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Search Results: 1 - 10 of 1883 matches for " Adolfo Maisel "
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Los bancos de Cartagena, 1874-1925
Adolfo Maisel
Lecturas de Economía , 1990,
Abstract: En este artículo el autor presenta los nueve bancos que se establecieron en Cartagena durante el período de surgimiento, auge y decline de los bancos regionales privados en Colombia (1872- 925). Con base en las cuentas de un balance semestral de tres de los bancos más importantes, se ilustran las operaciones que realizaron. Además, se muestra como estos establecimientos fueron dominados por las familias de importantes comerciantes cartageneros dedicados al comercio exterior, especialmente a la exportación de ganado hacia Centro América y el Caribe.
ISCB Honors Temple F. Smith and Eran Segal
Merry Maisel
PLOS Computational Biology , 2007, DOI: 10.1371/journal.pcbi.0030128
ISCB Honors Michael S. Waterman and Mathieu Blanchette
Merry Maisel
PLOS Computational Biology , 2006, DOI: 10.1371/journal.pcbi.0020105
Comparability of Results Between a Point-of-Care and an Automated Instrument for Measurement of B-Type Natriuretic Peptide
Shah, Kevin,Terracciano, Garrett J,Jiang, Kevin,Maisel, Alan S
Western Journal of Emergency Medicine : Integrating Emergency Care with Population Health , 2010,
Abstract: Objectives: Heart failure is one of the leading causes of death in the U.S. The incorporation of B-type natriuretic peptide (BNP) measurements when triaging patients presenting with shortness of breath has improved the diagnostic and prognostic ability of physicians. Currently, there are no point-of-care systems for quantifying BNP that can be used without sacrificing accuracy. We compared the analytical performance of the Abbott i-STAT analyzer, a handheld point-of-care system for measuring BNP, with the lab-based system, the Abbott ARCHITECT.Methods: One-hundred fifty samples were collected from three clinical settings: 41 from the Emergency Department, 58 from the inpatient wards, and 51 from heart failure outpatient clinics. Linear regression and bias difference analyses were run to evaluate the accuracy of the i-STAT. Correlation between the i-STAT and Architect BNP values were made with values of BNP.Results: The correlation coefficient was r=0.977 (N=150, p<.0001). The average bias was significant (-36) and there were concentration-dependent differences at higher BNP values. Precision of the i-STAT was poor compared to the lab-based platform.Conclusion: Although the precision of the i-STAT was poor, there was good clinical agreement between the i-STAT and the lab-based platform. [West J Emerg Med. 2010; 11(1):44-48].
A Pure Capital Market Complementarity between Immigrants and Natives  [PDF]
Adolfo Cristóbal Campoamor
Modern Economy (ME) , 2015, DOI: 10.4236/me.2015.612118
Abstract: This work presents a model aiming to evaluate the impact of rural-urban migration on the aggregate stock of loanable funds and investment by the urban population. Much higher investment costs for immigrants in cities prevent their acquisition of either human or physical capital. That is the reason why immigrants self-select as net lenders and affect urban labor earnings by means of the availability of new loanable funds for investment. This reduces the local interest rates and facilitates urban aggregate investment, especially by the new generations of natives. As a result of that, the aggregate labor income of natives increases unambiguously with the size of new immigration waves.
The “Price Puzzle” under Changing Monetary Policy Regimes  [PDF]
André Varella Mollick, Adolfo Sachsida
iBusiness (IB) , 2012, DOI: 10.4236/ib.2012.44040

This paper examines the “price puzzle”, the rise in the price level following a contractionary monetary policy shock, using monthly US data from 1960 to 2006. Deviating from the standard practice is including commodity prices to “solve the puzzle”, our benchmark VAR contains output, prices, the federal funds rate and M1 money stock, while the augmented VAR includes the 10-year long bond yield. Splitting the sample at October of 1979, we find very contrasting patterns and rationalize them under the changing relationship between money and the funds rate across periods. First, the price puzzle is confined to the pre-Volcker period. Second, in the pre-Volcker period the funds rate respond largely to their own shocks, while the post-Volcker period witnesses a larger role for output fluctuations. Third, positive output shocks are more recently followed by price increases, federal funds hikes, and monetary contractions, very much consistent with the “Taylor rule”. Fourth, the “monetarist experiment” of late 1979-1982 reinforces our basic results: the more explicit the reliance on money supply, the less visible the price puzzle becomes.

Koenigs-Knorr Glycosylation with Neuraminic Acid Derivatives
Galina Pazynina,Vitaly Nasonov,Ivan Belyanchikov,Reinchard Brossmer,Maxim Maisel,Alexander Tuzikov,Nicolai Bovin
International Journal of Carbohydrate Chemistry , 2010, DOI: 10.1155/2010/594247
Abstract: Earlier we reported a convenient and efficient method of preparing α2-6 sialooligosaccharides in conditions of Koenigs-Knorr reaction. The use of Ag2CO3 allowed carrying out α2-6 sialylation of galacto-4,6-diol of mono- and disaccharides with chloride of acetylated N-acetylneuraminic acid methyl ester as glycosyl donor. In this study we applied this approach to other derivatives of neuraminic acid, namely, Neu5Gc, 9-deoxy-9-NAc-Neu5Ac, Neu5Acα2-8Neu5Ac, and Neu5Acα2-8Neu5Acα2-8Neu5Ac as glycosyl donors; eight compounds were synthesized: Neu5Gcα-O(CH2)3NH2 (8), Neu5Gcα2-6Galβ1-4GlcNAcβ-O(CH2)3NH2 (10), 9-deoxy-9-NAc-Neu5Ac-O(CH2)3NH2 (15), 9-deoxy-9-NAc-Neu5Acα2-6Galβ1-4GlcNAcβ-O(CH2)3NH2 (17), Neu5Acα2-8Neu5Acα-O(CH2)3NH2(23) Neu5Acα2-8Neu5Acα-OCH3 (24), Neu5Acα2-8Neu5Acα-OCH2(p-C6H4)NHCOCH2NH2 (25), and Neu5Acα2-8Neu5Acα2-8Neu5Acα-O(CH2)3NH2 (32). These sialosides were used for characterization of siglecs and other carbohydrate-binding proteins. 1. Introduction Sialic acid family comprises over 40 neuraminic acid versions and monosaccharide derivatives; the number of biologically relevant sialic acid oligosaccharides is also very high. Sialic acids are a part of the most important molecules of life, since they occupy the terminal position on cell membrane glycoproteins and glycolipids. Given their location and ubiquitous distribution, sialic acids can mediate or modulate a wide range of physiological and pathological processes and play a role not only in the protection and adaptation of life, but also in being utilized by life-threatening infectious microorganisms [1]. Several families of sialic acid-binding proteins have been discovered over the last few decades, including mammalian selectins and siglecs [2]. Only a limited number of sialomolecules are available as the tools for the study of mammalian and microbial lectins and sialo-modifying enzymes. Due to this, the search of simple and efficient synthetic ways for sialosaccharides is very relevant. The methods of sialylation described in the literature [3–5] rarely give high yields and α-stereoselectivity but suggest complex modifications of donors; introduction and removal of substituents at C-3, C-4, C-5, and C-9 in order to improve sialylation stereoselectivity presume complex multistage synthesis of such compounds. In case of the use of 2-xantates, thiophosphates and various imidates, sialylation usually proceeds at ?50–70°C and requires strong Lewis acids as promoters, this posing the corresponding limitations to the repertoire of protective groups in glycosyl acceptor. Recently we have
The CoxD Protein, a Novel AAA+ ATPase Involved in Metal Cluster Assembly: Hydrolysis of Nucleotide-Triphosphates and Oligomerization
Tobias Maisel, Stephanie Joseph, Thorsten Mielke, J?rg Bürger, Stephan Schwarzinger, Ortwin Meyer
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047424
Abstract: CoxD of the α-proteobacterium Oligotropha carboxidovorans is a membrane protein which is involved in the posttranslational biosynthesis of the [CuSMoO2] cluster in the active site of the enzyme CO dehydrogenase. The bacteria synthesize CoxD only in the presence of CO. Recombinant CoxD produced in E. coli K38 pGP1-2/pETMW2 appeared in inclusion bodies from where it was solubilized by urea and refolded by stepwise dilution. Circular dichroism spectroscopy revealed the presence of secondary structural elements in refolded CoxD. CoxD is a P-loop ATPase of the AAA-protein family. Refolded CoxD catalyzed the hydrolysis of MgATP yielding MgADP and inorganic phosphate at a 1:1:1 molar ratio. The reaction was inhibited by the slow hydrolysable MgATP-γ-S. GTPase activity of CoxD did not exceed 2% of the ATPase activity. Employing different methods (non linear regression, Hanes and Woolf, Lineweaver-Burk), preparations of CoxD revealed a mean KM value of 0.69±0.14 mM ATP and an apparent Vmax value of 19.3±2.3 nmol ATP hydrolyzed min?1 mg?1. Sucrose density gradient centrifugation and gel filtration showed that refolded CoxD can exist in various multimeric states (2-mer, 4-mer or 6-mer), preferentially as hexamer or dimer. Within weeks the hexamer dissociates into the dimer, a process which can be reversed by MgATP or MgATP-γ-S within hours. Only the hexamers and the dimers exhibited MgATPase activity. Transmission electron microscopy of negatively stained CoxD preparations revealed distinct particles within a size range of 10–16 nm, which further corroborates the oligomeric organization. The 3D structure of CoxD was modeled with the 3D structure of BchI from Rhodobacter capsulatus as template. It has the key elements of an AAA+ domain in the same arrangement and at same positions as in BchI and displays the characteristic inserts of the PS-II-insert clade. Possible functions of CoxD in [CuSMoO2] cluster assembly are discussed.
The Roche Cancer Genome Database 2.0
Jan Küntzer, Daniela Maisel, Hans-Peter Lenhof, Stefan Klostermann, Helmut Burtscher
BMC Medical Genomics , 2011, DOI: 10.1186/1755-8794-4-43
Abstract: We have constructed an integrated biological information system termed the Roche Cancer Genome Database (RCGDB) combining different human mutation databases already publicly available. This data is further extended by hand-curated information from publications.The current version of the RCGDB provides a user-friendly graphical interface that gives access to the data in different ways: (1) Single interactive search by genes, samples, cell lines, diseases, as well as pathways, (2) batch searches for genes and cell lines, (3) customized searches for regularly occurring requests, and (4) an advanced query interface enabling the user to query for samples and mutations by various filter criteria.The interfaces of the presented database enable the user to search and view mutations in an intuitive and straight-forward manner. The database is freely accessible at http://rcgdb.bioinf.uni-sb.de/MutomeWeb/ webcite.Facilitated by the development of new high throughput techniques like SNP arrays the identification of genes involved in complex diseases such as cancer has made enormous progress over the recent years. This resulted in a huge amount of information on human genetic variations which have been described in various genes associated with a wide variety of diseases [1-3]. Sequence variations are being studied for a better understanding of the mechanism and development of cancer as a mutation-driven disease [4]. Furthermore, somatic mutations in cancer can be used in clinical studies and molecular pathology to characterize tumor types, to predict response to treatment, and to find the best suited treatment. Thus, mutation analysis can play an important role in drug discovery and personalized healthcare.The proportion of mutations causally implicated in cancer is still unknown especially due to the high number of mutations between different tumors [5-8]. Although the number of unique variations for each cancer genome can be very high [9,10], only a few somatic variations wil
How the aggregation of oxygen vacancies in rutile based TiO$_{2-δ}$ phases causes memristive behavior
Wolfgang Heckel,Michael Wehlau,Sascha B. Maisel,Thomas Frauenheim,Jan M. Knaup,Stefan Müller
Physics , 2015, DOI: 10.1103/PhysRevB.92.214104
Abstract: The results of a comprehensive and systematic ab-initio based ground-state search for the structural arrangement of oxygen vacancies in rutile phase TiO$_2$ provide new insights into their memristive properties. We find that O vacancies tend to form planar arrangements which relax into structures exhibiting metallic behavior. These meta-stable arrangements are structurally akin to, yet distinguishable from the Magn\'eli phase. They exhibit a more pronounced metallic nature, but are energetically less favorable. Our results confirm a clear structure-property relationship between segregated oxygen vacancy arrangement and metallic behavior in reduced oxides.
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