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Search Results: 1 - 10 of 400797 matches for " Abbasnejad M "
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The effect of co-administration of morphine and L-Arginine in hippocampal CA3 area on spatial learning and memory in male rats
Hoseinzadeh M,Pouraboli I,Abbasnejad M
Tehran University Medical Journal , 2009,
The Effect of Oral Ascorbic Acid Pretreatment on Feeding Changes Following Injection in Nucleus Accumbens Shell in Adult Male Rats
Salari S,Abbasnejad M,Badreh F,Esmaeili Mahani S
Tehran University Medical Journal , 2012,
Abstract: Background: Ascorbic acid (AA) is not synthesized in the brain but it is actively transported through blood-brain barrier by SVCT2 cotransporter and it is stored in high concentrations with heterogeneous distribution in areas such as nucleus accumbens shell (AcbSh) in the mammalian brain. Previous studies have shown that Ascorbic acid injection into AcbSh decreases feeding; therefore, in the present study we evaluated the effects of oral Ascorbic acid pretreatment on changes in feeding upon its injection in AcbSh in adult male rats.Methods: Sixty-three adult male rats (220-280 g) were divided into five treatment and five pretreatment groups. The treatment groups included the control (intact) group, sham-operated Ascorbic acid group that received normal saline as vehicle, and three other groups that received different doses of ascorbic acid (10, 50 and 250 μg/rat) by injection into AcbSh for four days. The pretreatment groups received Ascorbic acid (100 mg/kg) for 15 days via gastric gavage before receiving the aforementioned doses in treatment groups into intra nucleus AcbSh. Feeding measurement was repeated every 12 hours by automatic metabolic cage.Results: The results indicated that all injected doses of Ascorbic acid (10, 50 and 250 μg/rat) into nucleus accumbens shell decrease food intake (P<0.05) in rats and oral Ascorbic acid pretreatment had no effects in this regard.Conclusion: Our findings show that ascorbic acid is an effective factor in feeding regulation. Oral pretreatment seems to have no influence on the central effects of ascorbic acid in the nucleus accumbens shell.
The effect of Co-administrtion of Ascorbic acid and Bromocriptine in nucleus accumbens shell on locomotor activity in male rats by Open Field Test
Mehdi Abbasnejad,Fatemeh Shahsevari
Physiology and Pharmacology , 2013,
Abstract: Background: Ascorbic acid (AA) as a vitamin and neuromodulator is present in the most part of CNS such as nucleus accumbens shell (Acbsh), so the main purpose of this investigation was to evaluated the effect of AA and their Co-administration in Acbsh on anxiety and motor activity of rat by Open Field Test(OFT). Methods: Forty nine adult male Wistar rats (220-270 g) were used into 7 groups: control (intact), sham AA (injected normal salin as AA vehicle), 3 groups of AA (12,24 and 48 μg/rat/side), AA plus Br (24 and 25 μg/rat/side), sham AA plus Br. Drugs were injected (volum= 1μl) for one-day period , locomotor activity and anxiety behavior were assessed. Results: The result showed that; Intra-accumbance injection of AA (12, 24 and 48 μg/rat/side) increased locomotor activity and decreased anxiety. Co-administration of AA and Br, showed AA could attenuate the effect of Br. Conclusion: Our findings confirm the role of AA as an effective factor in locomotor activity and anxiety regulation in NAcS.
Sleep paralysis in medieval Persia – the Hidayat of Akhawayni (? –983 AD)
Golzari SE, Khodadoust K, Alakbarli F, Ghabili K, Islambulchilar Z, Shoja MM, Khalili M, Abbasnejad F, Sheikholeslamzadeh N, Shahabi NM, Hosseini SF, Ansarin K
Neuropsychiatric Disease and Treatment , 2012, DOI: http://dx.doi.org/10.2147/NDT.S28231
Abstract: ralysis in medieval Persia – the Hidayat of Akhawayni (? –983 AD) Review (2575) Total Article Views Authors: Golzari SE, Khodadoust K, Alakbarli F, Ghabili K, Islambulchilar Z, Shoja MM, Khalili M, Abbasnejad F, Sheikholeslamzadeh N, Shahabi NM, Hosseini SF, Ansarin K, Published Date June 2012 Volume 2012:8 Pages 229 - 234 DOI: http://dx.doi.org/10.2147/NDT.S28231 Received: 28 November 2011 Accepted: 18 February 2012 Published: 06 June 2012 Samad EJ Golzari,1 Kazem Khodadoust,5 Farid Alakbarli,6 Kamyar Ghabili,2 Ziba Islambulchilar,3 Mohammadali M Shoja,1 Majid Khalili,1 Feridoon Abbasnejad,1 Niloufar Sheikholeslamzadeh,7 Nasrollah Moghaddam Shahabi,4 Seyed Fazel Hosseini,2 Khalil Ansarin1 1Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences; 2Medical Philosophy and History Research Center, Tabriz University of Medical Sciences; 3Department of Pharmaceutics, Tabriz University of Medical Sciences; 4Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; 5Azerbaijan National Academy of Sciences; 6Institute of Manuscripts of the Azerbaijan National Academy of Sciences, Baku, Azerbaijan; 7Faculty of Law, Central Tehran Branch, Islamic Azad University, Tehran, Iran Abstract: Among the first three manuscripts written in Persian, Akhawayni's Hidayat al-muta`allemin fi al-tibb was the most significant work compiled in the 10th century. Along with the hundreds of chapters on hygiene, anatomy, physiology, symptoms and treatments of the diseases of various organs, there is a chapter on sleep paralysis (night-mare) prior to description and treatment of epilepsy. The present article is a review of the Akhawayni's teachings on sleep paralysis and of descriptions and treatments of sleep paralysis by the Greek, medieval, and Renaissance scholars. Akhawayni's descriptions along with other early writings provide insight into sleep paralysis during the Middle Ages in general and in Persia in particular.
The Effect of Co-Administration of Nitric Oxide and Morphine in CA3 of Hippocampus on Learning and Spatial Memory in Normal and Morphine Dependent Male Rats
Journal of Neurological Sciences , 2010,
Abstract: Induction of synaptic plasticity in hippocampus is the main mechanism of learning and memory and various agents can influence theme. Opioids resulted to tolerance, dependency and cognitive deficits But the effect of morphine dependency on learning and memory is still controversial. In this study the effect of co-administration of nitric oxide(NO) and morphine in CA3 of hippocampus on learning and spatial memory in normal and morphine dependent male rats was investigated. Male rats were anaesthetized and cannula implanted bilaterally in CA3 of hippocampus via stereotax. After recovery period, rats were used in 2 normal and morphine dependent groups, that in last group morphine dependency was induced by subcutaneous injection of morphine for 5 days. Then each group subdivided to 6 subgroups that received 1μl of drugs for 5 testing days. Drugs were saline, L-Arginine(0.3M and 3 μl/rat), L-NAME(0.3M), morphine(10mg) individually and L-Arginine with morphine or L-NAME with morphine. Then animals were trained in Morris water maze to evaluate learning and spatial memory. Results showed that in normal rats, L-Arginine improved learning and spatial memory and L-NAME or morphine impaired theme. In morphine dependent rats, L-NAME decreased learning but morphine did not affect learning and spatial memory. Co-administration of L-NAME with morphine in normal rats decreased learning more than morphine individually and in morphine dependent rats, co-administration of L-Arginine with morphine not only improved the effect of morphine on learning but also promote the effect of L-Arginine on learning.
Facial Expression Recognition Using Sparse Gaussian Conditional Random Field
Mohammadamin Abbasnejad,Mohammad Ali Masnadi-Shirazi
Computer Science , 2015,
Abstract: The analysis of expression and facial Action Units (AUs) detection are very important tasks in fields of computer vision and Human Computer Interaction (HCI) due to the wide range of applications in human life. Many works has been done during the past few years which has their own advantages and disadvantages. In this work we present a new model based on Gaussian Conditional Random Field. We solve our objective problem using ADMM and we show how well the proposed model works. We train and test our work on two facial expression datasets, CK+ and RU-FACS. Experimental evaluation shows that our proposed approach outperform state of the art expression recognition.
Valuation of Origanum vulgare (leaves, stems and flowers) extract on spatial learning in male rats
Mehdi Abbasnejad,Mansour Mirtajadini,Mohammad Reza Afarinesh,Neda Hassibi
Physiology and Pharmacology , 2006,
Abstract: Introduction: Origanum vulgare a rich source of natural phenolic antioxidants and has potential to be a source nutritional ingredients for functional food. Herbs such as Origanum have long been used in food preservation d in traditional medicine in the treatment of common ailments and have potential for positive modulation oxidation-linked diseases such as diabetes. Here we investigated the effect of aqueous extract of Origanum aves, stems and flowers) on spatial learning. Methods: After scientific identification, the leaves were used for extraction. 35 adult NMRI male rats weighing 0-350 gr were utilized in 5 groups. Control group (no injection), the second group (saline injected), the extracts h different doses (150, 300, 450) mg/kg were injected intraperitoneally to experimental animals. All animals re trained for a spatial learning task using T-maze and were then trained subsequently daily based on standard thod. Results: Statistic analysis ANOVA showed that Origanum aqueous extract significantly decreased the number learning and error in simple and reverse learning (p<0.05) and it had no significant effect on delay time in both e of learning. Conclusion: It can be concluded that the effect of Origanum extract on learning can be due to its antioxidant d presence of anti acetylcholine estrase compounds such as ursolic acid.
The Effect of Intrahippocampal Injection of Ascorbic Asid on Spatial Learning and Memory in Adult Male Rats
khadije esmaeilpour,mehdi abbasnejad,saeed esmaeili mahani,yaser masomi ardakani
Physiology and Pharmacology , 2010,
Abstract: Introduction: Ascorbic acid (AA) is present in high concentrations with heterogeneous distribution in the mammalian brain. Previous studies have shown that release of various neurotransmitters such as glutamate, acetylcholine and dopamine might be involved in the central AA release. On the other hand all of these neurotransmitters and the region CA1 of the hippocampus are involved in learning and memory. The aim of the present study was to evaluate the effects of ascorbic acid injection in the CA1 region on spatial learning and memory in adult male rats. Methods: 42 adult male NMRI rats (250-300 g) divided into 6 groups were used in this study. They included control group that received no injection, sham-operated group that received normal saline injection as vehicle and four groups that received different doses of ascorbic acid (6, 12, 24 and 48 μg/rat). All injections were given in 5 consecutive days and 30 min after each injection, the rats were tested in the Morris Water Maze test to measure learning and memory task. Spatial learning and memory parameters were subjected to analysis of variance (ANOVA). Results: The results indicated that intrahippocampal microinjection of AA (12 and 24 μg/rat) significantly increased some spatial learning and memory parameters such as escape latency and path length to reach the hidden platform. Conclusion: Our findings show that AA injection into the CA1 region has a negative effect on spatial learning and memory.
The effect of bilateral intrahippocampal injection of all–trans retinoic acid on spatial learning in adult male rats.
Mahmoud Aminizadeh,Mehdi Abbasnejad,Ahmad Ali Moazedi,AhmadAli Papahn
Physiology and Pharmacology , 2008,
Abstract: Introduction: Previous studies have shown that vitamin A and its derivatives such as retinoid and all-trans retinoic acid have a crucial role in memory, learning and synaptic plasticity. The receptors of vitamin A are seen in different parts of the brain such as hippocampus, where vitamin A has an important role in learning. In this study, the effect of intrahippocampal (CA1) injection of all – trans retinoic acid on spatial learning was investigated in adult male rats. Methods: 49 adult male rats divided in 7 groups were used. Test groups (1 – 4) received 1μl of all – trans retinoic acid dissolved in DMSO at concentrations of 1, 2, 4 and 8 μg/μl, for 4 consecutive days, 90 minutes before training. Group 5 received DMSO and 6th and 7th groups were designated as sham operation and control (intact) group, respectively. After each injection, Morris Water Maze (MWM) was used as a method to measure learning task. Results: This study showed that all – trans retinoic acid at the concentration of 1 μg/μl improved spatial learning in Morris Water Maze (p< 0.05). Conclusion: Our findings show that all – trans retinoic acid improves spatial learning in rats via enhancing the expression of learning related proteins.
The Effect of ascorbic acid injection into lateral ventricle on spatial learning and memory on adult male rats
mehdi abbasnejad,Sima Nasri,Habib Nazem,Mehri Bahaaddini
Physiology and Pharmacology , 2008,
Abstract: Introduction: Ascorbic acid (AA) acts as an antioxidant in the Central nervous system (CNS) of the mammalians. It is released from the some nerve ending together with neurotransmitters. The results have shown that Ascorbic acid could affect learning as well as memory. In this study, we examined the effect of ICV injection of ascorbic acid on learning and memory by Morris water maze. Method: In the present study, 42 adult male rats weighing 250-300 g were used. then cannula implanted bilaterally in LV (AP=-0.8, LA=±1.5, DV=3.4).After recovery period, the animals were divided into 6 groups including; control group(no injected), 4 groups as experimental groups (received different doses of ascorbic acid 25, 50, 100, 150 mg/kg), 5th group as Sham-operated group (received normal saline as vehicle). Injection period has taken five consecutive days. 30 min after each injection they were trained in Morris Water Maze (MWM). Spatial learning and memory parameters recorded and then were analyzed. Results: These results showed that ICV injection of ascorbic acid decreased learning and spatial memory in rats. Ascorbic acid (100 mg/kg) significantly decreased learning and spatial memory. Conclusion: It can be concluded that ascorbic acid decreased learning and spatial memory, directly or indirectly through interference to the neurotransmitters effects.
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