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Search Results: 1 - 10 of 385406 matches for " ANA L.; DE LA FUENTE ARZOLA "
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Pesquisaje de anticuerpos contra el virus linfotrópico de células T humanas tipo I (HTLV-I) en donantes de sangre y grupos de riesgo
Revista Cubana de Medicina Tropical , 1997,
Abstract: Se estudió la presencia de anticuerpos contra el virus linfotrópico de células T humanas tipo I (HTLV I) en 3 774 sueros; de ellos, 1 409 eran de donantes de sangre, 1 444 de pacientes que habían padecido recientemente alguna enfermedad de transmisión sexual (ETS) y 921 de enfermos politransfundidos. Se emplearon los sistemas DAVIH HTLV I (ELISA) y DAVIH BLOT HTLV I (Western Blot) producidos en Laboratorios DAVIH (La Habana, Cuba), para el pesquisaje y confirmación, respectivamente. De los 68 sueros reactivos en la prueba de ELISA, en 2 se confirmó la presencia de anticuerpos al HTLV I/II y 12 fueron considerados indeterminados por el Western Blot. It was studied the presence of HTLV-I antibodies in 3 774 sera, 1 409 of them were from blood donors, 1 444 were from patients who had suffered from some sexually transmitted disease recently, and 921 from transfused patients. The DAVIH HTLV I (ELISA) and DAVIH BLOT HTLV I (Western Blot) systems produced at the DAVIH Laboratories (Havana, Cuba) were used for screening and confirmation, respectively. Of the 68 reactive sera utilized in the ELISA test, it was confirmed the presence of HTLV I/II antibodies in 2, whereas 12 were considered as undetermined by the Western Blot.
Pesquisaje de anticuerpos contra el virus linfotrópico de células T humanas tipo I (HTLV-I) en donantes de sangre y grupos de riesgo
Revista Cubana de Medicina Tropical , 1997,
Abstract: it was studied the presence of htlv-i antibodies in 3 774 sera, 1 409 of them were from blood donors, 1 444 were from patients who had suffered from some sexually transmitted disease recently, and 921 from transfused patients. the davih htlv i (elisa) and davih blot htlv i (western blot) systems produced at the davih laboratories (havana, cuba) were used for screening and confirmation, respectively. of the 68 reactive sera utilized in the elisa test, it was confirmed the presence of htlv i/ii antibodies in 2, whereas 12 were considered as undetermined by the western blot.
Seroprevalencia de la infección por HTLV-1 en diferentes grupos de riesgo estudiados en Cuba
Lubián Caballero,Ana Luisa; Díaz Torres,Héctor Manuel; Silva Cabrera,Eladio; Pérez Guevara,María Teresa; Cruz Sui,Otto; de la Fuente Arzola,José Luis; Navea Leyva,Leonor; Noa Romero,Enrique;
Revista Cubana de Medicina , 1998,
Abstract: in the period between 1991 and 1996, 26 352 serum samples from different risk groups and blood donors, were studied to know the seroprevalence of antibodies against the human t-lymphotropic virus type i (htlv-i), and also as a continuation of researches carried out between 1989 and 1990. the elisa davih-htlv-i system was used for the antibodies investigation, and as a certifying test, the western blot davih-blot htlv-i was used too, both from the cuban davih laboratories. the presence of anti htlv-i antibodies was confirmed in 10 persons, and in most of them the epidemiologic study could elucidate the probable way of contagion. the seropositivity index observed was of 0,037 %, and is low if compared with the seroprevalence rates reported for the caribbean area.
Some considerations about the ecology of Triatominae
Noireau, Fran?ois;Carbajal-de-la-Fuente, Ana L.;Lopes, Catarina M.;Diotaiuti, Lileia;
Anais da Academia Brasileira de Ciências , 2005, DOI: 10.1590/S0001-37652005000300006
Abstract: observations on the ecology of silvatic triatominae are still fragmentary, principally because target species in control process are almost exclusively domestic. report of silvatic species invading human dwellings must lead research to be focused on their original ecology, in order to assist in understanding their process of domestication and devising strategies for surveillance.
Basic and instrumented life support intervention protocol in an adult patient in accordance to new ERC 2005 recommendations
Guillermo Arturo Ca?adas de la Fuente,Ana Belén López Bueno,Carolina Fernández Lao,Elena María Martín López
NURE Investigación , 2009,
Abstract: In this study we make a brief account of the last valid recommendations related to basic life support in 2005. They are the result of the study and the analysis by International Liaison Committee On Resuscitation (ILCOR) and the American Hearth Association (AHA).Like the European Resuscitation Council (ERC) did before, they adopted new rules published on international framework with his inherent changes. On the whole, they has not developed so much, nearly all of them were aimed to improve the efficiency on several skill that take part of the process. In this way, some changes has been justified as a result of obtained data on the study and previous normative test, therefore their modification had scientific evidence.Both, adopted modifications and protocol, are described in order to exemplify all health personnel and other professionals. Like a common aim these changes try to unify criteria to make a universal protocol, independent from professional category and people who applies basic or instrumented CPR.So, new guides try to simplify different techniques and to improve those improvable aspects, at the same time that support better multidisciplinary teams integration in a new algorithm just as we describe on the study.
Síndrome de Lynch: Caracterización genético clínica. Caso clínico
Zárate,Alejandro; álvarez,Karin; Wielandt,Ana María; Hevia,Montserrat; De la Fuente,Marjorie; Carvallo,Pilar; López-K?stner,Francisco;
Revista médica de Chile , 2008, DOI: 10.4067/S0034-98872008000600011
Abstract: hereditary non-polyposis colorectal cancer (hnpcc) or lynch syndrome is an autosomic dominant syndrome involving 596-1096 of colorectal cancer patients. mutations in mlh1 and msh2 genes account for most cases. these two genes particípate in the dna mismatch repair pathway. therefore mutation carriers show microsatellite instability (msi) in tumors. this syndrome is characterized by the early development of colorectal cancer (before 50 years) and an increased incidence of cancer in other organs. we report four siblings from a family diagnosed with hnpcc. all of them were subjected to colonic surgery for colorectal cancer moreover, one patient developed an ampulloma after her colon surgery. the molecular-genetic analysis revealed three brothers with microsatellite instability in the tumor tissue, the absence of the mlh1 protein, and the presence of a germ une mutation localized in introm 15 ofthe mlh1 gene
Regeneración de un "aulagar" con Ulex europaeus después de un incendio en el norte de Espa a
Vera de la Fuente, M. L.
Pirineos : Revista de Ecología de Monta?a , 1994,
Abstract: The recuperation of a shrubland characterized by the presence of Genista hispánica ssp. occidentalis, Ulex europaeus and Erica vagans after of a fire, near Oviedo (North Spain) is studied. The regeneration strategy of Erica vagans was by means of vegetative regrowth. The recolonization of Ulex europaeus and Genista hispánica ssp. occidentalis was both vegetative and from seed, although in the last species the establishment by seedlings was very infrequent. The post-fire vegetation development was affected by floristic composition of shrubland previous to the fire. [es] Se estudia la recuperación de un matorral caracterizado por la presencia de Genista hispánica ssp. occidentalis, Ulex europaeus y Erica vagans después de un incendio, en las proximidades de Oviedo. La estrategia regenerativa de Erica vagans es mediante rebrote vegetativo, mientras Ulex europaeus y Genista hispánica ssp. occidentalis tienen capacidad de regenerarse por rebrote vegetativo y por semilla, aunque en este último taxon, el mecanismo de regeneración a través de plántulas fue muy escaso. El desarrollo de la vegetación está muy marcado por la composición florística previa al fuego. [fr] On à étudié la récupération de broussailles caractérisées par la présence de Genista hispánica ssp. occidentalis, Ulex europaeus et Erica vagans, après un incendie prés d’Oviedo (Nord de Espagne). La stratégie de régénération d’Erica vagans se fait moyennant des pousses végétatives, tandis que la régénération d’Ulex europaeus et Genista hispánica ssp. occidentalis s'esf faite par pousses végétatives et par graines, bien que pour ce dernier taxon, le mécanisme de régénération au travers de plantules a été très rare. Le développement de la végétation est très marqué par la composition floristique existante durant l'incendie.
The Evolution of Primordial Binary Open Star Clusters: Mergers, Shredded Secondaries and Separated Twins
Raúl de la Fuente Marcos,Carlos de la Fuente Marcos
Physics , 2010, DOI: 10.1088/0004-637X/719/1/104
Abstract: The basic properties of the candidate binary cluster population in the Magellanic Clouds and Galaxy are similar. The fraction of candidate binary systems is $\sim$10% and the pair separation histogram exhibits a bimodal distribution commonly attributed to their transient nature. However, if primordial pairs cannot survive for long as recognizable bound systems, how are they ending up? Here, we use simulations to confirm that merging, extreme tidal distortion and ionization are possible depending on the initial orbital elements and mass ratio of the pair. The nature of the dominant evolutionary path largely depends on the strength of the local tidal field. Merging is observed for initially close primordial binary clusters but also for wider pairs in nearly parabolic orbits. Its characteristic timescale depends on the initial orbital semi-major axis, eccentricity, and cluster pair mass ratio, becoming shorter for closer, more eccentric equal mass pairs. Shredding or extreme tidal distortion of the less massive cluster and subsequent separation is observed in all pairs with appreciably different masses. Wide pairs steadily evolve into the separated twins state characterized by the presence of tidal bridges and separations of 200-500 pc after one Galactic orbit. In the Galaxy, the vast majority of observed binary candidates appear to be following this evolutionary path which translates into the dominant peak (25-30 pc) in the pair separation distribution. The secondary peak at smaller separations (10-15 pc) can be explained as due to close pairs in almost circular orbits and/or undergoing merging. Merged clusters exhibit both peculiar radial density and velocity dispersion profiles shaped by synchronization and gravogyro instabilities. Both simulations and observations show that, for the range of parameters studied here, long term binary cluster stability in the Galactic disk is unlikely.
Frontostriatal Cognitive Staging in Parkinson's Disease
Raúl de la Fuente-Fernández
Parkinson's Disease , 2012, DOI: 10.1155/2012/561046
Abstract: Cognitive impairment and behavioural disorders are often encountered in subjects with Parkinson's disease (PD). A simple PD-related frontostriatal cognitive dysfunction (PDFCD) staging is proposed. Executive dysfunction and mental fatigue (stage I), depression/anxiety (stage IIa), apathy/pain (stage IIb), and dementia (stage III) reflect a sequential process of dopamine depletion occurring in different regions of the striatum (stages I and II) and the frontal cortex (stage III). In addition to these nonmotor manifestations present in the unmedicated (OFF) state, the PDFCD model also predicts a number of complications related to dopaminergic treatment (ON state), from impulse control disorders (stages I and IIa) to hallucinations (stage IIb) and psychosis (stage III). Although the model admittedly needs further refinements, it provides a framework for hypothesis testing and may help clinicians optimize therapeutic strategies. 1. Introduction Parkinson’s disease (PD) is biochemically characterized by dopamine depletion [1, 2]. Although the loss of dopamine is particularly severe in the putamen, which explains the motor manifestations of the disease, other dopaminergic projections are also affected and contribute to the development of cognitive impairment and neuropsychiatric disorders [3, 4]. Thus, some degree of executive dysfunction is a virtually constant finding in PD, even in the early stages of the disease [5]. Apathy, depression, anxiety, and fatigue are present in one third of patients [6], and pain is also common [7]. Similarly, it has been estimated that approximately one third of PD subjects end up developing dementia [3, 4]. In this review, I will use a simple model to correlate these non-motor manifestations of the disease with different stages of frontostriatal dysfunction caused by dopamine depletion sequentially occurring in different regions of the striatum and the frontal cortex [8–11]. The PD-related frontostriatal cognitive dysfunction (PDFCD) staging here proposed (Figure 1) assumes that dopamine-dependent frontostriatal functioning follows an inverted U-shaped dose-response curve (Figure 2). The PDFCD model is mostly based on neuroimaging data and clinical observations, and offers stage-specific clinical predictions off and on dopaminergic medication. Figure 1: Parkinson’s disease-related frontostriatal cognitive dysfunction (PDFCD) staging. Three major frontostriatal loops are shown: (1) the loop connecting the dorsolateral prefrontal cortex (DLPFC) with the dorsal caudate nucleus (d-Caud), (2) the loop connecting the orbitofrontal
Impact of Neuroprotection on Incidence of Alzheimer's Disease
Raúl de la Fuente-Fernández
PLOS ONE , 2006, DOI: 10.1371/journal.pone.0000052
Abstract: Converging evidence suggests that high levels of education and intellectual activity increase the cognitive reserve and reduce the risk of dementia. However, little is known about the impact that different neuroprotective strategies may have on the incidence of Alzheimer's disease. Using a simple mathematical regression model, it is shown here that age-specific counts of basic cognitive units (surrogate of neurons or synapses) in the normal population can be estimated from Alzheimer's incidence rates. Hence, the model can be used to test the effect of neuroprotection on Alzheimer's incidence. It was found that the number of basic cognitive units decreases with age, but levels off in older people. There were no gender differences after correcting for survival. The model shows that even modest neuroprotective effects on basic cognitive units can lead to dramatic reductions in the number of Alzheimer's cases. Most remarkably, a 5% increase in the cognitive reserve would prevent one third of Alzheimer's cases. These results suggest that public health policies aimed at increasing the cognitive reserve in the general population (e.g., implementing higher levels of education) are likely the most effective strategy for preventing Alzheimer's disease.
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