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Search Results: 1 - 10 of 17590 matches for " Ahmed Mohamed Ahmed Othman "
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Treatment of Chronic Lateral Epicondylitis: Platelet Rich Plasma versus Extra-Corporeal Shock Wave Therapy  [PDF]
Ahmed Mohamed Ahmed Othman
Open Journal of Orthopedics (OJO) , 2014, DOI: 10.4236/ojo.2014.43013
Abstract: Background: Several treatment options have been proposed to treat lateral epicondylitis. Both Platelet rich plasma (PRP) and Extra-corporeal Shock Wave Therapy (ESWT) are new treatment modalities for tendinopathy. Patients and Methods: Thirty seven patients suffering from chronic lateral epicondylitis (tennis elbow) for at least six months were treated in this study. The patients were divided into two treatment groups, the first group including 20 patients treated by ESWT and the second group including 17 patients treated by local injection of platelet-rich plasma. The results were evaluated using the visual analogue scale and the DASH score. Results: In the first group (treated by ESWT), the average follow-up period was 21.55 months. The average VAS improved from 8.2 to 1.95 and the average DASH score improved from 72.25 to 51.7. Moreover, 11 cases were satisfied (55%), 3 cases (15%) were satisfied with reservation and 6 cases (30%) were not satisfied. In the second group (treated by PRP), the average follow-up period was 18.47 months. The average VAS improved from 8.52 to 1.47, the DASH score improved from 72 to 48.23. Concerning patient satisfaction, 13 cases were satisfied (83.33%), 3 cases (10.52%) were satisfied with reservation and 1 case (5.55%) was not satisfied. Conclusion: Platelet rich plasma was proved to achieve superior results when compared to ESWT as regards pain relief, improvement of elbow function and patient satisfaction at follow-up.
Open versus Arthroscopic Treatment of Post-Traumatic Stiff Elbow  [PDF]
Ahmed Mohamed Ahmed Othman
Open Journal of Orthopedics (OJO) , 2014, DOI: 10.4236/ojo.2014.411047
Abstract: Thirty three patients with post-traumatic stiff elbow were divided into two groups. The first group included 18 patients with an average age of 31.05 years treated by open arthrolysis. The second included 15 patients with an average age of 31.66 years treated by arthroscopic method. The results were evaluated using the Mayo clinic score and DASH score for elbow function. In the open group, after an average period of follow-up 19.33 months, the average range of flexion-extension movement improved from 51.11° to 103.94°. The average Mayo clinic score improved from 63.38 to 92.83 and the average DASH score improved from 68.1 to 40.23. There were 13 cases (72.22%) excellent, 4 cases (22.22%) good and 1 case (5.55%) with the poor result. In the arthroscopic group, after an average period of follow-up 17.73 months, the average range of flexion-extension movement improved from 59.46° to 101.53°. The average Mayo clinic score improved from 62.93 to 92.73 and the average DASH score improved from 69.25 to 46.4. There were 10 cases (66.66%) excellent, 3 cases (20%) good and 2 cases (13.33%) with the poor result. Both open and arthro-scopic treatment can be effective in treatment of post-traumatic stiff elbow. Arthroscopic treatment is associated with less post-operative pain and morbidity. However, open treatment provides better range of motion and marked improvement of elbow function.
Analytical Evaluation of Unfairness Problem in Wireless LANs
Ahmed Mohamedou,Mohamed Othman
Computer Science , 2010,
Abstract: The number of users using wireless Local Area Network is increasing exponentially and their behavior is changing day after day. Nowadays, users of wireless LAN are using huge amount of bandwidth because of the explosive growth of some services and applications such as video sharing. This situation imposes massive pressure on the wireless LAN performance especially in term of fairness among wireless stations. The limited resources are not distributed fairly in saturated conditions. The most important resource is the access point buffer space. This importance is a result of access point being the bottleneck between two different types of networks. These two types are wired network with relatively huge bandwidth and wireless network with much smaller bandwidth. Also the unfairness problem is keep getting worse because of the greedy nature Transmission Control Protocol (TCP). In this paper, we conduct a comprehensive study on wireless LAN dynamics and proposed a new mathematical model that describes the performance and effects of its behavior. We validate the proposed model by using the simulation technique. The proposed model was able to produce very good approximation in most of the cases. It also gave us a great insight into the effective variables in the wireless LAN behavior and what are the dimensions of the unfairness problem.
Treatment of Mild to Moderate Hallux Valgus, Percutaneous Osteotomy versus Distal Chevron Osteotomy  [PDF]
Ahmed Mohamed Ahmed Othman, Islam Hassan Ali Hegazy
Open Journal of Orthopedics (OJO) , 2016, DOI: 10.4236/ojo.2016.66023
Abstract: Objective: The aim of this study was to compare two different surgical techniques for treating mild to moderate cases of hallux valgus. Methods: Forty-one patients (58 feet) with mild to moderate hallux valgus were treated by either percutaneous technique (n = 24) patients (33 feet) or by distal chevron osteotomy (n = 17) (25 feet). Results: In the percutaneous group, after a mean follow up of 49.36 months, the mean correction of hallux valgus angle (HV) was 26.69°; in the intermetatarsal angle, average correction was 9.45°. The mean improvement of American Orthopedic Foot and Ankle Score (AOFAS) was 46.45 points. In the chevron osteotomy group, the mean follow up of 51.56 months, the mean correction of hallux valgus angle was 26.78°; in the intermetatarsal angle, average correction was 9°. The mean improvement of AOFAS was 44.76 points. Conclusion: Both techniques gave satisfactory results. However, the percutaneous technique is safer than the distal chevron osteotomy.
β-Oxoanilides in Heterocyclic Synthesis: Synthesis and Antimicrobial Activity of Pyridines, Pyrans, Pyrimidines and Azolo, Azinopyrimidines Incorporating Antipyrine Moiety  [PDF]
Abdel Haleem M. Hussein, Mohamed A. M. Gad-Elkareem, Abu-Bakr A. A. M. El-Adasy, Ahmed A. Khames, Ismail M. M. Othman
International Journal of Organic Chemistry (IJOC) , 2012, DOI: 10.4236/ijoc.2012.24047
Abstract: Condensation of β-Oxoanilide 1 with active methylene derivatives 2a,bafforded the pyridine derivative 5, and with crotononitrile afforded the pyridine 8. Compounds 9 and 11a-c were obtained by reaction of 1 with malononitrile dimer and arylidinemalononitrile 10a-10c. In contrast, when compound 1 reacted with ethoxymethylen malononitrile afforded the pyridine derivative 13. On the other hand, treatment of 1 with anthranilic acid gave the quinoline derivative 14. Also, reactions of 1 with isothiocyanate derivatives afforded compounds 16-18. The reaction of 1 with chalcone derivative afforded the pyridine derivative 22. Treatment of compound 1 with thiourea produced pyrimidine derivative 23. Furthermore, compound 1 converted into pyrimidinethione 24a and pyrimidinone 24b on treatment with a mixture of aromatic aldehydes and thiourea or urea respectively. Reaction of 24a with hydrazonyl halide, thiosemicarbazide and arylidinecyanothioacetamide afforded compounds 26, 28 and 29. Compound 29 was treated with chloroacetonitrile to afford compound 30. Six compounds from the newly synthesized were screened for antibacterial and antifungal activity against bacteria staphylococcus aureus, bacillus cereus and klebsiella pneumonia and fungi aspergillus flavus and aspergillus ochraceous, respectively. Some of the tested compounds showed significant antimicrobial activity. IR, 1H NMR, mass spectral data, and elemental analysis elucidated the structures of all the newly synthesized compounds.
Inhibition of Gene Expression of Organic Cation/Carnitine Transporter and Antioxidant Enzymes in Oxazaphosphorines-Induced Acute Cardiomyopathic Rat Models
Mohamed M. Sayed-Ahmed,Meshan Lafi Aldelemy,Mohamed M. Hafez,Othman A. Al-Shabanah
Oxidative Medicine and Cellular Longevity , 2012, DOI: 10.1155/2012/452902
Abstract: It is well documented that high therapeutic doses of oxazaphosphorines, cyclophosphamide (CP) and ifosfamide (IFO), are associated with cardiomyopathy. This study investigated whether oxazaphosphorines alter the expression of organic cation/carnitine transporter (OCTN2) and antioxidant genes and if so, whether these alterations contribute to CP and IFO-induced cardiotoxicity. Adult male Wistar albino rats were assigned to one of six treatment groups namely, control, L carnitine, CP, IFO, CP plus L carnitine and IFO plus L carnitine. In cardiac and kidney tissues, CP and IFO significantly decreased mRNA and protein expression of OCTN2. Oxazaphosphorines significantly increased serum acyl-carnitine/free carnitine ratio and urinary carnitine excretion and significantly decreased total carnitine in cardiac tissues. Interestingly, carnitine supplementation completely reversed the biochemical and gene expression changes-induced by oxazaphosphorines to the control values, except OCTN2 expression remained inhibited by IFO. Data from this study suggest that: (1) Oxazaphosphorines decreased myocardial carnitine content following the inhibition of OCTN2 mRNA and protein expression in cardiac tissues. (2) Oxazaphosphorine therapy increased urinary loss of carnitine secondary to the inhibition of OCTN2 mRNA and protein expression in proximal tubules of the kidney. (3) Carnitine supplementation attenuates CP but not IFO-induced inhibition of OCTN2 mRNA and protein expression in heart and kidney tissues.
Serum Levels of Interleukin-6 and Interleukin-10 as Biomarkers for Hepatocellular Carcinoma in Egyptian Patients
Mohamed S. Othman,Ahmed M. Aref,Amal A. Mohamed,Wesam A. Ibrahim
ISRN Hepatology , 2013, DOI: 10.1155/2013/412317
Abstract: Interleukin-10 (IL-10) and interleukin-6 (IL-6) have been reported to be related to hepatocellular carcinoma (HCC) prognosis. This study aimed to investigate the clinical usefulness of serum levels of IL-6 and IL-10 as biomarkers for HCC among high-risk patients. Materials and Methods. 80 individuals were enrolled in this study; they were categorized into 4 groups: group 1 healthy individuals (NC) ( ), group 2 chronic hepatitis C virus (HCV) patients ( ), group 3 cirrhotic patients (LC) ( ), and HCC group ( ). Using ELISA technique serum levels of IL-6, IL-10, and alpha fetoprotein (AFP) were evaluated in all groups. Results. The mean serum levels of IL-6 were significantly higher in HCC than in LC, HCV, and NC groups ( , , , and ), respectively ( ); also the serum levels of IL-10 were significantly higher in HCC compared with LC, HCV, and NC groups ( , , , and ) ( ). We also found that the tumor size is correlated strongly with IL-6 and IL-10 levels ( , ; , ), respectively. Conclusion. The combination of those markers may help to identify a group of HCC patients with low AFP. 1. Introduction Hepatocellular carcinoma is one of the most common malignant tumors, representing more than 5% of all cancers. The estimated annual number of cases exceeds 500,000, with a mean annual incidence of around 3-4%. In terms of relative frequencies, HCC ranks as the fifth most common cancer in the world; it is also the fifth among men and eighth among women; it is the second among cancers of the digestive tract after stomach cancer [1]. The main risk factors for HCC are hepatitis B virus (HBV), HCV, alcohol, aflatoxin, and possibly obesity and diabetes. Together, HBV and HCV account for 80% to 90% of all cases of HCC worldwide [2, 3]. Egypt has possibly the highest HCV prevalence in the world; 10%–20% of the general population is infected and HCV is the leading cause of HCC and chronic liver disease in the country. Approximately 90% of Egyptian HCV isolates belong to a single subtype, 4a, which responds less successfully to interferon therapy than other subtypes [4, 5]. The burden of HCC has been increasing in Egypt with a doubling in the incidence rate in the past 10 years [6]. The single most important tumor marker for HCC is AFP. HCC surveillance with serum AFP level and ultrasonography has been recommended for patients with cirrhosis. Although the detection of serum AFP level is well established in the screening and diagnostic purpose for HCC, a major shortcoming is that serum AFP is insensitive for the early cancer detection [7, 8]. In a prospective study by Marrero
Determination of Capsaicin and Dihydrocapsaicin in Capsicum Fruit Samples using High Performance Liquid Chromatography
Zeid Abdullah Al Othman,Yacine Badjah Hadj Ahmed,Mohamed Abdelaty Habila,Ayman Abdel Ghafar
Molecules , 2011, DOI: 10.3390/molecules16108919
Abstract: The aim of the present study was to determine the content of capsaicin and dihydrocapsaicin in Capsicum samples collected from city markets in Riyadh (Saudi Arabia), calculate their pungency in Scoville heat units (SHU) and evaluate the average daily intake of capsaicin for the population of Riyadh. The investigated samples consisted of hot chillies, red chillies, green chillies, green peppers, red peppers and yellow peppers. Extraction of capsaicinoids was done using ethanol as solvent, while high performance liquid chromatography (HPLC) was used for separation, identification and quantitation of the components. The limit of detection (LOD) of the method was 0.09 and 0.10 μg/g for capsaicin and dihydrocapsaicin, respectively, while the limit of quantification (LOQ) was 0.30 and 0.36 μg/g for capsaicin and dihydrocapsaicin, respectively. Hot chillies showed the highest concentration of capsaicin (4249.0 ± 190.3 μg/g) and the highest pungency level (67984.60 SHU), whereas green peppers had the lowest detected concentration (1.0 ± 0.9 μg/g); green peppers, red peppers and yellow peppers were non pungent. The mean consumption of peppers for Riyadh city population was determined to be 15.5 g/person/day while the daily capsaicin intake was 7.584 mg/person/day.
A second monoclinic polymorph of 3β-chlorocholest-5-ene
Mohd. Shaheen Khan,Othman Sulaiman,Issam Ahmed Mohamed,Chin Sing Yeap
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810015722
Abstract: The title compound, C27H45Cl, is a second monoclinic polymorph which crystallizes in the space group P21 with four crystallographically independent molecules in the asymmetric unit. The structure was previously reported [Bernal et al. (1940). Philos. Trans. R. Soc. London Ser. B, 239, 135–182; Vani & Vijayan (1979). Mol. Cryst. Liq. Cryst. 51, 253–264], also in the space group P21, but with two unique molecules in the asymmetric unit. As in the previously reported structures, rings A and C in the molecule adopt chair conformations with half-chair conformations for rings B and D. The ring junctions B–C and C–D are trans, whereas the junction A–B is quasi-trans. In the crystal structure, molecules are arranged in a head-to-tail fashion along a and are stacked along the b axis.
Synthesis and Antimicrobial Activities of Some New Heterocyclic Compounds Based on 6-Chloropyridazine-3(2H)-thione
Nasser M. Abd El-Salam,Mohamed S. Mostafa,Gamal A. Ahmed,Othman Y. Alothman
Journal of Chemistry , 2013, DOI: 10.1155/2013/890617
Abstract:
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