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Duchenne Muscular Dystrophy (DMD) is a severe childhood form of muscular dystrophy. Both the severe form and its milder form of Becker Muscular Dystrophy (BMD) are caused by the mutation of dystrophin gene. Different from some other genetic diseases such as hemophilia that can be treated by replacement therapy, there is no effective therapy for muscular dystrophy in conventional medication. Gene editing technology from the recently developed engineered nucleases such as TALENs has been successfully employed in genome modification of a variety of species, and will be applied in gene therapy of selected human diseases. The genetic basis of DMD and BMD indicates that DMD is a good target for gene therapy through returning the reading frame of dystrophin gene. Gene therapy strategies described here may apply to many other genetic diseases. Wider application of TALENs in gene therapy have the potential to dramatically prolong the lifespan of individuals with genetic diseases.
In our daily life,
accident would happen with arterial haemorrhage,and death would be brought out by
continuous arterial bleeding for little time if emergency has not been
implemented in time. This paper presents a humerus arterial bleeding simulation
model (HABSM) for hemostasia,which has a high-fidelity, practical model for the humerus arterial
hemostasia operation that is not only for the surgeons and nurses, but also for
commons in urgent bleeding accident. The functional components of HABSM are arm
model, fluid circulated pipeline and circuit controlling system. The arm model
is made of elastic material as human muscle. Fluid circulated pipeline contains
wiggly pump, inlet pipe and outlet pipe. And circuit controlling system has
single chip micyoco system (SCM), keyboard, pressure sensor and vision circuit.
SCM controls pump and valve to realize humerus arterial blood circulation. Both
surgeons and commons thought well of HABSM which provided a task trainer for humerus