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Search Results: 1 - 10 of 3162 matches for " Aigner Felix "
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Clinical anatomy of the pelvic floor
Aigner Felix
Acta Chirurgica Iugoslavica , 2006, DOI: 10.2298/aci0602011a
Abstract: The pelvic floor forms the supportive and caudal border of the human’s abdominopelvic cavity. A detailed anatomical understanding of its complex architecture is mandatory for the pelvic floor surgeon (general surgeon, gynaecologist and urologist) and for fundamental mechanisms of anorectal as well as urogenital dysfunctions as different anatomical systems join here. The diagnosis and treatment of complex anorectal disorders, however, require a multidisciplinary approach.
Delivery Systems for the Direct Application of siRNAs to Induce RNA Interference (RNAi) In Vivo
Achim Aigner
Journal of Biomedicine and Biotechnology , 2006, DOI: 10.1155/jbb/2006/71659
Abstract: RNA interference (RNAi) is a powerful method for specific gene silencing which may also lead to promising novel therapeutic strategies. It is mediated through small interfering RNAs (siRNAs) which sequence-specifically trigger the cleavage and subsequent degradation of their target mRNA. One critical factor is the ability to deliver intact siRNAs into target cells/organs in vivo. This review highlights the mechanism of RNAi and the guidelines for the design of optimal siRNAs. It gives an overview of studies based on the systemic or local application of naked siRNAs or the use of various nonviral siRNA delivery systems. One promising avenue is the the complexation of siRNAs with the polyethylenimine (PEI), which efficiently stabilizes siRNAs and, upon systemic administration, leads to the delivery of the intact siRNAs into different organs. The antitumorigenic effects of PEI/siRNA-mediated in vivo gene-targeting of tumor-relevant proteins like in mouse tumor xenograft models are described.
Osteoarthritis: degeneration of matrix or cells?
T Aigner
Arthritis Research & Therapy , 2004, DOI: 10.1186/ar1335
Abstract: Cartilage degeneration implies mostly a failure of the extracellular matrix of the articular cartilage. The matrix represents the functional component responsible for the biomechanical integrity of the tissue. Thus, many studies over decades in osteoarthritis and cartilage research have focused on the understanding of degenerative or degradative processes taking place within the matrix. This has led to significant continuous advances in our understanding of the biochemistry and pathobiochemistry of molecules and their assembly within the cartilage matrix.The cells of the tissue, which do not exert per se structural functions within the tissue, were considered largely responsible for the proper matrix turnover. They were thought to react to external mediators and biomechanical stimuli or assaults and to be more or less able to compensate for continuous (bio)mechanical tissue destruction. More recently, however, besides matrix (patho)biochemistry, the cellular phenotype during the disease process has come more and more into the focus of interest. This was induced on the one hand by upcoming (molecular) technology, but also by increasing evidence that also the cells degenerate per se. Osteoarthritic chondrocytes are not only no longer able to compensate for matrix degeneration, but themselves are (co)initiators and (co)promoters of the disease process.
News-Screen Psychiatrie
Aigner M
Journal für Neurologie, Neurochirurgie und Psychiatrie , 2009,
Abstract:
News-Screen Psychiatrie
Aigner M
Journal für Neurologie, Neurochirurgie und Psychiatrie , 2010,
Abstract:
DFP: Diagnose und Genese der Angstst rungen
Aigner M
Journal für Neurologie, Neurochirurgie und Psychiatrie , 2011,
Abstract: ngste geh ren zum basalen Verhaltensrepertoire des Menschen. Entsprechend finden wir schon in reflexnahen Verhaltensschablonen, dem so genannten Fluchtreflex , Angstsymptome zur Verhaltenssteuerung. Bei Angstst rungen verliert die Angst ihre ursprüngliche Warnfunktion und wird dysfunktional. Die Intensit t der Angstsymptomatik oder deren Dauer sind nicht mehr situationsad quat. Angstst rungen geh ren zu den h ufigsten psychischen St rungen. Die Angstst rungen werden in verschiedene Untergruppen eingeteilt. Dies wird aus pragmatischen Gründen nach unterschiedlichen Therapieindikationen vorgenommen, zum Teil lassen sich zugrunde liegende Funktionsbereiche erkennen. Gerichtete Angstst rungen (Phobien) werden von ungerichteten Angstst rungen unterschieden. Die Unterscheidung in eine kurz dauernde (phasische) und eine überdauernde (tonische) Angstreaktion wird mit der Trennung der Panikst rung von der generalisierten Angstst rung vollzogen. Pathophysiologische Modelle auf der neurobiologischen Ebene und im Bereich der Lerntheorien lassen die Entstehung und den Verlauf der Angstst rungen gut nachvollziehen. Die Pr vention von Angstst rungen erscheint wichtig und noch ausbaubar. An Therapieformen sind insbesondere die kognitive Verhaltenstherapie, die Pharmakotherapie bzw. deren Kombination zu nennen. Abh ngig von der Diagnose, Dauer der St rung und Komorbidit t ist die geeignete Therapieform zu w hlen und die Prognose zu stellen.
News-Screen Psychiatrie
Aigner M
Journal für Neurologie, Neurochirurgie und Psychiatrie , 2010,
Abstract:
News-Screen Psychiatrie
Aigner M
Journal für Neurologie, Neurochirurgie und Psychiatrie , 2011,
Abstract:
News-Screen Psychiatrie
Aigner M
Journal für Neurologie, Neurochirurgie und Psychiatrie , 2009,
Abstract:
News-Screen Psychiatrie
Aigner M
Journal für Neurologie, Neurochirurgie und Psychiatrie , 2009,
Abstract:
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