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Search Results: 1 - 10 of 219354 matches for " Adaeze C. Orioha "
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Biorthogonality in $\mathcal A$-Pairings and Hyperbolic Decomposition Theorem for $\mathcal A$-Modules
Patrice P. Ntumba,Adaeze C. Orioha
Mathematics , 2009,
Abstract: In this paper, as part of a project initiated by A. Mallios consisting of exploring new horizons for \textit{Abstract Differential Geometry} ($\grave{a}$ la Mallios), \cite{mallios1997, mallios, malliosvolume2, modern}, such as those related to the \textit{classical symplectic geometry}, we show that results pertaining to biorthogonality in pairings of vector spaces do hold for biorthogonality in pairings of $\mathcal A$-modules. However, for the \textit{dimension formula} the algebra sheaf $\mathcal A$ is assumed to be a PID. The dimension formula relates the rank of an $\mathcal A$-morphism and the dimension of the kernel (sheaf) of the same $\mathcal A$-morphism with the dimension of the source free $\mathcal A$-module of the $\mathcal A$-morphism concerned. Also, in order to obtain an analog of the Witt's hyperbolic decomposition theorem, $\mathcal A$ is assumed to be a PID while topological spaces on which $\mathcal A$-modules are defined are assumed \textit{connected}.
Investigation of Relationship between Sociodemographic Factors and HIV Counseling and Testing (HCT) among Young People in Nigeria  [PDF]
Adaeze Oguegbu
Advances in Infectious Diseases (AID) , 2016, DOI: 10.4236/aid.2016.61004
Abstract: The main purpose of this study was to examine the association between sociodemographic factors (gender, place of residence, level of education, geopolitical zone, and socioeconomic status) and HCT uptake among young people in Nigeria. The study is a quantitative research guided by one research question and one hypothesis. The target population comprised young people in Nigeria ages 15 to 24 years because the focus of this study was to identify the factors affecting HCT uptake among young people in this age cohort. The representative sample was obtained from the updated master sample frame of rural and urban zones developed by the National Population Commission in Nigeria. This master sample frame was a national survey that comprises all 36 states in Nigeria. Probability sampling technique was used to obtain a sample of 10,091 respondents (ages 15 to 24 years) for the study. The multistage cluster sampling was used to select suitable young people with known probability. Data were collected throughout Nigeria between September and December 2012 from 32,543 households (rural = 22,192; urban = 10,351) using structured and semi-structured questionnaires. The individual questionnaires asked about household characteristics, background characteristics of the respondents. Data were analyzed by inputting them into SPSS v21.0 for analysis and then coded them for each participant. The data were summed using descriptive statistics. Frequencies and percentages; measures of central tendencies were used to answer the research question while nonparametric test such as chi-square was used to analyze non-normally distributed data at 0.5 level of significance. Results of data analysis indicated that the sociodemographic variables of gender, place of residence, level of education, geopolitical zone, and SES were significantly associated with HCT uptake. Among others, it was recommended that examining the efficacy of HCT treatments in Nigeria, along with conducting a demographic analysis of the at-risk population, could be beneficial in informing the authorities who are responsible for allocating finite medical resources.
Relationship between Sexual Risk Behaviors and HIV Counseling and Testing (HCT) Uptake among Young People in Nigeria  [PDF]
Adaeze Oguegbu, Frazier Beatty
Health (Health) , 2016, DOI: 10.4236/health.2016.85049
Abstract: This study examined the relationship between sexual risk behavior and HIV counselling and testing uptake among young people in Nigeria. Probability sampling technique was used to obtain a sample of 10,091 respondents (ages 15 to 24 years) for the study. The multistage cluster sampling was used to select suitable young people with known probability. Data were collected throughout Nigeria between September and December 2012 from 32,543 households (rural = 22,192; urban = 10,351) using structured and semi-structured questionnaires. The data were summed using descriptive statistics. Frequencies and percentages; measures of central tendencies were used to answer the research question while nonparametric test such as chi-square was used to analyze non-normally distributed data at 0.5 level of significance. Results of data analysis indicated that sexual risk behaviors comprised three variables: sex with multiple partners, intergenerational sex (sex with partners 10 years older), and transactional sex. The results of the chi-square test of association between sex with multiple partners and HCT uptake showed that there was no statistically significant relationship between sex with multiple partners and HCT uptake among young people ages 15 to 24 years in Nigeria. It was among others recommended that sexually active young people in Nigeria should use protection against HIV infection.
Relationship between HIV Counseling and Testing (HCT) Awareness and HCT Uptake among Young People in Nigeria: Implications for Social Change  [PDF]
Adaeze Oguegbu, Frazier Beatty
World Journal of AIDS (WJA) , 2016, DOI: 10.4236/wja.2016.64016
Abstract: This study examined the relationship between HIV counselling and testing (HCT) awareness and HCT uptake among young people in Nigeria and their implications for social change. The study is a quantitative research guided by one research question and one hypothesis. The target population comprised young people in Nigeria ages 15 to 24 years because the focus of this study was to identify the factors affecting HCT uptake among young people in this age cohort. The representative sample was obtained from the updated master sample frame of rural and urban zones developed by the National Population Commission in Nigeria. This master sample frame was a national survey that comprised all 36 states in Nigeria. Probability sampling technique was used to obtain a sample of 10,091 respondents (ages 15 to 24 years) for the study. The multistage cluster sampling was used to select suitable young people with known probability. Data were collected throughout Nigeria between September and December 2012 from 32,543 households (rural = 22,192; urban = 10,351) using structured and semi-structured questionnaires. The individual questionnaires asked about household characteristics, background characteristics of the respondents. Data were analyzed by inputting them into SPSS v21.0 for analysis and then coded them for each participant. The data were summed using descriptive statistics. Frequencies and percentages; measures of central tendencies were used to answer the research question while nonparametric tests such as chi-square were used to analyze non-normally distributed data at 0.5 level of significance. The results of the chi-square test of association between HCT awareness and HCT uptake showed that there was a statistically significant relationship between HCT awareness and HCT uptake among young people ages 15 to 24 years in Nigeria, X2 (1, n = 8916) = 306.66, p < 0.001. In other words, knowledge of the availability of HCT services may have influenced the possibility that the participants would use them. Among others, it was recommended that government should examine the efficacy of HCT treatments in Nigeria, along with conducting a demographic analysis of the at-risk population.
Abstract Geometric Algebra. Orthogonal and Symplectic Geometries
PP Ntumba,Ac Orioha
Mathematics , 2008,
Abstract: Our main interest in this paper is chiefly concerned with the conditions characterizing \textit{orthogonal and symplectic abstract differential geometries}. A detailed account about the sheaf-theoretic version of the \textit{symplectic Gram-Schmidt theorem} and of the \textit{Witt's theorem} is also given.
Spectrophotometric Data in Human Immunodeficiency Virus (HIV)-Antiretroviral Drug Coated Blood Interactions  [PDF]
Okwuchukwu Ani, Adaeze Ani, Jeremiah Chukwuneke
Journal of Biosciences and Medicines (JBM) , 2015, DOI: 10.4236/jbm.2015.38005
Abstract: The spectrophotometric data in the interactions between the Human immunodeficiency virus (HIV) and blood cells treated with antiretroviral drug were collected to be used to show the effects of antiretroviral drugs on the absorbance characteristics of HIV infected and uninfected blood. The methodology involved the serial dilution of the five different antiretroviral drugs (two HAART/FDC and three single drugs) and the subsequent incubation with the blood samples collected from ten HIV infected persons who had not yet commenced treatment with the antiretroviral drugs, ten HIV infected persons who had already commenced treatment with the antiretroviral drugs, and ten HIV negative persons, for the absorbance measurements using a digital Ultraviolet Visible MetaSpecAE1405031Pro Spectrophotometer. The peak absorbance data for various interacting systems were measured. These were used to show that the antiretroviral drug had the effect of increasing the peak absorbance values of both the uninfected and infected blood components, i.e., the drugs were made able to increase the light absorption capacity of the blood cells. The use of the findings of this work in drug design may be expected to yield good results.
Mother-to-child transmission of HIV: the pre-rapid advice experience of the university of Nigeria teaching hospital Ituku/Ozalla, Enugu, South-east Nigeria
Ngozi S Ibeziako, Agozie C Ubesie, Ifeoma J Emodi, Adaeze C Ayuk, Kene K Iloh, Anthony N Ikefuna
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-305
Abstract: A retrospective study, involving HIV exposed infants seen at the pediatric HIV clinic of UNTH between March 2006 and September 2008. Relevant data were retrieved from their medical records. The overall rate of mother to child transmission of HIV in this study was 3.9% (95% CI 1.1%- 6.7%). However, in children breastfed for 3?months or less, the rate of transmission was 10% (95% CI ?2.5%-22.5%), compared to 3.5% (95% CI 0.5%-6.5%) in children that had exclusive replacement feeding.This retrospective observational study shows a 3.9% cumulative rate of mother-to-child transmission of HIV by 18?months of age in Enugu. Holistic but cost effective preventive interventions help in reducing the rate of mother-to-child transmission of HIV even in economically-developing settings like Nigeria.The first documented case of Acquired Immune Deficiency Syndrome (AIDS) in Nigeria was in 1986 in a 13?year old child in Calabar, Cross River State [1]. Since then, children have continued to remain vulnerable to this epidemic in Nigeria. Children can be infected with the virus through mother-to-child transmission (MTCT), blood transfusion, unprotected sex and through the use of non-sterile sharp objects [1,2]. MTCT is the most common route and is responsible for as much as 70 to 95% [3-6] of the infection in the pediatric age group. The next most common route of HIV transmission in children living in economically-developing countries is blood transfusion.[7,8]. This route accounts for about 5 to 20% of pediatric AIDS [3,4].MTCT can occur in utero, during labor and delivery, and postnatally through breastfeeding. A number of risk factors for MTCT of HIV have been documented. The risk factors associated with transmission during labor are prolonged rupture of uterine membrane for more than 4 hours, prolonged labor, mixing of maternal and fetal blood which happens more with tears and episiotomies [5,9]. The risk factors associated with transmission post-natally are breastfeeding and mixed f
Assessment of Immunization Status, Coverage and Determinants among under 5-Year-Old Children in Owerri, Imo State, Nigeria  [PDF]
Chukwuma B. Duru, Anthony C. Iwu, Kenechi A. Uwakwe, Kevin C. Diwe, Irene A. Merenu, Chima A. Emerole, Chioma A. Adaeze, Chinwe U. Onyekuru, Obinna Ihunnia
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102753
Abstract:
Background: Immunization coverage in different parts of the country varies widely despite efforts to improve the services. The immunization status of children is dependent on the dynamics of vaccination uptake which is complex and involves the interplay of different associated factors. Aim: To determine the immunization coverage, status and the determinants in under 5-year-old children in Owerri municipal, Imo State. Methods: The study was a community based cross-sectional study involving 420 women and 743 under 5-year-old children. A multistage sampling technique was employed and data were collected using a pretested, semi structured interviewer administered questionnaire. Data were analysed using a computer software SPSS-IBM version 20. Results: It revealed that 63.6% and 88.9% of children less than 12 months and between 12 - 59 months respectively according to households were fully immunized. The bivariate analysis showed statistically significant associations between the immunization status of the children and place of birth delivery (p < 0.0001), maternal age (p < 0.0001), level of maternal education (p < 0.01), level of maternal knowledge (p < 0.0001), religion (p < 0.05) and ethnicity (p < 0.01). Significant predictors of being fully immunized were; maternal age 25 - 29 years old (OR = 2.1), children aged 12 - 59 months (OR = 4.6), mother having tertiary education (OR = 5.4), being a Christian Catholic (OR = 12.5), hospital births (OR = 25.2) and good level of maternal knowledge (OR = 37.7). Conclusion: Immunization coverage is relatively high but not optimal among the studied population and thus there is a need to develop strategies aimed at achieving full immunization coverage as this is critical in the reduction of childhood morbidity and mortality.
Level of Adherence to Cytotoxic Drugs by Breast Cancer Patients’ in Lagos State University Teaching Hospital  [PDF]
Popoola Abiodun, Samira Makanjuola, Sowunmi Anthonia, Igwilo Adaeze, Mobolaji Oludara, Ibrahim Nasir, Omodele Foluso
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.64041
Abstract:

Background: Breast cancer is one of the most common malignant diseases in women and adjuvant combination chemotherapy has been shown to reduce mortality from this disease. Adherence to medical treatment is a multifaceted issue that can substantially alter the outcomes of therapy. Patient non-adherence to chemotherapy is the ultimate barrier to the treatment effectiveness. Objective: This study was carried out to determine the relationship between cancer chemotherapy adherence and breast cancer staging, patient’s perception of cancer care and patient’s socio-demographic characteristics. Material and method: This was a cross sectional study selection of respondents and was based on simple random sampling technique, 184 patients were interviewed and data was collected using a semi-structured questionnaire to obtain socio-demographic data, adherence data, and facility-related information. Results: There was a significant association between marital status and non-adherence (P= 0.013). Both separated and single subjects had higher proportion of non-adherence compared with married subjects. Analysis of perception of chemotherapy care revealed a significant association between the satisfaction score and non-adherence, with non-adherent patients showing higher scores or being less satisfied. The quality of service (P= 0.0052); rating of needs been met (P= 0.0079); rating on whether the services helped the subject (P= 0.0405); rating on the general satisfaction of the services provided (P= 0.0115); and rating on whether subject would seek help again (P= 0.0320) all had a significant association with non-adherence. Conclusion: The awareness of oncologist and patient of the problem of non-adherence and communication regarding the importance of adherence to therapy may improve health outcomes.

Thrombospondin-1 Interacts with Trypanosoma cruzi Surface Calreticulin to Enhance Cellular Infection
Candice A. Johnson, Yulia Y. Kleshchenko, Adaeze O. Ikejiani, Aniekanabasi N. Udoko, Tatiana C. Cardenas, Siddharth Pratap, Mark A. Duquette, Maria F. Lima, Jack Lawler, Fernando Villalta, Pius N. Nde
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0040614
Abstract: Trypanosoma cruzi causes Chagas disease, which is a neglected tropical disease that produces severe pathology and mortality. The mechanisms by which the parasite invades cells are not well elucidated. We recently reported that T. cruzi up-regulates the expression of thrombospondin-1 (TSP-1) to enhance the process of cellular invasion. Here we characterize a novel TSP-1 interaction with T. cruzi that enhances cellular infection. We show that labeled TSP-1 interacts specifically with the surface of T. cruzi trypomastigotes. We used TSP-1 to pull down interacting parasite surface proteins that were identified by mass spectrometry. We also show that full length TSP-1 and the N-terminal domain of TSP-1 (NTSP) interact with T. cruzi surface calreticulin (TcCRT) and other surface proteins. Pre-exposure of recombinant NTSP or TSP-1 to T. cruzi significantly enhances cellular infection of wild type mouse embryo fibroblasts (MEF) compared to the C-terminal domain of TSP-1, E3T3C1. In addition, blocking TcCRT with antibodies significantly inhibits the enhancement of cellular infection mediated by the TcCRT-TSP-1 interaction. Taken together, our findings indicate that TSP-1 interacts with TcCRT on the surface of T. cruzi through the NTSP domain and that this interaction enhances cellular infection. Thus surface TcCRT is a virulent factor that enhances the pathogenesis of T. cruzi infection through TSP-1, which is up-regulated by the parasite.
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