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Search Results: 1 - 10 of 104164 matches for " Aijuan Zhang "
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New Gene Therapy Strategies for the Deletion of Exon 44 of Dystrophin Gene Based on Gene Editing by TALENs  [PDF]
Ping Li, Yunzhi Pan, Alice S. S. Li, Aijuan Sun, Jia Zhang, H. L. Gao, Pierre Sirois, Kai Li
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.31001
Abstract:

Duchenne Muscular Dystrophy (DMD) is a severe childhood form of muscular dystrophy. Both the severe form and its milder form of Becker Muscular Dystrophy (BMD) are caused by the mutation of dystrophin gene. Different from some other genetic diseases such as hemophilia that can be treated by replacement therapy, there is no effective therapy for muscular dystrophy in conventional medication. Gene editing technology from the recently developed engineered nucleases such as TALENs has been successfully employed in genome modification of a variety of species, and will be applied in gene therapy of selected human diseases. The genetic basis of DMD and BMD indicates that DMD is a good target for gene therapy through returning the reading frame of dystrophin gene. Gene therapy strategies described here may apply to many other genetic diseases. Wider application of TALENs in gene therapy have the potential to dramatically prolong the lifespan of individuals with genetic diseases.

Conflict Analysis and Detection Based on Model Checking for Spatial Access Control Policy
Aijuan Zhang,Cheng Ji,Yu Bao,Xin Li
- , 2017, DOI: 10.23919/TST.2017.8030537
Abstract: In this paper, we propose a Multi-granularity Spatial Access Control (MSAC) model, in which multi-granularity spatial objects introduce more types of policy rule conflicts than single-granularity objects do. To analyze and detect these conflicts, we first analyze the conflict types with respect to the relationship among the policy rules, and then formalize the conflicts by template matrices. We designed a model-checking algorithm to detect potential conflicts by establishing formalized matrices of the policy set. Lastly, we conducted experiments to verify the performance of the algorithm using various spatial data sets and rule sets. The results show that the algorithm can detect all the formalized conflicts. Moreover, the algorithm’s efficiency is more influenced by the spatial object granularity than the size of the rule set.
Preconditioned AOR Iterative Method And Comparison Theorems For Irreducible L-matrices
Aijuan Li
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
Preconditioned SSOR Iterative Method For Linear System With M-Matrices
Aijuan Li
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
A New Preconditioned AOR Iterative Method and Comparison Theorems for Linear Systems
Aijuan Li
IAENG International Journal of Applied Mathematics , 2012,
Abstract:
Improving AOR Iterative Methods For Irreducible L-matrices
Aijuan Li
Engineering Letters , 2011,
Abstract:
Mesophilic anaerobic digestion of waste activated sludge after ultrasonic and NaClO pretreatment
超声与次氯酸钠耦合预处理剩余污泥的中温厌氧消化效果

Liu Dongfang,Wang Aijuan,Wang Wei,Zhang Youping,Li Kexun,Han Lei,
刘东方
,王爱娟,王伟,张友萍,李克勋,韩磊

环境工程学报 , 2012,
Abstract: The pretreatment process of waste activated sludge from wastewater treatment plant was carried out using the combination of ultrasonic and NaClO treatment,the effects of pretreatment on sludge disintegration and anaerobic digestion were studied.The results showed that the optimal ultrasonic power intensity of this synergetic pretreatment was 1.0 W/mL and the best disintegration time was 50 min.It was discovered that the treatment of ultrasonic in the presence of 4.023 mg/g SS NaClO under the conditions led to the best improvement of sludge anaerobic digestion.The biogas production ratio and methane content was enhanced by 69.73% and 10%,respectively.Meanwhile,the volatile solids removal ratio increased from 11.11% to 21.24%,the quantity of waste acitivated sludge was reduced to some extent.
Simulation Structural Properties of Ni Clusters by Transferable Tight-binding Potential
Chenglin LUO,Aijuan CAO,Yanhuai ZHOU,

材料科学技术学报 , 1999,
Abstract: A transferable tight-binding potential for Ni has been developed. Molecular dynamics methods and simulated annealing techniques have been used to study the structural properties of Ni clusters with this potential. We have obtained the structures of some Ni clusters. The average coordination number, ionization potentials and the stability of clusters have also been calculated.
A Humerus Arterial Bleeding Simulation Model for Hemostasia  [PDF]
Aijuan Ni, Qiuming Sun, Feng Tian, Gaofeng Wei, Jian Yang, Changjun Liu
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510B062
Abstract:

In our daily life, accident would happen with arterial haemorrhage,and death would be brought out by continuous arterial bleeding for little time if emergency has not been implemented in time. This paper presents a humerus arterial bleeding simulation model (HABSM) for hemostasia,which has a high-fidelity, practical model for the humerus arterial hemostasia operation that is not only for the surgeons and nurses, but also for commons in urgent bleeding accident. The functional components of HABSM are arm model, fluid circulated pipeline and circuit controlling system. The arm model is made of elastic material as human muscle. Fluid circulated pipeline contains wiggly pump, inlet pipe and outlet pipe. And circuit controlling system has single chip micyoco system (SCM), keyboard, pressure sensor and vision circuit. SCM controls pump and valve to realize humerus arterial blood circulation. Both surgeons and commons thought well of HABSM which provided a task trainer for humerus arterial hemostasia.

Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity
Huichang Bi,Fei Li,Kristopher W. Krausz,Aijuan Qu
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/985257
Abstract:
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