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Search Results: 1 - 10 of 7356 matches for " Adam Mole "
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Extending a metric on a simplicial complex
Adam Mole
Mathematics , 2013,
Abstract: We show how to extend a metric defined on the vertex set of a simplicial complex to the whole simplicial complex, thus correcting a mistake in Mineyev's construction of a flow space.
Equivariant Refinements
Adam Mole,Henrik Rueping
Mathematics , 2013,
Abstract: We show that if an open cover of a finite dimensional space is equivariant with respect to some finite group action on the space then there is an equivariant refinement of bounded dimension. This will generalize some constructions of certain covers. Those generalizations play a key role in the proof of the Farrell-Jones conjecture for the general linear group over a finite field.
The total surgery obstruction revisited
Philipp Kuehl,Tibor Macko,Adam Mole
Mathematics , 2011,
Abstract: The total surgery obstruction of a finite n-dimensional Poincare complex X is an element s(X) of a certain abelian group S_n (X) with the property that for n >= 5 we have s(X) = 0 if and only if X is homotopy equivalent to a closed n-dimensional topological manifold. The definitions of S_n (X) and s(X) and the property are due to Ranicki in a combination of results of two books and several papers. In this paper we present these definitions and a detailed proof of the main result so that they are in one place and we also add some of the details not explicitly written down in the original sources.
Establishing Rapport with Your Students
Ian Mole
Humanising Language Teaching , 2011, DOI: 17559715
Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)
Armin Thalhammer,Zuzana Bencokova,Rachel Poole,Christoph Loenarz,Julie Adam,Linda O'Flaherty,Johannes Sch?del,David Mole,Konstantinos Giaslakiotis,Christopher J. Schofield,Ester M. Hammond,Peter J. Ratcliffe,Patrick J. Pollard
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016210
Abstract: Human 2-oxoglutarate oxygenases catalyse a range of biological oxidations including the demethylation of histone and nucleic acid substrates and the hydroxylation of proteins and small molecules. Some of these processes are centrally involved in regulation of cellular responses to hypoxia. The ALKBH proteins are a sub-family of 2OG oxygenases that are defined by homology to the Escherichia coli DNA-methylation repair enzyme AlkB. Here we report evidence that ALKBH5 is probably unique amongst the ALKBH genes in being a direct transcriptional target of hypoxia inducible factor-1 (HIF-1) and is induced by hypoxia in a range of cell types. We show that purified recombinant ALKBH5 is a bona fide 2OG oxygenase that catalyses the decarboxylation of 2OG but appears to have different prime substrate requirements from those so far defined for other ALKBH family members. Our findings define a new class of HIF-transcriptional target gene and suggest that ALKBH5 may have a role in the regulation of cellular responses to hypoxia.
Information Systems Development Methodolgies in Developing Higher Education  [PDF]
Adam Marks
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.31019
Abstract: Studies concerned with the status of Information Systems Development Methodologies usage in many developing countries including the factors that influence and motivate their use, current trends, difficulties, and barriers to adoption are lacking, especially within the higher education sector. This paper examines these identified gaps in a developing country, namely the United Arab Emirates. The initial findings reveal that there is limited knowledge and understanding of the concept of ISDM in federal higher education institutions in the UAE. This is reflected in the quality of the software products being developed and released. However, the analysed data also reveals a trend whereby federal higher education institutions in the UAE are gradually moving towards increased ISDM adoption and deployment.
Introducing Liability Dollarization and Contractionary Depreciations to the IS Curve  [PDF]
Adam Honig
Modern Economy (ME) , 2012, DOI: 10.4236/me.2012.34061
Abstract: This paper presents a simple modification to the standard IS curve used, at least implicitly, by policymakers that allows capital flight to have a contractionary effect in emerging market economies. In the standard model, capital flight leads to an expansionary shift in the IS curve through an increase in net exports. However, in the presence of liability dollarization for domestic firms, a currency depreciation triggered by capital flight leads to an investment collapse. A simple adjustment to the standard investment schedule captures this channel and allows for the possibility that capital flight yields a contractionary shift in the IS curve.
Which Working Memory Components Predict Fluid Intelligence: The Roles of Attention Control and Active Buffer Capacity  [PDF]
Adam Chuderski
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.55043

This study tested which of two crucial mechanisms of working memory (WM): attention control, consisting of focusing attention on the proper task-set as well as blocking distraction, and the active buffer capacity, related to the number of chunks that can be actively maintained, plays a more important role in WM’s contribution to fluid intelligence. In the first study, the antisaccade task was used, the standard measure of attention control, in a modified variant which resulted in scores less sensitive to individual differences in the active buffer capacity, in comparison to the standard variant. In effect, attention control became a weak predictor of Gf, explaining less than one third of its variance accounted for by the capacity. In the second study, a variant of another attention control test, the Stroop task, was applied, which minimized the load on capacity, and no significant contribution of this task to Gf was found. Thus, when contribution of control and capacity were unconfounded, attention control mechanisms of WM contributed to fluid intelligence to a lesser extent than did the mechanisms related to the active buffer of WM.

ThermoSpots to Detect Hypothermia in Children with Severe Acute Malnutrition
Thomas B. Mole, Neil Kennedy, Noel Ndoya, Alan Emond
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045823
Abstract: Introduction Hypothermia is a risk factor for increased mortality in children with severe acute malnutrition (SAM). Yet frequent temperature measurement remains unfeasible in under-resourced units in developing countries. ThermoSpot is a continuous temperature monitoring sticker designed originally for neonates. When applied to skin, its liquid crystals are designed to turn black with hypothermia and remain green with normothermia. Aims To (i) estimate the diagnostic accuracy of ThermoSpots for detecting WHO-defined hypothermia (core temperature <35.5°C or peripheral temperature <35.0°C) in children with SAM and (ii) determine their acceptability amongst mothers. Methods Children with SAM in a malnutrition unit in Malawi were enrolled during March-July 2010. The sensitivity and specificity of ThermoSpots were calculated by comparing the device colour against ‘gold standard’ rectal temperatures taken on admission and follow up peripheral temperatures taken until discharge. Guardians completed a questionnaire to assess acceptability. Results Hypothermia was uncommon amongst the 162 children enrolled. ThermoSpot successfully detected the one rectal temperature and two peripheral temperatures recorded that met the WHO definition of hypothermia. Overall, 3/846 (0.35%) temperature measurements were in the WHO-defined hypothermia range. Interpreting the brown transition colour (between black and green) as hypothermia improved sensitivities. For milder hypothermia definitions, sensitivities declined (<35.4°C, 50.0%; <35.9°C, 39.2%). Specificity was consistently above 94%. From questionnaires, 40/43 (93%) mothers reported they were 90–100% happy with the device overall. Free-text answers revealed themes of “Skin Rashes”, “User-satisfaction” and “Empowerment". Conclusion Although hypothermia was uncommon in this study, ThermoSpots successfully detected these episodes in malnourished children and were acceptable to mothers. Research in settings where hypothermia is common is needed to determine performance with certainty. Instructing users to act when the device’s transition colour appears could improve accuracy. If reliable, ThermoSpots may offer simple, acceptable and continuous temperature measurement for high-burden areas and reduce the workload of over-stretched staff.
The use of a novel phage-based technology as a practical tool for the diagnosis of tuberculosis in Africa
Tracy Seaman, Andre Trollip, Richard Mole, Heidi Albert
African Journal of Biotechnology , 2003,
Abstract: Sub-Saharan Africa has experienced a significant increase in tuberculosis cases in recent years, fuelled by high rates of TB-HIV co-infection in the region. The diagnosis of tuberculosis is based largely on clinical assessment, sputum smear microscopy and chest radiography. Although smear microscopy is useful for detecting the most infectious cases, a significant portion of cases are negative on sputum smears, making diagnosis more difficult. New tests are urgently needed. The FASTPlaqueTB test, a bacteriophage-based method, has been evaluated in several studies in Africa and elsewhere. Studies in South Africa and Pakistan reported that between half and two-thirds of smear-negative culture-positive TB cases were detected by the FASTPlaqueTB test within 2 days. This suggests a beneficial role for this test in the early diagnosis of clinically suspected smear-negative cases. The same technology has been applied to develop a rapid test to indicate multi-drug resistant TB, FASTPlaqueTB-MDRi. This test gave equivalent results to conventional drug susceptibility methods, but with more rapid results. The tests are simple to perform and require no specialised equipment, making the technology suitable for widespread implementation. (African Journal of Biotechnology: 2003 2(2): 40-46)
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