospitals in general have lower incidence of exclusive microbial contamination, compared with community pharmacies. Conclusion: Tablets packed in large containers in retail pharmacies in Benin City are often contaminated with microbial growth. This has possible adverse consequences for those who obtain drugs stored in large containers.
Phytochemical and Antibacterial Evaluations of the Stem Bark of Newbouldia laevis against Isolates from Infected Wounds and Eyes
JO Akerele, BA Ayinde, J Ngiagah
Tropical Journal of Pharmaceutical Research , 2011,
Abstract: Purpose: To examine the phytochemical constituents and verify the ethnomedical claim of Newbouldia laevis (P.Beauv.) Seeman ex Bureau Bignoniaceae in treating septic wounds and eye problems. Methods: Applying standard methods, the phytochemical constituents of the stem bark were examined while the antibacterial potentials of the methanol extract of the stem bark and its organic solvent fractions were tested on clinical bacterial isolates from infected wounds and eyes using the agar - well diffusion method. Ciprofloxacin and gentamicin were used as standard controls. The time-kill kinetics of the methanol stem bark extract and ciprofloxacin were determined using isolates of Staphyloccocus aureus. Results: Phytochemical screening of the stem bark revealed the presence of flavonoids, tannins, saponins and alkaloids with no traces of cyanogenic glycosides. The 65 bacterial pathogens isolated included Proteus mirabilis (26.0 %) and Pseudomonas aeurginosa (17.4 %) from non-diabetic patients’ wounds; Staphylococcus aureus (32.0 %) and Escherichia coli (16.0%) from diabetic patients’ wounds; Staphylococcus aureus (35.3%) and Pseudomonas aeruginosa (35.3 %) from infected eyes. The chloroform fraction was observed to be more active on Gram- negative organisms while the aqueous fraction was more active on Gram-positive organisms. Time-kill kinetics of Staphylococcus aureus showed that the extract was bactericidal (99.9 % killing) at MIC and 2 x MIC after 24 and 3 hours, respectively. Conclusion: The study has established that the stem bark of Newbouldia laevis has antibacterial activities against bacterial isolates from infected wounds and eyes as claimed in ethnomedicinal practice
Post open prostatectomy bladder exteriorization mimicking “acquired bladder extrophy’’
AO Takure,VC Onuora,W Akerele
Open Access Journal of Urology , 2010,
Abstract: AO Takure1, VC Onuora2, W Akerele31Urology Division, Department of Surgery, University College Hospital, Ibadan, Nigeria; 2College of Health Sciences, Igbinedion University, Okada, Benin, Nigeria; 3Urology Unit, Department of Surgery, Irrua Specialist Teaching Hospital, Irrua, NigeriaAbstract: A 58-year-old Nigerian male had open prostatectomy undertaken in a private hospital 3 months before presenting at our out-patient clinic with leakage of urine and a widening supra pubic defect of 10 weeks duration. Examination showed the posterior bladder wall and visible trigone. Subsequently the defect was closed and he remained continent at follow up.Keywords: post open prostatectomy, bladder exteriorization, adult bladder exstrophy
An Analysis of the Impact of Global Financial Crisis on the Nigerian Stock Exchange
Z. Yakubu,A.O. Akerele
Current Research Journal of Social Science , 2012,
Abstract: The objective of this study is to analyze the impact of the global financial crisis on the Nigerian Stock Exchange from 2008 to 2011. Market Capitalization is the proxy of the Nigerian Stock Exchange while Capital Inflow and Foreign Exchange Rate are the proxy of global financial crisis on Nigerian Stock Exchange. Using the ordinary least square it was found that the global financial crisis has no significant effect on the Nigerian Stock Exchange. This means policy of regulators had deepened the recession on the Nigerian Stock Exchange. The government is therefore advised to put up measures to stem up investors’ confidence and activities in the market so that it could contribute significantly to the Nigerian economy.
Analysis of Poverty Profiles and Socioeconomic Determinants of Welfare among Urban Households of Ekiti State, Nigeria
D. Akerele and S.A. Adewuyi
Current Research Journal of Social Science , 2011,
Abstract: The study focused on assessment of household poverty and welfare among households in Ekiti State, Nigeria. Using a multistage sampling approach, a total of 80 households were selected and interviewed with the aid of well structured questionnaire. Data collected were subjected to analyses such as descriptive statistics, poverty index and multiple regression analysis. The result revealed the 38.30 percent of the households covered by the study were poor and would have to mobilize financial resources up to 41.80% of 1 US Dollar (N130) per day (for each household member) to be able to escape poverty. Female headed households in the study area appear to be more vulnerable to income poverty with poverty incidence, depth and severity of values 0.221 and 0.239, 0.402 and 0.191, respectively. Highest levels of poverty were found among household with 7-9 dependants with values 1.00, 0.715 and 0.511 for the incidence, depth and severity of poverty respectively. Educational levels of household head and spouse, gender of household head and dependency ratio are factors that exact significance influence on household welfare. In order to reduce poverty and promote peoples’ welfare, policies that would promote employment opportunities; educational status of household head, spouse and household members as well as efforts to enhance women access to more productive resources and investment in infrastructural development are recommended.
Antimicrobial activity of the ethanol extract and fractions of the seeds of Garcinia kola Heckel (Guttiferae)
JO Akerele, O Obasuyi, MI Ebomoyi, IE Oboh, OH wumarongie
African Journal of Biotechnology , 2008,
Abstract: The crude ethanol extract, aqueous and chloroform fractions of the seeds of Garcinia kola Heckel (Guttiferae) was investigated for antimicrobial activity. Agar well diffusion and minimum inhibitory concentration determinations were the methods employed for the study. Clinical bacterial and fungal isolates were used as indicator organisms while standard antimicrobial agents were included in the study. The crude ethanol extract showed significant inhibitory activity against clinical isolates of both Gram positive and Gram negative organisms. It was active against Staphylococcus aureus, Bacillus subtilis, Streptococcus viridans, Escherichia coli, Pseudomonas aeroginosa and Klebsiella pneumonia. It also showed significant inhibitory activity against fungi like Penicillium notatum, Aspergillus niger and Candida albicans. Both the aqueous and chloroform fractions showed activity against the clinical isolates of S. aureus, E. coli and P. aeruginosa. The MIC values obtained ranged between 2.5 and 7.5 mg/ml for bacteria and fungi isolates. The results showed that the crude ethanol extract has broad spectrum of activity, while the fractions exhibited narrow spectrum of activity, since they were active against S. aureus, E. coli, and P. aeruginosa only. These observations could be the basis for the usefulness of the seeds of G. kola in the treatment remedies for microbial infections.
Microbiological and toxicological studies on cellulose generated from agricultural wastes
RI Ozolua, EKI Omogbai, JO Akerele, AO Okhamafe
African Journal of Biotechnology , 2005,
Abstract: A pharmaceutical excipient is required to meet certain minimum standards for use in the manufacture of dosage forms. In this study, two of such requirements, microbiological and toxicological suitability, was investigated in respect of cellulose powder derived from an agricultural waste, maize cob. Microbial count data were obtained by inoculating a suspension of the cellulose into various types of agar. We also studied some of the possible toxicological effects of sub-acute ingestion of the cellulose in 2% tragacanth mucilage on adult male Wistar rats given 1.6 g/kg per day for 14 days. Weight changes, locomotor activity, some haematological parameters and the presence of gastrointestinal lesions were evaluated. Microbiological results indicate a ‘no growth’ status for yeast, fungi as well as for coliform and pseudomonas bacteria. The mesophilic bacterium, Bacillus subtilis returned a count of 100 cfu/g. Toxicological results show that animal weight was significantly (P < 0.05) reduced on the 14th day compared to weights on the 1st and 3rd days. Locomotor activity increased in a similar pattern being significantly higher (P < 0.05) on day 14 than on days 1 and 3. Platelet counts, white blood cell counts, and packed cell volume were not affected. There were no visible gastrointestinal (GI) lesions or morbidity and mortality in the animals. We conclude that the cellulose satisfied the British Pharmacopoeia requirement for pharmaceutical grade starch that it should be free from the coliform bacterium, Escherichia coli. Furthermore, the results obtained showed that the cellulose neither exerted adverse effects on the haematological status of the animals nor is it associated with any other significant toxicological event.
Antimicrobial activity of the ethanol extract of the aerial parts of sida acuta burm.f. (malvaceae)
I E Obah, J O Akerele, O Obasuyi
Tropical Journal of Pharmaceutical Research , 2007,
Abstract: Purpose: The antimicrobial activity of the 90 % ethanol extract of the aerial parts of Sida acuta Burm. F. (Malvaceae) was investigated in other to verify its claimed ethno medicinal use in the treatment of microbial infections. Method: The antimicrobial activity of the extract was tested against standard strains and clinical isolates of some aerobic bacteria and a fungus using the Agar well diffusion method. Commercial antibiotics were used as positive reference standards to determine the sensitivity of the strains. Results: The extracts showed significant inhibitory activity against standard strains and clinical isolates of Staphylococcus aureus, clinical isolates of Bacillus subtilis and Streptococcus faecalis. The MIC values obtained using the Agar-dilution test ranged from 5.0 mg/ml. – 10.0 mg/ml. Neither the concentrated extract nor its dilutions inhibited Esherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Candida albicans Conclusion: The results demonstrate that the crude extract of the aerial parts of Sida acuta has a narrow spectrum of activity and suggest that it may be useful in the treatment of infections caused by Gram positive aerobic bacteria.
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