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Search Results: 1 - 10 of 461751 matches for " A. Renshaw "
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Interpersonal Angular Relations between Players Constrain Decision-Making on the Passing Velocity in Futsal  [PDF]
Umberto Cesar Corrêa, Luis Vilar, Keith Davids, Ian Renshaw
Advances in Physical Education (APE) , 2014, DOI: 10.4236/ape.2014.42013
Abstract:

The aim of this study was to investigate the influence of interpersonal interactions between players on the regulation of ball passing velocity in the team sport of futsal. For this purpose 28 sequences of play, in which passes were performed between outfield players, were selected from an elite futsal competition and analyzed using TACTO software. Relative angles between attackers and defenders were used to examine interpersonal coordination tendencies that emerged during performance. Results showed that ball passing velocity was constrained by the rate of change of the angle created by the following vectors: “ball carrier-ball receiver” and “ball carrier-ball receiver’s nearest defender”. Passing velocity remained the same when that angular value remained within a critical threshold range between ?18.16°/s to 11.26°/s. Beyond those critical threshold values, angular relations between participants seemed to enter into a new critical state requiring the emergence of a new passing velocity for performance success. The findings of this study allowed us to conclude that passing velocity during competitive performance in futsal was regulated by the rate of change of an angle established by the interaction between the ball carrier to ball receiver vector with the ball carrier to ball receiver’s nearest defender vector.

Zebrafish models of the immune response: taking it on the ChIn
Stephen A Renshaw, Philip W Ingham
BMC Biology , 2010, DOI: 10.1186/1741-7007-8-148
Abstract: The rise of multicellular animals, to what we might consider the pinnacle of human culture, relies on their ability to defend themselves against unicellular organisms competing for the same environmental resources. To aid in the constant battle waged with would-be pathogens, powerful and complex immune structures have developed, built on a series of molecular and cellular advances made by evolution hundreds of millions of years ago. Over the past century, an increasing understanding of the immune system, together with advances in public health and antimicrobial chemotherapy, have had a huge impact in preventing infectious disease and extending human lifespan. In recent decades, however, the emergence of multi-drug-resistant bacteria and the inexorable rise in inflammatory diseases threaten to undermine these improvements in health: the need for a detailed understanding of the immune system has never been more pressing. In BMC Biology, d'Alen?on and colleagues [1] report a novel method for high-throughput in vivo analysis of immune-cell function that offers new and exciting prospects for our understanding of the immune system, as well as for the discovery of new drugs with which to manipulate it.Our understanding of innate immunity began with the observations of Elie Metchnikoff, who in 1882 pricked a starfish larva with a thorn from his garden. The insult provided an immune stimulus comprising both infection and tissue injury, prompting the recruitment of cells that attempted to ingest the thorn. The transparency of the starfish larva allowed Metchnikoff to observe the remarkable behavior of these cells, which we now know as phagocytes, thus founding the science of cellular immunology.A hundred and fifty years later, the model organism has changed, but the principles remain the same. In a recent paper in Cell, Tobin and colleagues [2] followed Metchnikoff's lead and injected transparent zebrafish larvae with the bacterium Mycobacterium marinum to identify mutants wi
Does the radiofrequency impedance-controlled endometrial ablation have any morphologic effects on uterine leiomyomata?: Report of 3 cases
Oluwole Fadare, Sa A Wang, Idris L Renshaw
Diagnostic Pathology , 2008, DOI: 10.1186/1746-1596-3-28
Abstract: Endometrial ablation entails the destruction of the endometrial lining by one of several energy forms that is delivered through a hysteroscope-like or similar instrument. Some of the available endometrial ablation technologies include The NovaSure? system [Hologic (Cytyc) Corporation, Marlborough, MA, USA, which ablates the endometrial surface via radiofrequency energy], the ThermaChoice UBT (Gynecare Inc, Somerville, NJ, USA) and Cavaterm (Wallsten Medical, Morges, Switzerland) systems (which deliver thermal energy from heated fluid in a balloon), the HerOption system [American Medical Systems Inc, Minnetonka, MN, USA, which is based on freezing the endometrium surface], the HTA system [BEI Medical/Boston Scientific, Natick, MA, USA, which is based on the use of heated saline], and the Microsulis system [Microsulis Medical Ltd, Pampano Beach, FL, USA, which is based on microwave energy].As noted previously, NovaSure? is one of several second-generation endometrial ablation systems and has been used with increasing frequency over the past decade. The NovaSure? system received approval from the United States Food and Drug Administration (FDA) in 2001 for the permanent ablation of the endometrial lining of women with menorrhagia that can be attributed to non-neoplastic causes [1,2]. The endometrial ablative power is derived from radiofrequency energy. Briefly, a conformable bipolar electrode array that is mounted on an expandable frame is transcervically inserted into the endometrial cavity. The array expands to form a confluent lesion on the entire internal surface of the endometrium. Radiofrequency energy is then transmitted for a period of approximately 90 seconds, and the endometrium and the superficial myometrium are thereby ablated. Increasing tissue depth of ablation causes an automatic cessation of power-delivery at a threshold of 50 ohms or at 120 seconds, and the maximum power requirements are predetermined [1,2] Recently, we encountered a distinctive uterus
Trends in the incidence and survival of multiple myeloma in South East England 1985-2004
Christine Renshaw, Nicolas Ketley, Henrik M?ller, Elizabeth A Davies
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-74
Abstract: Data on 15,010 patients diagnosed with multiple myeloma between 1985 and 2004 was extracted from the Thames Cancer Registry database. We calculated the yearly age-standardised incidence rates for males and females and age-specific incidence rates in 10-year age groups for both sexes combined. We also explored geographical variation in incidence across primary care trusts. We then used period analysis to calculate trends in 1- and 5-year relative survival over the 15 years 1990-2004, comparing survival by sex and by age group 59 years and below versus 60 years and above. Finally, we investigated 5-year relative survival for the period 2000-2004 by socio-economic deprivation, assigning patients to quintiles of deprivation using the Income Domain of the Index of Multiple Deprivation 2004 based on postcode of residence.The incidence of multiple myeloma was higher in males than in females and in patients over 70, throughout the period 1985-2004. No obvious geographical pattern of incidence by primary care trust emerged. The 1- and 5-year relative survival of male and female patients increased in both age groups and was statistically significant in males aged over 60. There was a tendency for better survival in patients resident in the most affluent areas, but this did not reach statistical significance.The trends in incidence of multiple myeloma in males and females are similar to that reported from other western populations. Relative survival was higher for younger patients although we found significant improvements in 1-year relative survival for male patients over 60 years old. The improved survival demonstrated for patients of all ages is likely to reflect increased detection, earlier diagnosis and the introduction of new treatments. Future studies should investigate the influence of ethnicity on incidence and survival, and the effect of specific treatments on survival and quality of life.Multiple myeloma is the second most common haematological cancer accounting for
"A eficácia simbólica" revisitada: cantos de cura ayoreo
Renshaw, John;
Revista de Antropologia , 2006, DOI: 10.1590/S0034-77012006000100012
Abstract: the aim of this paper is to consider a specific field of amerindian knowledge, namely the sarode or curing songs of the ayoreo of the gran chaco, and to try to elucidate some of the taken-for-granted metaphysical assumptions that underlie ayoreo epistemology. following the approach taken in joanna overing's introduction to reason and morality (1985), i will suggest that even these apparently simple, repetitive curing songs have to be understood as part of a broader corpus of "mythical" knowledge and acquire their effectiveness or power, not through suggestion or metaphor but rather by harnessing the power of the "mythical" world of the jnani bajade, the "original beings" that were and still are both ayoreo and the ancestors or masters of the present-day animals, plants and minerals.
Research and Development for a Gadolinium Doped Water Cherenkov Detector
Andrew Renshaw
Physics , 2012,
Abstract: The proposed introduction of a soluble gadolinium (Gd) compound into water Cherenkov detectors can result in a high efficiency for the detection of free neutrons capturing on the Gd. The delayed 8 MeV gamma cascades produced by these captures, in coincidence with a prompt positron signal, serve to uniquely identify electron antineutrinos interacting via inverse beta decay. Such coincidence detection can reduce backgrounds, allowing a large Gd-enhanced water Cherenkov detector to make the first observation of supernova relic neutrinos and high precision measurements of Japan's reactor antineutrino flux, while still allowing for all current physics studies to be continued. Now, a dedicated Gd test facility is operating in the Kamioka Mine. This new facility houses everything needed to successfully operate a Gd doped water Cherenkov detector. Successful running of this facility will demonstrate that adding Gd salt to SK is both safe for the detector and is capable of delivering the expected physics benefits.
Solar Neutrino Results from Super-Kamiokande
Andrew Renshaw
Statistics , 2014,
Abstract: Super-Kamiokande-IV (SK-IV) data taking began in September of 2008, after upgrading the electronics and data acquisition system. Due to these upgrades and improvements to water system dynamics, calibration and analysis techniques, a solar neutrino signal could be extracted at recoil electron kinetic energies as low as 3.5 MeV. When the SK-IV data is combined with the previous three SK phases, the SK extracted solar neutrino flux is found to be $[2.37\pm0.015\mbox{(stat.)}\pm0.04\mbox{(syst.)}]\times10^6$/(cm$^{2}$sec). The combination of the SK recoil electron energy spectra slightly favors distortions due to a changing electron flavor content. Such distortions are predicted when assuming standard solar neutrino oscillation solutions. An extended maximum likelihood fit to the amplitude of the expected solar zenith angle variation of the neutrino-electron elastic scattering rate results in a day-night asymmetry of $[-3.2\pm1.1$(stat.)$\pm0.5$(syst.)]$\%$. A solar neutrino global oscillation analysis including all current solar neutrino data, as well as KamLAND reactor antineutrino data, measures the solar mixing angle as $\sin^2\theta_{12}=0.305\pm0.013$, the solar neutrino mass squared splitting as $\Delta m^2_{21}=7.49^{+0.19}_{-0.17}\times10^{-5}$eV$^2$ and $\sin^2\theta_{13}=0.026^{+0.017}_{-0.012}$.
The molecular controls of resolution of inflammation: what can we learn from zebrafish?
Stephen. A. Renshaw,Catherine. A. Loynes,Daniel. M. Trushell,Philip. W. Ingham
European Respiratory Review , 2006,
Abstract: Although we are separated from zebrafish by 160 million years of evolution, we share many features of the innate and adaptive immune systems. In addition, we can manipulate the genome of zebrafish, and observe the effects on inflammation in vivo as they are transparent in their larval stages. This has exciting implications for the study of inflammatory diseases. We have established a model of inflammation in the zebrafish tail, in which caspase dependent cell death is required for resolution. For example, addition of the pan-caspase inhibitor zVD added at 4 hours after tailfin injury increases the number of neutrophils present from 6.0+/–1.0 to 28.9+/– 3.3 (mean +/– s.e.m. p<0.001 n = 3). The transparency of the larvae makes these an ideal model for the study of in vivo inflammation, and we have generated fluorescent systems for the easy visualisation of neutrophilic inflammation and resolution in vivo. We are also performing an unbiased forward genetic screen for mutants with defective resolution of inflammation, and to date have identified 38 putative mutants. These techniques allow new approaches to understanding the molecular controls of inflammation resolution.
Estimating attendance for breast cancer screening in ethnic groups in London
Christine Renshaw, Ruth H Jack, Steve Dixon, Henrik M?ller, Elizabeth A Davies
BMC Public Health , 2010, DOI: 10.1186/1471-2458-10-157
Abstract: We extracted 742,786 observations on attendance for routine appointments between 2004 and 2007 collected by the London Quality Assurance Reference Centre. Each woman was assigned to a lower super output (LSOA) based on her postcode of residence. The proportions of the ethnic groups within each LSOA are known, so that the likelihood of a woman belonging to White, Black and Asian groups can be assigned. We investigated screening attendance by age group, socioeconomic deprivation using the Index of Deprivation 2004 income quintile, invitation type and breast screening service. Using logistic regression analysis we calculated odds ratios for attendance based on ethnic composition of the population, adjusting for age, socioeconomic status, the invitation type and screening service.The unadjusted attendance odds ratios were high for the White population (OR: 3.34 95% CI [3.26-3.42]) and low for the Black population (0.13 [0.12-0.13]) and the Asian population (0.55 [0.53-0.56]). Multivariate adjustment reduced the differences, but the Black population remained below unity (0.47 [0.44-0.50]); while the White (1.30 [1.26-1.35]) and Asian populations (1.10 [1.05-1.15]) were higher. There was little difference in the attendance between age groups. Attendance was highest for the most affluent group and fell sharply with increasing deprivation. For invitation type, the routine recall was higher than the first call. There were wide variations in the attendance for different ethnic groups between the individual screening services.Overall breast screening attendance is low in communities with large Black populations, suggesting the need to improve participation of Black women. Variations in attendance for the Asian population require further investigation at an individual screening service level.The primary aim of the NHS breast screening programme is to reduce deaths from breast cancer by early detection. To be effective the screening programme requires a large proportion of the p
Direct integration of intensity-level data from Affymetrix and Illumina microarrays improves statistical power for robust reanalysis
Turnbull Arran K,Kitchen Robert R,Larionov Alexey A,Renshaw Lorna
BMC Medical Genomics , 2012, DOI: 10.1186/1755-8794-5-35
Abstract: Background Affymetrix GeneChips and Illumina BeadArrays are the most widely used commercial single channel gene expression microarrays. Public data repositories are an extremely valuable resource, providing array-derived gene expression measurements from many thousands of experiments. Unfortunately many of these studies are underpowered and it is desirable to improve power by combining data from more than one study; we sought to determine whether platform-specific bias precludes direct integration of probe intensity signals for combined reanalysis. Results Using Affymetrix and Illumina data from the microarray quality control project, from our own clinical samples, and from additional publicly available datasets we evaluated several approaches to directly integrate intensity level expression data from the two platforms. After mapping probe sequences to Ensembl genes we demonstrate that, ComBat and cross platform normalisation (XPN), significantly outperform mean-centering and distance-weighted discrimination (DWD) in terms of minimising inter-platform variance. In particular we observed that DWD, a popular method used in a number of previous studies, removed systematic bias at the expense of genuine biological variability, potentially reducing legitimate biological differences from integrated datasets. Conclusion Normalised and batch-corrected intensity-level data from Affymetrix and Illumina microarrays can be directly combined to generate biologically meaningful results with improved statistical power for robust, integrated reanalysis.
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