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Search Results: 1 - 10 of 3137 matches for " Aaron Isaacs "
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Strengthening research in community medicine
Isaacs Anton
Indian Journal of Community Medicine , 2007,
Measuring Inter Epidemic Risk in a Dengue Endemic Rural Area Using Aedes larval Indices
Isaacs N
Indian Journal of Community Medicine , 2006,
Endoscopic retrograde cholangiopancreatography training in the United Kingdom: A critical review
Peter Isaacs
World Journal of Gastrointestinal Endoscopy , 2011,
Abstract: Endoscopic retrograde cholangiopancreatography training used to be in virtually all district general hospitals, resulting in a large number of trainees with an inadequate case load and achieving poor levels of skill. Training is now restricted to a small number of trainees working in approved units. Continuous audit of outcomes and the appointment of a training lead in the unit are essential. Use of the global rating scale helps clinicians advise hospital administration on the priorities for a quality training program.
The Land and Nightfall…
Bruce Isaacs.
Nebula , 2005,
Abstract: A Poem.
Financial Crisis in Retrospect: Bad Luck or Bad Policies?  [PDF]
Gregory M. Dempster, Justin P. Isaacs
Theoretical Economics Letters (TEL) , 2014, DOI: 10.4236/tel.2014.41013

It is generally acknowledged that many recent financial crises, in both emerging and mature markets, are characterized by large scale coordination problems with common origins. Despite minimal consensus on their primary causes, most prominent theories suggest that these financial crises can be classified as either the result of bad policies or bad luck. In this paper, we attempt to outline the sources of coordination failure in financial markets due to the “soft budget constraints” produced by time-inconsistent policies in combination with elastic expectations on the part of financial investors. Thus, in our framework, financial crisis is conceived as the result of both bad policies and bad luck. That is, it results from a mismatch of institutional arrangements to the realities of human behavior.

Antibody engineering to develop new antirheumatic therapies
John D Isaacs
Arthritis Research & Therapy , 2009, DOI: 10.1186/ar2594
Abstract: The biological therapy 'revolution' was made possible by elucidation of the fine detail of the structure-function relationship in immunoglobulin molecules and the 'modular' organisation of the underlying genes. Antibodies are essentially multidomain adapter molecules used by the immune system to neutralise and/or destroy invading microorganisms and their products (antigens). They do this by connecting the antigen with various effector mechanisms. At one end of the antibody molecule (Figure 1), two identical variable (V) regions have a molecular structure that, in three dimensions, is highly complementary to the target antigen. Non-covalent molecular interactions between antibody and antigen ensure a tight fit. The constant (C) region, at the other end of the antibody molecule, determines the fate of the bound antigen.An antibody comprises four covalently linked polypeptide chains: two identical heavy chains and two identical light chains (Figure 1). The heavy chains usually contain four and the light chain two distinct domains, where a domain is a discrete, folded, functional unit (Figure 2a). The first domain in each chain is the V domain, VH and VL on the heavy and light chains, respectively. The rest of the heavy chain comprises three (four for IgE) constant domains (CH1 to CH3), whilst the light chains have one constant domain (CL). There is a flexible peptide segment (the hinge) between the CH1 and CH2 domains.The antibody V region is composed of the VH and VL domains. The C region is composed of the CL, CH1, CH2, and CH3 domains. Digesting an antibody with papain releases a single Fc (fragment crystallisable) fragment corresponding to the CH2 and CH3 domains (Figure 2a). Two Fab (fragment antigen-binding) fragments are also generated, corresponding to the antibody binding arms (Figure 2b).Within each VH and VL domain, three short polypeptide segments form the hypervariable or complementarity-determining regions (CDRs) (Figure 1). These segments have a highly v
Un continuo generado con el triángulo de Sierpinski usando límites inversos
Revista Integración , 2012,
Abstract: abstract. inverse limits are a tool to construct spaces with curious topological properties, from very simple spaces. in this paper, we use inverse limits and an inductive construction of the sierpinski triangle to build a continuum with very interesting topological properties, in particular, it is self-similar.
Does the sun play a role in the aetiology of malignant melanoma?
C Isaacs, M Ramsay
South African Medical Journal , 2007,
Abstract: The role of the sun in the aetiology of malignant melanoma is controversial. In 1992 Schuster1 wrote provocatively, ‘Despite the lack of evidence of a causal link between sun exposure and melanoma, fear has been used shamelessly to frighten people out of the sun and into pigmented lesion clinics.' He claimed that the main reason for the supposed increase in incidence of melanoma was that many lesions, previously regarded as benign, were being classified as malignant, and that melanomas were being invented not found. South African Medical Journal Vol. 97 (8) 2007: pp. 568-571
Implementing a structured triage system at a community health centre using Kaizen
AA Isaacs, DA Hellenberg
South African Family Practice , 2009,
Abstract: Background: More than 100 unbooked patients present daily to the Mitchell’s Plain Community Health Centre (MPCHC), and are triaged by a doctor, with the assistance of a staff nurse. The quality of the triage assessments has been found to be variable, with patients often being deferred without their vital signs being recorded. This leads to frustration, and a resultant increased workload for doctors; management is concerned with the medicolegal risk of deferring patients who have not been triaged in accordance with the guidelines; and patients are unhappy with the quality of service they receive. Aim: We set out to standardise the triage process and to manage unbooked patients presenting to the community health centre (CHC) in a manner that is medico-legally safe, cost efficient and patient friendly, using the Kaizen method. Methods: The principles of Kaizen were used to observe and identify inefficiencies in the existing triage process at the MPCHC. Findings were analysed and interventions introduced to improve outcomes. The new processes were, in turn, validated and standardised. Results: The majority of patients presenting to Triage were those needing reissuing of prescriptions for their chronic medication, and this prevented practitioners from timeously attending to other patients waiting to be seen. Reorganising of the process was needed; it was necessary to separate the patients needing triage from those requiring only prescriptions to be reissued. After the intervention, triage was performed by a staff nurse only, using the Cape Triage Score (CTS) method. Subsequent to the implementation of interventions, no patients have been deferred, and all patients are now assessed according to a standardised protocol. The reasons for patients requiring reissuing of prescriptions were numerous, and implementing countermeasures to the main causes thereof decreased the number of reissues by 50%. Conclusion: The Kaizen method can be used to improve the triage process for unbooked patients at the MPCHC, thereby improving the quality of services delivered to these patients. As the needs of the various CHCs differ quite widely across the service platform, the model needs to be adapted to suit local conditions.
An unsuccessful resuscitation: The families' and doctors' experiences of the unexpected death of a patient
I Isaacs, RJ Mash
South African Family Practice , 2004,
Abstract: Background: The objective was to elicit families' experience of the death of a family member at the Elsies River Community Health Centre, their feelings towards the staff involved in the resuscitation and their opinions about how things could be improved. The study also elicited the doctors' experiences of communicating with the families of patients who had died in the emergency unit. Methods: This was a qualitative study, using free attitude interviews for family members and focus group discussions for doctors. Twelve family members whose loved ones had died in the emergency room and 15 doctors who worked in the emergency room were included. Results: Key themes were identified, relating to issues in the pre-resuscitation period, the resuscitation, breaking the bad news, after breaking the bad news and post-event sequelae. In the pre-resuscitation period, there were problems in admitting, identifying and responding to acutely ill patients. During the resuscitation, the families and staff disagreed about witnessing the resuscitation. Breaking the bad news was often difficult for the doctors and hindered by the physical environment. Afterwards, there were mixed feelings about the quality of emotional support, the use of medication and bereavement counselling. All agreed that viewing the body was helpful and funeral arrangements were not a problem. There was no effective follow-up of the families and the doctors also experienced increased stress following unsuccessful resuscitations. Conclusion: The study found that the role of security staff should be clarified and a better triage system established to enable critically ill patients to be seen promptly. Families should be given the option of viewing the resuscitation and always be kept informed of progress. Doctors need better training in communication skills and breaking bad news, which should be done in a private area. Families should also be given the opportunity to view the body. Families should be assisted with contacting the undertaker and a follow-up visit should be organised after the initial shock, when further questions can be asked and abnormal grief reactions identified. Bereavement counselling should be available and community-based resources should be identified in this regard. Debriefing should also be available for staff involved in unsuccessful resuscitations. SA Fam Pract 2004;46(8): 20-25
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