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Search Results: 1 - 10 of 1883 matches for " Abeer Mostafa "
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Role of ghrelin in exhaustive exercise- induced oxidative stress in rat Brain and liver
Shereen Samir,Abeer Mostafa
International Journal of Applied Exercise Physiology , 2013,
Abstract: Strenuous exercise increases oxygen consumption and causes disturbance of intracellular pro-oxidant–antioxidant homeostasis. Ghrelin has been reported to possess free radical scavenging and antioxidant effect. in this study we aim to evaluate the beneficial effect of ghrelin on the oxidative stress and antioxidant enzyme systems in brain cortex and liver of rats after exhaustive swimming exercise. Sprague- Dawley rats (50) were subdivided into 3 main groups: control, exercise, exercise and ghrelin (50,100,200 ng) group. Animals in the two exercise groups swam for 5 days/week for 4 weeks. stress induced a decrease in the level of GSH and the activities of SOD, GST and catalase, while the levels of TBARS were found elevated. Ghrelin groups’ animals, especially G3 subgroup, have higher SOD, CAT, GSH and GST activity which reflect higher antioxidant enzyme activity and can be attributed to lower rates of oxidative stress which can be proved by reduced level of TBARS. The results of the study provides evidence that ghrelin pretreatment even in low dose reduces the level of lipid peroxidation and enhances the antioxidant defense against exercise-induced stress oxidative injury in rats’ vital organs like brain and liver.
Hypocalcemic Seizures in Breastfed Infants with Rickets Secondary to Severe Maternal Vitamin D Deficiency
Mostafa M. Salama,Abeer S. El-Sakka
Pakistan Journal of Biological Sciences , 2010,
Abstract: This study was done to evaluate if nursing mothers of infants with rickets have vitamin D deficiency, and to evaluate the relationship between maternal vitamin D levels with hypocalcemic seizures in infants with rickets. We selected a cohort of breastfed infants with rickets. Infants were included in this study if they were breastfed and presented with any of the following clinical criteria: delayed motor milestones or delayed teething, were found to have specific rachitic bony signs, or presented with hypocalcemic seizures. We checked serum calcium (Ca), phosphorus (P), alkaline phosphatase, 25 hydroxy vitamin D [25(OH)D] and parathyroid hormone (PTH) levels in both infants and their mothers. Out of 32 children who met the clinical criteria for rickets, 23 (72%) had vitamin D level less than 20 ng mL-1. Twenty two mothers (69%) had vitamin D deficiency (25 hydroxy vitamin D <20 ng mL-1). Mothers of nine infants who presented with hypocalcemic seizures had severe vitamin D deficiency, (p = 0.005). We conclude that maternal vitamin D deficiency is common in nursing mothers of infants diagnosed with rickets. Invariably mothers of infants presenting with hypocalcemic seizures have severe vitamin D deficiency. Hypocalcemic seizures in infants secondary to maternal vitamin D deficiency might be prevented by supplementation of vitamin D.
The effectiveness of evening primrose oil and alpha lipoic acid in recovery of nerve function in diabetic rats
Alaa Eldeen Ahmed El-kossi,Mostafa Mahmoud Abdellah,Abeer Mohamed Rashad,Sherifa Ahmad Hamed
Journal of Clinical and Experimental Investigations , 2011,
Abstract: Objectives: Diabetic polyneuropathy is a serious complication of diabetes mellitus and the most frequent neuropathy worldwide. Evening primrose oil (EPO) is rich in omega-6 essential fatty acid component and gamma-linolenic acid. Alpha lipoic acid (ALPA) has a protective effect against lipid peroxidation and helps in scavenging free radicals. Data regarding the effect of treatment with EPO on diabetic parameters and neuropathic manifestations are conflicting. This study aimed to determine the therapeutic efficacy of EPO and ALPA in correcting diabetic parameters and functional and structural neuropathic manifestations in streptozotocin (STZ) induced diabetic rats.Materials and methods: In this study, the effects of two week oral treatment with EPO (1.25 g/kg) was compared to that of ALPA (100 mg/kg) and insulin (2 IU/day), utilized singly or in combination.Results: Compared with untreated diabetic rats, EPO and ALPA resulted in reduction of serum levels of glucose (p<0.05), total cholesterol (p<0.01), triglycerides (p<0.01), low density lipoprotein cholesterol (p<0.01), thiobarbituric acid reactive substance (a marker of oxidative stress) (p<0.05), and increased in levels of high density lipoprotein cholesterol (p<0.05) and total antioxidant capacity (p<0.05). Enhanced positive effect was observed with combination therapy.Conclusion: This work indicates that EPO and ALPA, particularly when used in combination, improve glycemic control, lipid abnormalities and antioxidant capacity, thus restore the impaired functional properties of peripheral nerves to a great extent. J Clin Exp Invest 2011; 2 (3): 245-253.
Grape Seed Extract (Vitisvinifera) Alleviate Neurotoxicity and Hepatotoxicity Induced by Lead Acetate in Male Albino Rats  [PDF]
Abeer M. Waggas
Journal of Behavioral and Brain Science (JBBS) , 2012, DOI: 10.4236/jbbs.2012.22021
Abstract: Grape seed extracts (GSE) are very potent antioxidant and exhibit numerous interesting pharmacologic activities, including an antioxidant property, and has been suggested to be of use in treatment of several diseases. The present study has been undertaken to investigate the protective and therapeutic effect of GSE against lead-induced neuro and hepatotoxicity in rat. Male albino rats were divided into six groups: the 1st group, rats were injected daily with saline vehicle and served as negative control, the 2nd group (positive control group), the rats were injected (i.p.) with subacute dose (100 mg/kg b·w/day) of lead acetate (LA). The 3rd group (protective group), the rats were injected (i.p.) with LA (100 mg/kg b·w/day) for 7 days after treatment with GSE (100 mg/kg b·w/day) for 3 weeks. The 4th, 5th and 6th groups (therapeutics groups), rats were injected (i.p.) with subacut dose (100 mg/kg b·w/day) of lead acetate for 7 days, then treated with GSE (100 mg/kg b·w/day) for one, two and three weeks, respectively. The level of norepinephrine (NE), dopamine (DA), serotonin (5-HT) and 5-hydroxyindol acetic acid (5-HIAA) were evaluated in brain regions (cerebellum, brainstem, striatum, cerebral cortex, hypothalamus and hippocampus). The result indicated that the administration of subacute dose of LA (100 mg/kg/day, i.p.) induce a significant decrease in NE, DA, 5-HT and 5-HIAA content in all tested brain regions. Also the obtained data showed significant increase in liver enzymes: serum glutamate oxaloacetate transaminase (GOT), serum glutamate pyruvate transaminase (GPT) and Lactate dehydrogenase (LDH) level in group 2 (positive control). There is an improvement in neurotransmitters content. Also the obtained data showed significant in- crease in liver enzymes of protective (G3) and therapeutics groups (G4, G5 and G6) which received GSE compared with animal group that received lead acetate (G2). This is may be the presence of proanthocyanidins and procyanidins which have antioxidant and free radical scavenging activities. The result suggests that grape seed extract may prevent lead-induced neurotoxicity and hepatotoxicity.
Applying the WHO instead of CDC growth charts may double obesity rates  [PDF]
Abeer Yasin, Guido Filler
Open Journal of Pediatrics (OJPed) , 2013, DOI: 10.4236/ojped.2013.32025
Abstract:

Aims: This study compares the WHO (2007) and the National Health Examination Survey (NHANES III) reference intervals and investigates the differences when applied on a Canadian cohort of older children and adolescents. Methods: We calculated height, weight and BMI z-scores of 4375 consecutive patients (1993 female, 45.6%) aged 5 - 20 years attending outpatient clinics at a single tertiary care centre using reference data of the latest NHANES (III) survey and the WHO (2007) growth charts. To address age dependency, data was stratified into age groups. Results: Using the NHANES III reference intervals, medians of weight (+0.46), height (+0.29) and BMI z-scores (+0.46) were significantly non-zero. The WHO (2007) growth charts yielded medians of +2.05, +0.32, +0.53 for weight, height and BMI z-scores respectively, all significantly non-zero. When comparing both growth charts, Canadian children had significantly different weight and BMI z-scores (p < 0.0001) with WHO growth charts whereas height z-score did not differ. Obesity rates (BMI z-score > 95th percentile) doubled from 8.6% to 16.0%. A significant age dependency was observed with higher WHO (2007) weight z-scores (>7 years) and higher BMI z-scores (7 to 13 years) and no significant difference was observed for height z-scores across all age groups. Gender differences were observed for weight z-scores (>9 years) and BMI (males: 9 - 11 years, p = 0.0118; 11 - 13 years, p = 0.0069) whereas no significant difference was found in height z-scores across all age groups. Conclusion: Our results reveal substantial differences between both reference populations and thus interpretation needs be done with caution, especially when labelling results as abnormal.

Use of an Energy-Like Integral to Study the Motion of an Axi-Symmetric Satellite under Drag and Radiation Pressure  [PDF]
Ahmed Mostafa
International Journal of Astronomy and Astrophysics (IJAA) , 2015, DOI: 10.4236/ijaa.2015.53019
Abstract: The axi-symmetric satellite problem including radiation pressure and drag is treated. The equations of motion of the satellite are derived. An energy-like is given for a general drag force function of the polar angle θ, and then it is used to find a relation for the orbit equation of the satellite with initial conditions satisfying the vanishing of arbitrarily choosing higher derivatives of the velocity.
The Predictive Value of Biopsy of the Pancreas and Its Therapeutic Impact in Autoimmune Diabetes  [PDF]
Wael Nassar, Mostafa A. Mostafa
Journal of Diabetes Mellitus (JDM) , 2014, DOI: 10.4236/jdm.2014.44041
Abstract: Diabetes Mellitus is by definition an end-stage organ failure. Type 1 diabetes mellitus (T1DM) is an autoimmune disease. Auto-inflammatory infiltrate appears to characterize the insulitis associated with T2DM. Recently, in 2013, Eva Corpos and colleagues described a comprehensive composition of peri-islet capsules and their basement membrane (BM). Virtanen I, Otonkoski T and Irving-Rodgers H.F. have reported similar descriptions few years earlier which have not been taken seriously as they deserve. Bluestone JA, Virtanen I and Irving-Rodgers H.F. and other colleagues reported that accumulation of the lymphocytes around the islets without invasion of the BM is the first step in disease induction (non-destructive insulitis phase). Invasion of the BM byleucocytic infiltration (destructive insulitis phase) occurs over a period of several years offering a good window for therapeutic intervention. Clinical symptoms appear only when 70% - 90% of β-cell mass are destroyed. This data emphasize the importance of identification and classification of such pathologic features by performing a biopsy of the pancreas with histoimmunochemistry analysis at the pre-hyperglycemic stage in a high risk genetically predisposed autoimmune suspected patient which may at least in part help to achieve new therapeutic approaches and help in halting the progression to end stage pancreatic disease (ESPD) known as diabetes mellitus. In this review we are going to emphasize the predictive role biopsy of the pancreas can build up a solid gold standard tool in diagnosis, stage and therapeutically follow up autoimmune diabetes mellitus.
Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients
Abeer A Bahnassy, Abdel-Rahman N Zekri, Soumaya El-Houssini, Amal MR El-Shehaby, Moustafa Mahmoud, Samira Abdallah, Mostafa El-Serafi
BMC Gastroenterology , 2004, DOI: 10.1186/1471-230x-4-22
Abstract: The expression of cyclin D1, cyclin A, histone H3 and Ki-67 was examined in 60 colorectal cancer cases for co-regulation and impact on overall survival using immunohistochemistry, southern blot and in situ hybridization techniques. Immunoreactivity was evaluated semi quantitatively by determining the staining index of the studied proteins.There was a significant correlation between cyclin D1 gene amplification and protein overexpression (concordance = 63.6%) and between Ki-67 and the other studied proteins. The staining index for Ki-67, cyclin A and D1 was higher in large, poorly differentiated tumors. The staining index of cyclin D1 was significantly higher in cases with deeply invasive tumors and nodal metastasis. Overexpression of cyclin A and D1 and amplification of cyclin D1 were associated with reduced overall survival. Multivariate analysis shows that cyclin D1 and A are two independent prognostic factors in colorectal cancer patients.Loss of cell cycle checkpoints control is common in colorectal cancer. Cyclin A and D1 are superior independent indicators of poor prognosis in colorectal cancer patients. Therefore, they may help in predicting the clinical outcome of those patients on an individual basis and could be considered important therapeutic targets.Colorectal cancer (CRC) is the third most common cancer in Western countries [1]. In Egypt, CRC has unique characteristics that differ from that reported in other countries of the western society. It was estimated that 35.6% of the Egyptian CRC cases are below 40 years of age and patients usually present with advanced stage, high grade tumors that carry more mutations [2]. This uniquely high proportion of early-onset CRC, the early and continuous exposure to hazardous environmental agents, the different mutational spectrum and the prevalent consanguinity in Egypt justify further studies [3]. It was proved that most cancers result from accumulation of genetic alterations involving certain groups of genes, the
Genetic distance and heterogenecity between quasispecies is a critical predictor to IFN response in Egyptian patients with HCV genotype-4
Abdel Zekri, Hanaa El-Din, Abeer A Bahnassy, Mohsen M Khaled, Ashraf Omar, Inas Fouad, Mahmoud El-Hefnewi, Fouad Thakeb, Mostafa El-Awady
Virology Journal , 2007, DOI: 10.1186/1743-422x-4-16
Abstract: HCV genotype 4 quasispecies diversity within the 5' untranslated region (5'UTR) was studied in a series of 22 native Egyptian patients with chronic hepatitis C virus with no previous treatment who satisfied all NIH criteria for combined treatment of pegylated IFN and ribavirine and was correlated with the outcome of treatment. The study also included 7 control patients with no antiviral treatment. HCV sequencing was done using the TRUGENE HCV 5-NC genotyping kit.At the 48th week of treatment, 15 patients (68%) showed virological response. Whereas HCV-RNA was still detected in 7 patients (32%) in this period; of those, 6 experienced a partial virological response followed by viral breakthrough during treatment. Only one patient did not show any virological or chemical response. The four females included in this study were all responders. There was a significant correlation between the response rate and lower fibrosis (p = 0.026) as well as the total number of mutation spots (including all the insertions, deletions, transitions and transversions) (p = 0.007, p = 0.035).Patients who responded to interferon treatment had statistically significant less number in both transitions (p = 0.007) and the genetic distances between the quasispecies (p = 0.035). So, viral genetic complexity and variability may play a role in the response to IFN treatment. The consensus alignment of all three groups revealed no characteristic pattern among the three groups. However, the G to A transitions at 160 was observed among non responders who need further study to confirm this observation.Infection with hepatitis C virus (HCV) is a leading cause of chronic liver disease worldwide [1]. Despite recent success after the introduction of combination therapy with IFN-α and Ribavirin, about 60% of patients with HCV genotype 4 fail to respond [2,3]. Resistance to antiviral therapy remains a serious problem in the management of chronic hepatitis C.The basis of treatment of chronic hepatitis C is int
Heme Oxygenase-1 mRNA Expression in Egyptian Patients With Chronic Liver Disease
Sahar Saad El-Din Bessa,Ehab Mostafa Mohamed Ali,Abeer El-Sayed Abd El-Wahab,Sherif Abd El-Monem Nor El-Din
Hepatitis Monthly , 2012,
Abstract: Background: Chronic liver disease (CLD) is a global medical problem. This disease is associated with increased hepatic oxidative stress. One of the antioxidant enzymes that protect cells against this stress is heme oxygenase-1 (HO-1).Objectives: This study aimed to investigate the mRNA expression of HO-1 in Egyptian patients with CLD and its relation to oxidative stress biomarkers.Patients and Methods: Levels of serum ferritin, carboxyhemoglobin, malondialdehyde (MDA), and erythrocyte-reduced glutathione (GSH) were measured, and HO-1 mRNA expression was detected in 45 CLD patients (15 with nonalcoholic steatohepatitis [NASH], 15 with chronic hepatitis C, and 15 with liver cirrhosis) and 15 healthy controls.Results: HO-1 mRNA expression was increased in patients with NASH, chronic hepatitis C, and liver cirrhosis compared to controls. The expression in cirrhotic patients was significantly higher than that in patients with NASH and chronic hepatitis C. Compared to controls, patients with NASH, chronic hepatitis C, and liver cirrhosis had higher levels of ferritin, carboxyhemoglobin, and MDA and lower levels of GSH. HO-1 mRNA expression was positively correlated with levels of carboxyhemoglobin, serum ferritin, and serum MDA and negatively correlated with levels of erythrocyte GSH in CLD patients.Conclusions: HO-1 mRNA expression was significantly increased in CLD patients, and the increase reflected the severity of the disease. The significant relationship between the increased HO-1 expression and oxidative stress biomarkers in patients with CLD suggests that HO-1 may play an important role in protecting the liver from oxidative stress-dependent damage. Therefore, induction of HO-1 could be a novel therapeutic option for CLD.
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