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Search Results: 1 - 10 of 81 matches for " Aglais; Venet Cadet "
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Bases moleculares de las enfermedades mitocondriales
Arredondo Falagán,Aglais; Venet Cadet,Gleymis; Román Guerra,Olivia; Ramírez Delgado,Eglis Yanet;
MEDISAN , 2012,
Abstract: mitochondria are subcellular organelles whose primary role is to produce energy, which contain their own genetic system that encodes a small number of proteins that are part of the oxidative phosphorylation system. in recent years mutations in mitochondrial genetic material have been discovered, causing mitochondrial diseases. in order to increase and update the knowledge of the subject a literature survey was performed, where the relationship of mitochondria with conditions such as alzheimer's, parkinson's and diabetes mellitus, to name a few, is also stated.
Bases moleculares de las enfermedades mitocondriales Molecular basis of mitochondrial diseases
Aglais Arredondo Falagán,Gleymis Venet Cadet,Olivia Román Guerra,Eglis Yanet Ramírez Delgado
MEDISAN , 2012,
Abstract: Las mitocondrias son orgánulos subcelulares que tienen como misión principal la producción de energía, los cuales contienen su propio sistema genético que codifica un número peque o de proteínas que forman parte del sistema de fosforilación oxidativa. En los últimos a os han sido descubiertas mutaciones en el material genético mitocondrial que originan las enfermedades mitocondriales. Con el objetivo de contribuir a elevar y actualizar el conocimiento acerca del tema se realizó una revisión bibliográfica, donde se expone, además, la relación de las mitocondrias con afecciones como el alzheimer, el parkinson y la diabetes mellitus, por citar algunas. Mitochondria are subcellular organelles whose primary role is to produce energy, which contain their own genetic system that encodes a small number of proteins that are part of the oxidative phosphorylation system. In recent years mutations in mitochondrial genetic material have been discovered, causing mitochondrial diseases. In order to increase and update the knowledge of the subject a literature survey was performed, where the relationship of mitochondria with conditions such as Alzheimer's, Parkinson's and diabetes mellitus, to name a few, is also stated.
Valoración del perfil lipídico durante la descompensación metabólica de pacientes con diabetes mellitus de tipo 2 Assessment of the lipidic profile during the metabolic decompensation of patients with type 2 diabetes mellitus
Gleymis Venet Cadet,Aglais Arredondo Falagán,Karelis Fernández Arias,Eslaen Martorell Zamora
MEDISAN , 2010,
Abstract: Se realizó un estudio longitudinal y prospectivo de personas con diabetes mellitus de tipo 2, atendidas en el Hospital "Hermanos Ameijeiras" de La Habana, desde 1997 hasta 2005, en colaboración con la Facultad de Medicina No. 2 de la Universidad de Ciencias Médicas de Santiago de Cuba y The University of the West Indies en Jamaica, con el propósito de determinar la influencia del cambio de estado metabólico, según niveles de glucemia, en la manifestación del perfil lipídico, así como estudiar las variaciones del colesterol, los triglicéridos; las lipoproteínas de baja, muy baja y alta densidad, al variar de un estado metabólico compensado (glucemia: 3,0-6,9 mmol/L) a otro descompensado (glucemia: 10,0-20,0 mmol/L), pues durante esta última etapa no se apreciaron modificaciones importantes de los parámetros del perfil lipídico en dichos pacientes. A longitudinal and prospective study of people with type 2 diabetes mellitus , assisted in "Hermanos Ameijeiras" Hospital of Havana, from 1997 to 2005 was carried out, in collaboration with the Medicine Faculty No. 2 of the Medical Sciences University in Santiago de Cuba and The University of the West Indies in Jamaica, with the purpose of determining the influence of the change of metabolic state, according to glycemia levels, in the manifestation of the lipidic profile , as well as to study the variations of cholesterol, triglycerides; lipoproteins of low, very low and high density, when varying from a compensated metabolic state (glycemia: 3,0-6,9 mmol/L) to another descompensated (glycemia: 10,0-20,0 mmol/L), because during this last stage important modifications of the parameters of the lipidic profile were not appreciated in these patients.
Valoración del perfil lipídico durante la descompensación metabólica de pacientes con diabetes mellitus de tipo 2
Venet Cadet,Gleymis; Arredondo Falagán,Aglais; Fernández Arias,Karelis; Martorell Zamora,Eslaen; Martínez álvarez,Alejandro;
MEDISAN , 2010,
Abstract: a longitudinal and prospective study of people with type 2 diabetes mellitus , assisted in "hermanos ameijeiras" hospital of havana, from 1997 to 2005 was carried out, in collaboration with the medicine faculty no. 2 of the medical sciences university in santiago de cuba and the university of the west indies in jamaica, with the purpose of determining the influence of the change of metabolic state, according to glycemia levels, in the manifestation of the lipidic profile , as well as to study the variations of cholesterol, triglycerides; lipoproteins of low, very low and high density, when varying from a compensated metabolic state (glycemia: 3,0-6,9 mmol/l) to another descompensated (glycemia: 10,0-20,0 mmol/l), because during this last stage important modifications of the parameters of the lipidic profile were not appreciated in these patients.
Les difficultés méthodologiques posées par l’étude des massacres au cours des guerres napoléoniennes : le cas de l’insurrection calabraise de 1806-1807
Nicolas Cadet
La Révolution Fran?aise : Cahiers de l’Institut d’Histoire de la Révolution Fran?aise , 2011,
Abstract: L'occupation du royaume de Naples par les Fran ais, à l'hiver 1806, cristallise les tensions que conna t alors la société de l'Italie du sud, marquée par le poids d'un système archa que freinant tous progrès économiques et sociaux. La défaite subie par le général Reynier face aux Anglais à Maida, en juillet 1806, provoque une insurrection générale des provinces méridionales du royaume, notamment la Calabre. Ce soulèvement s'accompagne d'une impitoyable guerre civile entre Calabrais, les partisans du roi Ferdinand IV de Bourbon s'opposant à ceux du nouveau souverain, Joseph Bonaparte. Cette lutte fratricide se traduit par des explosions paroxystiques de violence et de fréquents massacres, mais les modalités de cette violence extrême ne se laissent guère appréhender, il est ardu d'en cerner les contours. Plusieurs difficultés compliquent en effet l'étude de ce phénomène. Incarnant par essence la rupture avec la norme, le temps du massacre ne laisse guère de place à l'observation détaillée et aux relations minutieuses. Outre le caractère lacunaire des sources, le chercheur se heurte au refus des acteurs de la violence de s'étendre sur les actes qu'ils ont vu ou commis. De fait, les XVIIIe et XIXe siècles coincident avec une évolution radicale des sensibilités, qui incite une part croissante de l'opinion à rejeter des pratiques de violence jusque là admises. La minceur ou l'opacité des sources conduisent ainsi à privilégier une approche comparatiste en cherchant dans des événements de même nature des éléments permettant de mieux cerner les spécificités des massacres calabrais, mais cette méthode fait courir le risque de sombrer dans la téléologie.Enfin, dans une société marquée par la résurgence des enjeux mémoriels et le tendance au compassionnel, l'historien du fait violent se heurte parfois à l'incrédulité, voire à l'hostilité de ses contemporains. En montrant combien la violence est "apocalypse", c'est à dire révélatrice du degré d'inhumanité auquel des individus peuvent parvenir, il fait figure de porteur de la mauvaise nouvelle. L'étude des phénomènes de la violence extrême constitu ainsi un champ d'investigations particulier, d'autant plus stimulant qu'il présente de difficultés. The occupation of the Kingdom of Naples by the French, during the 1806 winter, crystallizes the tensions that the Southern Italian society, then bearing the weight of an archaic system, curbing any kind of economic or social progress, is experiencing. The defeat inflicted by the British upon General Reynier in Maida, in July 1806, triggers a general uprising in the kingdom’s
Deformation quantization using groupoids. Case of toric manifolds
Frederic Cadet
Mathematics , 2003,
Abstract: In the framework of C*-algebraic deformation quantization we propose a notion of deformation groupoid which could apply to known examples e.g. Connes' tangent groupoid of a manifold, its generalisation by Landsman and Ramazan, Rieffel's noncommutative torus, and even Landi's noncommutative 4-sphere. We construct such groupoid for a wide class of T^n-spaces, that generalizes the one given for C^n by Bellissard and Vittot. In particular, using the geometric properties of the moment map discovered in the '80s by Atiyah, Delzant, Guillemin and Sternberg, it provides a \cstar-algebraic deformation quantization for all toric manifolds, including the 2-sphere and all complex projective spaces.
Amphetamine recapitulates developmental programs in the zebrafish
Jean Lud Cadet
Genome Biology , 2009, DOI: 10.1186/gb-2009-10-7-231
Abstract: The mammalian brain is characterized by neuroanatomical, biochemical and molecular complexities that drive cognitive and emotional responses. One of the brain's most notable functions is the evaluation of rewards that impact on daily activities and that help the individual to plan for future rewarding experiences. Unfortunately, the brain-rewarding system can be hijacked by psychostimulants that cause drug dependence and addiction in humans. Drug dependence and addiction are complex and vexing neuropsychiatric syndromes characterized by periods of escalated drug use, abstinence, repeated relapses and an array of adverse medical and biopsychosocial consequences [1]. Although efforts to treat addicted patients have met with some degree of success, the molecular neurobiology of these syndromes has remained mysterious.Several animal models have been devised in attempts to dissect the biochemical and molecular pathways that form the pathobiological substrates of drug addiction. Among these is the conditioned place preference (CPP), which has been used extensively to assess the rewarding effects of both licit and illicit drugs [2,3]. CPP has been used to investigate the motivational properties of an array of pharmacological agents, including amphetamine, cocaine, ethanol, marijuana, methamphetamine, nicotine and opiates [3]. In the CPP paradigm, the primary rewarding properties of a drug represent an unconditioned stimulus (UCS) that is paired to a neutral stimulus that acquires secondary rewarding properties that act as conditioned stimuli (CS) [4,5]. Descriptively, one compartment of a two-chamber apparatus is paired to injections of saline whereas the other compartment is paired to a psychoactive agent given repetitively over several days. Following the period of repeated exposure, the animals are then allowed free choice between the two compartments. This procedure leads to the development of preference for the drug-paired compartment [3,5].Such studies in rodents, in
R le potentiel des haies vives pour la gestion des nématodes sur les bassins versants de la zone soudano-sahélienne au Sénégal
Cadet, P.,Sanogo, D.
Tropicultura , 2007,
Abstract: Potential Role of Live Fences for Nematode Management on Watersheds in the Senegalese Sudano- Sahelian Area. The influence on the nematode communities of three type of live fences (Zizyphus mauritiana, Bauhinia rufescens and Acacia nilotica) was studied in Sinthiou Kohel, in the sudano-sahelian area of Senegal. Numbers of plant parasitic nematode were greater in the vicinity of the live hedge than in the adjacent fields. The effect was apparent to a depth of 40 cm and 2 to 8 m up and downhill. Fewer plant parasitic nematode were recovered from A. nilotica than from the two other plant species. The increase in size of the community was associated with an increase in species diversity, mainly in the Z. mauritiana rhizosphere. Live hedge supported nematode species that were not present in the adjacent fields. Free living nematodes were more abundant under the live fences, whatever the sampling depth. Live fences influenced these nematodes over almost 5 m downhill against only 2 to 3 m uphill. The importance of the live fences, established in this area to prevent erosion, is discussed in relation to their potential for the management of soil parasites and soil fertility factors, that can be transported in runoff water.
Additional bad news from regulatory T cells in sepsis
Guillaume Monneret, Fabienne Venet
Critical Care , 2010, DOI: 10.1186/cc9357
Abstract: Strong evidence indicates that, in septic conditions, increases in Tregs have deleterious consequences. In septic shock patients, augmented levels of Tregs significantly and inversely correlated with decreased lymphocyte proliferation [2]. This phenomenon, recapitulated after cecal ligation and puncture (CLP) in mice, was totally abrogated by using Foxp3 small interfering RNA (Foxp3 is a specific Treg transcription factor). In a similar model [3], after mild CLP, mice presented with immunosuppression that dampened defenses against secondary infectious challenge (Legionella pneumophilia inoculation 15 days after CLP). The restoration of efficient responses against infection was achieved thanks to anti-glucocorticoid-induced TNF receptor antibodies, known to abrogate Treg-mediated suppression. Lastly, a recent paper published in Blood [4] reported that sepsis-induced immunosuppression resulted in a reduced immune tolerance that facilitated the rapid growth of solid tumors. Foxp3+ Tregs were responsible for this effect. Although tumors were subcutaneously implanted (which is not relevant to septic patients), this indicates the occurrence of a major immunosuppressive state induced by sepsis and driven by Tregs in this model.Collectively, and beyond Tregs (unfortunately not the sole bad guys in the game), these data highlight the profound impact of sepsis/injury on immune functions. This should stimulate basic research and development of innovative therapies for rebalancing immune homeostasis in severe critical illness.CLP: cecal ligation and puncture; Treg: regulatory T cell.The authors declare that they have no competing interests.
Abstract Interpretation with Higher-Dimensional Ellipsoids and Conic Extrapolation
Mendes Oulamara,Arnaud Venet
Computer Science , 2015, DOI: 10.1007/978-3-319-21690-4_24
Abstract: The inference and the verification of numerical relationships among variables of a program is one of the main goals of static analysis. In this paper, we propose an Abstract Interpretation framework based on higher-dimensional ellipsoids to automatically discover symbolic quadratic invariants within loops, using loop counters as implicit parameters. In order to obtain non-trivial invariants, the diameter of the set of values taken by the numerical variables of the program has to evolve (sub-)linearly during loop iterations. These invariants are called ellipsoidal cones and can be seen as an extension of constructs used in the static analysis of digital filters. Semidefinite programming is used to both compute the numerical results of the domain operations and provide proofs (witnesses) of their correctness.
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