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Search Results: 1 - 10 of 461992 matches for " A. Moccia "
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Analysis of Spaceborne Tandem Configurations for Complementing COSMO with SAR Interferometry
A. Moccia,G. Fasano
EURASIP Journal on Advances in Signal Processing , 2005, DOI: 10.1155/asp.2005.3304
Abstract: This paper analyses the possibility of using a fifth passive satellite for endowing the Italian COSMO-SkyMed constellation with cross- and along-track SAR interferometric capabilities, by using simultaneously flying and operating antennas. Fundamentals of developed models are described and potential space configurations are investigated, by considering both formations operating on the same orbital plane and on separated planes. The study is mainly aimed at describing achievable baselines and their time histories along the selected orbits. The effects of tuning orbital parameters, such as eccentricity or ascending node phasing, are pointed out, and simulation results show the most favorable tandem configurations in terms of achieved baseline components, percentage of the orbit adequate for interferometry, and covered latitude intervals.
Effects of Orbit and Pointing Geometry of a Spaceborne Formation for Monostatic-Bistatic Radargrammetry on Terrain Elevation Measurement Accuracy
Alfredo Renga,Antonio Moccia
Sensors , 2009, DOI: 10.3390/s90100175
Abstract: During the last decade a methodology for the reconstruction of surface relief by Synthetic Aperture Radar (SAR) measurements – SAR interferometry – has become a standard. Different techniques developed before, such as stereo-radargrammetry, have been experienced from space only in very limiting geometries and time series, and, hence, branded as less accurate. However, novel formation flying configurations achievable by modern spacecraft allow fulfillment of SAR missions able to produce pairs of monostatic-bistatic images gathered simultaneously, with programmed looking angles. Hence it is possible to achieve large antenna separations, adequate for exploiting to the utmost the stereoscopic effect, and to make negligible time decorrelation, a strong liming factor for repeat-pass stereo-radargrammetric techniques. This paper reports on design of a monostatic-bistatic mission, in terms of orbit and pointing geometry, and taking into account present generation SAR and technology for accurate relative navigation. Performances of different methods for monostatic-bistatic stereo-radargrammetry are then evaluated, showing the possibility to determine the local surface relief with a metric accuracy over a wide range of Earth latitudes.
Rete di comunicazione e assetto del territorio nel PTCP di Napoli Communication Network and settlements in the PTCP of Naples
Francesco Domenico Moccia
TeMA : Journal of Land Use, Mobility and Environment , 2010, DOI: 10.6092/1970-9870/102
Abstract: Il PTCP nasce nel clima della pianificazione europea rivolta alla realizzazione della rete TenT e della ricerca di come questo sistema di connessione potesse diventare strumento di sviluppo e coesione territoriale. Nella stessa scia si colloca tanto il Quadro Strategico Nazionale che il Piano Strategico Ragionale nei quali si definisce il ruolo territoriale della metropoli napoletana nel contesto internazionale. Queste premesse forniscono utili indicazioni per determinare l’organizzazione generale del territorio napoletano sia perché determinano nuovi ingressi da attrezzare adeguatamente al ruolo di vetrine e di accoglienza, sia perché contribuiscono a realizzare il sistema policentrico locale e le connessioni nel sistema delle centralità regionali. Tra i problemi di maggior delicatezza che si pongono c’è l’equilibrio tra vecchie e nuove centralità, ovvero la scelta se procedere secondo uno sviluppo additivo al sistema urbano esistente con il rispetto del patrimonio culturale e delle radici storiche. L’altro fondamentale termine di confronto è costituito dalle esigenze ambientali affermate prioritariamente con la difesa delle aree agricole e degli spazi aperti, ma di cui non si possono trascurare altre implicazioni quali quelle della capacità di un sistema urbano concentrato di rafforzare la competitività della mobilità verde. The Territorial Plan of the Province of Naples (PTCP) framework is given by European Planning and research (ESDP and ESPON). Regional strategic spatial planning suggested development directions while making important investment in the rail transportation network. The cohesion spatial policy was focused on the controversial concept of mega-metropolis contrasted by the concept of the development platform. From such discussion cooperation programs come with the great cities of the Southern Italy Rome and Bari, the strengthening of transportation infrastructure and the development of the nodes of interrelations. Inside the metropolitan area, the high concentration in the city of Naples and the high density of the shoreline are the starting point for a policy of inland development according to strengting of the east-west corridor connecting the Tyrrhenian to the Adriatic See and the overseas lands of the south-east Europe. The paper analyses the transportation system supporting this more northern part of the Province and found some areas, in the middle, lacking of enough commuting facilities, even in the Regional plans evaluating a rail service or a new tramway network alternative. The paper shows what meaning polycentricity has in th
Burning Behaviour of High-Pressure CH4-H2-Air Mixtures
Vincenzo Moccia,Jacopo D'Alessio
Energies , 2013, DOI: 10.3390/en6010097
Abstract: Experimental characterization of the burning behavior of gaseous mixtures has been carried out, analyzing spherical expanding flames. Tests were performed in the Device for Hydrogen-Air Reaction Mode Analysis (DHARMA) laboratory of Istituto Motori—CNR. Based on a high-pressure, constant-volume bomb, the activity is aimed at populating a systematic database on the burning properties of CH 4, H 2 and other species of interest, in conditions typical of internal combustion (i.c.) engines and gas turbines. High-speed shadowgraph is used to record the flame growth, allowing to infer the laminar burning parameters and the flame stability properties. Mixtures of CH 4, H 2 and air have been analyzed at initial temperature 293÷305 K, initial pressure 3÷18 bar and equivalence ratio ?= 1.0. The amount of H 2 in the mixture was 0%, 20% and 30% (vol.). The effect of the initial pressure and of the Hydrogen content on the laminar burning velocity and the Markstein length has been evaluated: the relative weight and mutual interaction has been assessed of the two controlling parameters. Analysis has been carried out of the flame instability, expressed in terms of the critical radius for the onset of cellularity, as a function of the operating conditions.
Store-Operated Ca2+ Entry Is Remodelled and Controls In Vitro Angiogenesis in Endothelial Progenitor Cells Isolated from Tumoral Patients
Francesco Lodola, Umberto Laforenza, Elisa Bonetti, Dmitry Lim, Silvia Dragoni, Cinzia Bottino, Hwei Ling Ong, Germano Guerra, Carlo Ganini, Margherita Massa, Mariangela Manzoni, Indu S. Ambudkar, Armando A. Genazzani, Vittorio Rosti, Paolo Pedrazzoli, Franco Tanzi, Francesco Moccia, Camillo Porta
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042541
Abstract: Background Endothelial progenitor cells (EPCs) may be recruited from bone marrow to sustain tumor vascularisation and promote the metastatic switch. Understanding the molecular mechanisms driving EPC proliferation and tubulogenesis could outline novel targets for alternative anti-angiogenic treatments. Store-operated Ca2+ entry (SOCE), which is activated by a depletion of the intracellular Ca2+ pool, regulates the growth of human EPCs, where is mediated by the interaction between the endoplasmic reticulum Ca2+-sensor, Stim1, and the plasmalemmal Ca2+ channel, Orai1. As oncogenesis may be associated to the capability of tumor cells to grow independently on Ca2+ influx, it is important to assess whether SOCE regulates EPC-dependent angiogenesis also in tumor patients. Methodology/Principal Findings The present study employed Ca2+ imaging, recombinant sub-membranal and mitochondrial aequorin, real-time polymerase chain reaction, gene silencing techniques and western blot analysis to investigate the expression and the role of SOCE in EPCs isolated from peripheral blood of patients affected by renal cellular carcinoma (RCC; RCC-EPCs) as compared to control EPCs (N-EPCs). SOCE, activated by either pharmacological (i.e. cyclopiazonic acid) or physiological (i.e. ATP) stimulation, was significantly higher in RCC-EPCs and was selectively sensitive to BTP-2, and to the trivalent cations, La3+ and Gd3+. Furthermore, 2-APB enhanced thapsigargin-evoked SOCE at low concentrations, whereas higher doses caused SOCE inhibition. Conversely, the anti-angiogenic drug, carboxyamidotriazole (CAI), blocked both SOCE and the intracellular Ca2+ release. SOCE was associated to the over-expression of Orai1, Stim1, and transient receptor potential channel 1 (TRPC1) at both mRNA and protein level The intracellular Ca2+ buffer, BAPTA, BTP-2, and CAI inhibited RCC-EPC proliferation and tubulogenesis. The genetic suppression of Stim1, Orai1, and TRPC1 blocked CPA-evoked SOCE in RCC-EPCs. Conclusions SOCE is remodelled in EPCs from RCC patients and stands out as a novel molecular target to interfere with RCC vascularisation due to its ability to control proliferation and tubulogenesis.
Feasibility of the Laparoscopic Total Colectomy with Ileal j-Pouch-Rectal Anastomosis in the Treatment of Chronic Constipation Refractory to Medical Therapy: Observations about a Case Report  [PDF]
Alfredo Allaria, Vincenzo Napolitano, Maria Chiara Bondanese, Francesco Moccia, Marco Cimmino, Beniamino Pascotto, Francesco Orlando, Landino Fei
Surgical Science (SS) , 2013, DOI: 10.4236/ss.2013.49074

In October 2012, a 29-year-old woman affected by chronic constipation underwent surgery for a laparoscopic total colectomy with ileal j-pouch-rectal anastomosis. After a precise instrumental work-up, the patient was selected as a potential candidate for the surgical treatment after failing to respond to all other medical treatment. During the first three months following the surgery, the patient recorded 3 - 4 daily evacuations of soft stool. After the third month, the number of evacuations stabilised at 2 3 a day, with formed stool, and no mention of incontinence or abdominal pain. Although the laparoscopic total colectomy with ileorectal anastomosis (TC with IRA) and the laparoscopically assisted subtotal colectomy with cecorectal anastomosis (SC with CRA) are the most frequently practiced procedures in the surgical treatment of chronic constipation, the laparoscopic colectomy with ileal j-pouch has shown in our experience to be a feasible and effective procedure, with similar results to the two aforementioned procedures in terms of morbidity, mortality and quality of life. In fact, like the first two, the total colectomy with ileal j-pouch has demonstrated the advantages of laparoscopic surgery: low invasiveness, less post-operative pain or ileus, respect of parietal integrity, reduced hospitalization and, lastly, a better cosmesis.

Flight Performance Analysis of an Image Processing Algorithm for Integrated Sense-and-Avoid Systems
Lidia Forlenza,Giancarmine Fasano,Domenico Accardo,Antonio Moccia
International Journal of Aerospace Engineering , 2012, DOI: 10.1155/2012/542165
Abstract: This paper is focused on the development and the flight performance analysis of an image-processing technique aimed at detecting flying obstacles in airborne panchromatic images. It was developed within the framework of a research project which aims at realizing a prototypical obstacle detection and identification System, characterized by a hierarchical multisensor configuration. This configuration comprises a radar, that is, the main sensor, and four electro-optical cameras. Cameras are used as auxiliary sensors to the radar, in order to increase intruder aircraft position measurement, in terms of accuracy and data rate. The paper thoroughly describes the selection and customization of the developed image-processing techniques in order to guarantee the best results in terms of detection range, missed detection rate, and false-alarm rate. Performance is evaluated on the basis of a large amount of images gathered during flight tests with an intruder aircraft. The improvement in terms of accuracy and data rate, compared with radar-only tracking, is quantitatively demonstrated. 1. Introduction Following the hmost important guidelines about unmanned aerial systems (UASs) integration into civil airspace, the onboard avionics of these aircraft must include a sense-and-avoid (S&A) system that is capable to replace the human pilot in performing visual collision threat detection and avoidance. In general, the architectures of detect-sense-and-avoid (DS&A) systems, reported in literature [1–5], are comprised of two subsystems, such as the obstacle detection and tracking one and the collision avoidance one. Several solutions have been proposed to provide the “sense” function. They range from standalone electro-optical (EO) sensors to integrated architectures that comprise airborne radars and collaborative systems based on broadcasted information, such as TCAS (traffic collision avoidance system) and ADS-B (automatic-dependent surveillance-broadcast) [6–12]. A multiple sensor configuration allows compensating single sensor shortcomings as documented in detail in [7, 12]. Thus, in the framework of a research project carried out by the Italian Aerospace Research Center (CIRA) and the University of Naples “Federico II,” aimed at demonstrating a fully autonomous collision avoidance system in flight, an integrated radar/EO configuration was selected. Moreover, in order to satisfy required levels of accuracy, data rate, false alarm rate, and missed detection rate, a hierarchical logical architecture has been considered where the radar is the main sensor and the EO system
An Innovative Procedure for Calibration of Strapdown Electro-Optical Sensors Onboard Unmanned Air Vehicles
Giancarmine Fasano,Domenico Accardo,Antonio Moccia,Attilio Rispoli
Sensors , 2010, DOI: 10.3390/s100100639
Abstract: This paper presents an innovative method for estimating the attitude of airborne electro-optical cameras with respect to the onboard autonomous navigation unit. The procedure is based on the use of attitude measurements under static conditions taken by an inertial unit and carrier-phase differential Global Positioning System to obtain accurate camera position estimates in the aircraft body reference frame, while image analysis allows line-of-sight unit vectors in the camera based reference frame to be computed. The method has been applied to the alignment of the visible and infrared cameras installed onboard the experimental aircraft of the Italian Aerospace Research Center and adopted for in-flight obstacle detection and collision avoidance. Results show an angular uncertainty on the order of 0.1° (rms).
Real Time Corner Detection for Miniaturized Electro-Optical Sensors Onboard Small Unmanned Aerial Systems
Lidia Forlenza,Patrick Carton,Domenico Accardo,Giancarmine Fasano,Antonio Moccia
Sensors , 2012, DOI: 10.3390/s120100863
Abstract: This paper describes the target detection algorithm for the image processor of a vision-based system that is installed onboard an unmanned helicopter. It has been developed in the framework of a project of the French national aerospace research center Office National d’Etudes et de Recherches Aérospatiales (ONERA) which aims at developing an air-to-ground target tracking mission in an unknown urban environment. In particular, the image processor must detect targets and estimate ground motion in proximity of the detected target position. Concerning the target detection function, the analysis has dealt with realizing a corner detection algorithm and selecting the best choices in terms of edge detection methods, filtering size and type and the more suitable criterion of detection of the points of interest in order to obtain a very fast algorithm which fulfills the computation load requirements. The compared criteria are the Harris-Stephen and the Shi-Tomasi, ones, which are the most widely used in literature among those based on intensity. Experimental results which illustrate the performance of the developed algorithm and demonstrate that the detection time is fully compliant with the requirements of the real-time system are discussed.
Update on vascular endothelial Ca2+ signalling: A tale of ion channels, pumps and transporters
Francesco Moccia,Roberto Berra-Romani,Franco Tanzi
World Journal of Biological Chemistry , 2012, DOI: 10.4331/wjbc.v3.i7.127
Abstract: A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and forms a multifunctional transducing organ that mediates a plethora of cardiovascular processes. The activation of ECs from as state of quiescence is, therefore, regarded among the early events leading to the onset and progression of potentially lethal diseases, such as hypertension, myocardial infarction, brain stroke, and tumor. Intracellular Ca2+ signals have long been know to play a central role in the complex network of signaling pathways regulating the endothelial functions. Notably, recent work has outlined how any change in the pattern of expression of endothelial channels, transporters and pumps involved in the modulation of intracellular Ca2+ levels may dramatically affect whole body homeostasis. Vascular ECs may react to both mechanical and chemical stimuli by generating a variety of intracellular Ca2+ signals, ranging from brief, localized Ca2+ pulses to prolonged Ca2+ oscillations engulfing the whole cytoplasm. The well-defined spatiotemporal profile of the subcellular Ca2+ signals elicited in ECs by specific extracellular inputs depends on the interaction between Ca2+ releasing channels, which are located both on the plasma membrane and in a number of intracellular organelles, and Ca2+ removing systems. The present article aims to summarize both the past and recent literature in the field to provide a clear-cut picture of our current knowledge on the molecular nature and the role played by the components of the Ca2+ machinery in vascular ECs under both physiological and pathological conditions.
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