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Search Results: 1 - 10 of 462207 matches for " A. Monte "
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An essential reference for the drug safety practitioner
Monte Andrew A
Human Genomics , 2013, DOI: 10.1186/1479-7364-7-3
Abstract: Book details Cobert B Cobert's Manual of Drug Safety and Pharmacovigilance: Second Edition Sudbury: Jones & Bartlett Learning; 2012 408 pages, ISBN-13: 978–0763791599
A importancia do método de Hartree no ensino de química quantica
Monte, Silmar A. do;Ventura, Elizete;
Química Nova , 2011, DOI: 10.1590/S0100-40422011000300028
Abstract: hartree's original ideas are described. its connection with electrostatics can be explored in order to decrease the gap between teaching of physics and chemistry. as a consequence of its simplicity and connection with electrostatics, it is suggested that hartree's method should be presented before the hartree-fock method. besides, since the fundamental concepts of indistinguishibility of electrons along with the antissimetry of the wave function are missing in the hartree's product, the method itself can be used to introduce these concepts. despite the fact that these features are not included in the trial wavefunction, important qualitatively correct results can be obtained.
A Misleading Trismus
A. Galzerano,E. Sabatini,A. De Monte,D. Durì
Case Reports in Critical Care , 2011, DOI: 10.1155/2011/969621
Abstract: We report the case of a 73-year-old women admitted to ICU with a diagnosis of tetanum supported by a mild trismus and treated with potentially unsafe drugs until the correct diagnosis was made.
Transplanting Intact Donor Tissue Enhances Dopamine Cell Survival and the Predictability of Motor Improvements in a Rat Model of Parkinson’s Disease
Rosemary A. Fricker, Jan Herman Kuiper, Monte A. Gates
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047169
Abstract: Primary cell transplantation is currently the gold standard for cell replacement in Parkinson’s disease. However, the number of donors needed to treat a single patient is high, and the functional outcome is sometimes variable. The present work explores the possibility of enhancing the viability and/or functionality of small amounts of ventral mesencephalic (VM) donor tissue by reducing its perturbation during preparation and implantation. Briefly, unilaterally lesioned rats received either: (1) an intact piece of half an embryonic day 13 (E13) rat VM; (2) dissociated cells from half an E13 rat VM; or (3) no transplant. D-amphetamine- induced rotations revealed that animals receiving pieces of VM tissue or dissociated cells showed significant improvement in ipsilateral rotation 4 weeks post transplantation. By 6 weeks post transplantation, animals receiving pieces of VM tissue showed a trend for further improvement, while those receiving dissociated cells remained at their 4 week scores. Postmortem cell counts showed that the number of dopaminergic neurons in dissociated cell transplants was significantly lower than that surviving in transplants of intact tissue. When assessing the correlation between the number of dopamine cells in each transplant, and the improvement in rotation bias in experimental animals, it was shown that transplants of whole pieces of VM tissue offered greater predictability of graft function based on their dopamine cell content. Such results suggest that maintaining the integrity of VM tissue during implantation improves dopamine cell content, and that the dopamine cell content of whole tissue grafts offers a more predictable outcome of graft function in an animal model of Parkinson’s disease.
Kinetic modeling and exploratory numerical simulation of chloroplastic starch degradation
Ambarish Nag, Monte Lunacek, Peter A Graf, Christopher H Chang
BMC Systems Biology , 2011, DOI: 10.1186/1752-0509-5-94
Abstract: Simulation with 9 internal metabolites and 8 external metabolites, the concentrations of the latter fixed at reasonable biochemical values, leads to a single reference solution showing β-amylase activity to be the rate-limiting step in carbon flow from starch degradation. Additionally, the response coefficients for stromal glucose to the glucose transporter kcat and KM are substantial, whereas those for cytosolic glucose are not, consistent with a kinetic bottleneck due to transport. Response coefficient norms show stromal maltopentaose and cytosolic glucosylated arabinogalactan to be the most and least globally sensitive metabolites, respectively, and β-amylase kcat and KM for starch to be the kinetic parameters with the largest aggregate effect on metabolite concentrations as a whole. The latter kinetic parameters, together with those for glucose transport, have the greatest effect on stromal glucose, which is a precursor for biofuel synthetic pathways. Exploration of the steady-state solution space with respect to concentrations of 6 external metabolites and 8 dynamic metabolite concentrations show that stromal metabolism is strongly coupled to starch levels, and that transport between compartments serves to lower coupling between metabolic subsystems in different compartments.We find that in the reference steady state, starch cleavage is the most significant determinant of carbon flux, with turnover of oligosaccharides playing a secondary role. Independence of stationary point with respect to initial dynamic variable values confirms a unique stationary point in the phase space of dynamically varying concentrations of the model network. Stromal maltooligosaccharide metabolism was highly coupled to the available starch concentration. From the most highly converged trajectories, distances between unique fixed points of phase spaces show that cytosolic maltose levels depend on the total concentrations of arabinogalactan and glucose present in the cytosol. In additio
Utiliza??o do 131I no tratamento da doen?a de Basedow-Graves na infancia e adolescência
Monte, Osmar;Calliari, Luis Eduardo P.;Longui, Carlos A.;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2004, DOI: 10.1590/S0004-27302004000100018
Abstract: while the diagnosis of graves' disease in childhood and adolescence is relatively straightforward, its treatment remains controversial. the first choice therapy is the use of anti-thyroid drugs, although side effects are more frequent than in adults and remission is low. surgery is not usually indicated as initial treatment. instead, it is generally recommended after recidive of the disease or due to side effects of medical treatment. the use of radioiodine therapy is increasing in this age group, especially in north america, and control of the hyperthyroidism is achieved in 3 to 6 months in 90% of the cases. there is no evidence that radioiodine therapy is associated with a higher risk of thyroid cancer, and the occurrence of side effects is lower than surgery. based on the positive results obtained with this therapy, patients with poor responsiveness to medical treatment should be considered for early radioiodine therapy.
Moderate intensity physical training accelerates healing of full-thickness wounds in mice
Zogaib, F.G.;Monte-Alto-Costa, A.;
Brazilian Journal of Medical and Biological Research , 2011, DOI: 10.1590/S0100-879X2011007500115
Abstract: physical training influences the cells and mediators involved in skin wound healing. the objective of this study was to determine the changes induced by different intensities of physical training in mouse skin wound healing. ninety male c57bl6 mice (8 weeks old, 20-25 g) were randomized into three physical training groups: moderate (70% vo2max), high (80% vo2max), and strenuous intensity (90% vo2max). animals trained on a motorized treadmill for 8 weeks (elesion: physical training until the day of excisional lesion, n = 10) or 10 weeks (eeuthan: physical training for 2 additional weeks after excisional lesion until euthanasia, n = 10), five times/week, for 45 min. control groups (cg) trained on the treadmill three times/week only for 5 min (n = 10). in the 8th week, mice were anesthetized, submitted to a dorsal full-thickness excisional wound of 1 cm2, and sacrificed 14 days after wounding. wound areas were measured 4, 7, and 14 days after wounding to evaluate contraction (d4, d7 and d14) and re-epithelialization (d14). fragments of lesion and adjacent skin were processed and submitted to routine histological staining. immunohistochemistry against alpha-smooth muscle actin (α-sma) was performed. moderate-intensity training (m) until lesion (m/elesion) led to better wound closure 7 days after wounding compared to controls and m/eeuthan (p < 0.05), and both moderate-intensity groups showed better re-epithelialization rates than controls (m/elesion = 85.9%, m/eeuthan = 96.4% and m/cg = 79.9%; p < 0.05). sections of m/elesion and m/eeuthan groups stained with hematoxylin-eosin, picrosirius red and α-sma showed the most mature granulation tissues among all trained groups and controls. thus, moderate-intensity physical training improves skin wound healing.
Prevalencia del "síndrome de quemarse por el trabajo" (burnout) en pediatras de hospitales generales
Gil-Monte,Pedro R; Marucco,Mariana A;
Revista de Saúde Pública , 2008, DOI: 10.1590/S0034-89102008000300009
Abstract: objective: to assess the prevalence of burnout in pediatricians of general hospitals. methods: non-randomized cross-sectional study carried out in the city of buenos aires, argentina, in 2006. the study sample comprised 123 pediatricians working in pediatrics services of general hospitals, 89 women (72.4%) and 34 men (27.6%). data were gathered through an anonymous, self-administered questionnaire. burnout was measured using the maslach burnout inventory, and different approaches were employed to estimate burnout prevalence. results: the prevalence of burnout was different according to the approach used: the prevalence was 10.6% by the united states criteria; 24.4% by the spanish criteria; 37.4% by the argentinean criteria and 3.25% by the dutch clinical criteria. conclusions: burnout prevalences varied significantly depending on the approach used due to cross-cultural influences.
Response of pediatric uveitis to TNFα inhibitors
Lerman Melissa A,Mills Monte,Joffe Marshall,Finkel Terri H
Pediatric Rheumatology , 2012, DOI: 10.1186/1546-0096-10-s1-a79
{Bis[2-(diphenylphosphino)ethyl]phenylphosphine-κ3P,P′,P′′}chloridoplatinium(II) hexafluoridophosphate
Scott A. Heston,Bruce C. Noll,Monte L. Helm
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809022405
Abstract: In the title compound, [PtCl(C34H33P3)]PF6, the PtII cation adopts a distorted square-planar PtClP3 geometry, arising from the P,P′,P′′-tridentate triphos ligand and a chloride ion. Four of the F atoms of the PF6 anion are disordered over two sets of positions in a 0.614 (17):0.386 (17) ratio.
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