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Search Results: 1 - 10 of 645684 matches for " A.D.T. Goji "
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Effect of Aqueous-Methanolic Stem Bark Extract of Acacia polyacantha on Blood Glucose Levels on Normoglycemic Wistar Rats
A.O. Okpanachi,A.D.T. Goji,I. Ezekiel,K.Y. Musa
International Journal of Animal and Veterinary Advances , 2012,
Abstract: This study was carried out to investigate the blood glucose reducing effect (hypoglycemic effect) of stem bark extract of Acacia polyacantha on normal wistar rats over a 24 h period. Three groups of previously fasted wistar rats, with each group made up of 5 rats each were administered with 100, 200 and 400 mg/kg p.o of aqueous methanolic stem bark extract of A. polyacantha. The hypoglycemic effect of A . polyacantha stem bark aqueous methanolic extract was compared with that of Metformin (250 mg/kg) in fasted normal rats. Following treatment, relatively moderate to high doses of A. polyacantha (100, 200 and 400 mg/kg p.o.) produced a dose-dependent, significant reduction (p<0.05) in blood glucose levels of fasted normal rats. The three doses of the extract did not significantly alter the blood glucose levels after 2 h of extract administration. After 8 and 16 h of extract administration at a dose of 200 mg/kg significantly (p<0.05) decreased the blood glucose levels when compared to control, while the dose of 400 mg/kg significantly decreased the blood glucose levels after 4, 8 and 16 h of extract administration when compared with the control group. The Preliminary phytochemical screening revealed the presence of alkaloids, tannins, flavonoids, triterpenoids, anthraquinones, steroids and saponins. The median lethal dose (LD50) in rats was calculated to be 3807.9 mg/kg body weight. In conclusion the aqueous methanolic extract of Acacia polyacantha possesses hypoglycemic activity in normoglycemic rats.
Evaluation of Some Risk Factors for Atherosclerosis in the Circle of Willis Observed at Autopsy in University Collegehospital, Ibadan, Nigeria
J. Olusakin,A.D.T. Goji,I. Ezekiel,O.O. Oladipo
Asian Journal of Medical Sciences , 2011,
Abstract: There has been a steady change in lifestyle of the Nigerians causing the increase in vulnerability of cerebrovascular disease like atherosclerosis. This study was aimed at evaluating some risk factors for atherosclerosis in the circle of Willis autopsy. The clinical record of patients were retrieved from their case files in order to obtain information on the sex, age, clinical diagnosis, past medical history and presence or absence of cardiovascular risk factors such as cigarette smoking, alcohol intake, diabetes, and hypertension. Samples were obtained from 44 consecutive brains in autopsies conducted on subjects aged 15 years and above at the University College Hospital, Ibadan. With ethical clearance, the subject’s case files were retrieved for some data. Twenty-six (59.1%) of the subjects had no identifiable risk factors for atherosclerosis in their medical history. Eighteen (40.9%) of the subjects had at least one risk factor of atherosclerosis in their history. The risk factors identified were hypertension in 10 (55.6%) cases, hypertension combined with previous alcohol ingestion in 3 (16.7%) cases, hypertension combined with diabetes mellitus in 3 (16.7%) cases, and alcohol ingestion in 2 (11.1%) cases (Thus, a total of 16 (61.5%) patients had hypertension, 6 (33.3%) patients had a history of alcohol ingestion.
Effect of Ethanolic Leaves Extract of Moringa oleifera on Blood Glucose Levels of Streptozocin-Induced Diabetics and Normoglycemic Wistar Rats
J.A. Tende,I. Ezekiel,A.A.U. Dikko,A.D.T. Goji
British Journal of Pharmacology and Toxicology , 2011,
Abstract: This study was undertaken to determine the hypoglycemic effect of Moringa oleifera [family: Moringaceae] ethanolic extract in normal (normoglycemic) and STZ induced diabetic Wistar rats. In one set of experiment, graded doses of the leaves extract (250 and 500 mg/kg i.p.) were separately administered to groups of fasted normal and fasted STZ diabetic rats. The hypoglycemic effect of the ethanolic leaves extract was compared with that of insulin 6 i.u/kg in fasted normal and STZ diabetic rats. Following treatment, relatively moderate to high do ses of Moringa oleifera (250 and 500 mg/kg i.p.) produced a dose-dependent, significant reduction (p<0.05) in blood glucose levels of fasted STZ diabetic rats only. A significant decrease in the blood glucose levels after 1-7 h of administration with the doses of 250 and 500 mg/kg was observed in the STZ diabetic group when compared to control. As regards to the dose of 250 and 500 mg/kg for the fasted normal rats, there was significant increase in the blood glucose levels when compared to control. In conclusion the ethanolic extract of the leaves of Moringa oleifera possesses hypoglycemic activity in STZ induced diabetic Wistar rats only.
Effects of Wood Dust on Cardiopulmonary Functions and Anthropometric Parameters of Carpenters and Non-Carpenters in Sabon Gari Local Government Area, Kaduna State, Nigeria
Y. Tanko,Y. Olakunle, A. Jimoh, A. Mohammed, A.D.T. Goji and K.Y. Musa
Asian Journal of Medical Sciences , 2011,
Abstract: The aim of the study is to assess the blood pressure, pulse rate, peak expiratory flow rate, Forced Expiratory Volume in 1 sec (FEV1), and Forced Vital Capacity (FVC) of carpenters and non-carpenters in Sabon- Gari local government area, Zaria. Their Body Mass Index (BMI) and other anthropometric data were also obtained. 200 males between the ages of 18 and 35 were used for this research. 100 were carpenters and 100 were non carpenters. As regard to the pulse rate there was no significant change in the carpenters when compared with the non-carpenters. In relation to the systolic, diastolic and mean arterial blood pressure, there was a significant increase (p<0.05) in the carpenters when compared with the non-carpenters. Regarding the Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 sec (FEVI), (FEV1%), and peak expiratory flow rate, there was a significant decrease (p<0.05) in the carpenters when compared with the non-carpenters. Also, in the anthropometric parameters measured (height, weight, and BMI) there was no significant change in the carpenters when compared with the non-carpenters. In conclusion, the effect of wood dust on carpenters increases the arterial blood pressure, decreases the forced vital capacity, forced expiratory volume in 1 sec and peak expiratory flow rate.
Effects of Aqueous Extract of Anacardium occidentale (Cashew) Leaf on Pregnancy Outcome of Wistar Rats
S.S. Dare,W.O. Hamman, S. Musa, A.D.T. Goji, A.A. Oyewale, S. Abba and I. Ezekiel
International Journal of Animal and Veterinary Advances , 2011,
Abstract: Anacardium occidentale (cashew) leaf extract is used medicinally to treat various kinds of diseases such as diabetes, fever, bronchitis etc, in different parts of the world including Nigeria. This study investigates the effect of A. occidentale leaf extract on reproductive outcome of Wistar rats. Twenty female wistar rats were divided into 4 groups (I, II, III, and IV), n = 5 in each group. Group I is the control while groups II, III and IV are experimental groups. 300 mg/kg of aqueous leaf extract of A. occidentale was administered orally to group II, III and IV during early (days 1-7) mid- (days 7-14) and late (days 14-21) pregnancy respectively. The leaf extract significantly (p<0.05) shows low birthweight on the pupsborn in early and mid pregnancy but high birthweight in late pregnancy: (Control vs treatment; early pregnancy, 7.220±0.030 vs 5.753±0.166 g; mid pregnancy, 7.220±0.030 g vs 5.431±0.149 g; late pregnancy, 7.220±0.030 vs 7.60±0.00 g), Crown-rump length (control vs treatment: early pregnancy, 6.450±0.050 vs 5.875±0.139 g; mid pregnancy, 6.450±0.050 vs 5.713±0.064 g; late pregnancy, 6.450±0.050 vs 6.50±0.00 g), Head Circumference, (control vs treatment: early pregnancy, 1.150±0.05 vs 1.225±0.016 g; mid pregnancy, 1.150±0.05 vs 1.138±0.026 g; late pregnancy, 1.150±0.05 vs 1.30±0.00 g). Life birth index is unaltered. Quantal pregnancy (%) in groups I, II, III and IV is 75, 80, 80 and 75, respectively. Litter size in group I, II, III and IV is 2, 8, 8 and 1, respectively. Gestation length is unaltered. The leaf extract was non teratogenic. In conclusion, the leaf extract of A. occidentale administered revealed low birthweight, crown-rump length in early and mid pregnancy but increased birthweight and crown-rump length in late pregnancy.
Preliminary Evaluation of Anti-Diarrheal, Ulcer-Protective and Acute Toxicity of Aqueous Ethanolic Stem Bark Extract of Ficus trichopoda in Experimental Rodents
S.O. Balogun,J.K. Tanayen, A.M. Ajayi, A. Ibrahim, J.O.C. Ezeonwumelu, A.A. Oyewale, O.J. Oloro, A.D.T. Goji, D.M. Kiplagat and B. Adzu
Asian Journal of Medical Sciences , 2011,
Abstract: Ficus trichopoda, Baker, is a medicinal plant belonging to the Moraceae family used popularly as a ‘multi-purpose’ herb in Uganda. The aim of this study was to evaluate the anti-diarrheal, ulcer protective effects of 70% ethanolic extract of Ficus trichopoda stem bark (FTE) and its acute toxicity. The anti-diarrheal effect was evaluated using castor-oil induced diarrhea model while anti-ulcer effect was evaluated using ethanol-induced ulcer model using rats. Loperamide and misoprostol were used as standard drugs for diarrhea and ulcer studies respectively. The extract was administered orally at three different doses of 125, 250 and 500 mg/kg. Acute toxicity was evaluated by oral administration of the extract at 1000, 2000 and 4000 mg/kg body weight in mice. The extract exhibited a graded dose-dependent inhibition of the castor oil induced diarrhea. The onset-time and severity of diarrhea was significantly reduced (p<0.05). Anti-diarrhea activity exerted was significant at 250 mg/kg (66.67% inhibition) and maximal at 500 mg/kg (88.89% inhibition). The inhibition at 500 mg/kg compared well with the standard drug, Loperamide which produced 100% inhibition of diarrhea in rats. Also, oral administration of FTE produces a dose-dependent inhibition of ethanol-induced gastric ulcer with maximal effect at 500 mg/kg (49.05%). The oral LD50 value obtained was >4000 mg/kg in mice. Preliminary phytochemical screenings indicated the presence of reducing sugar, alkaloids, saponnins, pyrocathecolic tannins and free amino acids/amines. This study confirmed the antidiarrheal properties of this plant as it is used in traditional medicine.
Important amino acid residues of potato plant uncoupling protein (StUCP)
Jezek, P.;Costa, A.D.T.;Vercesi, A.E.;
Brazilian Journal of Medical and Biological Research , 2000, DOI: 10.1590/S0100-879X2000001200003
Abstract: chemical modifications were used to identify some of the functionally important amino acid residues of the potato plant uncoupling protein (stucp). the proton-dependent swelling of potato mitochondria in k+-acetate in the presence of linoleic acid and valinomycin was inhibited by mersalyl (ki = 5 μm) and other hydrophilic sh reagents such as thiolyte mb, iodoacetate and 5,5'-dithio-bis-(2-nitrobenzoate), but not by hydrophobic n-ethylmaleimide. this pattern of inhibition by sh reagents was similar to that of brown adipose tissue uncoupling protein (ucp1). as with ucp1, the arginine reagent 2,3-butadione, but not n-ethylmaleimide or other hydrophobic sh reagents, prevented the inhibition of stucp-mediated transport by atp in isolated potato mitochondria or with reconstituted stucp. the results indicate that the most reactive amino acid residues in ucp1 and stucp are similar, with the exception of n-ethylmaleimide-reactive cysteines in the purine nucleotide-binding site.
Important amino acid residues of potato plant uncoupling protein (StUCP)
Jezek P.,Costa A.D.T.,Vercesi A.E.
Brazilian Journal of Medical and Biological Research , 2000,
Abstract: Chemical modifications were used to identify some of the functionally important amino acid residues of the potato plant uncoupling protein (StUCP). The proton-dependent swelling of potato mitochondria in K+-acetate in the presence of linoleic acid and valinomycin was inhibited by mersalyl (Ki = 5 μM) and other hydrophilic SH reagents such as Thiolyte MB, iodoacetate and 5,5'-dithio-bis-(2-nitrobenzoate), but not by hydrophobic N-ethylmaleimide. This pattern of inhibition by SH reagents was similar to that of brown adipose tissue uncoupling protein (UCP1). As with UCP1, the arginine reagent 2,3-butadione, but not N-ethylmaleimide or other hydrophobic SH reagents, prevented the inhibition of StUCP-mediated transport by ATP in isolated potato mitochondria or with reconstituted StUCP. The results indicate that the most reactive amino acid residues in UCP1 and StUCP are similar, with the exception of N-ethylmaleimide-reactive cysteines in the purine nucleotide-binding site.
Cosmic rays and global warming
Erlykin A.D.,Sloan T.,Wolfendale A.W.
Europhysics News , 2010, DOI: 10.1051/epn/2010104
Abstract:
Computer Simulation of Temperature Profiles for E-beam Modification of Ni- Based Plasma Detonation Coatings
Alontseva D.L.,Krasavin A.L.,Kolesnikova T.A.,Pogrebnjak A.D.
Proceedings of the International Conference Nanomaterials : Applications and Properties , 2012,
Abstract: The paper presents the calculation of the distribution of the temperature profile in two-layer metallic materials under direct current low-energy electron beam irradiation and proposes explicit parameters of the electron beam for modification of thick (150-300 microns) plasma detonation Ni-based coatings by irradiation. Ni-based coatings deposited onto steel substrates were interpreted as a Ni-Fe two-layer sample irradiated on the coating side. The numerical simulation methods were used for solving the heat equation. The model takes into account the electron beam travelling, dependence of heat conductivity and specific thermal capacity coefficients on the temperature and heat loss for emission from the surface. The design modes were used to carry out the modification by e-beam.
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