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Search Results: 1 - 10 of 35679 matches for " Adriana; González Otero "
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Las movilidades del turismo y las migraciones de amenidad: problemáticas y contradicciones en el desarrollo de centros turísticos de monta a
Rodrigo González,Adriana Otero,Lía Nakayama,Susana Marioni
Revista de Geografía, Norte Grande , 2009,
Abstract: Las distintas movilidades que el turismo genera, construyen y deconstruyen los destinos turísticos que, como lugares de juego, compiten en el mercado de viajes para ser sustentables en el largo plazo. Cumpliendo este rol, los gestores de las políticas turísticas de los destinos en la mayoría de los casos se focalizan en generar condiciones para atraer inversiones a cualquier costo. Se genera así un nuevo tipo de movilidad, ya no de turistas, sino de personas que desean una mejor calidad de vida y encuentran distintos tipos de desarrolladores de sus anhelos. Este segundo tipo de movilidades produce lo que se denomina la sombra del turismo. El fenómeno de migración de amenidad puede ser interpretado entonces como una sombra, ya que las movilidades que produce son regresivas en términos de desarrollo local. Este artículo analiza cuatro casos de estudio en Argentina: San Martín de los Andes, Villa La Angostura, El Bolsón y Villa General Belgrano, con el objeto de contribuir a una mejor comprensión de los cambios que produce la migración de amenidad en centros turísticos de monta a. Se puede extraer que la principal amenaza que significa este proceso en términos de desarrollo local es su poder para ocultar la falta de competitividad del sector turístico en estos destinos.
Estudio del reordenamiento molecular de los genes TEL/AML1 en la leucemia linfocítica aguda: Resultados preliminares Study of the molecular rearrangement of TEL/AML 1 genes in acute lymphocytic leukemia: Preliminary results
Niubys Cayado Gutiérrez,Adriana Mu?iz Fernández,Alejandro González Otero,Eva Svarch
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2000,
Abstract: La leucemia linfocítica aguda (LLA) representa aproximadamente el 80 % dentro de las leucemias pediátricas. Recientemente se ha demostrado por biología molecular la existencia de una translocación críptica, la t (12;21) (p12;q22) en la LLA de tipo B, que no se detecta por las técnicas citogenéticas convencionales e involucra los oncogenes TEL y AML1. Esta alteración es actualmente la más común en esta leucemia y se observa aproximadamente en el 25 % de los casos. Diversos investigadores han planteado que dicha translocación identifica a un subgrupo de pacientes con una evolución muy favorable, por lo que se considera un indicador de buen pronóstico. La determinación de la t (12;21) en el estudio de LLA tiene importancia pronóstica, además de servir como marcador para la detección de la enfermedad mínima residual. En nuestro trabajo estandarizamos la técnica de RT-PCR para la detección de la t (12;21) y además analizamos muestras de 20 pacientes pediátricos con LLA tipo B, que en el momento del estudio se encontraban en la fase de diagnóstico inicial o en recaída. En el estudio, 5 de los 20 pacientes mostraron reordenados los genes TEL/AML 1, lo que representa el 25 % de los casos. Esta frecuencia concuerda con lo comunicado en la literatura hasta el momento Acute lymphocytic leukemia (ALL) represents approximately 80% of the pediatric leukemias.The existance of a cryptic translocation, the t (12;21) (p12;q22) in the type B ALL, which is not detected by the conventional cytogenetic techniques and involve the TEL and AML1 oncogenes, has been recently shown by molecular biology. This alteration is at present the most common in this leukemia and it is observed approximately in 25% of the cases. Some authors have stated that such translocation identifies a group of patients with a very favorable evolution and that's why it is considered as an indicator of good prognosis. The determination of the t (12;21) in the study of ALL has a prognostic importance and it also serves as a marker for the detection of the minimal residual disease. In our paper, we standardized the RT-PCR technique for the detection of the t (12;21) and we also analized samples from 20 pediatric patients with type B ALL, which at the time of the study was in the phase of initial diagnosis or on relapse. In the study, 5 of the 20 patients showed rearranged TEL/AML l genes, which accounted for 25% of the cases. This frequency agrees with what is reported in literature up to now
Estudio del reordenamiento molecular de los genes TEL/AML1 en la leucemia linfocítica aguda: Resultados preliminares
Cayado Gutiérrez,Niubys; Mu?iz Fernández,Adriana; González Otero,Alejandro; Svarch,Eva; Martínez Antu?a,Gisela;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2000,
Abstract: acute lymphocytic leukemia (all) represents approximately 80% of the pediatric leukemias.the existance of a cryptic translocation, the t (12;21) (p12;q22) in the type b all, which is not detected by the conventional cytogenetic techniques and involve the tel and aml1 oncogenes, has been recently shown by molecular biology. this alteration is at present the most common in this leukemia and it is observed approximately in 25% of the cases. some authors have stated that such translocation identifies a group of patients with a very favorable evolution and that's why it is considered as an indicator of good prognosis. the determination of the t (12;21) in the study of all has a prognostic importance and it also serves as a marker for the detection of the minimal residual disease. in our paper, we standardized the rt-pcr technique for the detection of the t (12;21) and we also analized samples from 20 pediatric patients with type b all, which at the time of the study was in the phase of initial diagnosis or on relapse. in the study, 5 of the 20 patients showed rearranged tel/aml l genes, which accounted for 25% of the cases. this frequency agrees with what is reported in literature up to now
Los anticuerpos y su papel como herramientas analíticas en los ensayos inmunoenzimáticos
Otero González,Anselmo J.;
Revista Cubana de Medicina Tropical , 2010,
Abstract: this paper presented the history and evolution of the antibodies since their discovery. it also elucidated their complex structure and function that have served at a given time as methodological basis for creating unimaginable paradigms such as fine recognition specificity, and also for destroying other apparently immutable ones as invariability and universality of the cellular genome. a review was made of the evolution of antigen-antibody reaction-based analytical systems up to the present, the situation of infectious diseases and the determining role that detection and monitoring of infectious agents play in their control. the extraordinary capability of antibodies to discriminate antigenically similar structures allows them to be fundamental tools in immunoassays and also in a well-established discipline at present, that is, immunotechnology.
Inmunoensayos enzimáticos para detectar agentes infecciosos o sus productos: algunos dise?os y aplicaciones
Otero González,Anselmo J;
Revista Cubana de Medicina Tropical , 2010,
Abstract: this paper assessed the impact of the immunoenzymatic assays on the field of the immunochemistry-based analytics for the last 40 years, and on the detection of infectious agents or the products related to their presence and/or pathogenic activity. it also addressed some designs and formats of these immunoassays from electrochemical methods of detection, assays to determine proteolytic microbial activity and their inhibitors as possible therapeutical targets, more sensitive direct triple antibody systems, alternative enzymatic activity detectors, assays for viral serology of minimal determinations to competitive assays for evaluation of vaccinal candidate effectiveness based on selected peptide combinations. finally, it provided a rapid overview of the near future of this type of immunoassays in the light of the emerging detection analytical technologies.
Inmunoensayos enzimáticos para detectar agentes infecciosos o sus productos: algunos dise os y aplicaciones Enzymatic immunoassays for the detection of infectious agents or their products: presentation of some designs and applications
Anselmo J Otero González
Revista Cubana de Medicina Tropical , 2010,
Abstract: Se hizo una valoración del impacto de los ensayos inmunoenzimáticos en la analítica de base inmunoquímica en las últimas 4 décadas, en la detección de agentes infecciosos o los productos asociado a su presencia y(o) actividad patogénica. Además se hace una incursión en algunos dise os y formatos que han tenido estos inmunoensayos desde los métodos electroquímicos de detección, los ensayos para detectar actividad proteolítica de origen microbiano y sus inhibidores como posibles blancos terapéuticos, los inmunoensayos directos de triple anticuerpo para lograr mayor sensibilidad, reveladores alternativos de la actividad enzimática, ensayos para el estudio de la serología viral con un mínimo de determinaciones, así como ensayos de competencia para evaluar la efectividad de candidatos vacunales basados en combinaciones peptídicas seleccionadas. Se concluyó con una rápida visión del futuro inmediato de este tipo de inmunoensayos a la luz de las tecnologías analíticas emergentes de detección. This paper assessed the impact of the immunoenzymatic assays on the field of the immunochemistry-based analytics for the last 40 years, and on the detection of infectious agents or the products related to their presence and/or pathogenic activity. It also addressed some designs and formats of these immunoassays from electrochemical methods of detection, assays to determine proteolytic microbial activity and their inhibitors as possible therapeutical targets, more sensitive direct triple antibody systems, alternative enzymatic activity detectors, assays for viral serology of minimal determinations to competitive assays for evaluation of vaccinal candidate effectiveness based on selected peptide combinations. Finally, it provided a rapid overview of the near future of this type of immunoassays in the light of the emerging detection analytical technologies.
Los anticuerpos y su papel como herramientas analíticas en los ensayos inmunoenzimáticos The antibodies and their role as analytic tools in immunoenzymatic assays
Anselmo J. Otero González
Revista Cubana de Medicina Tropical , 2010,
Abstract: En este trabajo se presentó la historia y evolución, desde el descubrimiento, de los anticuerpos, así como la elucidación de su compleja estructura y función que ha servido de base metodológica para crear paradigmas inimaginables en su momento, como la fina especificidad de reconocimiento; también derrumbar otros, aparentemente inamovibles, como la invariabilidad y universalidad del genoma celular. Se revisó la evolución de los sistemas analíticos basados en la reacción antígeno-anticuerpos para llegar al estado actual y problemática de las enfermedades infecciosas y el determinante papel que desempe an en su control la detección y el monitoreo de agentes infecciosos. La extraordinaria capacidad de los anticuerpos para discriminar estructuras antigénicamente similares, les permite ser parte fundamental de los inmunoensayos como herramientas básicas de lo que es hoy día una disciplina productiva muy bien establecida: la inmunotecnología. This paper presented the history and evolution of the antibodies since their discovery. It also elucidated their complex structure and function that have served at a given time as methodological basis for creating unimaginable paradigms such as fine recognition specificity, and also for destroying other apparently immutable ones as invariability and universality of the cellular genome. A review was made of the evolution of antigen-antibody reaction-based analytical systems up to the present, the situation of infectious diseases and the determining role that detection and monitoring of infectious agents play in their control. The extraordinary capability of antibodies to discriminate antigenically similar structures allows them to be fundamental tools in immunoassays and also in a well-established discipline at present, that is, immunotechnology.
Diagnóstico molecular de la leucemia aguda promielocítica: Resultados preliminares
Martínez Antu?a,Gisela; Cayado Gutiérrez,Niubys; Mu?iz Fernández,Adriana; Espinosa Martínez,Edgardo; Dorticós Balea,Elvira; González Otero,Alejandro; Carnot Uría,José; Fernández Ramos,Oscar; Hernández Ramírez,Porfirio;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2000,
Abstract: acute promyelocytic leukemia (apl) is characterized by the reciprocal translocation t(15; 17) that results in fusion gene pml-rara formation. as apl is considered to be an hematological emergency and also is given a very specific treatment with retinoic acid (atra), then it is very important to diagnose quickly and accurately which makes it possible in many cases to save the patient's life. at present rt- pcr methods have been developed to detect pml-rara gen. these molecular techniques have been extremely useful in diagnosing this entity. this paper sets forth the preliminary results of molecular diagnoses of apl in 38 patients. 36 cases presented the fusion gene and 2 did not. of the total number of positive patients, 19(55%) were bcr 1, 2 (5%) were bcr 2 and 14(40%) bcr 3. all the patients with positive results were responsive to treatment with atra. one of the two patients with negative results showed the existence of t (11; 17). these two patients did not respond to treatment with atra
Aportes al estudio de la drepanocitosis: Análisis clínico y hematológico en los primeros 5 a?os de la vida
García Peralta,Tania; Nordet Carrera,Ileana; Machín García,Sergio; González Otero,Alejandro; Mu?iz Fernández,Adriana; Martínez Antu?a,Gisela; Wade Mateo,Maura; Svarch,Eva;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 1999,
Abstract: 104 patients under 6 were studied. in 93,1 % of them the diagnosis was made before the first year of life, whereas in 47.6 % it was prenatal. the median of follow-up was 31 months (1-108). the highest incidence of clinical events in sickle cell anemia (sca) occurred between 1 and 3 years old. 91.6 % of the infections were pulmonary and 21.7 % of the respiratory episodes were considered as acute chest syndrome. the events in hemoglobinopathy sc (hsc) were less frequent than in sickle cell anemia. only one patient died in a period of almost 10 years since the study began. hemoglobin and fetal hemoglobin (hbf) were higher among females with sca. the commonest haplotypes of the block of genes b were benin and bantu. it was observed a frequency of thalassemia of 23.8 % in sickle cell anemia and of 23.7 % in hsc. bantu and non-bantu haplotypes and a thalassemia were not associated with the clinical manifestations or with the hematological parameters. the systematic follow-up of the patients since the first years of life reduces mortality in this period
On Alternative and Additional Certifications in English Language Teaching: The Case of Colombian EFL Teachers' Professional Development*
González Moncada,Adriana;
íkala, Revista de Lenguaje y Cultura , 2009,
Abstract: national policies for english-spanish bilingualism require the availability of more and better prepared efl teachers in colombia. this paper critically analyzes the use of two international models of teacher development that play the role of alternative and additional certifications for elt professionals in the country. through the review of literature in the field, the author argues that the current promotion of the use of the in-service certificate in english language teaching (icelt) and the teaching knowledge test (tkt) as additional and alternative teaching certifications may represent some forms of standardization, exclusion, inequality, and businessification in the professional development of efl teachers. conclusions suggest the need for more critical voices from teacher educators, better communication strategies among different educational actors and the construction of a more pluralistic view of the professional development of efl teachers that values local knowledge.
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