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THE PREVALANCE OE ALLERGIC RHINITIS IN 11-15 YEAR- OLD CHILDREN IN SHIRAZ (IRAN)
R. Amini H. Akbari
Acta Medica Iranica , 1999,
Abstract: The first epidemiologic survey of childhood allergic rhinitis in Iran was carried out from May 1995 until April 1996.. A questionnaire was distributed among 4584, 11-15 year-old children of both sexes, to be completed under supervision of medical students. Nasal smears were collected from the cases with allergic rhinitis (n = 445, 5.8%.), and from 340 healthy children for comparison. Significant nasal eosinophilia was present in 62% (274) of the chidren with allergic rhinitis. Classic allergic rhinitis was seen in 226 cases. In conclusion, allergic-rhinitis is one of the major health problems in Shiraz school children. Eosinophilia of nasal secretions has a specificity of 96% and sensitivity 62%, and seems to he somewhat valuable as a screening test for nasal allergy.
PREVALENCE OF Y CHROMOSOME MICRODELETIONS IN IRANIAN INFERTILE MEN
F. Akbari Asbagh,A. Sina,H. Najmabadi,M. T. Akbari
Acta Medica Iranica , 2003,
Abstract: This study was designed to determine the frequency of Y chromosome AZF (Azoospermia Factor ) subregions, microdeletions in patients with idiopathic nonobstructive azoospermia and severe oligozoospermia. Subjects included 40 men who had been referred to infertility clinics for assisted reproduction, 37 were azoospermic and 3 had severe oligospermia. Medical history and physical exam revealed no evidence of infection, obstruction of seminal tract, endocrine failure or chromosomal anomalies. Hormonal study was performed for all patients. Twenty six men had biopsies of the testes including 11 patients with hypospermatogenesis, 9 patients with maturation arrest, 4 patients with sertoli cell only syndrome and 2 patients with tubular sclerosis. In 14 men who did not have a testicular biopsy multiple, epididymal and testicular sperm aspirations under anesthesia failed and testicular sperm extraction was subsequently performed for ICSI. DNA was isolated from blood samples. Polymerase chain reaction (PCR) amplification of 11 loci spanning the AZFa, AZFb and AZFc subregions of the Y chromosome using sY81, sY83, sY127, sY130, sY131, sY147, sY149, sY157, sY158, sY254 and sY276 was performed. Microdeletions of the Y chromosome were found in two of the patients (5%), who had azoospermia. Deletions were restricted to DAZ (deleted in azoospermia ) locus in AZFc subregion. One of the patients had a history of cryptorchidism and the second had undergone a left side varicocelectomy. Testicular pathology showed sertoli cell only syndrome in both of them. Our experience adds to the current logic that men with azoospermia or severe oligospermia should be evaluated for Yq11 microdeletions before deciding to operate varicoceles or else scheduling them for assisted reproductive techniques.
Margin Status Influence on the Outcome of Patients Treated with Breast Conserving Surgery
Akbari ME,Akbari M,Zirakzadeh H,Nafisi N
Iranian Journal of Cancer Prevention , 2011,
Abstract: Background: Breast conserving surgery (BCS) followed by local radiotherapy is the standard treatment for early stage of breast cancer. Margin status may have an important impact on local recurrence and overall survival of patients treated with BCS, but this has not been defined adequately. In this study, we investigated the relationship between microscopic margins and outcome of BCS.Methods: Three hundred eighty four patients treated with BCS between 1999 and2010 were included in our study. All surgeries were performed by a single surgical team. Margins were defined as close if surgical margins were less than 2 mm, as free if surgical margins were more than 2 mm and as positive if malignant cells were present in one of the tissue edges. Demographic, clinical, and pathological factors as well as biological markers, recurrence, and survival rates were compared between the close and the free margins groups.Results: The mean age of patients at the time of diagnosis was 54.2 years. There were 34 (9%) recurrence cases and overall survival was 128.7 months and ten years survival rate was 81%. There was no significant difference between the close and the free margins groups in terms of demographic parameters, tumor characteristics, biological factors (estrogen and progesterone receptor status) and lymphovascular invasion. Also recurrence rate did not differ significantly between these two groups.Conclusion: Our study indicates that there is no significant difference between the patients with close and the free margins in terms of treatment results. There is no clear consensus in the surgeons’ community over the definition of acceptable margin width in BCS, so additional studies are required to find the right answer.
"Emergence of Multidrug Resistant Strains of Escherichia coli Isolated from Urinary Tract Infections"
R Moniri,A Khorshidi,H Akbari
Iranian Journal of Public Health , 2003,
Abstract: The emergence of multidrug resistant strains of Escherichia coli has complicated treatment decision and may lead to treatment failures. From April to November 2001 we prospectively evaluated the prevalence of resistance to trimethoprim-sulfamethoxazole (SXT), gentamicin, cephalothin, ciprofloxacin, and nitrofurantoin in 220 Escherichia coli isolates from patients with urinary tract infections in kashan, Iran. To assess the current breadth of multidrug resistance among urinary isolates of E. coli. of total isolates, 10.9% were resistant to three or more agents and considered multidrug resistant. Among the multidrug resistant isolates, 91.7% were resistant to SXT, 75% to gentamicin, 58.3% to cephalothin, 54.2% to ciprofloxacin and 45.8% to nitrofurantoin. The predominant phenotype among multidrug resistant isolates (29.2%) included resistance to SXT, gentamicin, and cephalothin. Rates of multidrug resistance were demonstrated to be higher among males (13.2%) than females (10.4%). There was no significant association between gender and reduced susceptibility. Continued local surveillance studies are urged to monitor emerging antimicrobial resistance and to guide interventions to minimize its occurrence.
Teratogenic effects of Gentamicin on skeletal system of rat fetuses
Marzban H,Akbari M,Toobak M
Tehran University Medical Journal , 1999,
Abstract: Gentamicin was evaluated for developmental toxicity in pregnant Sprague-Dawley rat. Gentamicin was administered subcutaneously on days 6-15 gestation at dose of 100 mg/kg. On gestation day 21, all live fetuses were examined for external and skeletal malformations and variations. Increased resorptions and dead fetuses, and reduced fetal body weight were observed at dose of 100 mg/kg. Gentamicin caused severe skeletal anomalies, such as: wavy ribs, incomplete ossification of sternebrae, tail vertebra, metacarpus, metatarsus and calvaria. These results indicate the nature and extent of embryotoxicity and teratogenicity of gentamicin in Sprague-Dawley rats.
A VARIATION IN THE COURSE OF THE HUMAN VERTEBRAL ARTERY: ANATOMICAL AND CLINICAL SIGNIFICANCE
M. Akbari,H. Marzban M. Toback
Acta Medica Iranica , 1999,
Abstract: The macroscopic study of 31 adult cadavers proved a variation to Matula and Lang's study. In 2 cases (6.4%) a prevertebral segment ran up to Cy in one of which (3.2%) the middle cervical ganglion was pierced. This, we believe, is significant not only in diagnosis but also in surgical and endovascular treatment.
Epidemiology of depression among infertile and fertile couples in Shiraz, Southern Iran
Ashkani H,Akbari A,Heydari S
Indian Journal of Medical Sciences , 2006,
Abstract: BACKGROUND: Depression is considered as one of the main psychological disorders associated with infertility. Depression may play a significant role in the life of infertile individuals, their infertility treatment follow-up and in their hopefulness for the future; it may also influence the intensity and continuousness of the mutual relationship of the affected couple. AIMS: This study was done to determine the depression rate and make a comparison between infertile and fertile couples with respect to the same. SETTING AND DESIGN: The depression rate was evaluated between two groups - infertile couples (case group) and fertile couples (control group). MATERIALS AND METHODS: Ninety-one infertile couples (cases) and 9l fertile ones (controls) were randomly enrolled in our study. Beck depression inventory (BDI) and demographic information were provided. STATISTICAL ANALYSIS: We used Chi-square, t-test; and one-way Analysis of Variance (ANOVA) was performed to find out significant difference between infertility duration in various couples and its effect on the score of depression. RESULTS: The BDI mean difference between infertile and fertile couples was significant (P=0.015). It was significantly more among couples with infertility from 1-3 years′ duration compared to those with infertility of 1-year duration or less. CONCLUSION: Regarding the high rate of depression among infertile couples, it seems necessary to pay more attention to infertility centers that offer psychological and psychiatric services.
Acidity Rate and Fluoride Content of Consumed Beverages in Kerman/Iran
SH Dolatshahi,M Malakootian,H Akbari
Journal of Research in Health Sciences , 2011,
Abstract: Background: High consumption of nonalcoholic beverages is one of the causes of dental erosion. Annual consumption of beverages in Iran is 48 LPCY (Lit per capita per year) that is equal to 144 bottles per capita in year and is relatively a high rate. Taking this into consideration, the present study was planned to determine the pH and fluoride content of beverages consumed in Kerman, south east of Iran. Methods: In a descriptive cross-sectional study during 2006-2007, samples of any type of beverages in Kerman were taken once every 4 months and each sample was examined for its acidity and fluoride content in ambient and refrigerator temperatures. A total of 744 experiments were conducted on 62 brands of beverages with different colors to determine the acidity and on 31 brands of beverages to determine their fluoride content. Acidity was determined by pH-meter in the ambient temperature and refrigerator temperature (+4a—| C). Fluoride content was determined using specific electrode method. Data analysis was done by SPSS software package.
Effect of Low-Level Administration of Aflatoxin B1 into Diet on Performance and Activity of Some Blood Enzymes in Broiler Chickens
H. Kermanshahi,M. R. Akbari,N. Afzali
Journal of Science and Technology of Agriculture and Natural Resources , 2007,
Abstract: A feeding trail was conducted to evaluate the effects of diets contaminated with Aflatoxin B1 (AFB1) on the performance and blood enzymes of broiler chickens. In a randomized complete-block design with 4 blocks and 4 treatments, 112 day-old male broiler chicks were divided into 16 groups, 7 chicks per. Treatments consisted of three levels of AFB1 in starter diet (0.4, 0.8, and 1.2 ppm) along with a control group (no AFB1). Feed intake and body weight gain were recorded on a weekly basis. On days 7, 14, 21, and 28, one bird from each replicate was weighed, and killed to collect the blood samples, and to weigh its proventriculus, gizzard, duodenum and pancreas, heart, liver, spleen, bursa of fabricius, and brain. Feeding AFB1 significantly decreased feed intake and body weight gain and increased relative weight of liver (p
Survival after in-hospital Cardiopulmonary Resuscitation
M Adib Hajbaghery,H Akbari,GA Mousavi
Journal of Research in Medical Sciences , 2005,
Abstract: Background: During recent years, cardiopulmonary resuscitation (CPR) in hospital has received much attention. However, the survival rate of CPR in Iran’s hospitals is unknown. This study was designed to evaluate outcome of in-hospital CPR in Kashan. Methods: A longitudinal case registry study was conducted on all cases of in-hospital CPR during 6 months at 2002. Necessary data including; age, sex, underlying disease, working shift, time from cardiac arrest until initiating of CPR and until defibrillation, duration and result of CPR, frequency of tracheal intubations and time served for it were collected in a checklist. Results: In six months study, 206 cases of cardiopulmonary resuscitation attempted. The survival rate was similar for both sexes. Short-term survival observed in19.9% of cases and only 5.3% survived to discharge. Conclusions: Duration of CPR, time of the first defibrillation, response time and the location of cardiac arrest are the key predictors of survival to hospital discharge and in-hospital CPR strategies require improvement. This study promotes a national study on post CPR survival for accurate data on our performance in attention to chain of survival. KeyWords: Cardiopulmonary Resuscitation (CPR), Survival rate, Iran
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