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Search Results: 1 - 10 of 361887 matches for " Agustín Lage Dávila "
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Global pharmaceutical development and access: critical issues of ethics and equity
Dávila,Agustín Lage;
MEDICC Review , 2011, DOI: 10.1590/S1555-79602011000300005
Abstract: the article presents global data on access to pharmaceuticals and discusses underlying barriers. two are highly visible: pricing policies and intellectual property rights; two are less recognized: the regulatory environment and scientific and technological capacities. two ongoing transitions influence and even distort the problem of universal access to medications: the epidemiologic transition to an increasing burden of chronic non-communicable diseases; and the growing role of biotechnology products (especially immunobiologicals) in the pharmacopeia. examples from cuba and brazil are used to explore what can and should be done to address commercial, regulatory, and technological aspects of assuring universal access to medications.
El doble paradigma de la investigación clínica The double paradigm of the clinical research
Agustín Lage Dávila
Revista Cubana de Farmacia , 2011,
Abstract:
El espacio de la biotecnología en el control del cáncer: oportunidades y desafíos en Cuba The place of biotechnology in the control of cancer: opportunities and challenges in Cuba
Agustín Lage Dávila
Revista Cubana de Salud Pública , 2011,
Abstract:
Global pharmaceutical development and access: critical issues of ethics and equity
Agustín Lage Dávila
MEDICC Review , 2011,
Abstract: The article presents global data on access to pharmaceuticals and discusses underlying barriers. Two are highly visible: pricing policies and intellectual property rights; two are less recognized: the regulatory environment and scientific and technological capacities. Two ongoing transitions influence and even distort the problem of universal access to medications: the epidemiologic transition to an increasing burden of chronic non-communicable diseases; and the growing role of biotechnology products (especially immunobiologicals) in the pharmacopeia. Examples from Cuba and Brazil are used to explore what can and should be done to address commercial, regulatory, and technological aspects of assuring universal access to medications.
La ciencia y la cultura: las raíces culturales de la productividad
Agustín Lage Dávila
Educaci?3n M??dica Superior , 2001,
Abstract:
Del nuevo producto biológico para el cáncer al impacto en la salud poblacional From the new biologic cancer drug to the impact in population health
Agustín Lage Dávila,Tania Crombet Ramos
Revista Cubana de Salud Pública , 2012,
Abstract: La investigación clínica no termina con el registro del nuevo medicamento, sino con la modificación de los indicadores de salud poblacional. Este artículo ilustra la experiencia de la biotecnología cubana en el propósito de contribuir a la reducción de la mortalidad por tumores malignos. En el control del cáncer, la biotecnología tiene cuatro espacios de impacto: el primero es en la prevención primaria mediante vacunas profilácticas, el segundo, consiste en las técnicas de diagnóstico precoz, el tercero es la estratificación de los pacientes mediante marcadores moleculares pronósticos o predictivos y el cuarto rol radica en el tratamiento de la enfermedad diseminada con vacunas terapéuticas y anticuerpos monoclonales que reconocen blancos específicos en los tumores. El uso de estas terapias ha traído consigo un cambio de paradigma del tratamiento del cáncer. La experiencia cubana ha sido exitosa debido a la existencia de un sistema de salud con altos estándares basado en la cobertura completa y equidad de acceso, el desarrollo del nivel primario de atención médica, centro de gravedad del sistema cubano y el desarrollo en las últimas tres décadas de una industria biotecnológica nacional, innovadora y con capacidad productiva para cubrir las necesidades nacionales de productos y exportar. A pesar de los avances, quedan grandes retos técnicos y metodológicos. La investigación científica posregistro permitirá trazar la estrategia para optimizar el impacto de los nuevos productos en la salud poblacional, encaminada a incrementar la esperanza de vida de los cubanos. The clinical research does not finish with the registration of a new drug, but with the modification of the population health indexes. This paper set forth the experience of the Cuban biotechnology in cancer control, in order to achieve the reduction of mortality rate from malignant tumors. Biotechnology has four areas of remarkable impact in cancer control: first, the primary prevention by means of prophylactic vaccines; second, the techniques for early diagnosis; third, the stratification of patients according to the molecular prognostic or predictive biomarkers and fourth, the treatment of advanced disseminated cancer with therapeutic cancer vaccines and monoclonal antibodies that detect specific targets in tumors. The use of these therapies has entailed a shift of paradigm in the cancer therapy. The Cuban experience has been successful due to the existence of a high standard health system based on complete coverage and equal access, the development of the primary medical care- the core of the
La investigación en salud como elemento integrador entre la universidad y los servicios de salud1
Agustín Lage Dávila,José R Molina García,Eduardo L Bascó Fuentes,Francisco Morón Rodríguez
Educaci?3n M??dica Superior , 1995,
Abstract:
Volumen Control vs. Presión Control: Repercusión Hemodinámica
Soler Morejón,Caridad; Lage Dávila,Jorge;
Revista Cubana de Medicina , 1999,
Abstract: it is stated in literature that the pressure control ventilation malaties have known advantages over the volumen control modalities, mainly from the hemodynamic point of view. starting from this criterion, 30 patients who were admitted at the intensive care unit of the center of medical and surgical research in january, 1996, and that required mechanical ventilation as part of the treatment were studied. these patients were hemodynamically stable and had no history of respiratory affections. they were coupled to an artificial respirator (servo 900 c or servo 300) by endotracheal tube and were ventilated for an hour under volume control regime. variables such as compliance, intrapulmonary pressures, hemodynamic data (fc, pa, pvc, diuresis) and gasometric data were checked at the end. during the second hour they were ventilated under pressure control regime and the same parameters were evaluated. it was proved that mechanical pressure control ventilation produced less hemodynamic repercussions in our patients.
Volumen Control vs. Presión Control: Repercusión Hemodinámica
Caridad Soler Morejón,Jorge Lage Dávila
Revista Cubana de Medicina , 1999,
Abstract: Se ha se alado, en la literatura, que las modalidades de ventilación reguladas por presión tienen ventajas conocidas sobre las modalidades controladas por volumen, sobre todo desde el punto de vista hemodinámico. Se estudiaron, partiendo de estos criterios, 30 pacientes que ingresaron en la Unidad de Cuidados Intensivos del CIMEQ, desde enero de 1996 y que requirieron ventilación mecánica como parte del tratamiento, pero que se encontraban hemodinámicamente estables y no tenían antecedentes de afecciones respiratorias. Se acoplaron a un respirador artifical (Servo 900 C o Servo 300) mediante cánula endotraqueal y se ventilaron durante 1 hora en régimen de volumen control, chequeando al término variables como compliance, presiones intrapulmonares, datos hemodinámicos (FC, PA, PVC, diuresis) y gasométricos. Durante la 2da. hora fueron ventilados en régimen de presión control y se evaluaron iguales parámetros de estudio. Se comprobó que la ventilación mecánica controlada por presión produjo menores repercusiones hemodinámicas en nuestros pacientes. It is stated in literature that the pressure control ventilation malaties have known advantages over the volumen control modalities, mainly from the hemodynamic point of view. Starting from this criterion, 30 patients who were admitted at the Intensive Care Unit of the Center of Medical and Surgical Research in January, 1996, and that required mechanical ventilation as part of the treatment were studied. These patients were hemodynamically stable and had no history of respiratory affections. They were coupled to an artificial respirator (Servo 900 C or Servo 300) by endotracheal tube and were ventilated for an hour under volume control regime. Variables such as compliance, intrapulmonary pressures, hemodynamic data (FC, PA, PVC, diuresis) and gasometric data were checked at the end. During the second hour they were ventilated under pressure control regime and the same parameters were evaluated. It was proved that mechanical pressure control ventilation produced less hemodynamic repercussions in our patients.
Dicephalus dibraqui dipus
Abel García Valdés,Heenry Luis Dávila Gómez,Yunior Castillo Blanco,Agustín Pe?a Licea
Revista Cubana de Obstetricia y Ginecolog?-a , 2009,
Abstract: Uno de los estados más interesantes y a la vez complejos a la hora de enfrentar desde el punto de vista médico de los embarazos múltiples son los gemelos siameses, o simplemente la fusión anatómica parcial en grado variable de sus estructuras orgánicas. En el presente artículo se presentan los datos generales y obstétricos más relevantes de uno de estos embarazos, ocurrido en la Isla de la Juventud en el a o 2006, se convirtió en el primer embarazo de este tipo del que se tiene conocimiento en nuestro territorio. El caso resulta interesante a la vez por lo poco común que resultan muchos de los hallazgos encontrados en estos gemelos, en comparación con casos similares recogidos en la literatura, la no concomitancia de este caso con factores de riesgo comunes y la certeza del diagnóstico imagenológico. One of more interesting and at the same time complex challenges the multiple pregnancies is the presence of Siamese twins, or simply, a varying degree partial anatomic fusion of its organic structures. In present paper are included the more relevant general and obstetric data from one of these pregnancies occurred in Isla de la Juventud en 2006, becoming the first pregnancy of this type in our country. This case is interesting too by the unusual findings present in these twins compared to other similar cases present in the literature, the non-concomitance of this case with common risk factors and the accuracy of imaging diagnosis.
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