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Search Results: 1 - 10 of 12346 matches for " Adriana Hung "
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A comparison of flow cytometry detection of minimal residual disease and chimerism kinetics in chronic lymphocytic leukemia patients after allogeneic hematopoietic stem cell transplantation  [PDF]
Adriana Plesa, Xavier Thomas, Quoc Hung Le, Anne-Sophie Michallet, Valérie Dubois, Charles Dumontet, Mauricette Michallet
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.43024
Abstract: Determination of minimal residual disease (MRD) remains crucial for the follow-up after therapy in chronic lymphocytic leukemia (CLL) patients. Chimerism was assessed by short tandem repeat (STR)-PCR and single nucleotide polymorphisms (SNP)-PCR, and MRD by a multicolor flow cytometric approach in 12 consecutive patients with CLL after they received allogeneic stem cell transplantation (SCT). Overall, 11 patients achieved MRD flow negativity [10 had full donor chimerism (FDC) and one had mixed chimerism (MC)]. Only one patient remained with MRD flow positivity and displayed MC. Fifty-six samples were concomitantly studied by both chimerism and MRD flow. A significant correlation was observed between MRD flow data and chimerism in both PB and BM by using a mixed effect linear regression (p < 0.001). Flow cytometry approach of MRD can be easily combined with chimerism during the follow-up post-allogeneic SCT. Both techniques appeared complementary for guiding post-transplant immunomodulation.
The Initial Vascular Access Type Contributes to Inflammation in Incident Hemodialysis Patients
Mala Sachdeva,Adriana Hung,Oleksandr Kovalchuk,Markus Bitzer,Michele H. Mokrzycki
International Journal of Nephrology , 2012, DOI: 10.1155/2012/917465
Abstract: Background. The contribution of the hemodialysis (HD) vascular access type to inflammation is unclear. Methods. We conducted a prospective observational study in an incident HD population. C-reactive protein (CRP), interleukin-6 (IL-6), and interferon-γ-induced protein (IP-10) were measured before and at 6-time points after access placement for 1 year. Results. Sixty-four incident HD patients were included (tunneled catheter (TC), , arteriovenous fistula (AVF), , and arteriovenous graft (AVG), ). A mixed effects model was performed to adjust for age, sex, race, coronary artery disease, diabetes mellitus, infections, access thrombosis, initiation of HD, and days after access surgery. In comparison to AVFs, the presence of a TC was associated with significantly higher levels of CRP ( ), IL-6 ( ), and IP-10 ( ). The presence of an AVG was associated with increases in CRP ( ) and IP-10 ( ). Conclusions. Patients who initiate HD with a TC or an AVG have a heightened state of inflammation, which may contribute to the excess 90-day mortality after HD initiation. 1. Introduction The most recent 2009 USRDS report observed high first- and second-month death rates after HD initiation [1]. The type of HD vascular access is significantly associated with risk of death. The CHOICE study reported 50% higher mortality rates in patients initiating HD with a TC as compared to patients with an AVF. There was a trend toward higher mortality rates (21% increased) in incident HD patients with an AVG compared to those with an AVF; however this did not achieve statistical significance [2]. A recently published Canadian study in 40,526 incident dialysis patients reported an 80% higher 1-year mortality for HD patients with a TC compared to PD patients and HD patients with an AVF or AVG [3]. Potential reasons for these findings include the higher rate of infection and sepsis associated with TCs, relative to AVFs; however the contribution of the vascular access type, independent of infection, may also be a factor. The prevalence of chronic inflammation is high (35–65%) in the chronic kidney disease (CKD) and end-stage renal disease (ESRD) populations [4–7]. Inflammation, as assessed by using C-reactive protein (CRP) level, is a strong predictor of all-cause and cardiovascular mortality in ESRD patients [5–9]. Multiple clinical factors and intercurrent clinical events may contribute to inflammation [10–14]. Studies analyzing the relationship between TCs and CRP levels have reported contradictory findings. Although several small studies reported an association between TCs and
A Two-Stage Dimension Reduction Method for Induced Responses and Its Applications
Hung Hung
Statistics , 2012,
Abstract: Researchers in the biological sciences nowadays often encounter the curse of high-dimensionality, which many previously developed statistical models fail to overcome. To tackle this problem, sufficient dimension reduction aims to estimate the central subspace (CS), in which all the necessary information supplied by the covariates regarding the response of interest is contained. Subsequent statistical analysis can then be made in a lower-dimensional space while preserving relevant information. Oftentimes studies are interested in a certain transformation of the response (the induced response), instead of the original one, whose corresponding CS may vary. When estimating the CS of the induced response, existing dimension reduction methods may, however, suffer the problem of inefficiency. In this article, we propose a more efficient two-stage estimation procedure to estimate the CS of an induced response. This approach is further extended to the case of censored responses. An application for combining multiple biomarkers is also illustrated. Simulation studies and two data examples provide further evidence of the usefulness of the proposed method.
Harmonizing Budgeting and Accounting: The Case of Italy  [PDF]
Adriana Bruno
Open Journal of Accounting (OJAcct) , 2014, DOI: 10.4236/ojacct.2014.31005
Abstract: Many reforms have been undertaken in recent years; indeed, scholars have concentrated their attention on ac-counting techniques, financial management, and the potential for adding tools to support managerial reform agendas [1-3]. This paper extends prior research by focusing on the manner of diffusion ongoing reform process, through the adoption of the new version of Financial Management Reform process model [3]. The objective of this research is to investigate how a new accounting system has been introduced in the public sector in a processual and outcome-oriented analysis [4]. The study setting for this research is the Italian government, specifically the intermediate or regional level government, Campania Region, where a trial period is underway. The objective is to discover what obstacles and difficulties might exist when implementing a harmonized accounting and budgeting system while moving toward an accrual accounting system. The study reveals the main paradox in the implementation of the reform. This kind of study could add fresh knowledge to the literature and highlight common problems encountered when implementing accounting reforms. Additionally it could help set a standard to assist public entities in developing and implementing accounting guidelines.
Ongoing Blood Pressure Change in Both Upper Extremities: An Unusual Presentation of Aortic Dissection  [PDF]
Hung Yi Chen
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.24078
Abstract: Aortic dissection is a critical condition requiring immediate assessment and management. Patients with this condition usually present with severe chest pain and high blood pressure. However, because of the variety of presenting symptoms and features, it is a challenge to identify this condition, and patients are frequently misdiagnosed. The potentially critical course of aortic dissection can result in tragedy. We present the case of a 46-year-old woman who initially presented with a light headache and sensory loss in her right upper limb. She had a medical history of hypertension without regular medication, and her blood pressure (BP) was 110/67 mmHg on arrival. Four days later, she was sent to the emergency department again because she experienced transient loss of consciousness lasting for a few minutes. Her BP was 94/57 mmHg in the right arm and 89/54 in the left arm. She was admitted to the hospital, and the pulses in both upper limbs were impalpable on the following day. Chest magnetic resonance imaging (MRI) was arranged, and subsequently, aortic dissection was diagnosed. The case presented with unusual characteristics, which increased the difficulty in immediate correct diagnosis.
Influence of the Neutron Flux Characteristic Parameters in the Irradiation Channels of Reactor on NAA Results Using k0-Standardization Method  [PDF]
Tran Van Hung
American Journal of Analytical Chemistry (AJAC) , 2012, DOI: 10.4236/ajac.2012.33033
Abstract: An approximation method using to estimate the influence of the uncertainties of the neutron flux characteristic parameters in the irradiation positions on the NAA results using k0-standardization technique was presented. Those are the epithermal reactor neutron spectrum shape-factor α, the effective resonace energy Ε for a given nuclide and the thermal to epithermal neutron flux ratio f. The method is applied to estimate the effect of the uncertainties in the determination of α Ε, and f on final NAA results for some irradiation channels of the Dalat reactor. It also shows that presented method is suitable in practical use for the estimation of the errors due to the uncertainty of the neutron flux characteristic parameters at the irradiation position.
Laser Surface Annealing of Plasma Sprayed Coatings  [PDF]
Ahmed Ibrahim, Yue Hung
Journal of Surface Engineered Materials and Advanced Technology (JSEMAT) , 2012, DOI: 10.4236/jsemat.2012.223033
Abstract: Laser surface annealing provides a rapid and efficient means for surface alloying and modification of ceramic materials. In this study, Alumina-13% Titania coatings were sprayed with a water-stabilized plasma spray gun. The coated surface was treated by Excimer laser having a wavelength of 248 nm and pulse duration of 24 ns. The surface structure of the treated coating was examined by field emission scanning electron microscope and X-ray diffraction (XRD). A detailed analysis of the effects of various laser parameters including laser energy density (fluence), pulse repetition rate (PRR), and number of pulses on the morphology and the microstructure of the coatings are presented.
Distinguish the Effects of Food Availability and Food Prices on Fat Intakes of the Chinese Adults  [PDF]
Hung-Hao Chang
Modern Economy (ME) , 2012, DOI: 10.4236/me.2012.34056
Abstract: Remarkable economic growth in China has resulted in a change in the diet behavior of adults. This paper examines how changing socio-demographic characteristics, local food availability, and food prices may affect the fat intake among Chinese adults as a result of the economic growth. This paper goes beyond existing studies on the similar topic by two fronts. Instead of using a simple cross-sectional survey, a longitudinal sample of 2242 adults aged 20 and above in 1997 and 2006 was constructed. In addition, we estimated a fat intake equation using the quantile regression model to investigate the heterogeneous effects of the exogenous factors on the fat intake distribution. Results indicate that the fat intake of Chinese adults has increased over time. In particular, the increase in food availability significantly affects the fat intake of the Chinese adults.
Congenital Club Foot in Children Younger than 24 Months: Decancelous Cuboid Combined with Selective Soft Tissue Release  [PDF]
Nguyen Ngoc Hung
Open Journal of Orthopedics (OJO) , 2012, DOI: 10.4236/ojo.2012.23019
Abstract: Purpose: To evaluate 2 surgical prosedures in treatment of congenital clubfeet in children younger than 24 months. Materials and methods: Data were analyzed on 319 patients (448 feet) from July 1990 to December 2005. Clinical and classification for all patients according to Diméglio. Operated patients were devided into two group: Group1, selective soft tissue release; and Group 2, selective soft tissue release combined with cuboid decancelation. Surgical result were classified according to McKay’s system. Results: There were 103 females (32.3%) and 216 males (67.7%) in this study. There were 192 patients (268 feet) in group 1, 127 patients (180 feet) in group 2. Bilateral involvement was found in 129 patients (40.4%), only the left foot affected in 65 patients (20.4%), and only the right in 125 patients (39.2%). According to the classification of Diméglio Grade II was seen in 32.4%, Grade III in 53,1%, and Grade IV in 14.5%. Postoperatively, in group 1, we got excellent result in 29.1%, good result in 49.2%, fair result in 18.3%, and poor result in 3.4%. In group 2, we attained excellent result in 50.6%, good result in 42.2%, fair result in 6.1% and poor result in 1.1%. The good to excellent result in group 2 was significantly higher in group 1 with p = 0.000042. There was no failure in both groups. Residual adduction of forefoot in frontal plane was seen in 78.0% of group 1, and 10.6% of group 2, which was also statistically significant with p ~ 0. Conclusion: Generally speaking, the procedure of selective soft tissue releases combined with cuboid decancelation showed an outstanding result with good to excellent result of 92.8%. Surgical procedure is simple, safe, and applicable for all patients with clubfeet’s deformyties.
Large renal carbuncle mimicking intra-abdominal neoplasm on Ga-67 scintigraphy: A case of fever of unknown origin  [PDF]
Yu-Hung Chen
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.23059

Fever of unknown origin is still a medical challenge. 67Ga single photon emission computed tomography/computed tomography images are commonly used to evaluate the final diagnosis of fever of unknown origin. We presented a case of fever of unknown origin undergone 67Ga scintigraphy and an intra-abdominal 67Ga avid tumor was detected which suspected to be a neoplasm. Further contrast enhanced computed tomography revealed that the lesion was a large renal carbuncle. We concluded that the contrast-enhanced CT or single photon emission computed tomography/computed tomography with contrast enhancement can be performed to further improve diagnostic performance.

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