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The present study explores the chemical and economic aspects of pesticide contamination of marinefishery in relation to nutritional values Marine Pollution of pesticides poses signify can tricks to the environment and non-target organisms ranging from beneficial marine micro organisms, to insects, seaweeds, fish, and mangroves at Karachi Coast. Fish typically contains good quality nutrition, particularly oily fish has maximum commercial values but contamination of fishery is the major problem caused by pesticides and PCBs pollution resulting in serious health hazards. A number of fish and shell fish samples were analyzed for determination of pesticides contamination due to marine environment pollution. It was found that most pesticides pose risk to humans, fishery or the environment because they are designed to kill or adversely affect living organisms. Quantitative analysis of pesticides and PCBs was performed using GC equipped with ECD and the FPD for organophosphorus and GC-MS. The arithmetic mean concentrations of each pesticide were calculated and statistical evaluation was done. Relationship of protein and pesticides level has been determined to determine impact of pesticide on protein content of each type of fish. There is a considerable difference found in the pesticides contents of each type of fishery, which reveals that environmental pollution status that attributes towards pesticides distribution.