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Search Results: 1 - 10 of 654163 matches for " A. J. McCafferty "
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Integrable operators and squares of Hankel Matrices
A. J. McCafferty
Mathematics , 2007,
Abstract: In this note, we find sufficient conditions for an operator with kernel of the form $A(x)B(y)-A(x)B(y)/(x-y)$ (which we call a Tracy-Widom type operator) to be the square of a Hankel operator. We consider two contexts: infinite matrices on $\ell^2$, and integral operators on the Hardy space $H^2(\mathbb{T})$. The results can be applied to the discrete Bessel kernel, which is significant in random matrix theory.
Discrete Tracy-Widom Operators
G. Blower,A. J. McCafferty
Mathematics , 2008,
Abstract: Integrable operators arise in random matrix theory, where they describe the asymptotic eigenvalue distribution of large self-adjoint random matrices from the generalized unitary ensembles. This paper considers discrete Tracy-Widom operators, and gives sufficient conditions for a discrete integrable operator to be the square of a Hankel matrix. Examples include the discrete Bessel kernel and kernels arising from the almost Mathieu equation and the Fourier transform of Mathieu's equation.
Insecta, Ephemeroptera: range extensions and new Alabama state records
McCafferty, W. P.,Webb, J. M.
Check List , 2006,
Insecta, Ephemeroptera: range extensions and new Iowa state records
McCafferty,W. P., T. Hubbard,J. M. Webb
Check List , 2006,
Citizens and Tribesmen: Two "Nations" in the Siege Narrative of Ulster Unionist rhetoric
Kevin McCafferty
Nordlit : Tidsskrift i litteratur og kultur , 1999,
Citizens and Tribesmen: Two "Nations" in the Siege Narrative of Ulster Unionist rhetoric
Kevin McCafferty
Nordlit : Tidsskrift i litteratur og kultur , 1999,
Private Heat for Public Warmth: How Huddling Shapes Individual Thermogenic Responses of Rabbit Pups
Caroline Gilbert, Dominic J. McCafferty, Sylvain Giroud, André Ancel, Stéphane Blanc
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033553
Abstract: Background Within their litter, young altricial mammals compete for energy (constraining growth and survival) but cooperate for warmth. The aim of this study was to examine the mechanisms by which huddling in altricial infants influences individual heat production and loss, while providing public warmth. Although considered as a textbook example, it is surprising to note that physiological mechanisms underlying huddling are still not fully characterised. Methodology/Principal Findings The brown adipose tissue (BAT) contribution to energy output was assessed as a function of the ability of rabbit (Oryctolagus cuniculus) pups to huddle (placed in groups of 6 and 2, or isolated) and of their thermoregulatory capacities (non-insulated before 5 days old and insulated at ca. 10 days old). BAT contribution of pups exposed to cold was examined by combining techniques of infrared thermography (surface temperature), indirect calorimetry (total energy expenditure, TEE) and telemetry (body temperature). Through local heating, the huddle provided each pup whatever their age with an ambient “public warmth” in the cold, which particularly benefited non-insulated pups. Huddling allowed pups facing a progressive cold challenge to buffer the decreasing ambient temperature by delaying the activation of their thermogenic response, especially when fur-insulated. In this way, huddling permitted pups to effectively shift from a non-insulated to a pseudo-insulated thermal state while continuously allocating energy to growth. The high correlation between TEE and the difference in surface temperatures between BAT and back areas of the body reveals that energy loss for non-shivering thermogenesis is the major factor constraining the amount of energy allocated to growth in non-insulated altricial pups. Conclusions/Significance By providing public warmth with minimal individual costs at a stage of life when pups are the most vulnerable, huddling buffers cold challenges and ensures a constant allocation of energy to growth by reducing BAT activation.
Production of soluble mammalian proteins in Escherichia coli: identification of protein features that correlate with successful expression
Michael R Dyson, S Paul Shadbolt, Karen J Vincent, Rajika L Perera, John McCafferty
BMC Biotechnology , 2004, DOI: 10.1186/1472-6750-4-32
Abstract: Several protein features correlated with soluble protein expression yield including molecular weight and the number of contiguous hydrophobic residues and low complexity regions. There was no relationship between successful expression and protein pI, grand average of hydropathicity (GRAVY), or sub-cellular location. Only small globular cytoplasmic proteins with an average molecular weight of 23 kDa did not require a solubility enhancing tag for high level soluble expression. Thioredoxin (Trx) and maltose binding protein (MBP) were the best N-terminal protein fusions to promote soluble expression, but MBP was most effective as a C-terminal fusion. 63 of 95 mammalian proteins expressed at soluble levels of greater than 1 mg/l as N-terminal H10-MBP fusions and those that failed possessed, on average, a higher molecular weight and greater number of contiguous hydrophobic amino acids and low complexity regions.By analysis of the protein features identified here, this study will help predict which mammalian proteins and domains can be successfully expressed in E. coli as soluble product and also which are best targeted for a eukaryotic expression system. In some cases proteins may be truncated to minimise molecular weight and the numbers of contiguous hydrophobic amino acids and low complexity regions to aid soluble expression in E. coli.The production of purified proteins is important for several experimental approaches aimed to assign gene function including antibody generation for immunocytochemistry and immunoprecipitation studies [1-3], in vitro mapping of protein – protein, protein – DNA or protein – RNA interactions [4,5] and structure determination [6]. The availability of proteins is also important for biomedical applications such as small molecule drug discovery and the production of therapeutic proteins and vaccines. In these situations it is essential to be able to reliably express the proteins in a heterologous system and purify them so that they possess the
Insecta, Ephemeroptera: Range extensions and new records for Ontario and Canada
McCafferty, W. P.,Jacobus, L. M.,Webb, J. M.,Meyer, M. D.
Check List , 2008,
Mayflies (Insecta: Ephemeroptera) of Yellowstone National Park, U.S.A.
McCafferty, W. P.
Check List , 2007,
Abstract: The Ephemeroptera (Insecta) fauna ofYellowstone National Park consists of 46 speciesin 24 genera among eight families. These speciesare listed, and fifteen of the species (includingcollection data) are reported for the first time.Another 13 species have been taken adjacent tothe park in Wyoming and Montana and noted asexpected to occur in the park.
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