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Search Results: 1 - 10 of 4771 matches for " Abdul-Ghani Kibbi "
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HLA Allele Associations and V-Beta T-Lymphocyte Expansions in Patients With Psoriasis, Harboring Toxin-Producing Staphylococcus aureus
Rola Ajib,Lori Janbazian,Elias Rahal,Ghassan M. Matar,Shukrallah Zaynoun,Abdul-Ghani Kibbi,Alexander M. Abdelnoor
Journal of Biomedicine and Biotechnology , 2005, DOI: 10.1155/jbb.2005.310
Abstract: HLA alleles have been associated with psoriasis. Toxin-producing strains of Staphylococcus aureus behave as superantigens, and if present in patients, might play a role in the exacerbation of psoriatic lesions by activating certain V-beta (Vβ) T-lymphocyte subsets. Allele frequencies in 22 patients and 22 controls (alleles determined by DNA/SSP typing) were used to calculate a relative risk of 4.7 (P<.05) for HLA-Cw6. S aureus was isolated from the throat of 11 patients. Enterotoxins A and C were detected by agglutination in the culture filtrate of one isolate. The enterotoxin A and/or C genes were detected by PCR in 9 isolates, and transcripts were detected by RT-PCR in 7 of them. None of the isolates from controls harbored enterotoxin genes. Vβ expansions were detected by RT-PCR in all 22 patients. Low or no Vβ expansions were obtained in controls. The association of HLA-Cw6 with psoriasis in Lebanese concurs with that reported for other ethnic groups. Toxin-producing isolates that colonize patients might play a role in the exacerbation of psoriatic lesions.
Synthesis and Characterization of New Schiff Bases Derived from N (1)-Substituted Isatin with Dithiooxamide and Their Co(II), Ni(II), Cu(II), Pd(II), and Pt(IV) Complexes
Ahlam J. Abdul-Ghani,Asmaa M. N. Khaleel
Bioinorganic Chemistry and Applications , 2009, DOI: 10.1155/2009/413175
Abstract: Three new Schiff bases of N-substituted isatin LI, LII, and LIII = Schiff base of N-acetylisatin, N-benzylisatin, and N-benzoylisatin, respectively, and their metal complexes C1a,b=[Co2(LI)2Cl3]Cl, C2=[Ni(LI)2Cl2]0.4BuOH, C3=[CuLICl(H2O)]Cl?0.5BuOH, C4=[Pd(LI)2Cl]Cl, C5=[Pt(L1)2Cl2]Cl2?1.8EtOH.H2O, C6a=[CoLIICl]Cl?0.4H2O?0.3DMSO, C6b=[CoLIICl]Cl?0.3H2O?0.1BuOH,C7=[NiLIICl2], C8=[CuLII]Cl2?H2O00000, C9=[Pd(LII)2]Cl2, C10=[Pt(LII)2.5Cl]Cl3, C11a=[Co(LIII)]C12?H2O, C11b=[Co(LIII)]Cl2?0.2H2O, and C12=[Ni(LIII)2]Cl2, C13=[Ni(LIII)2]Cl2 were reported. The complexes were characterized by elemental analyses, metal and chloride content, spectroscopic methods, magnetic moments, conductivity measurements, and thermal studies. Some of these compounds were tested as antibacterial and antifungal agents against Staphylococcus aureus, Proteus vulgaris, Candida albicans, and Aspergillus niger.
Pathogenesis of Insulin Resistance in Skeletal Muscle
Muhammad A. Abdul-Ghani,Ralph A. DeFronzo
Journal of Biomedicine and Biotechnology , 2010, DOI: 10.1155/2010/476279
Abstract: Insulin resistance in skeletal muscle is manifested by decreased insulin-stimulated glucose uptake and results from impaired insulin signaling and multiple post-receptor intracellular defects including impaired glucose transport, glucose phosphorylation, and reduced glucose oxidation and glycogen synthesis. Insulin resistance is a core defect in type 2 diabetes, it is also associated with obesity and the metabolic syndrome. Dysregulation of fatty acid metabolism plays a pivotal role in the pathogenesis of insulin resistance in skeletal muscle. Recent studies have reported a mitochondrial defect in oxidative phosphorylation in skeletal muscle in variety of insulin resistant states. In this review, we summarize the cellular and molecular defects that contribute to the development of insulin resistance in skeletal muscle.
Efficacy of low-dose myrrh protocols in the treatment of experimental schistosomiasis mansoni: hepatic improvement without parasitologic cure
Rashad Abdul-Ghani, Naguiba Loutfy, Manal Sheta, et al
Research and Reports in Tropical Medicine , 2010, DOI: http://dx.doi.org/10.2147/RRTM.S14231
Abstract: acy of low-dose myrrh protocols in the treatment of experimental schistosomiasis mansoni: hepatic improvement without parasitologic cure Original Research (5759) Total Article Views Authors: Rashad Abdul-Ghani, Naguiba Loutfy, Manal Sheta, et al Published Date November 2010 Volume 2010:1 Pages 65 - 71 DOI: http://dx.doi.org/10.2147/RRTM.S14231 Rashad Abdul-Ghani1, Naguiba Loutfy2, Manal Sheta3, Azza Hassan2 1Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen; 2Tropical Health Department, High Institute of Public Health, 3Department of Pathology, Medical Research Institute, Alexandria University, Alexandria, Egypt Abstract: There is a new trend of “back to nature” in searching for antischistosomal drugs, particularly after the concerns raised about the possible emergence of schistosome isolates resistant/tolerant to praziquantel as well as for their relative safety and fewer side effects. Many plant derivatives have been investigated for efficacy against the Egyptian strain of Schistosoma mansoni, but much attention has been paid to myrrh extract, which is a purified sap obtained from Commiphora molmol. This extract has been produced and marketed in Egypt as a pharmaceutical preparation, but with a great discrepancy in its antischistosomal activity in both experimental and clinical studies. Most previous experimental studies used myrrh in the dosing protocol of 500 mg/kg/day for five days. In the present study, we investigated the therapeutic efficacy of three low-dose myrrh protocols against experimental schistosomiasis mansoni. All these protocols showed no significant efficacy in reducing parasite burdens and tissue egg loads or in changing oogram patterns. Nevertheless, there was an amelioration of hepatic lesions, with reductions in mean counts of hepatic granulomas as well as marked healing of these granulomas.
Chemotherapeutic efficacy of a natural combination in the treatment of mansonic schistosomiasis: an experimental study
Rashad Abdul-Ghani, Naguiba Loutfy, Manal Sheta, et al
Research and Reports in Tropical Medicine , 2011, DOI: http://dx.doi.org/10.2147/RRTM.S15608
Abstract: therapeutic efficacy of a natural combination in the treatment of mansonic schistosomiasis: an experimental study Original Research (3015) Total Article Views Authors: Rashad Abdul-Ghani, Naguiba Loutfy, Manal Sheta, et al Published Date January 2011 Volume 2011:2 Pages 1 - 7 DOI: http://dx.doi.org/10.2147/RRTM.S15608 Rashad Abdul-Ghani1, Naguiba Loutfy2, Manal Sheta3, Azza Hassan2 1Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen; 2Tropical Health Department, High Institute of Public Health, 3Department of Pathology, Medical Research Institute, Alexandria University, Alexandria, Egypt Purpose: Combination chemotherapy of Schistosoma mansoni has been studied previously, with praziquantel being the basis of combination. Artemether and myrrh are compounds of a natural origin that have been investigated experimentally and clinically against schistosomiasis. Artemether is used as an antimalarial drug, and has been used as a chemoprophylactic drug against Schistosoma japonica in China whereas myrrh extract is manufactured and prescribed as an antischistosomal drug in Egypt. The present study investigated the experimental efficacy of combining artemether and myrrh using three different protocols in mice infected with the Egyptian strain of S. mansoni. Methods: Experiments were performed on 40 eight-week-old female Swiss albino mice divided into three experimental groups and one control group. Assessment of efficacy was based on a suite of parasitologic and histopathologic parameters. Parasitologic parameters included reductions in total and female worm burdens, reductions in hepatic and intestinal wall tissue egg loads, and alterations in oogram patterns in the experimental groups compared to the infected untreated control. Histopathologic parameters comprised microscopic examination of liver sections stained with hematoxylin and eosin to study the reductions in the mean counts and diameters of hepatic granulomas as well as their healing ratios compared to the control. Results: Reductions of 43.9%–58.2% in total worm burdens and 42.4%–63.7% in female worm burdens were induced. Meanwhile, significant reductions of 63.1%–77.8% in eggs per gram of small intestinal tissue and of 56.5%–66.3% in eggs per gram of liver tissue were also observed. The combination also caused alterations in the oogram pattern as well as amelioration of hepatic lesions as evidenced by increased ratios of healed granulomas in the treated groups compared to the control. Conclusion: The experimental efficacy of the artemether–myrrh combination against the Egyptian strain of S. mansoni was evident, but not to an extent that would warrant clinical trials in humans.
Contamination of irrigation systems of dental units with Cryptosporidium species in Alexandria, Egypt: a neglected disinfection pitfall
Hassan A, Farouk H, Abdul-Ghani R, Hassanein F
Risk Management and Healthcare Policy , 2012, DOI: http://dx.doi.org/10.2147/RMHP.S35257
Abstract: ntamination of irrigation systems of dental units with Cryptosporidium species in Alexandria, Egypt: a neglected disinfection pitfall Short Report (1380) Total Article Views Authors: Hassan A, Farouk H, Abdul-Ghani R, Hassanein F Published Date August 2012 Volume 2012:5 Pages 93 - 95 DOI: http://dx.doi.org/10.2147/RMHP.S35257 Received: 21 June 2012 Accepted: 06 July 2012 Published: 17 August 2012 Azza Hassan,1 Hanan Farouk,1 Rashad Abdul-Ghani,2,3 Faika Hassanein1 1Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt; 2Parasitology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt; 3Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen Purpose: To investigate the contamination of the dental irrigation systems with Cryptosporidium species in Alexandria, Egypt. Methods: Forty water samples from all 20 working dental irrigation machines in a dental center in Alexandria were included in the study. Water samples were taken from the handpieces of dental irrigation machines in all studied units. After filtration through a membrane filter, water sample residues were stained using modified Ziehl–Neelsen staining and examined microscopically for Cryptosporidium spp. Results: Cryptosporidium spp. was found as a contaminant in 27.5% of water samples taken from dental irrigation machines. Conclusion: This indicates a contamination by the public water supplies to which these dental irrigation machines are connected. This disinfection pitfall may pose an infection risk to those seeking dental care.
Efficacy of low-dose myrrh protocols in the treatment of experimental schistosomiasis mansoni: hepatic improvement without parasitologic cure
Rashad Abdul-Ghani,Naguiba Loutfy,Manal Sheta,et al
Research and Reports in Tropical Medicine , 2010,
Abstract: Rashad Abdul-Ghani1, Naguiba Loutfy2, Manal Sheta3, Azza Hassan21Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen; 2Tropical Health Department, High Institute of Public Health, 3Department of Pathology, Medical Research Institute, Alexandria University, Alexandria, EgyptAbstract: There is a new trend of “back to nature” in searching for antischistosomal drugs, particularly after the concerns raised about the possible emergence of schistosome isolates resistant/tolerant to praziquantel as well as for their relative safety and fewer side effects. Many plant derivatives have been investigated for efficacy against the Egyptian strain of Schistosoma mansoni, but much attention has been paid to myrrh extract, which is a purified sap obtained from Commiphora molmol. This extract has been produced and marketed in Egypt as a pharmaceutical preparation, but with a great discrepancy in its antischistosomal activity in both experimental and clinical studies. Most previous experimental studies used myrrh in the dosing protocol of 500 mg/kg/day for five days. In the present study, we investigated the therapeutic efficacy of three low-dose myrrh protocols against experimental schistosomiasis mansoni. All these protocols showed no significant efficacy in reducing parasite burdens and tissue egg loads or in changing oogram patterns. Nevertheless, there was an amelioration of hepatic lesions, with reductions in mean counts of hepatic granulomas as well as marked healing of these granulomas.Keywords: Schistosoma mansoni, schistosomiasis mansoni, myrrh, Commiphora molmol, antischistosomal chemotherapy
Chemotherapeutic efficacy of a natural combination in the treatment of mansonic schistosomiasis: an experimental study
Rashad Abdul-Ghani,Naguiba Loutfy,Manal Sheta,et al
Research and Reports in Tropical Medicine , 2011,
Abstract: Rashad Abdul-Ghani1, Naguiba Loutfy2, Manal Sheta3, Azza Hassan21Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen; 2Tropical Health Department, High Institute of Public Health, 3Department of Pathology, Medical Research Institute, Alexandria University, Alexandria, EgyptPurpose: Combination chemotherapy of Schistosoma mansoni has been studied previously, with praziquantel being the basis of combination. Artemether and myrrh are compounds of a natural origin that have been investigated experimentally and clinically against schistosomiasis. Artemether is used as an antimalarial drug, and has been used as a chemoprophylactic drug against Schistosoma japonica in China whereas myrrh extract is manufactured and prescribed as an antischistosomal drug in Egypt. The present study investigated the experimental efficacy of combining artemether and myrrh using three different protocols in mice infected with the Egyptian strain of S. mansoni.Methods: Experiments were performed on 40 eight-week-old female Swiss albino mice divided into three experimental groups and one control group. Assessment of efficacy was based on a suite of parasitologic and histopathologic parameters. Parasitologic parameters included reductions in total and female worm burdens, reductions in hepatic and intestinal wall tissue egg loads, and alterations in oogram patterns in the experimental groups compared to the infected untreated control. Histopathologic parameters comprised microscopic examination of liver sections stained with hematoxylin and eosin to study the reductions in the mean counts and diameters of hepatic granulomas as well as their healing ratios compared to the control.Results: Reductions of 43.9%–58.2% in total worm burdens and 42.4%–63.7% in female worm burdens were induced. Meanwhile, significant reductions of 63.1%–77.8% in eggs per gram of small intestinal tissue and of 56.5%–66.3% in eggs per gram of liver tissue were also observed. The combination also caused alterations in the oogram pattern as well as amelioration of hepatic lesions as evidenced by increased ratios of healed granulomas in the treated groups compared to the control.Conclusion: The experimental efficacy of the artemether–myrrh combination against the Egyptian strain of S. mansoni was evident, but not to an extent that would warrant clinical trials in humans.Keywords: Schistosoma mansoni, combination chemotherapy, artemether, myrrh, natural drugs
Parental transmission of type 2 diabetes mellitus in a highly endogamous population
Abdulbari Bener,Mohammad T Yousafzai,Abdulla OAA Al-Hamaq,Abdul-Ghani Mohammad
World Journal of Diabetes , 2013, DOI: 10.4239/wjd.v4.i2.40
Abstract: AIM: To determine the parental transmission of diabetes mellitus (DM) and evaluate its influence on the clinical characteristics. METHODS: This was a cross sectional study. The survey was carried out in urban and semi-urban primary health care centers. Of the 2400 registered with diagnosed diabetes, 1980 agreed and gave their consent to take part in this study, thus giving a response rate of 82.5%. Face to face interviews were conducted using a structured questionnaire followed by laboratory tests. DM was defined according to the World Health Organization expert group. A trained nurse performed physical examinations and measurements. RESULTS: Of the study population, 72.9% reported a family history of DM. Family history of DM was significantly higher in females (54.2%; P = 0.04) and in the age group below 30 years (24%; P < 0.001). The prevalence of diabetes was higher among patients with a diabetic mother (25.4% vs 22.1%) and maternal aunts/uncles (31.2% vs 22.2%) compared to patients with a diabetic father and paternal aunts/uncles. Family history of DM was higher in patients of consanguineous parents (38.5%) than those of non-consanguineous parents (30.2%). The development of type 2 diabetes mellitus (T2DM) complications was higher in patients with either a paternal or maternal history of DM than in those without. No significant difference was observed in the metabolic characteristics of patients with/without family history of DM except for hypertension. Complications were higher in diabetic patients with a family history of DM. CONCLUSION: The present study found a significant maternal effect in transmission of T2DM. Family history is associated with the increased incidence of diabetes.
Impacts of Residential Areas and Aquaculture on the Sediment Quality of Semariang Batu River in Sarawak, Malaysia
Ling T.,Abdul-Ghani R.,Hamdan N. A.,Nyanti L.
International Journal of Chemical and Environmental Engineering , 2012,
Abstract: The Semariang Batu River is an important spawning ground for fish. Sediment quality affects the overlying water quality. However, sediment quality has not been investigated in detail. Therefore, in this study, surface sediment was sampled at eleven stations including residential areas and aquaculture stations. Results show that pH near riverside village was the lowest among the stations. Organic carbon, total nitrogen and total phosphorus were the highest near the riverside village. At shrimp farm discharge, phosphorus concentration in the sediment ranked second highest among all stations studied. Mean concentration of heavy metals were in decreasing order of zinc>chromium>nickel>lead>copper. Zinc was the highest near the riverside residential village showing residential contributions. Nickel was the highest downstream of riverside village near a cage culture site but was not significantly different from other stations that receive inputs from residential areas. Lead was the second highest near the riverside residential village and the concentrations were higher mostly in the main river, the Semariang River, compared to its tributary likely due to anthropogenic inputs. Copper at shrimp farm discharge ranked the highest but not significantly different from the riverside village station. All heavy metals investigated did not exceed the Consensus–Based Threshold Effect Concentration of USEPA indicating that harmful effects are unlikely to be observed at the stations.
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