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Chronic folliculitis in Sri Lanka
Kumarasinghe S,Kumarasinghe M
Indian Journal of Dermatology, Venereology and Leprology , 1996,
Abstract: Chronic folliculitis (CF) is a chronic infection of hair follicles leading to atrophy and loss of the affected hairs. This study was done on 51 patients with CF presenting at the Dermatology Clinic at General Hospital Matara, Sri Lanka, to identify specific clinical features and aetiological factors, and to study histopathology. Pus cultures were done on 25 cases. Biopsies were done on 6 patients. CF was commoner in males (59%); 76% were under 34 years, and 39% had occupational exposure to possible irritants. Thirty five precent admitted of scrubbing legs with rough objects. Ichthyosis vulgaris was evident in 47%. All pus cultures revealed Staphylococcus aureus. Clinical features and histopathological features were similar to those described by Harman (1968). Rough scrubbing, ichthyosis and occupational exposure to irritants may be aetiologically relevant.
Predictors of Diabetic Foot and Leg Ulcers in a Developing Country with a Rapid Increase in the Prevalence of Diabetes Mellitus
Kumarasinghe A. Sriyani, Sudharshani Wasalathanthri, Priyadharshika Hettiarachchi, Shamini Prathapan
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0080856
Abstract: Objective To identify the socio demographic, life style and foot examination related predictors of diabetic foot and leg ulcers with a view to develop a screening tool appropriate for the use in an outpatient setting. Research design and methods This cross sectional study included type 2 diabetes mellitus (DM) patients; 88 subjects with leg and foot ulcers and 80 non ulcer controls. Socio demographic data and life style factors were documented. Foot was examined for skin changes and structural abnormalities. Distal peripheral neuropathy was assessed by pressure sense, vibration sense and joint position sense. Multivariate analysis by logistic regression was used to determine the significant predictors in screening for foot ulcers. Results Education of grade 6 and below (OR - 1.41, 95% CI; 1.03 - 4.68), low income (OR - 23.3, 95% CI; 1.5 - 34.0), impaired vibration sense (OR - 24.79, 95% CI; 9.3 - 66.2), abnormal monofilament test on first (OR - 1.69, 95% CI; 1.36 - 16.6), third (OR - 3.4, 95% CI; 1.1 - 10.6) and fifth (OR - 1.8, 95% CI; 1.61- 12.6) toes are found to be predictors of increased risk whereas incidental diagnosis of DM (OR - 0.03, 95% CI; 0.003 - 0.28), wearing covered shoes (OR - 0.003, 95% CI; 0.00 - 0.28), presence of normal skin color (OR - 0.01, 95% CI; 0.001 - 0.14) and normal monofilament test on first metatarsal head (OR - 0.10, 95% CI; 0.00 - 0.67) are protective factors for ulcers. Conclusions Ten independent risk and protective factors identified in this study are proposed as a simple screening tool to predict the risk of developing leg and foot ulcers in patients with DM.
The Role and Perceptions of Middle Managers and Their Influence on Business Performance: The Case of Sri Lanka
Sriya Kumarasinghe,Yasuo Hoshino
International Business Research , 2010, DOI: 10.5539/ibr.v3n4p3
Abstract: This paper investigates the role and perceptions of middle managers and how they influence business performance in Sri Lankan companies. The study presented here is based on a questionnaire survey of 121 middle managers regarding issues of communication, group decision making, and organizational leadership. Quantitative analysis of the responses suggests that organizations with collectivistic leaders achieve better performance. As a result, it is argued that collectivism, which includes middle management, can positively contribute to Sri Lanka’s business development and economic recovery.
Entry Mode Strategies and Performance of Japanese MNCs in Australia and New Zealand: the Role of Japanese Employees
Sriyalatha Kumarasinghe,Yasuo Hoshino
Asian Journal of Finance & Accounting , 2009, DOI: 10.5296/ajfa.v1i1.92
Abstract: This study investigates different entry modes and staffing practices, and their influence on performance in Japanese subsidiaries in Australia and New Zealand. Data from 275 Japanese subsidiaries were derived from the Toyo Keizai data bank of Japanese overseas investments (Kaigai Shinshutsu Kigyou Souran) for the period from 2003 to 2008. The major assumption of this paper is that Japanese multinational corporations (MNCs) use their staffing policies as a means of exerting more influence on performance combined with other factors such as experience, industry, and the type of ownership. The study reveals that within the sample Japanese subsidiaries in Australia have a higher percentage of high performance companies than in New Zealand. The existence of Japanese employees, ownership and industry are shown as predictors of performance. Keywords: Japanese multinational corporations, ownership, performance, staffing policies, Australia, New Zealand JEL Classifications: G320, G340
A HRM Real-Time PCR Assay for Rapid and Specific Identification of the Emerging Pest Spotted-Wing Drosophila (Drosophila suzukii)
Manpreet K. Dhami, Lalith Kumarasinghe
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0098934
Abstract: Spotted wing drosophila (Drosophila suzukii) is an emerging pest that began spreading in 2008 and its distribution now includes 13 countries across two continents. Countries where it is established have reported significant economic losses of fresh produce, such as cherries due to this species of fly. At larval stages, it is impossible to identify due to its striking similarities with other cosmopolitan and harmless drosophilids. Molecular methods allow identification but the current technique of DNA barcoding is time consuming. We developed and validated a rapid, highly sensitive and specific assay based on real-time PCR and high resolution melt (HRM) analysis using EvaGreen DNA intercalating dye chemistry. Performance characteristics of this qualitative assay, validation and applicability in a New Zealand quarantine framework are discussed. Application of this robust and independently validated assay across the spectrum of key food production and border protection industries will allow us to reduce the further spread of this damaging species worldwide.
An attempt to reduce impacts of limestone quarries through biodiversity assessment and translocation: A case study at the Holcim Limestone Quarry Site in Puttalam, Sri Lanka
A. Kumarasinghe,W.A.A.D.G. Pradeep,P.I.K. Peabotuwage,R.G.A.T.S. Wickramaarachchi
Asian Journal of Conservation Biology , 2013,
Abstract: A conservation project was implemented at a commercial limestone quarry site in Sri Lanka managed by Holcim Lanka (Pvt.) Ltd. The project intended to assess the biodiversity of a proposed excavation site and to translocate fauna that will be affected by quarry operations such as forest clearance and blasting. The biodiversity of the area was surveyed using a rapid assessment technique, prior to the initiation of forest clearance and blasting. A total of 41 floral species and 220 faunal species were recorded from the project site. Around 90 % of the fauna were amphibians, reptiles and butterflies. Among these species, one endemic tree, a theraposid spider and 20 endemic vertebrates. Among the vertebrates documented, 9 species are categorized as nationally threatened. A total of 141 vertebrates and 85 arthropods and mollusks including endemics threatened species were captured and translocated to Sethtavilluwa area. This project is the first ever initiative in Sri Lanka aimed at reducing impacts of quarry operation on biota through rehabilitation and rescue operations. Such projects are invaluable as they will, at least in part assist in safeguarding biota that will be vulnerable to local extinction as a result of developmental projects.
Comparative Economic Performance and Stock Market Performance: Some Evidence from the Asia-Pacific Region
Sayeeda Bano,Sriya Kumarasinghe,Yih Pin Tang
Asian Journal of Finance & Accounting , 2011, DOI: 10.5296/ajfa.v3i1.716
Abstract: This study looks at interdisciplinary research in the fields of economics, finance and socioeconomic relations addressing the question whether the ranking of countries by major economic, social, and financial performance indicators provide any guide to the rate and pattern of growth and development in the Asia-Pacific region. The paper also examines the extent of balanced and sustained growth in selected 14 Asia-Pacific countries. It analyses data on MSCI returns, GDP growth, and HDI to rank and correlate the overall performance of each country during the 1993-2009 period. Gini Index and CPI are also included to provide added insights. The results show that developing countries like India, Indonesia, Pakistan, and Sri Lanka are at the top on most of the financial and economic indicators, while Japan is the lowest except on HDI, where the bottom rankings goes to India, Indonesia and Pakistan. Overall, the results indicate no significant relationships between a country’s stock market returns and its GDP growth. Nonetheless, the results suggest that for balanced and sustainable well-being, economic growth in the less-developed countries need to be matched by concomitant improvements in social welfare, income distribution, transparency and accountability.
1-(4-Methoxyphenyl)-3-phenyl-1H-pyrazol-5-amine
Isuru R. Kumarasinghe,Victor J. Hruby,Gary S. Nichol
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809015463
Abstract: The synthesis of the title compound, C16H15N3O, is regiospecific and single-crystal X-ray diffraction provides the only means of unambiguous structural analysis, with the benzene ring bonded to the imine C atom. The phenyl ring and the essentially planar (r.m.s. deviation 0.0354 ) methoxybenzene group are rotated by 29.41 (5) and 37.01 (5)°, respectively, from the central pyrazole ring. An intermolecular N—H...N hydrogen bond links symmetry-related molecules into a C(5) chain, which runs parallel to the b axis.
Larvicidal efficacy of essential oil of betel leaf ( Piper betle ) on the larvae of the old World screwworm fly, Chrysomya bezziana in vitro
Wardhana April,Kumarasinghe Sujith Prasad,Arawwawala LDAM,Arambewela Lakshmi
Indian Journal of Dermatology , 2007,
Abstract: Larvae of Chrysomya bezziana are the commonest cause of wound myiasis in some parts of the world. This obligatory parasite is important in humans and in commercial livestock. Kumarasinghe et al have reported that essential oil of betel leaf (EOBL) is larvicidal to C. megacephala but there are no publications on its effect on C. bezziana . This study was done to evaluate the efficacy of essential oil of betel leaf ( Piper betle ) against the larvae of C. bezziana in vitro . EOBL was prepared at the Industrial Technology Institute Colombo, Sri Lanka, according to a standard protocol. The experiment on larvae was carried out at the Research Institute for Veterinary Sciences in Bogor, Indonesia. EOBL concentrations of 2%, 3% and 4% were prepared with Tween 80. Two ml of 4%, 3% and 2% EOBL in 1% Tween 80 (v/v/aq) were poured into separate Petri dishes. Ten 1st and 2nd instar larvae were placed in each Petri dish. Asuntol (Chaumaphos) 1% was used as positive control and distilled water with 1% tween 80 was the negative control. Larval mortality was assessed half-hourly. The experiment was repeated five times and averages were compared. Sustained immobility of the larvae, after exposure to the relevant substances was considered as death. The efficacy of EOBL depended on, the stages of C. bezziana larvae and the concentration. With 4% EOBL, all first instar larvae were killed within two hours and the second instar larvae were killed by four hours. The positive control showed no mortality until four hours but all larvae were weak, from the first 30 minutes. In the negative control, larvae were mobile and active. EOBL 3% killed all the first instar larvae by 150 minutes and 74% of the second instar at four hours. By 210 minutes, 2% preparation had killed 100% of the first instars. EOBL is an effective larvicidal for C. bezziana first and second instar larvae in vitro . This natural product has a great potential to be developed as a novel larvicide against this parasite.
Primary Graft Failure after Heart Transplantation
Arjun Iyer,Gayathri Kumarasinghe,Mark Hicks,Alasdair Watson,Ling Gao,Aoife Doyle,Anne Keogh,Eugene Kotlyar,Christopher Hayward,Kumud Dhital,Emily Granger,Paul Jansz,Roger Pye,Phillip Spratt,Peter Simon Macdonald
Journal of Transplantation , 2011, DOI: 10.1155/2011/175768
Abstract: Primary graft failure (PGF) is a devastating complication that occurs in the immediate postoperative period following heart transplantation. It manifests as severe ventricular dysfunction of the donor graft and carries significant mortality and morbidity. In the last decade, advances in pharmacological treatment and mechanical circulatory support have improved the outlook for heart transplant recipients who develop this complication. Despite these advances in treatment, PGF is still the leading cause of death in the first 30 days after transplantation. In today's climate of significant organ shortages and growing waiting lists, transplant units worldwide have increasingly utilised “marginal donors” to try and bridge the gap between “supply and demand.” One of the costs of this strategy has been an increased incidence of PGF. As the threat of PGF increases, the challenges of predicting and preventing its occurrence, as well as the identification of more effective treatment modalities, are vital areas of active research and development.
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