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Search Results: 1 - 10 of 2941 matches for " Abbas Abdollahi "
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Analysis of Bacterial Contamination in Anesthetic Equipments in Operation Room of Vali-E-Asr Hospital of Fasa; Efficiency of Disinfection Methods
Abbas Abdollahi,saeid khademi
Journal of Fasa University of Medical Sciences , 2011,
Abstract: Background & Objectives: Anesthetic equipments could be one of the factors transmitting infection in a surgical operation. We could be prevent infection transmission to a great extend, by providing efficient methods of disinfection of anesthetic equipments. The purpose of the present research is to analyze the bacterial contamination in anesthetic equipment in operation rooms of Vali-e-Asr hospital in Fasa city, Fars province, and evaluate the efficiency of the applied disinfection methods. Materials & Methods: In this cross-sectional & analytical study, sampling from anesthetic equipment was done by sterile swap and culture on nutrient media, irregularly and randomly, before and after using and washing tools. Used anesthetic equipment in such operation rooms have been washed with Betadine 7.5% by experts and technicians of anesthetic section and were prepared for the next operation. Results: Total contamination was 2.3% in 210 samples taken. 5 culture items indicated the existence of bacterial contamination, among which 2 contamination cases were observed in nasal airway (coagulase negative Staphylococcus, non pathogen Neisseria), 2 contamination cases in red rubber endotracheal tube (nonpathogen Neisseria and Klebsiella pneumonia) and 1 contamination case in oxygen mask (Escherichia coli). Conclusion: The very low level of contamination (20-85% contamination in anesthetic equipments) in our research is probably due to application of a appropriate disinfection method used by educated personnel in operation rooms. This could have a significant role in decreasing the infection rate in one hand and decreasing expenses and time on the other hand.
Evaluation of Drug Resistance Pattern of Escherichia coli Strains Isolated from Fasa Vali-e-Asr Hospital Patients
Sara Abdollahi Kheirabadi,Sohrab Najafipour,Farshid Kafilzadeh,Abbas Abdollahi
Journal of Fasa University of Medical Sciences , 2013,
Abstract: Background & Objective: Antibiotic resistance due to the widespread use of antibiotics is one of the major causes of failure in antibiotic treatment. The aim of this study was to investigate the rates of antibiotic resistance among Escherichia coli isolates from Fasa Vali-e-Asr Hospital patients. Materials & Methods : In total, 234 isolates of Escherichia coli strains, obtained from inpatients and outpatients, were studied. The identity of the isolated strains was confirmed by bacteriologic methods. T he drug sensitivity definition test to 17 antibiotics was done via the disk diffusion antibiogram method. Minimum inhibitory concentration (MIC) of the resistant isolates to Ciprofloxacin and Imipenem was measured using the s erial dilution method according to the CLSI standards. Results : The resistance rates of the isolates to Ciprofloxacin and Imipenem by disk diffusion antibiogram method were 22.65% and 11.11% and by serial dilution method were 19.66 % and 9.4% of all the isolates, respectively. Conclusion: These results show higher resistance of Escherichia coli to Ciprofloxacin and Imipenem as compared to the results in previous studies. Further investigation will shed light on how to more effectively battle antibiotic resistance of virulent microorganisms.
Monitoring of National Drug Policy (NDP) and its standardized indicators; conformity to decisions of the national drug selecting committee in Iran
Shekoufeh Nikfar, Abbas Kebriaeezadeh, Reza Majdzadeh, Mohammad Abdollahi
BMC International Health and Human Rights , 2005, DOI: 10.1186/1472-698x-5-5
Abstract: To identify strengths and weaknesses of pharmaceutical policy formation and implementation in Iran, four standard questionnaires of the World Health Organization (WHO) were used. To assess the agreement between decisions of IDSC and standardized NDP indicators in the last 5 years (1998–2002), a weighted questionnaire by nominal group technique based on the questions that should be answered during discussion about one drug in IDSC was designed and used.There is a totally generics based NDP with 95% local production, that provides affordable access to drugs. The system, structures, and mechanisms were in place; however, they did not function properly in some topics. Assessment of 59 dossiers of approved drugs for adding to NDL during last 5 years showed that IDSC's members pay more attention to efficacy, safety, and rationality in use rather than accessibility and affordability.Revision of drug system in term of implementation of the processes to achieve NDP's objectives is necessary to save public health. Clarification of NDP's objectives and their impact for IDSC's members will result in improvement of the equity in access to pharmaceuticals.The enjoyment of the highest attainable standard of health is one of the fundamental rights of every human being without distinction of race, religion, political belief, and economic or social condition [1]. Everyone has the right to a standard of living adequate for the health of himself and of his family, including food, clothing, housing, necessary social services, and medical care [2]. Governments and the international community have an obligation to see the right to health progressively realized which includes the responsibility for prevention, treatment and control of disease; and the creation of conditions to ensure access to health facilities, goods and services [3]. Access to goods and services include of course the provision of essential medicines necessary for the prevention and treatment of prevalent diseases [4]. In
Severe Hypoglycemia Following Acute Aluminum Phosphide (Rice Tablet) Poisoning; A Case Report and Review of the Literature
Omid Mehrpour,Abbas Aghabiklooei,Mohammad Abdollahi,Surjit Singh
Acta Medica Iranica , 2012,
Abstract: Aluminum phosphide (AlP) as 3 g tablet is widely used in Iran to protect stored food grains from pests. Hyperglycemia following its ingestion has been already reported in the recent years but severe hypoglycemia is uncommon. Here, we report a 19 year old male who attempted suicide with one tablet of AlP and demonstrated severe hypoglycemia. Despite restoration of blood glucose concentration to normal, he failed to respond to supportive treatment and died. The possible mechanisms leading to severe hypoglycemia are discussed. Though severe hypoglycemia is rare following AlP poisoning, physicians managing such patients should be aware of it.
Effect of Phlomis persica on glucose levels and hepatic enzymatic antioxidants in streptozotocin-induced diabetic rats
Sarkhail Parisa,Abdollahi Mohammad,Fadayevatan Sedigheh,Shafiee Abbas
Pharmacognosy Magazine , 2010,
Abstract: Methanol extract of the aerial parts of Phlomis persica Boiss. (Lamiaceae) (PPE) was studied to evaluate the effects of antidiabetic potential, by measuring fasting blood glucose, insulin, total antioxidant power (TAP), using ferric reducing antioxidant power (FRAP), lipid peroxidation (using thiobarbituric acid reactive substances, TBARS), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) on streptozotocin-induced diabetes in rats. Male Wistar rats were randomly divided into five groups of six animals each. Oral administration of PPE at doses of 100 and 200 mg/kg once a day for 10 days resulted in a significant reduction in fasting blood glucose and an increase in serum insulin levels, in comparison with diabetic control group. It also prevented diabetes-induced loss in body weight. Hepatic TAP increased and TBARS decreased following PPE treatments. The extract at 100 and 200 mg/kg increased the activity of hepatic SOD, CAT, and GPx in diabetic rats. It is concluded that PPE has antidiabetic potential that is comparable with glibenclamide. In conclusion, the results of the present study show positive effects of P. persica on experimental diabetes and thus the antidiabetic effect of PPE is related to its potential to inhibit hepatocellular oxidative stress.
DARU : Journal of Pharmaceutical Sciences , 1999,
Abstract: A relatively simple normal phase high performance liquid chromatography (HPLC) method was modified for determination of nifedipine in human plasma. The method is based on ultraviolet detection at 235 nm and acidic plasma extraction by a mixture of dichioromethane (30%) and n-hexane (70%) using nimodipine as an internal standard. The system was stabilized with the use of n-hexane (80%), chloroform (17%) and methanol (3%) as mobile phase. The assay was linear up to at least 120 ng/ml of nifedipine in plasma. The limit of reliable determination was at least 3 ng/ml plasma. The reproducibility of the method was satisfactory. The procedure can be used effectively to quantitate nifedipine in the human plasma.
Salmonella enterica: Serotyping, Drug Resistance & Extended Spectrum of β-Lactamase (ESBLs)
Abbas Abdollahi,Sohrab Najafipour,Seyyed Amin Kouhpayeh,Mohammad Hassan Meshkibaf
Journal of Fasa University of Medical Sciences , 2011,
Abstract: Background & Objective: Genus Salmonella has more than 2400 serotypes. The two major groups are S.enterica and S.bongori. Important serotypes are situated in S.enterica group. Antibiotic therapy in salmonellosis is restricted to typhoid fever and acute infections. After the first reporting of resistance in S.Typhimurium DT 104, nowadays, developing of resistance in Salmonella, specially, ESBL producing species is an important issue in salmonellosis. We evaluated serotyping, drug resistance and extended spectrum beta lactamase (ESBL) in Salmonella enterica, collected from patients. Materials & Methods: We collected fecal samples in an 18 months period of time. Samples were cultured on selective, differential Medias. Serotyping was done with Biomérieux serotyping kit. After antibiogram, MIC was evaluated with E-test strips. By using ESBL disks in Double- Disk synergy method, ESBL phenotypes were distinguished. Results: We isolated 96 S.enterica serotypes, including: 35Typhimurium, 22Enteritidis, 11Typhi, 8Paratyphi B, 4Newport, 3Derby, 1Virchow, 1Infantis and 11untypable serotypes. 36isolates were sensitive to all of antibiotics, but, in 60 isolates, there were at least one resistance. In 45 isolates there were Multi Drug Resistance (MDR) phenotypes. Resistance to ampicilin was the highest percent, whereas, there was not any resistance to imipenem and ciprofloxacin. ESBL evaluation shown producing cefotaxime ESBL in 5 isolates and ceftazidim ESBL in 4 isolates. Conclusion: With furthermore epidemiologic studies on Salmonella serotyping and antibiotic resistance, using suitable drugs in treatment, we can restrict the spreading of resistant Salmonella (specially, species with animal source).
Evaluation of Apolipoprotein A5 Polymorphism in Coronary- Heart Disease Patients
Somayeh Haqparast,Peyman Izadpanah,Abbas Abdollahi,Sohrab Najafipoor
Journal of Fasa University of Medical Sciences , 2012,
Abstract: Background and Objectives: Apolipoprotein A5 (APOA5) gene is important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. Mutation in this gene affected plasma triglyceride level. We looked for possible associations of the APOA5 gene polymorphism S19W with coronary heart disease (CHD) in a sample of Iranian population. Materials and Methods: A total of 73 CHD patients and 55 controls were genotyped by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) for this single nucleotide polymorphism. Serum lipids and Fast Blood Sugar concentrations were measured in all subjects with enzymatic method. Results: Allele frequencies observed in our population were 0.041 for the W allele and 0.959 for the S allele which are similar to other populations (p>0.05). There is no evidence that APOA5 S19W, is a risk factor of CHD in our sample (p>0.05). In addition, we observed no association between the APOA5 W allele and elevated plasma TG levels (p>0.05) in the CHD group. This result was also present in the control group (p>0.05). Conclusion: The APO A5 gene polymorphism in S19W gene has no association with the high susceptibility to CHD.
Phenotypical Evaluation of Multi-Drug Resistant Acinetobacter Baumannii
Somayyeh Jafari,Sohrab Najafipour,Mohammad Kargar,Abbas Abdollahi
Journal of Fasa University of Medical Sciences , 2013,
Abstract: Background & Objective: Resistance patterns among nosocomial bacterial pathogens in hospitals may vary widely from country to country at any given point and within the same country over time. Acinetobacter baumannii is one of the most important bacteria that cause hospital-acquired infections. Therefore, surveillance of the antibiotic resistance of Acinetobacter baumannii is necessary, especially in our country, where there is death of relevant data. Materials & Methods: This cross-sectional-descriptive study was performed on 63 MDR isolates of acinetobacter baumannii isolated from patients in Fars province hospitals. After acinetobacter baumannii diagnosis with bacteriological standard tests , we determined their susceptibility to the following antibiotics via the antibiogram method (disk diffusion): cefoxitine; polymixin B; nalidixic acid; meropenem; tobramycin; imipenem; trimethoprim sulphametoxazole; ampicilin-sulbactam; azteronam; rifampicin; ceftazidim; gentamycin; cefotaxim; piperacillin; ciprofloxacin; streptomycin; amikacin; and polymixin B. Minimum inhibitory concentration (MIC ( for imipenem and ciprofloxacin against acinetobacter baumannii isolates was determined using the serial dilution method according to the CLSI guideline. Results: The percentage of acinetobacter baumannii isolates that were resistant to ciprofloxacin, imipenem, and meropenem in the serial dilution method was 77.7%, 40.9%, and 60%, respectively. Conclusion: High antimicrobial resistance in acinetobacter baumannii species was observed in the present study; therefore, it is necessary to implement some approaches for the prevention of bacterial spread.
Assessing the effectiveness and cost-effectiveness of audit and feedback on physician’s prescribing indicators: study protocol of a randomized controlled trial with economic evaluation
Fatemeh Soleymani, Arash Rashidian, Rassoul Dinarvand, Abbas Kebriaeezade, Mostafa Hosseini, Mohammad Abdollahi
DARU Journal of Pharmaceutical Sciences , 2012, DOI: 10.1186/2008-2231-20-88
Abstract: A four-arm randomized trial with economic evaluation will be conducted in Tehran. Three interventions (routine feedback, revised feedback, and printed educational material) and a no intervention control arm will be compared. Physicians working in outpatient practices are randomly allocated to one of the four arms using stratified randomized sampling. The interventions are developed based on a review of literature, physician interviews, current experiences in Iran and with theoretical insights from the Theory of Planned Behavior. Effects of the interventions on improving antibiotics and corticosteroids prescribing will be assessed in regression analyses. Cost data will be assessed from a health care provider’s perspective and incremental cost-effectiveness ratios will be calculated.This study will determine the effectiveness and cost-effectiveness of three interventions and allow us to determine the most effective interventions in improving prescribing pattern. If the interventions are cost-effective, they will likely be applied nationwide.Iranian Registry of Clinical Trials Registration Number: IRCT201106086740N1Pharmaceutical Sciences Research Center of TUMS Ethics Committee Registration Number: 90-02-27-07Over the past decades, new generations of antibiotics, analgesics, corticosteroids and other medicines have been introduced to the pharmaceuticals market. At the same time, health care systems are confronted with a continuing pressure to provide high-quality care in the face of increasing costs and limited financial resources.Due to the rising pharmaceutical expenditures in the world, governments are struggling to keep costs under control [1-3]. There are valid concerns about the rationality of use of medicines, mostly as a result of inappropriate physician prescribing. Physicians’ prescribing is the most common medical intervention with a high impact on health care costs [4]. Improving and promoting rational use of medicines contributes to a more efficient use o
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