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PHYTOCHEMICAL EVALUATION & ANTIMICROBIAL EFFICIENCY OF THREATENED MEDICINAL PLANT OF ANDHRA PRADESH PTEROSPERMUM XYLOCARPUM (THADA TREE)
K. Narendra,K. M. Sowjanya,J. Swathi,A. Krishna Satya
International Research Journal of Pharmacy , 2013,
Abstract: Pterospermum. Xylocarpum (Family: Sterculiaceae) is a wild medicinal plant distributed throughout India and south East Asia. It is used against treatment of joint diseases like gout, rheumatism, arthritis. In present study acetone, hexane, chloroform and methanol extracts were prepared from the leaf of P.xylocarpum and phytochemical analysis was done to screen alkaloids, steroids, saponins, tri terpinoidal saponins, carbohydrates, flavonoids, polyphenols, tannins and glycosides. Antimicrobial activity was tested against nine bacterial and nine fungal species. Among the four extracts methanol and acetone extracts showed significant anti bacterial activity and there is no significant activity against fungal strains and it was found to be effective against two tested bacterial species viz, xanthomonas campestis and E.Coli. Methanol crude extract was prepared by the cold maceration process and it was optimized for the yield, the crude extract was tested for anti bacterial activity at different concentrations viz, 250,500,1000mg/ml among them 500mg/ml concentration has shown significant antibacterial activity and in the methanol crude extract the phytochemical analysis showed the presence of alkaloids, steroids, phenols and cardiac glycosides.
Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum
Awasthi, Gauri;Satya, Godavarthi Bhogendra Krishna;Das, Aparup;
Memórias do Instituto Oswaldo Cruz , 2012, DOI: 10.1590/S0074-02762012000100018
Abstract: mutations in the pfcrt gene that change the resulting amino acids and form different haplotypes are common and correlate with the prevalence of chloroquine resistant (cqr) field isolates of the malaria parasite, plasmodium falciparum. this correlation provides opportunities to infer the global evolutionary history of cq resistance by analysing cqr pfcrt haplotype data. we collated data on the pfcrt haplotypes from different global studies and performed evolutionary genetic analysis to present comprehensive and comparative information on the global distribution of five major cqr-pfcrt haplotypes and evolutionary inter-relationships among 38 different countries. using the haplotype diversity data, inter-continental genetic differentiation was also ascertained.
SPC for Software Reliability-Imperfect Software Debugging Model
R Satya Prasad,N Supriya,G Krishna Mohan
International Journal of Computer Science Issues , 2011,
Abstract: Software reliability process can be monitored efficiently by using Statistical Process Control (SPC). It assists the software development team to identify failures and actions to be taken during software failure process and hence, assures better software reliability. In this paper, we consider a software reliability growth model of Non-Homogenous Poisson Process (NHPP) based, that incorporates imperfect debugging problem. The proposed model utilizes the failure data collected from software development projects to analyze the software reliability. The maximum likelihood approach is derived to estimate the unknown point estimators of the model. We investigate the model and demonstrate its applicability in the software reliability engineering field.
Pediculosis palpebrarum (le)
Krishna A
Indian Journal of Dermatology, Venereology and Leprology , 1998,
Abstract:
On the Rate of Change of Period for Accelerated Motion and Their Implications in Astrophysics
Rajamohan R.,Satya Narayanan A.
Progress in Physics , 2007,
Abstract: We have derived in this paper, the relationship that needs to be satisfied when length measurements are expressed in two different units. Interesting relationships emerge when the smaller of the two units chosen is a function of time. We relate these results to the expected periodicities in the observed data when a system of objects are revolving around a common center of mass. We fi nd that these results are highly intriguing and can equally well account for some of the major results in the field of astrophysics.
“Unsteady Gait”: An Uncommon Presentation and Course of Malignant Melanoma in Terminal Ileum—A Case Report and Review of Literature
Satya Allaparthi,Khalid A. Alkimawi
Case Reports in Gastrointestinal Medicine , 2013, DOI: 10.1155/2013/958041
Abstract: Malignant melanoma within the gastrointestinal tract is an uncommon neoplasm that is usually metastatic in origin, with primary melanomas being relatively uncommon. Embryologically melanocytes normally exist in the esophagus, stomach, small bowel, and anorectum and this theory supports the primary melanoma of the gastrointestinal tract that has been confirmed for lesions occurring through several published reports. However, most patients with brain metastases from malignant melanoma are diagnosed after treatment for known extracranial metastases and have poor outcomes. Our case is unique in that we discuss an unusual case of 69-year-old female patient presented with unsteady gait as the first symptom of disease and where the presumed primary lesion later was found in the terminal ileum on colonoscopy. Treatment consisted of surgical removal of the terminal ileal lesion with chemotherapy, whole-brain radiotherapy, and cyberknife radiosurgical procedure. Patient was in remission for more than 14 months and later succumbed to disease. Despite the advances in therapeutic options, prognosis for patients with melanoma brain metastases remains poor with a median survival time of six months after diagnosis. 1. Introduction Next to lung cancer, malignant melanoma is the most frequent cause of brain metastasis. In a large series from the Metropolitan Detroit Cancer, the cumulative incidence of melanoma brain metastasis is <10% and usually develop late in the course of the disease [1, 2]. Metastatic spread of tumor cells detached from melanoma into the central nervous system (CNS) occurs haematogenically since lymphatic drainage is absent in the brain. The blood-brain barrier is usually intact in metastases that are smaller than 0.25?mm in diameter because melanoma micrometastases are common in the brain and patients can harbor numerous metastases in the brain without any neurological deficits [3, 4]. Furthermore, while melanoma can present in the brain as the first site of metastasis, it is more common for brain metastasis to present later in the course of disease, most often acting as a harbinger of terminal disease. The course of disease is typically characterized by rapid extra cranial progression and short overall survival time despite various local and systemic treatment approaches. While surgery and radiotherapy interventions can prolong the disease-free interval when solitary, large metastases in the brain are found early in the course of melanoma metastasis; these treatments provide only short-term, but nevertheless important, palliation in patients with
CLUSTER-ID ROUTING SCHEME IN WIRELESS SENSOR NETWORKS
Y.Srinivas,,J.Vijayasekhar,,Dr.R.Satya Prasad,,N.Vamsi Krishna
Indian Journal of Computer Science and Engineering , 2011,
Abstract: One of the major issues in wireless sensor network is developing an energy-efficient routing protocol. Since the sensor nodes have limited available power, energy conservation is a critical issue in wireless sensor network for nodes and network life. There are several existing routing protocols to solve this problem. LEACH (Low-Energy Adaptive Clustering Hierarchy), a clustering-based protocol that utilizes randomized rotation of local cluster base stations (cluster-heads) to evenly distribute the energy load among the sensors in the network. LEACH has a drawback that the cluster is not evenly distributed due to its randomized rotation of local clusterhead.A new routing protocol has been proposed known as CIDRSN (Cluster ID based Routing in Sensor Networks). CIDRSN takes the cluster-ID as next hop address in routing table and eliminate the cluster formationphase and routing phase in each round. Both cluster formation phase and routing phase are only executed during the initialization of network. CIDRSN constructs clusters based on the number of cluster members. The cluster topology in the network is distributed more equally through our cluster constructing. And cluster heads for thenext round will be elected based on the remaining battery level of the nodes. All routes are based on cluster-ID rather than cluster head ID. This reduces the energy consumption and increases network life time.
DETECTION OF RELIABLE SOFTWARE USING SPRT
Dr. R.Satya Prasad,N. Supriya,G.Krishna Mohan
International Journal of Advanced Computer Sciences and Applications , 2011,
Abstract: In Classicy. The procedure adopted for this is, Sequential Probabilital Hypothesis testing volumes of data is to be collected and then the conclusions are drawn which may take more time. But, Sequential Analysis of statistical science could be adopted in order to decide upon the reliable / unreliable of the developed software very quickly Ratio Test (SPRT). In the present paper, we have proposed the performance of SPRT on Time domain data using exponential imperfect debugging model and analyzed the results by applying on 5 data sets. The parameters are estimated by using Maximum Likelihood Estimation.
A Routing-Driven Public-Key Cryptosystem Based Key Management Scheme for a Sensor Network
Satya Venkatesh Kadali#1, O.Srinivasa Rao*2, Dr MHM Krishna Prasad#3
International Journal of Computer Trends and Technology , 2011,
Abstract: In homogeneous sensor networks, many-to-one traffic pattern dominates and hence a sensor may only communicate with a small portion of its neighbors. So, the homogeneous sensor networks have poor performance and scalability. Most existing key management schemes try to establish shared keys for all pairs of neighbor sensors, no matter whether these will communicate with each other or not, and this causes large overhead. This project proposes a novel routing-driven key management scheme, which establishes shared keys only for those neighboring sensors that communicate with each other by using RSA public-key algorithm along with Quantum Key Distribution Protocols (QKDPs). Quantum cryptography easily resists replay and passive attacks. Classical cryptography enables efficient key verification and user authentication. This work integrates the advantages of these two techniques along with QKDPs so that the eavesdroppers can be detected, replay attacks can be easily avoided. This project also proposes how user authentication and session key verification can be done in a single step process at the receiving end.
CHEMICAL MODIFICATION AND CHARACTERIZATION OF PECTIN AS A POTENTIAL DRUG RELEASE RETARDANT
Harika Puppala Satya Krishna,Bharath Srinivasan,Basavaraj Basappa Veerabhadraiah,Deveswaran Rajamanickam
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: The present study deals with the chemical modification of pectin by acetylation of their free hydroxyl groups to yield high ester pectin and to evaluate its solubility and swelling behaviour along with the effect on the release pattern of the drug. Modified pectins were prepared by acetylation process using various strengths of 20%, 40% and 60% v/v acetyl chloride in ethanol. The prepared modified pectins were subjected to various physico-chemical characteristics like solubility, gelling studies, acid value, saponification value and ester value. FTIR studies were carried out to confirm the chemical modification of pectin. Matrix tablets of tramadol were formulated using various strengths of modified pectins in different concentrations and its impact on drug release was studied. All the formulated batches were subjected to weight variation, hardness, friability, drug content and the values obtained were within the acceptable range. The in-vitro drug release characteristics from the formulated tablets were compared with commercial sustained release tablet of tramadol. The optimized tablet formulation F4 sustained the drug release over a period of 8hours as comparable to the marketed product. Thus the synthesized modified pectin proved to be an ideal drug release retarding polymer.
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