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quinoline derivatives form (1:1) complexes with nickel chloride, nickel acetate
and copper acetate which were syntheses. The three complexes are non-electrolyte in dimethylsulfoxide (DMF).
The results of electronic and magnetic measurements show that these complexes
are of octahedral structures. The oxygen and nitrogen donate their lone-pair
electrons to metal ion to form chelates with formula [MLRm.nH2O].
The relative stabilities of the complexes have been calculated from TG curve
using Coats-Redfern and Ozawa methods.
Thermal analysis of some antihypertensive drugs,
Telmisartan, Cilazapril and Terazosin HCL was achieved. Thermogravimetry,
derivative thermogravimetry and differential thermal analysis were used through
the work. Thermogravimetric parameters such as activation energy, frequency
factor and reaction order were calculated. The results show the stability value
decrease in the order Telmisartan > Cilazapril > Terazosin. This
method can be used in the quality control of pharmaceutical compounds because it is simple, fast and cheap.