Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2019 ( 200 )

2018 ( 2222 )

2017 ( 2109 )

2016 ( 2090 )

Custom range...

Search Results: 1 - 10 of 126955 matches for " Aijuan Li "
All listed articles are free for downloading (OA Articles)
Page 1 /126955
Display every page Item
Preconditioned AOR Iterative Method And Comparison Theorems For Irreducible L-matrices
Aijuan Li
Lecture Notes in Engineering and Computer Science , 2010,
Preconditioned SSOR Iterative Method For Linear System With M-Matrices
Aijuan Li
Lecture Notes in Engineering and Computer Science , 2010,
A New Preconditioned AOR Iterative Method and Comparison Theorems for Linear Systems
Aijuan Li
IAENG International Journal of Applied Mathematics , 2012,
Improving AOR Iterative Methods For Irreducible L-matrices
Aijuan Li
Engineering Letters , 2011,
New Gene Therapy Strategies for the Deletion of Exon 44 of Dystrophin Gene Based on Gene Editing by TALENs  [PDF]
Ping Li, Yunzhi Pan, Alice S. S. Li, Aijuan Sun, Jia Zhang, H. L. Gao, Pierre Sirois, Kai Li
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.31001

Duchenne Muscular Dystrophy (DMD) is a severe childhood form of muscular dystrophy. Both the severe form and its milder form of Becker Muscular Dystrophy (BMD) are caused by the mutation of dystrophin gene. Different from some other genetic diseases such as hemophilia that can be treated by replacement therapy, there is no effective therapy for muscular dystrophy in conventional medication. Gene editing technology from the recently developed engineered nucleases such as TALENs has been successfully employed in genome modification of a variety of species, and will be applied in gene therapy of selected human diseases. The genetic basis of DMD and BMD indicates that DMD is a good target for gene therapy through returning the reading frame of dystrophin gene. Gene therapy strategies described here may apply to many other genetic diseases. Wider application of TALENs in gene therapy have the potential to dramatically prolong the lifespan of individuals with genetic diseases.

Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity
Huichang Bi,Fei Li,Kristopher W. Krausz,Aijuan Qu
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/985257
Conflict Analysis and Detection Based on Model Checking for Spatial Access Control Policy
Aijuan Zhang,Cheng Ji,Yu Bao,Xin Li
- , 2017, DOI: 10.23919/TST.2017.8030537
Abstract: In this paper, we propose a Multi-granularity Spatial Access Control (MSAC) model, in which multi-granularity spatial objects introduce more types of policy rule conflicts than single-granularity objects do. To analyze and detect these conflicts, we first analyze the conflict types with respect to the relationship among the policy rules, and then formalize the conflicts by template matrices. We designed a model-checking algorithm to detect potential conflicts by establishing formalized matrices of the policy set. Lastly, we conducted experiments to verify the performance of the algorithm using various spatial data sets and rule sets. The results show that the algorithm can detect all the formalized conflicts. Moreover, the algorithm’s efficiency is more influenced by the spatial object granularity than the size of the rule set.
Proteomic Analysis of Honeybee (Apis mellifera L.) Pupae Head Development
Aijuan Zheng, Jianke Li, Desalegn Begna, Yu Fang, Mao Feng, Feifei Song
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0020428
Abstract: The honeybee pupae development influences its future adult condition as well as honey and royal jelly productions. However, the molecular mechanism that regulates honeybee pupae head metamorphosis is still poorly understood. To further our understand of the associated molecular mechanism, we investigated the protein change of the honeybee pupae head at 5 time-points using 2-D electrophoresis, mass spectrometry, bioinformatics, quantitative real-time polymerase chain reaction and Western blot analysis. Accordingly, 58 protein spots altered their expression across the 5 time points (13–20 days), of which 36 proteins involved in the head organogenesis were upregulated during early stages (13–17 days). However, 22 proteins involved in regulating the pupae head neuron and gland development were upregulated at later developmental stages (19–20 days). Also, the functional enrichment analysis further suggests that proteins related to carbohydrate metabolism and energy production, development, cytoskeleton and protein folding were highly involved in the generation of organs and development of honeybee pupal head. Furthermore, the constructed protein interaction network predicted 33 proteins acting as key nodes of honeybee pupae head growth of which 9 and 4 proteins were validated at gene and protein levels, respectively. In this study, we uncovered potential protein species involved in the formation of honeybee pupae head development along with their specific temporal requirements. This first proteomic result allows deeper understanding of the proteome profile changes during honeybee pupae head development and provides important potential candidate proteins for future reverse genetic research on honeybee pupae head development to improve the performance of related organs.
Differential Protein Expression in Honeybee (Apis mellifera L.) Larvae: Underlying Caste Differentiation
Jianke Li,Jing Wu,Desalegn Begna Rundassa,Feifei Song,Aijuan Zheng,Yu Fang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013455
Abstract: Honeybee (Apis mellifera) exhibits divisions in both morphology and reproduction. The queen is larger in size and fully developed sexually, while the worker bees are smaller in size and nearly infertile. To better understand the specific time and underlying molecular mechanisms of caste differentiation, the proteomic profiles of larvae intended to grow into queen and worker castes were compared at 72 and 120 hours using two dimensional electrophoresis (2-DE), network, enrichment and quantitative PCR analysis. There were significant differences in protein expression between the two larvae castes at 72 and 120 hours, suggesting the queen and the worker larvae have already decided their fate before 72 hours. Specifically, at 72 hours, queen intended larvae over-expressed transketolase, aldehyde reductase, and enolase proteins which are involved in carbohydrate metabolism and energy production, imaginal disc growth factor 4 which is a developmental related protein, long-chain-fatty-acid CoA ligase and proteasome subunit alpha type 5 which metabolize fatty and amino acids, while worker intended larvae over-expressed ATP synthase beta subunit, aldehyde dehydrogenase, thioredoxin peroxidase 1 and peroxiredoxin 2540, lethal (2) 37 and 14-3-3 protein epsilon, fatty acid binding protein, and translational controlled tumor protein. This differential protein expression between the two caste intended larvae was more pronounced at 120 hours, with particular significant differences in proteins associated with carbohydrate metabolism and energy production. Functional enrichment analysis suggests that carbohydrate metabolism and energy production and anti-oxidation proteins play major roles in the formation of caste divergence. The constructed network and validated gene expression identified target proteins for further functional study. This new finding is in contrast to the existing notion that 72 hour old larvae has bipotential and can develop into either queen or worker based on epigenetics and can help us to gain new insight into the time of departure as well as caste trajectory influencing elements at the molecular level.

MENG Qinghui,GU Aijuan,LIANG Guozheng,YUAN Li,

高分子学报 , 2010,
Abstract: 将共聚改性与端氨基超支化聚硅氧烷(HBPSi(N))的合成一步完成,建立了一步法制备改性双马来酰亚胺树脂(记为B/D/H(N))的方法.以N,N′-4,4′-二苯甲烷双马来酰亚胺(BMI)、二烯丙基双酚A(DBA)组成的体系(记为B/D)为对比,探讨了HBPSi(N)含量对B/D/H(N)树脂性能的影响.研究结果表明,HBPSi(N)含量对B/D/H(N)树脂的性能有重要影响.少量HBPSi(N)的加入不仅可以显著提高固化物的韧性,而且能有效加快树脂的凝胶时间,同时大幅度提高固化树脂的耐热性、介电性能和耐湿性.这些性能的改善主要缘于HBPSi(N)的加入改变了交联网络的分子结构.B/D/H(N)体系优异的综合性能使之在制备先进树脂基复合材料、胶黏剂方面显示出很大的应用潜力.
Page 1 /126955
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.