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Search Results: 1 - 10 of 461974 matches for " A. Mandegary "
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Effects of arsenic trioxide, all-trans-retinoic acid and dexamethasone on NB4 cell line
A Mandegary,M Mehrabani
DARU : Journal of Pharmaceutical Sciences , 2010,
Abstract: Background and the purpose of the study: Experimental and preclinical observations have indicated that combination therapy with all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) may strongly enhance their therapeutic effects in the treatment of acute promyelocytic leukemia (APL). Whilst dexamethasone (Dex) is routinely used for the control of APL-differentiation syndrome, its effect on the pharmacodynamics of ATO is not clear. Therefore, in this study, effects of therapeutic concentrations of ATO, ATRA and Dex and their sequential usages on the proliferation, differentiation and apoptosis in t(15;17)-positive NB4 cells was investigated. Methods: Cells were treated with therapeutic concentrations of ATO, ATRA and Dex either as single or in combination and cell proliferation was assessed by XTT assay. Expression of CD11b as an indicator of cell differentiation and the percentage of 7-AAD positive cells as a marker of apoptosis were determined by flow cytometry. Results: ATO, but not ATRA and Dex, decreased proliferation of the cells dose-dependently. Pre-treatment of the cells with any of the drugs did not alter the effects of other drugs on the proliferation. Pre-treatments with Dex blocked the apoptotic effect of ATO (1 mM). Conclusion: No improvement or antagonistic effects was observed with the pretreatment/combination of the ATO and ATRA on the differentiation and apoptosis of the cells. It is possible that concomitant usage of Dex with apoptotic doses of ATO in APL patients counteract therapeutic effects of ATO.
Anticonvulsant Effect of Methanolic Extract of Echium amoenum Fisch and C.A. Mey. Against Seizure Induced by Picrotoxin in Mice
M. R. Heidari,A. Mandegary,A. Hosseini,M. Vahedian
Pakistan Journal of Biological Sciences , 2006,
Abstract: The effect of methanolic extract of Echium amoenum Fisch and C.A. Mey. against Picrotoxin induced seizure in mice. The extract with doses of 3.125, 6.25, 12.5 and 25 mg kg-1 were injected intraperitoneally to mice, 20 min before picrotoxin 10 mg kg-1. The latency of seizure, death time and percentage of mortality were measured in animals. The latency of seizure was increased in groups that pretreated with different doses of extract and this effect was only significant at the dose of 6.25 mg kg-1 (p<0.05). Meanwhile, this dose delayed the death time and decreased the percentage of mortality significantly (p<0.01), as well. The results of this study revealed the anticonvulsant effect of methanol extract of E. amoenum (FM) and introduced this plant as a good candidate for further studies in the other models of convulsion.
Pharmacokinetic of Arsenic Trioxide in Newly Diagnosed Acute Promyelocytic Leukemia Patients
R. Hosseini,A. Mandegary,K. Alimoghaddam,A. Ghavamzadeh
Journal of Applied Sciences , 2008,
Abstract: The high complete remission rate with arsenic trioxide (ATO) in relapsed Acute Promyelocytic Leukemia (APL) patients has been led to its use in newly diagnosed patients. Twenty newly diagnosed APL patients between January 2006 and 2007 received 2 h intravenous infusion of 10 mg day-1 arsenic trioxide for induction therapy until achieving complete remission. Plasma arsenic concentration was analyzed by graphite furnace atomic absorption method by dilution of plasma with a suitable matrix modifier. The concentration of arsenic in 24 h urine of patients was measured by using a valid standard addition method and a suitable matrix modifier. The Limits of Detection (LOD) were 1.2 and 1.5 μg L-1 for arsenic in plasma and urine, respectively. Pharmacokinetic parameters of 20 patients were as following: Cmax: 43.6 ±19.5 μg L-1, tmax: 2.15±0.7 h, AUC0-24: 683±317 μg h L-1, AUC0-∞: 2027±958 μg h L-1, t1/2: 41±10 h, kel: 0.02±0.01 h-1, Vd: 5.6±3.6 L kg-1 and Cltotal: 0.1±0.05 L kg-1 h-1. During the first day of induction, 1.4±0.2% of administrated arsenic excreted into urine. Renal clearance was 5.1±4.1 mL kg-1 h-1. However, the results showed that the pharmacokinetic of ATO in newly diagnosed APL patients weren`t dependent to the sex of patients.
"Antinociceptive and Anti-inflammatory Activity of the Seed and Root Extracts of Ferula Gummosa Boiss in Mice and Rats "
Ali Mandegary,Mohammad Sayyah,Mahmood Reza Heidari
DARU : Journal of Pharmaceutical Sciences , 2004,
Abstract: Ferula gummosa Boiss (Apiaceae) has been used in Iranian traditional medicine for the relief of stomach pain. In this study, effects of aqueous, methanolic and acetone extracts of the seed and root of this plant in experimental models of acute pain (Tail-flick=TF), chronic pain (Formalin test=FT) and inflammation (Cotton pellet granuloma=CPG) was investigated. The results showed that the highest non-sedative dose of each of these three extracts had no effect in TF. Among the extracts, only the acetone extract of the root could reduce licking and biting time in the late phase of FT, although this effect might be to some extent due to the solvent (Tween 80). None of the extracts had anti-inflammatory effect in CPG. Preliminary phytochemical analysis of methanol and acetone extracts showed presence of terpenoids and alkaloids and small amounts of cardenolids. The results of our study suggest further evaluation of antinociceptive and anti-inflammatory effects of other kinds of extracts in order to determine the best extract with highest efficacy and lowest side effects
Determination of Residual Methylmethacrylate Monomerin Denture Base Resins by Gas Chromatography
Khosrou Abdi,Ali Mandegary,Mohsen Amini,Mozhgan Bagheri
Iranian Journal of Pharmaceutical Research , 2005,
Abstract: Acrylic base resins are widely used in orthopedics and dental surgery. It is generally accepted that due to the incomplete conversion of methyl methacrylate (MMA) monomer to the polymer form during polymerization of the resin, some MMA monomers remain in thehardened material. MMA monomer has been reported to cause abnormalities or lesions in several organs of animals. Study of the literatures showed that there are no perfect and valid methods for analysis of MMA. The aim of this study was to develop a simple and valid method for determination of MMA residual monomer in the denture base resins. We have developed and validated an analytical procedure employing gas chromatography with flame ionization detector (GC-FID), with temperature programming, and a close analogueinternal standard for fast and repeatable analysis of MMA residual monomer contents in denture base polymers. For quantification of monomer, two calibration curves were used by two different methods of solution preparation and they were compared to each other. Theassay was linear over the range of 0.03-0.6 mg/ml MMA with correlation coefficients (r2) of greater than 0.99. Accuracy, intra-day (Error<9.1%) and inter-day (Error<6.6%) , precision (RSD<5.5% and RSD<6.5%, respectively) were in acceptable values over the examined concentration range. Limit of detection (LOD) and limit of Quantification (LOQ) for MMA were 0.01 and 0.02 mg/ml, respectively. In conclusion, the proposed method was a simple and fast assay for MMA residual monomer in denture base resins.
Antioxidant Activity of Iranian Echium amoenum Fisch & C.A. Mey Flower Decoction in Humans: A cross-sectional Before/After Clinical Trial
Akram Ranjbar,Sara Khorami,Mehdi Safarabadi,Amene Shahmoradi,Ali Akbar Malekirad,Katyon Vakilian,Ali Mandegary,Mohammad Abdollahi
Evidence-Based Complementary and Alternative Medicine , 2006, DOI: 10.1093/ecam/nel031
Abstract: Medicinal plants are recognized as sources of natural antioxidants that can protect from biological system oxidative stress. The present cross-sectional before/after clinical trial was carried out to investigate the antioxidant properties of the decoction of the flowers of Echium amoenum Fisch & C.A. Mey in humans. A group of 38 healthy subjects was invited to use the E. amoenum (7 mg kg−1) twice daily for 14 days. Blood samples before and after entering the study were measured for lipid peroxidation level (LPO), total antioxidant capacity (TAC) and total thiol (SH) molecules. A significant reduction of blood LPO (24.65 ± 11.3 versus 19.05 ± 9.7, P = 0.029) was observed after 14 days of E. amoenum consumption. Blood TAC (1.46 ± 0.51 versus 1.70 ± 0.36, P = 0.018) and total thiol molecules (0.49 ± 0.11 versus 0.56 ± 0.12, P = 0.001) increased after 14 days of E. amoenum consumption. In conclusion, this antioxidative stress potential of E. amoenum may be due to its bioactive antioxidant components, especially rosmarinic acid and flavonoids. In recent years the importance of oxidative stress in the pathophysiology of many human disorders has been confirmed, thus use of this plant as a dietary supplement is highly recommended.
The Spread of Infectious Disease on Network Using Neutrosophic Algebraic Structure  [PDF]
A. Zubairu, A. A. Ibrahim
Open Journal of Discrete Mathematics (OJDM) , 2017, DOI: 10.4236/ojdm.2017.72009
Abstract: Network theory and its associated techniques has tremendous impact in various discipline and research, from computer, engineering, architecture, humanities, social science to system biology. However in recent years epidemiology can be said to utilizes these potentials of network theory more than any other discipline. Graph which has been considered as the processor in network theory has a close relationship with epidemiology that dated as far back as early 1900 [1]. This is because the earliest models of infectious disease transfer were in a form of compartment which defines a graph even though adequate knowledge of mathematical computation and mechanistic behavior is scarce. This paper introduces a new type of disease propagation on network utilizing the potentials of neutrosophic algebraic group structures and graph theory.
A Comparative Investigation of Lead Sulfate and Lead Oxide Sulfate Study of Morphology and Thermal Decomposition  [PDF]
S. A. A. Sajadi
American Journal of Analytical Chemistry (AJAC) , 2011, DOI: 10.4236/ajac.2011.22024
Abstract: The compound lead oxide sulfate PbSO4.PbO was prepared in our laboratory. The Thermal behavior of PbSO4 was studied using techniques of Thermogravimetry under air atmosphere from 25 to 1200°C. The identity of both compounds was confirmed by XRD technique. Results obtained using both techniques support same decomposition stages for this compound. The electron microscopic investigations are made by SEM and TEM. The compound is characterized by XRD and the purity was determined by analytical Methods. Also a series of thermogravimetric analysis is made and the ideal condition is determined to convert this compound to pure lead oxide.
Metal ion-binding properties of L-glutamic acid and L-aspartic acid, a comparative investigation  [PDF]
S. A. A. Sajadi
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.22013
Abstract: A comparative research has been developed for acidity and stability constants of M(Glu)1, M(Asp)2 and M(Ttr)3 complexes, which have been determined by potentiometric pH titration. Depending on metal ion-binding properties, vital differences in building complex were observed. The present study indicates that in M(Ttr) com-plexes, metal ions are arranged to the carboxyl groups, but in M(Glu) and M(Asp), some metal ions are able to build chelate over amine groups. The results mentioned-above demonstrate that for some M(Glu) and M(Asp) complexes, the stability constants are also largely determined by the affinity of metal ions for amine group. This leads to a kind of selectivity of metal ions, and transfers them through building complexes accompanied with glutamate and aspartate. For heavy metal ions, this building complex helps the absorption and filtration of the blood plasma, and consequently, the excursion of heavy metal ions takes place. This is an important method in micro-dialysis. In this study the different as-pects of stabilization of metal ion complexes regarding to Irving-Williams sequence have been investigated.
Determining the Basaltic Sequence Using Seismic Reflection and Resistivity Methods  [PDF]
A. Alanezi, A. Qadrouh
Open Journal of Geology (OJG) , 2013, DOI: 10.4236/ojg.2013.32B004

This study was carried out in Harat Rahat (south of Almadinah Almonwarah) using seismic reflection and resistivity methods. The main objectives of this study are to determine the extent of the basaltic layer and to define the subsurface faults and fractures that could affect and control the groundwater movement in the study area. A 2D seismic profile was acquired and the result shows that the subsurface in the study area has a major fault. We obtained a well match when the seismic result was compared with drilled wells. As a complementary tool, the resistivity method was applied in order to detect the groundwater level. The results of the resistivity method showed that six distinct layers have been identified. The interpretation of these six layers show that the first three layers, the fourth layer, the fifth layer and the bottom of the section indicated various subsurface structures and lithologies; various basaltic layers, fractured basalt, weathered basement and fresh basaltic layers, respectively. It is obvious that the eventual success of geophysical surveys depend on the combination with other subsurface data sources in order to produce accurate maps.

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