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Search Results: 1 - 10 of 677270 matches for " A.; Sánchez-Moreno "
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Cuando una Constitución es una Constitución: el caso peruano
María McFarland Sánchez-Moreno
Pensamiento Constitucional , 2002,
Abstract: No presenta resumen.
Information-theoretic-based spreading measures of orthogonal polynomials
Jesus S. Dehesa,A. Guerrero,Pablo Sánchez-Moreno
Physics , 2013, DOI: 10.1007/s11785-011-0136-3
Abstract: The macroscopic properties of a quantum system strongly depend on the spreading of the physical eigenfunctions (wavefunctions) of its Hamiltonian operador over its confined domain. The wavefunctions are often controlled by classical or hypergeometric-type orthogonal polynomials (Hermite, Laguerre and Jacobi). Here we discuss the spreading of these polynomials over its orthogonality interval by means of various information-theoretic quantities which grasp some facets of the polynomial distribution not yet analyzed. We consider the information-theoretic lengths closely related to the Fisher information and R\'enyi and Shannon entropies, which quantify the polynomial spreading far beyond the celebrated standard deviation.
Complexity analysis of hypergeometric orthogonal polynomials
J. S. Dehesa,A. Guerrero,P. Sánchez-Moreno
Physics , 2014, DOI: 10.1016/j.cam.2014.08.013
Abstract: The complexity measures of the Cr\'amer-Rao, Fisher-Shannon and LMC (L\'opez-Ruiz, Mancini and Calvet) types of the Rakhmanov probability density $\rho_n(x)=\omega(x) p_n^2(x)$ of the polynomials $p_n(x)$ orthogonal with respect to the weight function $\omega(x)$, $x\in (a,b)$, are used to quantify various two-fold facets of the spreading of the Hermite, Laguerre and Jacobi systems all over their corresponding orthogonality intervals in both analytical and computational ways. Their explicit (Cr\'amer-Rao) and asymptotical (Fisher-Shannon, LMC) values are given for the three systems of orthogonal polynomials. Then, these complexity-type mathematical quantities are numerically examined in terms of the polynomial's degree $n$ and the parameters which characterize the weight function. Finally, several open problems about the generalised hypergeometric functions of Lauricella and Srivastava-Daoust types, as well as on the asymptotics of weighted $L_q$-norms of Laguerre and Jacobi polynomials are pointed out.
Jensen divergence based on Fisher's information
P. Sánchez-Moreno,A. Zarzo,J. S. Dehesa
Mathematics , 2010, DOI: 10.1088/1751-8113/45/12/125305
Abstract: The measure of Jensen-Fisher divergence between probability distributions is introduced and its theoretical grounds set up. This quantity, in contrast to the remaining Jensen divergences, is very sensitive to the fluctuations of the probability distributions because it is controlled by the (local) Fisher information, which is a gradient functional of the distribution. So, it is appropriate and informative when studying the similarity of distributions, mainly for those having oscillatory character. The new Jensen-Fisher divergence shares with the Jensen-Shannon divergence the following properties: non-negativity, additivity when applied to an arbitrary number of probability densities, symmetry under exchange of these densities, vanishing if and only if all the densities are equal, and definiteness even when these densities present non-common zeros. Moreover, the Jensen-Fisher divergence is shown to be expressed in terms of the relative Fisher information as the Jensen-Shannon divergence does in terms of the Kullback-Leibler or relative Shannon entropy. Finally the Jensen-Shannon and Jensen-Fisher divergences are compared for the following three large, non-trivial and qualitatively different families of probability distributions: the sinusoidal, generalized gamma-like and Rakhmanov-Hermite distributions.
The impact of the number of episodes on the outcome of Bipolar Disorder
Marzo,S. Di; Giordano,A.; Pacchiarotti,I.; Colom,F.; Sánchez-Moreno,J.; Vieta,E.;
The European Journal of Psychiatry , 2006, DOI: 10.4321/S0213-61632006000100003
Abstract: background: bipolar disorder is a highly recurrent severe psychiatric disorder. the number of episodes has been found consistently associated with poor outcome. it has been suggested that bipolar patients with long duration of illness and highly recurrent course show great impairment of global functioning. objectives the aim of this study is to assess the clinical course and outcome of patients with bipolar disorder i and ii with a high number of mood episodes. methods: we compared a group of bipolar i and ii subjects whose number of episode was higher than ten (n = 167) with a similar-size representative sample of bipolar patients whose number of episodes was lower or equal than ten (n = 131). results: bipolar patients with more than 10 episodes have a more severe outcome of bipolar disorder. qualification and occupational status was clearly worse for the highly recurrent group which showed a predominance of depressive polarity. conclusions: these data suggest that bipolar patients with a highly recurrent course have significant functional impairment. with the passing of time, bipolar illness tends to be ruled by depressive features. treatment strategies may need to address this issue.
Quantum Entanglement in $(d-1)$-Spherium
I. V. Toranzo,A. R. Plastino,P. Sánchez-Moreno,J. S. Dehesa
Mathematics , 2015,
Abstract: There are very few systems of interacting particles (with continuous variables) for which the entanglement of the concomitant eigenfunctions can be computed in an exact, analytical way. Here we present analytical calculations of the amount of entanglement exhibited by $s$-states of \emph{spherium}. This is a system of two particles (electrons) interacting via a Coulomb potential and confined to a $(d-1)$-sphere (that is, to the surface of a $d$-dimensional ball). We investigate the dependence of entanglement on the radius $R$ of the system, on the spatial dimensionality $d$, and on energy. We find that entanglement increases monotonically with $R$, decreases with $d$, and also tends to increase with the energy of the eigenstates. These trends are discussed and compared with those observed in other two-electron atomic-like models where entanglement has been investigated.
Novel Drug Delivery System Based on Docetaxel-Loaded Nanocapsules as a Therapeutic Strategy Against Breast Cancer Cells
Paola Sánchez-Moreno,Houria Boulaiz,Juan Luis Ortega-Vinuesa,José Manuel Peula-García,Antonia Aránega
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13044906
Abstract: In the field of cancer therapy, lipid nanocapsules based on a core-shell structure are promising vehicles for the delivery of hydrophobic drugs such as docetaxel. The main aim of this work was to evaluate whether docetaxel-loaded lipid nanocapsules improved the anti-tumor effect of free docetaxel in breast cancer cells. Three docetaxel-loaded lipid nanocapsules were synthesized by solvent displacement method. Cytotoxic assays were evaluated in breast carcinoma (MCF-7) cells treated by the sulforhodamine B colorimetric method. Cell cycle was studied by flow cytometry and Annexin V-FITC, and apoptosis was evaluated by using propidium iodide assays. The anti-proliferative effect of docetaxel appeared much earlier when the drug was encapsulated in lipid nanoparticles than when it was free. Docetaxel-loaded lipid nanocapsules significantly enhanced the decrease in IC 50 rate, and the treated cells evidenced apoptosis and a premature progression of the cell cycle from G(1) to G(2)-M phase. The chemotherapeutic effect of free docetaxel on breast cancer cells is improved by its encapsulation in lipid nanocapsules. This approach has the potential to overcome some major limitations of conventional chemotherapy and may be a promising strategy for future applications in breast cancer therapy.
Violencia contra periodistas e impunidad
José Ugaz Sánchez-Moreno
Derecho PUCP , 2008,
Abstract: No contiene resumen
In vitro evaluation of new terpenoid derivatives against Leishmania infantum and Leishmania braziliensis
Ramírez-Macías, Inmaculada;Marín, Clotilde;Chahboun, Rachid;Olmo, Francisco;Messouri, Ibtisam;Huertas, Oscar;Rosales, María Jose;Gutierrez-Sánchez, Ramón;Alvarez-Manzaneda, Enrique;Sánchez-Moreno, Manuel;
Memórias do Instituto Oswaldo Cruz , 2012, DOI: 10.1590/S0074-02762012000300012
Abstract: the activity of five (1-5) abietane phenol derivatives against leishmania infantum and leishmania braziliensis was studied using promastigotes and axenic and intracellular amastigotes. infectivity and cytotoxicity tests were performed with j774.2 macrophage cells using glucantime as a reference drug. the mechanisms of action were analysed by performing metabolite excretion and transmission electron microscopy ultrastructural studies. compounds 1-5 were more active and less toxic than glucantime. the infection rates and mean number of parasites per cell observed in amastigote experiments showed that derivatives 2, 4 and 5 were the most effective against both l. infantum and l. braziliensis. the ultrastructural changes observed in the treated promastigote forms confirmed that the greatest cell damage was caused by the most active compound (4). only compound 5 caused changes in the nature and amounts of catabolites excreted by the parasites, as measured by 1h nuclear magnetic resonance spectroscopy. all of the assayed compounds were active against the two leishmania species in vitro and were less toxic in mammalian cells than the reference drug.
Motor speed predicts stability of cognitive deficits in both schizophrenic and bipolar I patients at one-year follow-up
Salazar-Fraile,J.; Balanzá-Martínez,V.; Selva-Vera,G.; Martínez-Aran,A.; Sánchez-Moreno,J.; Rubio,C.; Vieta,E.; Gómez-Beneyto,M.; Tabarés-Seisdedos,R.;
The European Journal of Psychiatry , 2009, DOI: 10.4321/S0213-61632009000300007
Abstract: background: we examined whether motor speed assessed by the finger tapping test predicts generalized and specific stable deficits because of a common pathogenic process in bipolar and schizophrenic patients. methods: one hundred and two patients underwent a battery of neuropsychological tests. patients with a score of less than one standard deviation from their siblings', sample in two assessments with an interval of one year were defined as suffering from stable deficits because of a common pathogenic process. in addition to univariate analyses, factor analyses, ordinal logistic regression, and multiple linear regressions were used. a general score was also calculated. results: no differences were found between schizophrenic and bipolar patients in the deficits of verbal fluency, shift reasoning ability and executive attention. schizophrenic patients had greater persistent cognitive deficit because of a common pathogenic factor in the verbal memory dimension than bipolar patients. motor speed predicted the specific deficits of verbal fluency, shift reasoning, executive attention and the general deficit of both bipolar i and schizophrenic patients. bipolar patients suffered a lesser specific deficit in the verbal memory dimension than schizophrenic patients did, this domain not being predicted by motor speed. motor speed predicted the generalized deficit and the specific dimensions in which schizophrenic and bipolar patients showed no differences. conclusions: these results suggest the presence of general and specific stable cognitive deficits because of a common pathogenic factor related to psychomotor slowness. motor speed seems to be suitable endophenocognitype for schizophrenia and bipolar disorder.
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