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Search Results: 1 - 10 of 461732 matches for " A Sasse "
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CD4 count evolution of HIV-infected patients in follow-up as an indicator of quality of care
A Sasse,D Van Beckhoven
Journal of the International AIDS Society , 2012, DOI: 10.7448/ias.15.6.18102
Abstract: Objective: To study the evolution of CD4 count of HIV-infected patients in follow-up as an indicator of quality of care. Methods: Adult patients newly diagnosed with HIV in 2007 who entered in care in the AIDS Reference Centres (ARC) and remained in care for at least one year were studied until end 2009. Optimal CD4 evolution was defined as having a CD4 count above 350 cells/mm3 after 1 year in HIV care, or an increasing rate exceeding 50 cells/mm3 per year, and this regardless of antiviral therapy. The proportion of patients with optimal CD4 evolution was measured and factors associated with outcome were identified by logistic regression. Results: 482 patients were included. Median age was 37 years, 31.1% were females, 51.7% Belgians, 32.2% from Sub-Saharan Africa, 50.5% heterosexual, 48.7% MSM. 59.5% had a CD4 count above 350 at entry in care, 11.2% did not have a regular retention in care (at least 1 consultation/6-month period). 401 (83.2%) patients had an optimal CD4 evolution after 1 year in care. 60.5% of patients with non-optimal evolution had a CD4 count below 350 at entry in care. Although the proportion of female sex, heterosexual transmission, Sub-Saharan nationality and low retention in care was higher in the non-optimal CD4 evolution group compared to the optimal group, none of these characteristics showed a significant association with non-optimal CD4 count evolution. Conclusion: 83.2% of patients had an optimal CD4 evolution after at least 1 year in HIV care. This indicator, analysed together with indicators of entry and retention in care, could contribute to a better monitoring of the HIV epidemic and to identify more precisely the steps in care system that could be improved. These indicators should be fully integrated in HIV surveillance.
Induced Cycles in Graphs
Michael A. Henning,Felix Joos,Christian L?wenstein,Thomas Sasse
Mathematics , 2014,
Abstract: The maximum cardinality of an induced $2$-regular subgraph of a graph $G$ is denoted by $c_{\rm ind}(G)$. We prove that if $G$ is an $r$-regular graph of order $n$, then $c_{\rm ind}(G) \geq \frac{n}{2(r-1)} + \frac{1}{(r-1)(r-2)}$ and we prove that if $G$ is a cubic claw-free graph on order $n$, then $c_{\rm ind}(G) > 13n/20$ and this bound is asymptotically best possible.
Locating-dominating sets in twin-free graphs
Florent Foucaud,Michael A. Henning,Christian L?wenstein,Thomas Sasse
Mathematics , 2014,
Abstract: A locating-dominating set of a graph $G$ is a dominating set $D$ of $G$ with the additional property that every two distinct vertices outside $D$ have distinct neighbors in $D$; that is, for distinct vertices $u$ and $v$ outside $D$, $N(u) \cap D \ne N(v) \cap D$ where $N(u)$ denotes the open neighborhood of $u$. A graph is twin-free if every two distinct vertices have distinct open and closed neighborhoods. The location-domination number of $G$, denoted $\gamma_L(G)$, is the minimum cardinality of a locating-dominating set in $G$. It is conjectured [D. Garijo, A. Gonz\'alez and A. M\'arquez. The difference between the metric dimension and the determining number of a graph. Applied Mathematics and Computation 249 (2014), 487--501] that if $G$ is a twin-free graph of order $n$ without isolated vertices, then $\gamma_L(G)\le \frac{n}{2}$. We prove the general bound $\gamma_L(G)\le \frac{2n}{3}$, slightly improving over the $\lfloor\frac{2n}{3}\rfloor+1$ bound of Garijo et al. We then provide constructions of graphs reaching the $\frac{n}{2}$ bound, showing that if the conjecture is true, the family of extremal graphs is a very rich one. Moreover, we characterize the trees $G$ that are extremal for this bound. We finally prove the conjecture for split graphs and co-bipartite graphs.
Gameplay experience in a gaze interaction game
Lennart E. Nacke,Sophie Stellmach,Dennis Sasse,Craig A. Lindley
Computer Science , 2010,
Abstract: Assessing gameplay experience for gaze interaction games is a challenging task. For this study, a gaze interaction Half-Life 2 game modification was created that allowed eye tracking control. The mod was deployed during an experiment at Dreamhack 2007, where participants had to play with gaze navigation and afterwards rate their gameplay experience. The results show low tension and negative affects scores on the gameplay experience questionnaire as well as high positive challenge, immersion and flow ratings. The correlation between spatial presence and immersion for gaze interaction was high and yields further investigation. It is concluded that gameplay experience can be correctly assessed with the methodology presented in this paper.
Estudo de custo-efetividade do anastrozol adjuvante no cancer de mama em mulheres pós-menopausa
Sasse, Andre Deeke;Sasse, Emma Chen;
Revista da Associa??o Médica Brasileira , 2009, DOI: 10.1590/S0104-42302009000500015
Abstract: objectives: carry out an economic analysis of the incorporation of anastrozole as adjuvant hormone therapy in postmenopausal women with breast cancer in a brazilian setting. methods: the cost-effectiveness estimate comparing anastrozole to tamoxifen was made from the perspectives of the patient, private health insurance, and government. a markov model was designed based on data from atac trial after 100 months follow-up in a hypothetical cohort of 1000 postmenopausal women in brazil, using outcomes projections for a 25-year period. resource utilization and associated costs were obtained from preselected sources and specialists' opinions. treatment costs varied according to the perspective used. the incremental benefit was inserted in the model to obtain the cost of quality-adjusted life-year gained (qaly). results: benefit extrapolations for a 25-year time line showed an estimate of 0.29 qaly gained with anastrozole compared to tamoxifen. the cost-effectiveness ratio per qaly gained depended on which perspective was used. there was an increment of r$ 32.403,00/qaly in the public health system/government, r$ 32.230,00/qaly for private health system, and r$ 55.270,00/qaly for patients. conclusion: the benefit from adjuvant anastrozole in postmenopausal patients with breast cancer is associated to major differences in cost-effectiveness ratio and varies with the different perspectives. according to current who parameters, the increment is considered acceptable under public and private health system perspectives, but not from that of the patient.
Monitoring the Monitors: EU Enlargement Conditionality and Minority Protection in the CEECs
James Hughes,Gwendolyn Sasse
Journal on Ethnopolitics and Minority Issues in Europe , 2003,
Abstract: The issue of minority protection is an extreme case for analyzing the problem of linkage between EU membership conditionality and compliance by candidate countries. while EU law is virtually non-existent, EU practice is divergent, and international standards are ambiguous, the issue has been given high rhetorical prominence by the EU during enlargement. The analysis in this article follows a tracking approach to study the relationship of EU conditionality to changes in minority rights protection in the CEECs. The authors examine how the EU's monitoring process has operated, what its benchmarks have been, how the EU process has interacted with those of other international organizations, such as the Council of Europe and OSCE, and evaluate what its impact has been on the candidate countries. In conclusion, the authors find that EU conditionality is not closely temporally correlated with the emergence of new strategies and laws on minority protection in the CEECs. Instead, the EU's main instrument for accession and convergence, the Regular Reports, have been characterized by ad hocism, inconsistency, and a stress on formal measures rather than substantive evaluation of implementation.
Disseminated multiorgan MDR-TB resistant to virtually all first-line drugs
J. Sasse,D. Teichmann
European Respiratory Review , 2009,
Abstract: The emergence of multidrug-resistant tuberculosis (MDR-TB) is a major global concern since, despite a complex treatment regime, it still remains a lethal threat. A 21-yr-old male HIV-negative migrant from Burma presented with a disseminated tuberculosis affecting the lung, spleen, liver, mediastinal and abdominal lymph nodes. This particular strain of Mycobacterium tuberculosis proved to be resistant to all but one (pyrazinamide) of the first-line drugs, i.e. rifampicin, isoniazid and ethambutol, plus streptomycin, rifabutin and ofloxacin. On the mere account of its susceptibility concerning kanamycin it could not be labelled as extensively drug-resistant tuberculosis. After 1 month of a standard first-line four-drug regimen and a subsequent 4 months of second-line treatment with amikacin, moxifloxacin, terizidone, protionamide, linezolid and pyrazinamide, sputum cultures eventually yielded constantly negative results. Likewise, the organ manifestations decreased significantly, so as to be virtually undetectable in computed tomography scans after 1 yr of continuous treatment. A moderate pancytopenia reversed completely after dose adjustment of linezolid. Disseminated tuberculosis manifestations without typical pulmonary cavernous lesions are likely to represent primary infection rather than reactivation. Even a multiorgan disseminated MDR-TB with an extensive resistance pattern (including fluoroquinolones) can be successfully treated with an individual second-line treatment and result in considerably few adverse events.
Tissue-specific regulation of IRS-1 in unilaterally nephrectomized rats
Sasse A.D.,Chen E.,Carvalho C.R.O.,Gontijo J.A.R.
Brazilian Journal of Medical and Biological Research , 1997,
Abstract: Insulin stimulates the tyrosine kinase activity of its receptor, resulting in the phosphorylation of its cytosolic substrate, insulin receptor substrate 1 (IRS-1). IRS-1 is also a substrate for different peptides and growth factors, and a transgenic mouse "knockout" for this protein does not have normal growth. However, the role of IRS-1 in kidney hypertrophy and/or hyperplasia was not investigated. In the present study we investigated IRS-1 protein and tyrosine phosphorylation levels in the remnant kidney after unilateral nephrectomy (UNX) in 6-week-old male Wistar rats. After insulin stimulation the levels of insulin receptor and IRS-1 tyrosine phosphorylation were reduced to 79 ± 5% (P<0.005) and 58 ± 6% (P<0.0001), respectively, of the control (C) levels, in the remnant kidney. It is possible that a circulating factor and/or a local (paracrine) factor playing a role in kidney growth can influence the early steps of insulin action in parallel. To investigate the hypothesis of a circulating factor, we studied the early steps of insulin action in liver and muscle of unilateral nephrectomized rats. There was no change in pp185 tyrosine phosphorylation levels in liver (C 100 ± 12% vs UNX 89 ± 9%, NS) and muscle (C 100 ± 22% vs UNX 91 ± 17%, NS), and also there was no change in IRS-1 phosphorylation levels in both tissues. These data demonstrate that after unilateral nephrectomy there is a decrease in insulin-induced insulin receptor and IRS-1 tyrosine phosphorylation levels in kidney but not in liver and muscle. It will be of interest to investigate which factors, probably paracrine ones, regulate these early steps of insulin action in the contralateral kidney of unilaterally nephrectomized rats.
Contra??o de Lorentz, lei de Gauss e lei de Ampère
Ortiz, Olivia;Sasse, F. D.;
Revista Brasileira de Ensino de Física , 2003, DOI: 10.1590/S1806-11172003000300004
Abstract: we show how to obtain the expression for the lorentz length contraction, using only gauss and ampère laws, assuming no previous knowledge of einstein's theory of special relativity. we also show that this result is consistent with the relativistic transformation of the electric and magnetic fields.
Contra o de Lorentz, lei de Gauss e lei de Ampère
Ortiz Olivia,Sasse F. D.
Revista Brasileira de Ensino de Física , 2003,
Abstract: Mostramos como obter a express o para a contra o de Lorentz dos comprimentos, a partir das leis de Gauss e Ampère, sem qualquer conhecimento da teoria da relatividade especial de Einstein. Mostramos em seguida que tal resultado é consistente com a transforma o relativística dos campos elétrico e magnético.
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