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Search Results: 1 - 10 of 462016 matches for " A. Prameela Rani "
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Effect of Polyvinylpyrrolidone on Complexation and Dissolution Rate of Beta Cyclodextrin and Hydroxypropyl Beta Cyclodextrin Complexes of Piroxicam
Otra Kumar,A. Prameela Rani
International Journal of Pharmaceutical and Phytopharmacological Research , 2012,
Abstract: Complexation of Piroxicam with β-Cyclodextrin and hydroxypropyl-β-Cyclodextrin in the presence and absence of polyvinylpyrrolidone and the effect of polyvinylpyrrrolidone on the solubilizing efficiency of Cyclodextrins and on the dissolution rate of Piroxicam from the Cyclodextrin complexes were investigated. The phase solubility studies indicated the formation of Piroxicam-β-Cyclodextrin and Piroxicam-hydroxypropyl-β-Cyclodextrin inclusion complexes at a 1:1 M ratio in solution, both in the presence and absence of polyvinylpyrrolidone. The complexes formed were quite stable. The solubility and dissolution rate of Piroxicam were markedly enhanced by complexation with β-Cyclodextrin and hydroxypropyl- β-Cyclodextrin. Piroxicamhydroxypropyl-β-Cyclodextrin(1:2) inclusion complex gave a 36.52-fold increase in the dissolution rate of Piroxicam. Addition of polyvinylpyrrolidone resulted in higher complexation efficiency and markedly enhanced solubilizing efficiency of β-Cyclodextrin and hydroxypropyl-β-Cyclodextrin. Solid inclusion complexes of Cyclodextrins with polyvinylpyrrolidone gave several times higher rates of dissolution than those of Piroxicam and its complexes with Cyclodextrins alone.
Development and validation of spectrophotometric method for the determination of DPP-4 inhibitor, sitagliptin, in its pharmaceutical preparations
Sekaran, C. Bala;Rani, A. Prameela;
Eclética Química , 2010, DOI: 10.1590/S0100-46702010000300003
Abstract: a simple, sensitive and reproducible spectrophotometric method was developed for the determination of sitagliptin phosphate in bulk and in pharmaceutical formulations. the proposed method is based on condensation of the primary amino group of sitagliptin phosphate with acetyl acetone and formaldehyde producing a yellow colored product, which is measured spectrophotometrically at 430nm. the color was stable for about 1 hour. beer's law is obeyed over a concentration range of 5-25 μg/ml. the apparent molar absorptivity and sandell sensitivity values are 1.067 x 104 lmol-1cm-1 and 0.0471 μgcm-2 respectively. all the variables were studied to optimize the reaction conditions. no interference was observed in the presence of common pharmaceutical excipients. the validity of the method was tested by analyzing sitagliptin phosphate in its pharmaceutical preparations. good recoveries were obtained. the developed method was successfully employed for the determination of sitagliptin phosphate in various pharmaceutical preparations.
High Performance Liquid Chromatographic Analysis of Almotriptan Malate in Bulk and Tablets
Petikam lavudu,Avula Prameela Rani,Chepuri Divya,Chandra Bala Sekaran
Advanced Pharmaceutical Bulletin , 2013, DOI: 10.5681/apb.2013.030
Abstract: Purpose: A simple RP-HPLC method has been developed and validated for the determination of almotriptan malate (ATM) in bulk and tablets. Methods: Chromatographic separation of ATM was achieved by using a Thermo Scientific C18 column. A Mobile phase containing a mixture of methanol, water and acetic acid (4:8:0.1 v/v) was pumped at the flow rate of 1 mL/min. Detection was performed at 227 nm. According to ICH guidelines, the method was validated. Results: The calibration curve was linear in the concentration range 5–60 μg/mL for the ATM with regression coefficient 0.9999. The method was precise with RSD <1.2%. Excellent recoveries of 99.60 - 100.80% proved the accuracy of the method. The limits of detection and quantification were found to be 0.025 and 0.075 μg/mL, respectively. Conclusion: The method was successfully applied for the quantification of ATM in tablets with acceptable accuracy and precision.
Extractive Spectrophotometric Determination of Ambrisentan
Namasani Santhosh Kumar,Avula Prameela Rani,Telu Visalakshi,Chandra Bala Sekaran
Advanced Pharmaceutical Bulletin , 2013,
Abstract: Purpose: Ambrisentan (ABS) is an antihypertensive drug used in the treatment of pulmonary atrial hypertension. The survey of literature for ABS revealed only two spectrophotometric methods for its quantification. The reported methods lack the sensitivity. This study is aimed at developing two sensitive extractive spectrophotometricmethods for the determination of ABS in bulk and in tablets. Methods: The proposed methods are based on the formation of colored chloroform extractable ion-pair complexes of ABS with methylene blue (MB method) and safranine O (SO method) in buffered solution at pH 9.8. The extracted complexes showed maximum absorbance at 525 and 515 nm for methylene blue and safranine O, respectively. Results: In both themethods, the calibration curve was linear from 1–15 μg mL 1 of drug. Apparent molar absorpitivities were 1.7911 x 105, 2.3272 x 105 L mol 1 cm 1; Sandell’s sensitivities were 0.0215, 0.0162 μg cm-2; LOD were 0.182, 0.175 μg mL 1; LOQ were 0.551, 0.531 μg mL 1 for methods MB and SO, respectively. The relative standard deviation and percent recovery ranged from 0.206–1.310% and 99.0–101.5%, respectively.Conclusion: The results demonstrate that the proposed methods are sensitive, precise, accurate and inexpensive. These methods can easily be used for the assay of ABS in quality control laboratories.
Haematological and Biochemical changes of stunting syndrome in Broiler chicken
M. Prameela Rani,N. Nissar Ahmad,P. Eswara Prasad and Ch. Sri Latha
Veterinary World , 2011,
Abstract: An experiment was carried out to study the haematological and biochemical changes of stunting syndrome in broiler chicken from day old ( group I) and 3 weeks (group III) of age to 8 weeks of age in two phases along with group II and group IV as control. Birds were slaughtered at 3, 5 ,7 and 8 weeks of age and the blood samples were collected and analyzed. The mean PCV, Hb, TEC values were reduced significantly (P<0.01) in stunted birds. Increased AHC, AMC and ABC values along with decreased ALC values were obtained. Significantly (P<0.01) lower serum total protein values and increased serum Amylase ALP, AST and ALT activity were observed in stunted groups ( I and III) whereas blood glucose values among the groups were not significant. The decreased haematological and biochemical parameters in the present study indicates a decrease in the absorption and digestion of protein and damage to liver and intestines in stunting syndrome of broiler chicken. [Vet. World 2011; 4(3.000): 124-125]
Effect of Ni Doping on the Growth and Properties of Mn-L-Histidine Hydrochloride Monohydrate Crystals
J. Sai Chandra,P. N. V. V. L. Prameela Rani,V. Parvathi,Y. Sunandamma
International Journal of Inorganic Chemistry , 2013, DOI: 10.1155/2013/716819
Abstract: The main focus of this work had been to grow good quality crystals from amino acids and amino acid-based materials for nonlinear optics (NLO) applications. For the first time, a series of amino acid complexes doped with transition metal ions were grown in our laboratory from aqueous solutions by slow evaporation technique. Ni(II) ion doped Manganese L-Histidine hydrochloride monohydrate (Ni(II)-MnLHICl) crystals were grown on the same lines and were characterized by powder X-ray diffraction (XRD), optical absorption, electron paramagnetic resonance, and infrared absorption studies. From Powder XRD, the unit cell lattice parameters were calculated as ?nm, ?nm and ?nm. From electron paramagnetic resonance (EPR) spectra, isotropic “g” factor and spin hamiltonian parameter A all were calculated as 2.0439 and , respectively. From optical absorption studies, crystal field splitting value ( ) and the interelectron repulsion parameters B and C were calculated for Ni2+ and Mn2+ as ?cm?1, ?cm?1, ?cm?1 and ?cm?1, ?cm?1, ?cm?1, respectively. The presence of various functional groups and the modes of vibrations were confirmed by FTIR studies. 1. Introduction Doping is a well-chosen and widely accepted technique for incorporating the required physical properties in a bulk material for technological applications [1–3]. The technique has been extensively explored to modify the properties like electrooptical (photoluminescence), conductivity and crystal growth [4]. It has also been demonstrated that metal ion dopants are the most versatile in modifying the properties of a compound [5]. Metal amino acid interactions have been widely studied because of their biological importance. Metal amino acid complexes constitute very important model systems in order to understand the electronic properties of metal ions in biologically important macromolecules [6]. Amino acid complexes doped with transition metal ions are suitable model systems for understanding the basic aspects of role of metals in proteins [7, 8]. L-Histidine is an optically active α-amino acid in its laevo-form and is a tridentate ligand that has an imidazole ring, amino, and carboxylate groups. It is also a protein-forming amino acid playing a fundamental role in several biological mechanisms including the formation of hemoglobin and is being used in the treatment of allergic diseases and anemia [9]. Complexes of amino acids with metal ion dopants combine the advantage of organo amino acid with that of inorganic metal ions [10]. Multidentate complexes of amino acids with metal ion dopants are at present
Hot Corrosion Behavior of Superalloy in Different Corrosive Environments  [PDF]
Subhash Kamal, Korada Viswanath Sharma, A. M. Abdul-Rani
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2015, DOI: 10.4236/jmmce.2015.31004
Abstract: Hot corrosion is a serious problem in aircraft, marine, industrial and land-base gas turbines. To obviate these problems, superalloy superfer 800H (Midhani grade) is one of the prominent materials for the high temperature applications. The present work investigates hot corrosion behaviour of superfer 800H exposed to two different molten salt environments Na2SO4 + 60% V2O5 and Na2SO4 + 5% V2O5 + 5% NaCl respectively, at 900oC under cyclic conditions. The weight change measurements made on during the experiments are used to determine the kinetics of hot corrosion. It is observed that the formation of scale rich in Cr2O3, NiO and spinel NiCr2O4 has contributed for the better hot corrosion resistance of superfer 800H. Inspection for 10, 20, 35 and 50 cycles reveals that after 10 cycles Crack has been initiated in the scale and it is clearly visible in the presence of NaCl salt. On subsequent cycles, crack propagates perpendicular to surface and as it encounters inclusions.
A bony canal in the basilar part of occipital bone
Chauhan NK,Chopra J,Rani A,Rani A
International Journal of Anatomical Variations , 2010,
Abstract: Clivus is a gradual slopping process behind the dorsum sellae that runs obliquely backwards. An unusual 6 mm long and 1 mm wide bony canal was observed on the lower one third of clivus in an adult human dry skull. The internal end of the canal was opening in the midline. The canal was directed downwards, forwards and laterally. The external opening was present antero-lateral to the pharyngeal tubercle on the left side.Presence of any canal in the clivus is a rare occurrence. There could be two possible explanations for its formation. It could be because of presence of a connecting vein or it might have contained the remnant of notochord. We believe that in the present case more likely a venous communication existed between the basilar and pharyngeal venous plexuses, which led to the formation of this bony canal. The canal of the clivus might interfere with the neurosurgical operations in the clival region or can be confused for a fracture of clivus.
Authentication of DICOM Medical Images using Multiple fragile watermarking Techniques in Wavelet Transform Domain
A Kannammal,A. Kannammal,S. Subha Rani,S. Subha Rani
International Journal of Computer Science Issues , 2011,
Abstract: A multiple, fragile image authentication scheme is proposed for DICOM images using discrete wavelet transform. This scheme addresses critical health information management issues, including source authentication, data authentication and transfer of patient diagnosis details. The robustness of the method is enhanced through a form of hybrid coding, which includes repetitive embedding of BCH encoded watermarks. The watermarked images were tested with common attacks to evaluate the behaviour of the algorithm. Conclusions were drawn based on the algorithms performance when the images were subjected to various attacks. The algorithm was also tested by changing the wavelet function used in the algorithm and the results show that the Haar wavelet is the most suitable wavelet. The experimental results on different medical images demonstrate the efficiency and transparency of the watermarking scheme, which fulfils the strict requirements concerning the acceptable alterations of medical images.
International Journal of Innovative Research in Computer and Communication Engineering , 2013,
Abstract: Using multiple mobile agents (MA) in WSNs significantly improves the network efficiency and scalability of its data fusion applications. In multiple MA based computing, MA Itinerary Planning plays an important role and a badly designed Itinerary Plan severely affects the network and application performance. There are several approaches and schemes proposed and presented for the mobile agent’s itinerary planning in resource constrained WSNs. Genetic Algorithm based optimization schemes are explored very little for efficient MIP (Multiple Mobile Agents Itinerary Planning) solutions. Here we proposed a two phase design model (GA-OIP-MMA) with Genetic Algorithm for global optimal itinerary planning of MAs followed by local dynamic in-network route adaptation by individual MAs to design optimal MIP solutions for WSNs
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